Sermorelin ntsiav tshuajyog ib qho kev npaj qhov ncauj nrog Sermorelin ua nws cov khoom tseem ceeb. Sermorelin yog ib qho kev sib txuas ua ke 29 peptide nrog cov qauv tshuaj zoo ib yam rau cov amino davhlau ya nyob twg 1-29 ntu ntawm cov tshuaj endogenous loj hlob hormone tso tawm (GHRH). Nws qhov hnyav molecular yog 3357.88 thiab nws cov tshuaj formula yog C ₁₄₉ H ₂₄₆ N ₄₄ O ₄₂ S. Raws li ib qho analog ntawm GHRH, Sermorelin txhawb kev tso tawm ntawm kev loj hlob hormone (GH) los ntawm lub anterior pituitary caj pas, kev loj hlob ntawm cov qog nqaij hlav, thiab kev loj hlob ntawm cov qog nqaij hlav. tiv thaiv kev ua haujlwm. Nws qhib lub adenylate cyclase (AC) - cyclic adenosine monophosphate (cAMP) - protein kinase A (PKA) taw qhia txoj hauv kev los ntawm kev khi rau GHRH receptors nyob rau saum npoo ntawm lub hlwb anterior pituitary, txhawb GH gene transcription thiab GH granule tso tawm. Cov txheej txheem no tsis zoo tswj hwm los ntawm somatostatin, ua rau lub cev circadian secretion qauv. Ib txhij, nws tsis ncaj qha tswj hwm kev tiv thaiv kab mob los ntawm GH-IGF-1 axis thiab tuaj yeem ua ncaj qha rau GHRH receptors ntawm lub cev tiv thaiv kab mob (xws li macrophages thiab T lymphocytes) txhawm rau txhim kho lub cev tiv thaiv kab mob. Tsis tas li ntawd, kev sim tsiaj tau pom tias Sermorelin tuaj yeem txhawb txoj kev ciaj sia ntawm hippocampal neurons, txhim kho kev txawj ntse, thiab muaj peev xwm kho tus nqi rau cov kab mob neurodegenerative xws li Alzheimer's disease.
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Sermorelin COA
Sermorelin ntsiav tshuaj ntawm lub plab hnyuv siab raum thiab Vaginal Reflex
Sermorelin ntsiav tshuajyog ib qho kev tsim tawm kev loj hlob hormone tso tawm cov tshuaj hormones (GHRH) analogue, nws cov qauv tshuaj zoo ib yam rau 1-29 fragments ntawm endogenous human GHRH. Raws li cov cuab yeej tseem ceeb rau kev kuaj xyuas kev loj hlob hormone tsis txaus, nws ua rau lub cev muaj zog los ntawm kev txhawb nqa lub caj pas pituitary kom tso tawm cov tshuaj hormones loj hlob (GH). Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias Sermorelin tsis tsuas yog koom nrog hauv kev tswj hwm neuroendocrine, tab sis tseem cuam tshuam rau lub paj hlwb enteric (ENS) thiab vagus paj hlwb reflex los ntawm kev sib txuam neural immune endocrine network.
Kev tswj cov nyhuv ntawm Sermorelin ntsiav tshuaj ntawm txoj hnyuv plab
Cov qauv thiab kev ua haujlwm ntawm cov hnyuv hauv lub paj hlwb
Lub paj hlwb enteric (ENS) yog hu ua 'thib ob lub hlwb', muaj kwv yees li 100 lab neurons uas tsim kev ywj pheej neural networks. ENS tswj kev ua haujlwm ntawm plab hnyuv los ntawm enteric myenteric plexus (uas tswj kev ua haujlwm ntawm plab hnyuv) thiab submucosal plexus (uas tswj kev zais cia thiab nqus), thiab nws cov haujlwm yog tswj hwm los ntawm ob qho tib si hauv nruab nrab paj hlwb (CNS) thiab cov neurotransmitters hauv zos xws li serotonin thiab acetyl.
Qhov cuam tshuam ncaj qha thiab tsis ncaj ntawm Sermorelin ntawm ENS
GH thiab IGF-1 tuaj yeem ua ncaj qha rau ENS neurons los ntawm cov ntshav- lub hlwb thaiv. Kev tshawb fawb tau pom tias GH tuaj yeem txhawb nqa kev muaj sia nyob ntawm neuronal, tsim synaptic, thiab kev tso tawm neurotransmitter, thaum IGF-1 inhibits neuronal apoptosis los ntawm kev ua kom txoj hauv kev PI3K / Akt. Hauv cov qauv tsiaj, GH tsis muaj peev xwm ua rau txo qis ntawm enteric plexus neurons thiab plab hnyuv motility; Tom qab ntxiv Sermorelin, tus naj npawb ntawm cov neurons rov qab los thiab qhov zaus ntawm plab hnyuv peristalsis nce, qhia tias GH-IGF-1 axis muaj kev tiv thaiv ncaj qha rau ENS.
Cov teebmeem tsis ncaj ncees: kev tiv thaiv kev tiv thaiv kab mob thiab kev tswj xyuas neuroinflamation
Sermorelin tswj lub cev tiv thaiv kab mob ua haujlwm los ntawm GH raws txoj hauv kev, cuam tshuam tsis ncaj rau ENS. Piv txwv li:
Macrophage activation: GH tuaj yeem txhim kho macrophage phagocytic muaj nuj nqi, txo cov kab mob hauv plab hnyuv, thiab txo qis hauv zos inflammatory teb.
T cell sib txawv: GH txhawb CD4+T cell sib txawv rau hauv Th1 hom, txhim khu kev tiv thaiv kab mob ntawm tes, thiab inhibits kev ua kom ntau dhau ntawm Th17 hlwb, txo cov plab hnyuv puas.
Cytokine tshuav nyiaj li cas: GH txo qis cov qib ntawm pro- cov kab mob inflammatory xws li TNF - thiab IL-6, upregulates qhov kev qhia ntawm cov tshuaj tiv thaiv kab mob xws li IL-10, thiab tswj cov kab mob hauv plab hnyuv homeostasis.
Nyob rau hauv tus qauv inflammatory plob tsis so tswj kab mob (IBD), Sermorelin muaj peev xwm txo tau qhov chaw ntawm plab hnyuv mucosal ulcers, txo myeloperoxidase (MPO) kev ua, thiab txhim kho plab hnyuv muaj nuj nqi. Nws cov txheej txheem muaj feem cuam tshuam nrog GH kho cov kab mob tiv thaiv kab mob.
Kev tswj cov nyhuv ntawm Sermorelin ntsiav tshuaj ntawm vagus paj hlwb reflex
Anatomical thiab physiological hauv paus ntawm vagus paj hlwb reflex
Cov hlab ntsha vagus yog cov ceg tseem ceeb ntawm lub paj hlwb parasympathetic, thiab nws cov fibers afferent (80%) xa cov kab mob peripheral inflammatory (xws li IL-1 , TNF -) mus rau hauv tib neeg txoj hlab ntsws (NTS), qhib lub hypothalamic pituitary o thiab adrenal axis. Cov fibers efferent (20%) tso tawm acetylcholine (ACh) los ntawm cholinergic anti-inflammatory pathway (CAP), uas ua rau cov macrophage 7 nicotinic acetylcholine receptor (7nAChR) thiab inhibits kev tso tawm ntawm pro-inflammatory yam xws li TNF {ocgu} ntxiv rau cov kab mob qog noj ntshav, txoj kev splenic sympathetic nervous pathway, tsim ib tug multi-theem anti-inflammatory network.
Sermorelin's bidirectional kev cai ntawm vagus reflex
Txhim kho vagus hlab ntsha conduction ntawm cov khoom xa tuaj
Sermorelin ntsiav tshuajupregulates neurotransmitter tso tawm los ntawm vagus paj afferent fibers los ntawm GH nyob rau hauv txoj kev. Piv txwv li:
5-hydroxytryptamine (5-HT) synthesis: GH tuaj yeem txhawb kev tso tawm ntawm 5-HT los ntawm plab hnyuv chromaffin hlwb, uas ua raws li cov hlab ntsha vagus signaling molecule los txhim kho NTS 'kev xaav ntawm cov teeb liab inflammatory.
Neuropeptide Y (NPY) kev qhia: GH txhawb kev qhia ntawm NPY hauv vagus paj hlwb ganglia. NPY indirectly txhim kho vagus hlab ntsha nro los ntawm inhibiting sympathetic paj hlwb kev ua si, tsim ib tug "sympathetic parasympathetic tshuav nyiaj li cas".
Hauv kev sim tsiaj, cov tshuaj tiv thaiv - mob ntawm HPA axis tau txo qis hauv cov nas uas kho nrog Sermorelin tom qab vagotomy, qhia tias Sermorelin tuaj yeem ua kom zoo rau hauv nruab nrab los tiv thaiv - inflammatory teb los ntawm kev txhim kho vagus paj afferent signals.
Ua kom cholinergic los tiv thaiv- txoj kev inflammatory (CAP)
Sermorelin tsis ncaj qha txhim kho CAP kev ua haujlwm los ntawm GH kev tswj hwm kev tiv thaiv kab mob. Piv txwv li:
Macrophage 7nAChR qhia: GH tuaj yeem txhim kho qhov ceev ntawm 7nAChR ntawm qhov chaw ntawm macrophages, txhim kho cov tshuaj tiv thaiv - mob ntawm ACh. Hauv cov qauv sepsis, Sermorelin pretreatment txo cov ntshav TNF - qib, thiab nws cov txiaj ntsig tau muab piv rau cov paj hlwb vagus stimulation (VNS).
T cell acetylcholinesterase (AChE) kev ua: GH inhibits T cell AChE qhia, txo ACh degradation, thiab ncua sij hawm CAP ua haujlwm. Hauv cov qauv autoimmune encephalomyelitis, Sermorelin ua ke nrog VNS tuaj yeem cuam tshuam T cell infiltration thiab alleviate central nervous system o.
Regulating sympathetic nervous txoj kev ntawm tus po
Txawm hais tias muaj kev sib cav txog qhov kev sib txuas ncaj qha ntawm cov hlab ntsha vagus thiab tus po, GH tuaj yeem cuam tshuam ncaj qha rau tus po txoj haujlwm los ntawm txoj hauv qab no:
Norepinephrine (NE) tso tawm: GH txhawb kev tso tawm ntawm NE los ntawm splenic sympathetic paj hlwb xaus, ua rau lymphocyte 2 adrenergic receptors, inducing lymphocyte secretion ntawm ACh, thiab tsim ib tug "sympathetic cholinergic" cascade cov tshuaj tiv thaiv.
Lymphocyte migration: GH txhawb kev qhia ntawm splenic chemokine receptors (xws li CCR7), txhawb nqa lymphocyte tsiv teb tsaws mus rau qhov chaw mob, thiab txhim kho kev tiv thaiv kab mob hauv zos.
Kev siv tshuaj kho mob thiab muaj peev xwm kho tus nqi
Functional Gastrointestinal Diseases (FGIDs)
FGIDs (xws li chim siab plob tsis so tswj syndrome thiab functional dyspepsia) yog ze ze rau ENS dysfunction thiab txo vagal suab. Sermorelin txhim kho cov tsos mob los ntawm cov txheej txheem hauv qab no:
Kev tswj lub plab zom mov: GH tuaj yeem txhim kho cov haujlwm ntawm enteric plexus neurons, txhawb kev sib koom ua ke ntawm plab hnyuv, thiab txo cov tsos mob xws li tsam plab thiab cem quav.
Txo visceral hypersensitivity: GH suppresses excitability ntawm tus txha caj qaum dorsal horn neurons, nce qhov mob, thiab txo qhov mob plab.
Txhim kho kev puas siab puas ntsws: Cov neeg mob nrog FGIDs feem ntau raug kev ntxhov siab thiab kev nyuaj siab. Sermorelin tswj lub hlwb lub plab axis muaj nuj nqi thiab txo cov tsos mob ntawm kev puas siab puas ntsws los ntawm GH mediated 5-HT synthesis.
Inflammatory bowel disease (IBD)
Qhov pib ntawm IBD (xws li Crohn's disease thiab ulcerative colitis) yog txuam nrog kev tiv thaiv kab mob thiab kev ua haujlwm ntawm plab hnyuv. Sermorelin siv cov kev kho mob los ntawm cov hauv qab no:
Inhibition ntawm inflammatory teb: GH downregulates cov theem ntawm pro-inflammatory yam xws li TNF - thiab IL-17, upregulates cov kev qhia ntawm anti-inflammatory yam xws li IL-10, thiab alleviates plab hnyuv mucosal puas.
Txhawb txoj hnyuv mucosal kho: GH activates IGF-1 / Akt txoj kev, txhim kho plab hnyuv epithelial cell proliferation thiab tsiv teb tsaws, thiab accelerates rwj kho.
Kev tswj cov plab hnyuv microbiota: GH tuaj yeem ua rau kom muaj ntau ntawm probiotics (xws li Bifidobacterium thiab Lactobacillus), inhibit pathogen colonization, thiab tswj microbiota tshuav nyiaj li cas.
Postoperative plab hnyuv paralysis (POI)
POI yog ib qho teeb meem tshwm sim tom qab kev phais plab, cuam tshuam nrog cov hlab ntsha hauv plab thiab overactivation ntawm inflammatory teb. Sermorelin shortens POI ntev los ntawm cov txheej txheem hauv qab no:
Txhim kho vagus paj hlwb: GH upregulates 5-HT synthesis nyob rau hauv vagus paj afferent fibers, activates CAP, thiab inhibits kev tso tawm ntawm inflammatory yam.
Txhawb txoj kev rov ua kom lub plab zom mov: GH ncaj qha ua rau cov leeg nqaij plexus, txhim kho plab hnyuv peristalsis, thiab ua kom lub plab zom mov.
Txo cov teeb meem: Sermorelin tuaj yeem txo qhov kev pheej hmoo ntawm POI ntsig txog kab mob, txo lub sijhawm pw hauv tsev kho mob, thiab txo nqi kho mob.
Kev ruaj ntseg thiab kev tshawb fawb yav tom ntej
Kev soj ntsuam kev ruaj ntseg
Tam sim no, cov kev tshawb fawb soj ntsuam tau pom tias qhov tsis zoo tshwm sim ntawmSermorelin ntsiav tshuajFeem ntau yog mob taub hau me ntsis, qhov mob ntawm qhov chaw txhaj tshuaj, thiab cov ntshav qabzib hloov pauv hloov mus ib ntus, tsis muaj cov ntaub ntawv qhia txog cov xwm txheej tsis zoo. Kev siv lub sijhawm ntev yuav tsum tau saib xyuas qhov kev pheej hmoo ntawm acromegaly tshwm sim los ntawm kev tso tawm GH ntau dhau, tab sis qis - noj tshuaj raws sijhawm tuaj yeem zam qhov teeb meem no.
Cov lus qhia kev tshawb fawb yav tom ntej
Cov txheej txheem sib sib zog nqus: Siv ib zaug - xovtooj sib txuas thev naus laus zis los tshuaj xyuas cov teebmeem tshwj xeeb ntawm Sermorelin ntawm ENS neuronal subpopulations thiab qhia meej nws lub hom phiaj molecular rau tswj vagus reflex.
Kev sib xyaw ua ke: Tshawb xyuas cov txiaj ntsig ntawm Sermorelin nrog VNS, probiotics, lossis immunomodulators txhawm rau txhim kho cov phiaj xwm kho mob rau FGIDs thiab IBD.
Cov tshuaj kho tus kheej: Raws li genetic polymorphism (xws li GHRHr genotype), cov koob tshuaj raug tsim los txhim kho kev ua tau zoo thiab txo cov kev tsis zoo.
Cim npe nrov: Sermorelin ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom