Tricllabendazerazoleyog ib qho kev sib tw ntawm benzimidazole, nrog lub npe tshuaj 5 {{{{}} chloro-6- dichlorophenoxy) -2-benzimidazole. Nws cov mis nyuj molecular yog c14h9Cl3n2os thiab nws cov molecular hnyav yog 359.66 g / mol. Cov khoom siv lub cev ntawm nws cov hmoov dawb crystalline txiav txim siab txog nws cov txheej txheem tsim ua kom zoo nkauj ntawm cov hmoov, thiab txhuas ntawv ntim tshuab hluav taws xob tau siv kom tsis txhob muaj lub teeb cia. Raws li tsuas yog tso cai yeeb tshuaj uas tau pom zoo los ntawm kev kho mob ntawm fasciola hepatica, nws txoj kev kho mob hepatica thiab fasciola gigantica, npog ob peb theem ntawm kev kho mob.
Peb Cov Khoom
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Tricllabendazice hmoov | Tricllabendazerazole | Triclabendaze Txhaj |
| Khoom Yam | Hmoov | Phau ntawv | Kev txhaj tshuaj |
| Khoom Siv Purity | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho | Tau sib kho |
| Khoom Pob | Tau sib kho | Tau sib kho | Tau sib kho |
Peb Cov Khoom
Triclabendazole +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
Triclabendazerazole | |
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Cas Tsis tau. |
68786-66-3 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
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Lauj tsis tau. |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2029 |
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Lub tsev |
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| Kuaj Tus Qauv | GB / T24768-2009 kev lag luam. Stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
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Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E. coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib qho chaw sib khi, qhov chaw tsaus thiab qhuav ntawm-20 degrees |
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Tom qab thiab cov Milestones Kev Txhim Kho
Kev txhim kho ntawm Triclosan tau pib xyoo 1980s. Hauv kev teb rau qhov tsis txaus ntseeg ntawm cov tshuaj txau cov pa dej (xws li albendazole) hauv kev kho cov menyuam yaus sab sib txuas los ntawm kev ua kom lub hom phiaj ntawm parasite microrotubule tshuab. Nyob rau hauv 1998, European Union thawj pom zoo ua ntej nws siv nyob rau hauv lub teb ntawm cov kws kho tsiaj; Xyoo 2019, FDA pom zoo nws cov lus qhia rau tib neeg kev siv raws li cov ntaub ntawv muaj kev sim siab, kos tus tsiaj tseem ceeb los ntawm tsiaj rau tib neeg siv rau cov tshuaj.
Ntiaj teb no Epidemiological xav tau
Fascioliasis tau faib rau hauv ntiaj teb, nrog cov cheeb tsam siab nyob rau hauv thaj chaw kub thiab muaj huab cua, thiab tus lej kwv yees ntau tshaj 2.4 lab. Hauv kev tshawb nrhiav kabmob hauv cov tebchaws xws li Nyab Laj, kev sib faib ua feem ntawm cov neeg mob hauv cov mob hnyav tau txog 35%, nrog kev mob siab, thiab siab dua Eosinophils; Cov neeg mob chronic feem ntau tshwm sim nrog cholungitis thiab tus mob. Kev pom zoo ntawm Trichlorothiazide fills qhov sib txawv hauv tib neeg anti fasciola colilic cov neeg mob (ntau dua lossis sib npaug nrog tus nqi kho mob.
Tricllabendazerazoleyog chav kawm ntawm benzimidazole derivative tshuaj, tshwj xeeb hauv kev sib tua ntawm cov kws kho mob ntawm cov schistosomiasis, qhov chaw uas lawv tuav cov chaw kuaj mob Irreplace. kev siv
1.1 kab mob keeb kwm yav dhau los thiab cov kab mob epidemiological
Fascioliasis yog tus kab mob parasitic tshwm sim los ntawm fasciola hepatica thiab ntau tshaj li 2.4 lab tus kab mob thoob ntiaj teb thiab muaj ntau yam li vietnam, Peru, thiab Bolivia. Nws cov kev kis tau yog kev noj haus dej lossis cov nroj tsuag tsis huv nrog cov dej cawv, ua rau mob siab thiab mob siab xws li mob theem ua mob plab thiab mob siab.
1.2 Lub tshuab kho kom zoo thiab zoo ntawm trichlorobakothiazole
Trichhloronazole tiav kev txiav tawm los ntawm ob lub tshuab ob zaug ntawm kev ua:
Tubulin inhibition: khi rau parasite - tubulin, thaiv microoobuy polymerization, thiab ua rau poob ntawm Parasite lub zog. Cov kev sim tau qhia tau hais tias ntawm 10 μ G / ML, kev ua haujlwm ntawm cov neeg muaj peev xwm ntawm cov neeg laus nyob hauv 24 teev nyob hauv 48 teev.
Enzyme system cuam tshuam: tiv thaiv kev tso tawm ntawm hydrolytic kev tiv thaiv los ntawm inset lub cev, cuam tshuam cov zaub mov muaj txiaj ntsig thiab cov khib nyiab pov tseg. Kev soj ntsuam hluav taws xob tsom iav tsom iav qhia tau tias tom qab noj tshuaj, qhov chaw tso quav ntawm inset tau pore zoo li kev puas tsuaj, thiab atpase kev ua puas tsuaj los ntawm 60%.
Nws cov kev ua haujlwm zoo yog qhov tseem ceeb:
Cov Spectral cov tshuaj tua kab mob: Ua kom muaj zog rau ob tus neeg laus thiab muaj kev nkag siab rau cov menyuam yaus uas tsis tau paub txog 90% ntawm cov menyuam hluas.
Kev nyab xeeb zoo tshaj: Cov menyuam yaus (ntau dua lossis sib npaug nrog 6 xyoo) muaj qhov kev ua tau zoo thiab qhov tshwm sim tsawg ntawm cov tsos mob uas tsis tshua muaj tshwm sim).
Cov tshuaj yooj yim: FDA pom zoo regimen yog 10 mg / kg ntawm andally, ob zaug ib hnub twg nrog 12 teev. Cov 250 mg ntsiav tshuaj tuaj yeem muab faib kom raug rau 125 mg ib nrab ntsiav tshuaj kom ua tau raws li cov neeg mob hnyav nrog lub cev hnyav.
1.3 Cov ntaub ntawv pov thawj thiab cov pov thawj ua tau zoo
TSEEM CEEB TOOM: Cov theem III mus sib hais hauv Nyab Laj suav nrog 50 tus neeg mob hauv theem mob. Tom qab 3 lub hlis ntawm district nrog triclosan, fecal lub qe hloov dua siab tshiab tau mus txog 92%, uas tau zoo dua li pawg tswj (76%).
Kev teb kev sib raug zoo: Ntau qhov chaw kawm tau lees tias tus kho tus nqi ntawm 20 MG / KG pab pawg tsuas yog 50%, tsim muaj ntau txoj kev siv tshuaj.
Tshuaj Yeeb Tshuaj Xyuas: Tsis muaj tshuaj {{- Cov nqi tiv taus hauv qee thaj chaw ntawm Peru tau nce mus rau 15%, uas yuav cuam tshuam nrog tus neeg mob tsis txaus lossis muaj tus mob sib kis.
Kev Siv Ntxiv: los ntawm ib tus kab mob rau ntau tus kab mob parasitic
2.1 Kev Kho Mob Sib Txawv
Trichhloronazole kuj tseem ua tau zoo tawm tsam cov cab cab no xws li cov hloov hloov duab, cov niam txiv kab ntxwv, thiab nws lub tshuab muaj xws li:
Cov piam thaj hauv kev cuam tshuam: cuam tshuam nrog lub zog metabolism ntawm cov cab, ua rau tuag.
Neural Conduction Blockade: Cov lus qhia ua rau muaj kev cuam tshuam spasmodic ntawm cov leeg, txhawb nqa cov cua nab.
Piv txwv li, hauv kev tshawb fawb Epidemiological hauv Peru, cov neeg mob uas tau txais tus kab mob ib puag ncig uas tau txais cov tshuaj ntsuab uas tau txais nrog Trichhloronazole tau muaj kev tshem tawm tus nqi ntau dua 90% rau ob qho cab.
2.2 Kev Siv Txuas Txuas Ntxiv hauv Kev Siv Tsiaj
Raws li qhov tsis txaus ntseeg rau tsiaj, Triclosan tau siv dav hauv daim siab ntawm daim siab ntawm daim siab mob hauv ruminant tsiaj xws li nyuj thiab yaj
Pharcaconinetic Zoo: Cov ntshav ntshav siab xav txog 15 μ ml 24- 36 teev tom qab lub sij hawm ntawm li 22 teev. Nws cov xyoob ntoo yog 5-20 lub sij hawm uas ntawm lwm benzimidazole tshuaj.
Kev Siv Tshuaj Siv: Rau cov nyuj, noj ib zaug ntawm 12 mg / kg lub cev hnyav, thiab rau cov yaj, thiab rau ib qho ntawm 10 mg / kg lub cev hnyav. Tus Kho Mob tus nqi tshaj 95%.
Cov Kev Tshawb Nrhiav Kev Taw Qhia: Los ntawm cov kev siv uas twb muaj lawm rau cov ntawv thov tshiab
4.1 Kev tsim kho tshuaj tiv thaiv Network
Tsim kom muaj lub ntiaj teb genomic database ntawm fasciola hepatica thiab taug qab cov khoom siv genome los ntawm tag nrho cov ntaub ntawv pov thawj rau cov tshuaj kho mob. Piv txwv li, kev ua tsis tiav ntawm cov neeg tsis ua haujlwm ntawm qee thaj chaw ntawm Peru qhia txog qhov yuav tsum tau ua rau muaj kev soj ntsuam hauv nroog.
4.2 Kev Txhim Kho ntawm Txoj Kev Kho Mob
Ua ke siv nrog Nitrozotocinide: tuaj yeem ua kom luv rau cov kev kawm ua haujlwm mus rau 1 hnub thiab nce tus nqi kho rau 95%. Nws cov txheej txheem yuav cuam tshuam nrog Nitrozotocinide cuam tshuam txoj kev redox sib npaug ntawm cov cab.
Ua ntu zus nrog Artemnt nrog Artemnet: tuaj yeem txo qhov kev rov muaj dua rau 5%, haum rau cov neeg mob nrog cov kab mob sib xyaw.
4.3 Kev loj hlob ntawm cov qauv tshiab
Nanocrystal Tshuab: Homogenization Kev Kub Siab yog siv los npaj nanosuspensions nrog tsawg dua 200 nm, uas tuaj yeem nce bioavailability los ntawm 2.6 zaug thiab txo cov plab zom mov.
Transdermal patch: Utilizing microneedle array technology for non-invasive drug delivery, animal experiments have shown that the time to reach blood drug concentation standards has been shortened to 30 minutes.
4.4 Kev tshawb nrhiav ntawm anti - cov qog muaj peev xwm
Cov kev tshawb fawb tsis ntev los no tau pom tiasTricllabendazerazole(40 {{- 160 μg messural) tuaj yeem ua rau lub cev nqaij hlav cancer nyuj (MCF}}}}. Nyob rau hauv tus poj niam liab qab hloov cov qauv qog, kev txhaj tshuaj IntraperStendendonal ntawm 20-100 mg / kg pom kev ua haujlwm qog nqaij hlav, muab cov kev taw qhia tshiab rau kev tsim qauv tshuaj theem.
Raws li kev siv yeeb hauv cov tshuaj hauv cov tshuaj ntsuab Hepatica, Triclosan ntsiav tshuaj muaj cov ntawv thov ua mob tseem ceeb Los ntawm koob tshuaj zoo, cov pej xeem kev tswj hwm tshwj xeeb, thiab kev sib xyaw ua ke kho cov tswv yim, nws cov kev kho mob tseem ceeb txuas ntxiv kom tob dua. Yav tom ntej, nrog kev txhim kho ntawm cov tshuaj tiv thaiv kev tswj hwm thiab cov leeg cov khoom lag luam tshiab ntawm cov kab mob partmilt, pab txhawb lub zog tseem ceeb rau kev noj qab haus huv thoob ntiaj teb.
Kev npaj npaj thiab kev tswjhwm zoo
Cov Txheej Txheem Tseem Ceeb
Siv cov celling cellulose tau siv los ua cov nplaum kom tswj tau qhov loj me rau ntawm cov ntsiav tshuaj hauv cov ntsiav tshuaj ntawm cov ntsiav tshuaj hauv cov ntsiav tshuaj
Txheej txheej thev naus laus zis: Siv obadai II soluble zaj duab xis txheej, nce phaus los ntawm 3%, tuaj yeem thaiv kev pom kev zoo thiab txhim kho kev nqos kev ua raws.
Kev kawm ruaj khov: Tom qab kev kuaj ruaj khov ntawm 40℃/ 75% RH rau 6 lub hlis, tag nrho cov nyiaj tau nce ntxiv los ntawm 0.8%, uas ua tau raws li cov kev cai ntawm ich (tsawg dua lossis sib npaug ntawm 2%).
Cov Qauv Txheej Txheem Zoo
Cov Ntsiab Lus Kev Txiav Txim: HPLC cov qauv siv, nrog cov dej acetonitrile (60:40) raws li cov khoom siv mobile ntawm 255.0% -105.0% ntawm tus nqi.
Hais txog cov tshuaj: ib qho kev cuam tshuam ib qho tsis pub dhau 1.0%, tag nrho cov impurities yuav tsum tsis pub tshaj 3.0%, nrog rau kev tsom mus rau Sulfoxide metaboles (tsis pub dhau 0.5%).
Tus lej kawg: Raws li qhov xwm txheej ntawm 50 RPM siv lub duav,TricllabendazerazoleKev sib cais yuav tsum tsis pub tsawg tshaj 85% tsis pub dhau 30 feeb.
Cim npe nrov: Tricllabendazerazole ntsiav tshuaj, lwm tus neeg, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag