Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm ethyl (3r) -piperidine-3-carboxylate cas 25137-01-3 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale zoo ethyl (3r)-piperidine-3-carboxylate cas 25137-01-3 rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Tshaj tawm
Peb tsis muab txhua yam tshuaj ntawm piperidine series, txawm tias muaj peev xwm tau txais piperidine los yog piperidone chemicals!
Txawm yuav txwv los tsis tau! Peb tsis muab!
Yog hais tias nws yog nyob rau hauv peb lub webiste, nws tsuas yog mus xyuas cov ntaub ntawv ntawm cov tshuaj compound.
Peb Hlis . 25th 2025
Ethyl (3R) -piperidine-3-carboxylateyog ib qho organic compound nrog lub cev thiab tshuaj lom neeg thiab cov ntaub ntawv kev nyab xeeb, thiab nws lub npe tshuaj yog 3-ethylpiperidine-3-carboxylate ethyl ester. Cov tsos mob yog lub teeb daj ua kua. Nws tuaj yeem ua haujlwm nruab nrab lossis siv los npaj lwm yam tshuaj thiab tshuaj, thiab tej zaum yuav muaj peev xwm siv tau rau hauv tshuaj synthesis thiab lwm yam haujlwm.
Cov ntaub ntawv ntxiv ntawm chemical compound:
|
Tshuaj Formula |
C8H15NO2 |
|
Exact Mass |
157.11 |
|
Molecular Luj |
157.21 |
|
m/z |
157.11 (100.0%), 158.11 (8.7%) |
|
Elemental Analysis |
C, 61.12; H, 9.62; N, 8.91; O, 20.35 |
|
Boiling point |
110℃/ 20mmHg |
|
Qhov ntom |
1,02 g / cm3 |
|
|
|
Organic synthesis intermediates
Ethyl (3R) -piperidine-3-carboxylate, raws li ib qho organic compound, yuav yog siv los ua ib qho nruab nrab hauv cov organic synthesis. Nws tuaj yeem hloov mus rau lwm cov tebchaw nrog cov haujlwm tshwj xeeb los ntawm cov tshuaj tiv thaiv kab mob kom tau raws li cov ntawv thov tshwj xeeb.
Kev Txhim Kho Tshuaj
Hauv kev tshawb nrhiav tshuaj thiab kev tsim tshuaj, (R)-3-piperidinecarboxylic acid ethyl ester tuaj yeem ua rau muaj peev xwm ua haujlwm tshuaj thiab tuaj yeem ua tus tseem ceeb chiral precursor rau complex tshuaj synthesis. Txawm li cas los xij, nws yuav tsum tau muab sau tseg kom meej tias qhov sib xyaw no tsis yog tsim los ncaj qha lossis siv los ua cov tshuaj tiav, tab sis ua raws li cov cuab yeej siv tshuaj tseem ceeb thiab cov khoom siv hluavtaws hauv kev tshawb fawb thiab kev tsim kho thaum ntxov.
Kev tshawb fawb tshuaj
Hauv kev tshawb fawb tshuaj, (R) -3-piperidinecarboxylic acid ethyl ester tej zaum yuav raug siv los tshawb nrhiav cov tshuaj tiv thaiv kab mob tshiab, cov txheej txheem synthesis, lossis cov khoom siv tshuaj.
Tsis tas li ntawd, nws kuj tseem tuaj yeem ua tus qhia reagent hauv kev kawm chemistry, siv los qhia lossis qhia txog cov ntsiab lus ntawm cov organic chemistry.
Lwm thaj chaw
Ntxiv nrog rau cov ntawv thov saum toj no, (R) -3-piperidinecarboxylic acid ethyl ester kuj tseem tuaj yeem muaj peev xwm siv tau hauv lwm qhov chaw, xws li cov ntaub ntawv tshawb fawb, kev tshawb fawb ib puag ncig, thiab lwm yam. Txawm li cas los xij, cov ntawv thov hauv cov teb no yuav xav tau kev tshawb fawb thiab kev tshawb fawb ntxiv.
Kev piav qhia ntawm kev hloov pauv rau cov organic compound no
Vim qhov zoo sib xws stereochemical zog ntawm Ethyl (3R) - piperidine-3-carboxate thiab chiral pyridine derivatives, lawv cov derivatives yuav muaj peev xwm hloov cov tshuaj no. Cov hauv qab no yog ib qho kev piav qhia rau chiral pyridine derivatives:
Lus Txhais thiab Qauv
Chiral pyridine derivatives xa mus rau cov tebchaw nrog cov khoom sib txawv ntawm lub nplhaib pyridine thiab lub chaw chiral. Piperidine nplhaib yog 6 tus tswv cuab nitrogen heterocyclic nplhaib nrog cov qauv ruaj khov thiab hloov kho tshuaj yooj yim, yog li chiral pyridine derivatives muaj ntau hom tshuaj lom neeg thiab cov khoom siv.
Synthesis method
Chiral pyridine derivatives tuaj yeem ua ke los ntawm ntau txoj hauv kev, qee qhov uas muaj ntau thiab suav nrog:
Asymmetric hydrogenation los yog hloov hydrogenation
Chiral pyridine tau ncaj qha los ntawm kev txo cov pyridine los ntawm asymmetric hydrogenation lossis hloov hydrogenation. Txoj kev no muaj cov yam ntxwv ntawm luv luv synthesis cov kauj ruam, ntsuab thiab huv si, siab enantioselectivity, thiab pheej yig thiab yooj yim tau txais raw cov ntaub ntawv.
Hetero Diels Alder cov tshuaj tiv thaiv
Synthesize chiral pyridine derivatives siv intramolecular lossis intermolecular Diels Alder cov tshuaj tiv thaiv.
Txoj kev no tuaj yeem sib txuas rau 6 tus tswv cuab heterocycles nrog rau kev ua haujlwm lom neeg, thiab cov tshuaj tiv thaiv mob me me thiab yooj yim los tswj.
Chiral catalyst
Nyob rau hauv qhov kev txiav txim ntawm chiral catalysts, chiral pyridine derivatives yog synthesized los ntawm tej yam tshuaj tiv thaiv. Txoj kev no tuaj yeem tau txais cov khoom lag luam nrog siab enantioselectivity thiab cov tshuaj tiv thaiv me me.
Ntuj thiab kev thov
Tshuaj Chemistry
Chiral pyridine derivatives muaj ntau yam kev siv hauv tshuaj chemistry. Vim qhov tseeb tias cov tshuaj receptors feem ntau tsuas yog xaiv tau los ntawm ib qho tshuaj chiral molecule, chiral pyridine derivatives ua lub luag haujlwm tseem ceeb hauv kev tsim tshuaj. Lawv tuaj yeem siv los ua cov khoom ua ntej lossis cov khoom xyaw nquag rau cov tshuaj los kho ntau yam kab mob.
Organic Chemistry
Chiral pyridine derivatives pab raws li ib qho tseem ceeb hluavtaws intermediates nyob rau hauv cov organic chemistry, siv rau synthesizing ntau complex molecules.
Lawv muaj cov qauv tshuaj sib txawv thiab cov khoom thiab tuaj yeem koom nrog ntau yam tshuaj lom neeg.
Xws li cov tshuaj tiv thaiv ntxiv, hloov cov tshuaj tiv thaiv, thiab lwm yam.
Kev tshawb fawb txog biological
Chiral pyridine derivatives kuj muaj ntau yam kev siv hauv kev tshawb fawb lom neeg.
Lawv tuaj yeem ua haujlwm raws li kev sojntsuam lossis ligands rau bioactive molecules, siv los kawm txog cov qauv thiab kev ua haujlwm ntawm biomolecules. Tsis tas li ntawd, chiral pyridine derivatives kuj tuaj yeem siv rau kev paub txog molecular, kev tsim qauv, thiab kev tshawb fawb txog kev hloov pauv hauv cov txheej txheem lom neeg.
Kev tshawb nrhiav thiab kev tshawb fawb ntawm cov compound no
Lub discovery thiab kev tshawb fawb ntawmEthyl (3R) -piperidine-3-carboxylateFeem ntau tsom rau nws cov txheej txheem synthesis thiab muaj peev xwm siv tau. Nov yog qee cov ntsiab lus tseem ceeb:
Kev tsim cov txheej txheem synthesis.
Ib qho tshiab palladium catalyzed cov tshuaj tiv thaiv tau tsim los rau kev sib txuas ntawm asymmetric diamide scaffolds uas muaj alpha ketoester pawg, koom nrog cov synthesis ntawm Ethyl (3R) - piperidine-3-carboxate
Txoj kev no yog atomically yig, maj mam, thiab ua tau zoo, thiab tuaj yeem tau txais cov khoom lag luam nrog cov txiaj ntsig siab.
Kev soj ntsuam ntawm cov kab mob tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob.
Cov khoom tsim tawm tshiab, tshwj xeeb tshaj yog 2- (2-benzobenzamido) ethyl 2-oxo-2-arylacetate derivatives (3i thiab 3r), tau raug soj ntsuam rau lawv cov tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob hauv vitro thiab pom cov haujlwm tseem ceeb.
Spectral technology thiab X-ray crystallographic tsom xam.
Cov khoom sib txuas tau lees paub los ntawm cov txheej txheem spectroscopic (xws li FT-IR, 1H NMR, 13C NMR, HRMS spectroscopy) thiab X-ray crystallographic tsom xam
Synthesis thiab purity ntawm chiral compounds.
Thaum lub sij hawm txheej txheem synthesis, tshwj xeeb yog them rau cov synthesis thiab purity ntawm chiral tebchaw, xws li Methyl (3R, 4R) -3- (7H-pyrrolo [2,3-d] pyridine 7-yl) -4-vinyltetrahydrofuran-3-carboxylate (3g) thiab lwm yam high purity (3g) thiab lwm yam purity % 2. yield (piv txwv li. 86%)
Cov txheej txheem tshuaj ntsuam xyuas rau Ethyl (3R) - piperidine-3-carboxate: Qhia qhov tseeb ntawm Lub Xeev
Ethyl (3R) -piperidine-3-carboxylate((R) -3-piperidinecarboxylate) yog ib qho tseem ceeb organic compound nrog ib tug molecular mis ntawm C ₈ H ₁ NO ₂ thiab molecular hnyav ntawm 157.21. Raws li chiral compound, nws muaj ntau yam kev siv hauv tshuaj synthesis, asymmetric catalysis, thiab lwm yam. Txawm li cas los xij, muaj kev tshawb fawb me me ntawm nws cov khoom siv hauv lub xeev, tshwj xeeb tshaj yog hais txog cov qauv siv lead ua, thermal stability, solubility, thiab lwm yam.
X-ray diffraction (XRD)
XRD yog ib txoj hauv kev ncaj qha thiab siv tau zoo rau kev kawm cov qauv siv lead ua. XRD tuaj yeem txiav txim siab qhov tsis sib xws ntawm lattice, pawg chaw, atomic txoj haujlwm, thiab lwm yam ntaub ntawv ntawm cov siv lead ua, yog li nthuav tawm cov microstructure ntawm cov siv lead ua.
XRD tuaj yeem siv los txiav txim siab muaj ntau cov qauv siv lead ua thiab cov qauv sib txawv ntawm cov qauv siv lead ua sib txawv ntawm Ethyl (3R) - piperidine-3-carboxate.
Sib txawv Scanning Calorimetry (DSC)
DSC yog cov txheej txheem kev ntsuas cua sov uas kawm txog kev hloov pauv thermal ntawm tus qauv, xws li melting, crystallization, thiab iav hloov, los ntawm kev ntsuas cov cua sov los yog tso tawm thaum cua sov lossis cua txias.
Rau Ethyl (3R) - piperidine-3-carboxate, DSC tuaj yeem siv los txiav txim siab nws qhov melting point, thermal stability, thiab muaj kev hloov pauv ntawm polymorphic.
Thermogravimetric Analysis (TGA)
TGA kuj tseem yog cov txheej txheem kev ntsuas cua sov uas tuaj yeem kawm txog tus cwj pwm thermal decomposition ntawm tus qauv los ntawm kev ntsuas qhov kev hloov pauv ntawm cov qauv thaum cua sov.
TGA tuaj yeem siv los txiav txim siab thermal decomposition kub, decomposition khoom, thiab thermal stability ntawm Ethyl (3R) - piperidine-3-carboxate.
Infrared Spectroscopy (IR)
IR yog cov txheej txheem molecular vibrational spectroscopy uas txiav txim siab cov tshuaj sib txuas thiab cov pab pawg ua haujlwm tam sim no hauv cov qauv los ntawm kev ntsuas nws qhov nqus ntawm lub teeb infrared.
Rau Ethyl (3R) - piperidine-3-carboxate, IR tuaj yeem siv los lees paub nws cov qauv tshuaj, tshwj xeeb tshaj yog muaj cov pab pawg ua haujlwm.
Nuclear Sib Nqus Resonance (NMR)
NMR yog cov txheej txheem spectroscopic raws li lub sijhawm sib nqus ntawm atomic nuclei.
Los ntawm kev ntsuas lub resonance zaus ntawm atomic nuclei nyob rau hauv ib tug magnetic teb nyob rau hauv ib tug qauv, cov tshuaj ib puag ncig, molecular qauv, thiab molecular dynamics ntawm atomic nuclei nyob rau hauv ib tug molecule yuav txiav txim.
NMR tuaj yeem siv los txiav txim siab cov qauv stereochemical, molecular conformation, thiab intermolecular kev sib cuam tshuam ntawm Ethyl (3R) - piperidine-3-carboxate.
IR tsom xam
Sib tov Ethyl (3R) - piperidine-3-carboxate qauv sib npaug nrog KBr thiab nias rau hauv cov ntsiav tshuaj, tom qab ntawd luam theej duab nws siv lub ntsuas hluav taws xob infrared. Qhov kev tshuaj ntsuam xyuas yog 4000 ~ 400 cm ⁻¹, nrog rau kev daws teeb meem ntawm 4 cm ⁻¹.The IR spectrum qhia tau hais tias lub ncov dav ze li ntawm 3300 cm ⁻¹ rau Ethyl (3R) - piperidine-3-carboxate, sib xws rau NH impibities ntawm kev co ntawm cov dej (posces); Muaj ntau lub ncov nyob rau hauv thaj tsam ntawm 2950-2850 cm ⁻¹, sib xws rau CH stretching vibration.
Muaj lub ncov muaj zog nyob ze ntawm 1730 cm ⁻¹, sib haum mus rau qhov ncab kev co ntawm C=O (ester pawg); Muaj ntau lub ncov nyob rau hauv thaj tsam ntawm 1600-1450 cm ⁻¹, sib xws rau C-N thiab C-C stretching vibrations. Cov yam ntxwv ncov no zoo ib yam nrog cov qauv tshuaj ntawm Ethyl (3R) - piperidine-3-carboxate.
Kev tshuaj xyuas lub xeev ntawm Ethyl (3R) - piperidine-3-carboxate
XRD Analysis
Muab cov Ethyl (3R) - piperidine-3-carboxate qauv rau ntawm XRD qauv theem thiab luam theej duab nws siv Cu K hluav taws xob (λ=1.5418 Å). Lub scanning ntau yam yog 2 θ=5℃~ 50 degree, nrog ib kauj ruam loj ntawm 0.02℃thiab ib tug scanning ceev ntawm 2℃/ min.Tus qauv XRD qhia tau hais tias muaj ntau yam diffraction peaks nyob rau hauv lub cheeb tsam ntawm 2 θ=10℃~ 30℃rau Ethyl (3R) - piperidine, 3-carating crystal box Los ntawm kev sib piv cov qauv daim npav thiab cov duab simulated, nws cov qauv siv lead ua tuaj yeem txiav txim siab ua ntej.Kev soj ntsuam ntxiv qhia tias cov khoom sib xyaw yuav muaj nyob rau hauv ntau cov ntaub ntawv siv lead ua, nrog rau qhov sib txawv ntawm diffraction ncov txoj hauj lwm thiab kev siv ntawm cov ntaub ntawv sib txawv.
Qhov no tej zaum yuav yog vim qhov sib txawv ntawm kev sib cuam tshuam xws li hydrogen bonding, π - π stacking, thiab lwm yam.
DSC tsom xam
Noj li 5 mg ntawm Ethyl (3R) - piperidine-3-carboxate qauv thiab muab tso rau hauv DSC aluminium crucible. Kub nws los ntawm chav tsev kub txog 200 ° C ntawm tus nqi ntawm 10 ° C / min nyob rau hauv ib qho chaw nitrogen.DSC nkhaus qhia tau hais tias Ethyl (3R) - piperidine-3-carboxate nthuav tawm lub ncov endothermic ntawm kwv yees li 90 ° C, sib xws rau nws cov txheej txheem melting.
Tsis tas li ntawd, tsis muaj lwm yam kev hloov pauv hloov pauv tau pom tseeb tau pom thaum lub sijhawm cua sov, qhia tias qhov sib xyaw tsis tau dhau los ntawm polycrystalline lossis iav hloov ua ntej melting. Txawm li cas los xij, nws tsim nyog sau cia tias cov khoom sib txawv ntawm cov qauv yuav muaj qhov sib txawv ntawm qhov sib txawv vim qhov kev npaj sib txawv, xws li crystallization tus nqi, hnyav hom, thiab lwm yam.
TGA analysis
Noj li 10 mg ntawm Ethyl (3R) - piperidine-3-carboxate qauv thiab muab tso rau hauv TGA crucible. Kub nws los ntawm chav tsev kub txog 500 ° C ntawm tus nqi ntawm 10 ° C / min nyob rau hauv ib qho chaw nitrogen.
TGA nkhaus qhia tau hais tias Ethyl (3R) - piperidine-3-carboxate pib poob qhov hnyav ntawm ib ncig ntawm 150 ° C thiab ua kom tiav qhov hnyav ntawm ib ncig ntawm 300 ° C.Qhov no qhia tau hais tias cov compound pib undergo thermal decomposition ntawm ib ncig ntawm 150 ° C, thiab cov khoom decomposition tej zaum yuav muaj xws li carbon dioxide, dej, thiab lwm yam organic compounds. Kev tsom xam ntxiv qhia tias cov txheej txheem thermal decomposition yuav cuam tshuam nrog hydrolysis ntawm ester pawg thiab lub nplhaib qhib kev cuam tshuam ntawm pyridine rings.
FAQ
Ethyl (3R) -piperidine-3-carboxylate yog dab tsi?
Qhov no yog ib tug raug chiral piperidine heterocyclic compound nrog siab optical purity. Nws nta ib tug piperidine rau - koom nrog nitrogen heterocycle, nrog ib pawg ethyl carboxylate txuas ntawm 3-txoj hauj lwm hauv R configuration. Raws li ib qho tseem ceeb chiral tsev thaiv nyob rau hauv kws tshuaj chemistry, nws muaj cov qauv molecular ruaj khov thiab zoo tshuaj reactivity, uas tuaj yeem hloov kho ntxiv los ntawm ester hydrolysis, amination thiab cyclization cov tshuaj tiv thaiv kom tau txais ntau yam ntawm cov khoom siv bioactive molecules.
Dab tsi yog nws qhov tseem ceeb siv?
Nws yog siv los ua chiral intermediate rau tshuaj synthesis.
Puas yog qhov no ncaj qha siv los ua tshuaj kho mob?
Yeej tsis yog. Qhov chiral ester compound no tsuas yog ua raws li cov khoom siv ua ntej thiab cov khoom siv tshuaj lom neeg nyob rau theem pib ntawm kev txhim kho tshuaj, thiab tsis tau tsim los rau hauv kev npaj tshuaj tiav rau cov tshuaj kho mob ncaj qha. Nws yuav tsum tau ua ntau yam -txheej txheem kev ua kom zoo, derivatization thiab tshuaj ntsuam xyuas tshuaj ua ntej tau txais cov neeg sib tw tshuaj molecules nrog cov txiaj ntsig zoo, thiab nws tsis tuaj yeem siv nws tus kheej rau kev kho mob lossis kev kho mob txhua hnub.
Dab tsi yog nws cov kev cai cia khoom?
Sau thiab khaws cia rau hauv qhov chaw qhuav, txias thiab tsaus.
Cim npe nrov: ethyl (3r) -piperidine-3-carboxylate cas 25137-01-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom