Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm sclareolide cas 564-20-5 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo sclareolide cas 564-20-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Sclareolideyog ib hom roj tsis hloov pauv hauv cov nroj tsuag, nrog rau cov ntxhiab tsw ntxhiab thiab lom zem xws li tshuaj tua kab mob thiab tiv thaiv- mob. Nws yog cov hmoov tsis muaj xim lossis dawb nrog cov ntxhiab tsw tshwj xeeb. Muaj ntau ntau ob daim ntawv cog lus thiab hydroxyl pawg nyob rau hauv nws cov qauv molecular, ua rau nws cov polar thiab hydrophilic. Lub boiling point yog kuj siab, nyob ib ncig ntawm 250-260 degree. Nws yog ib qho yooj yim rau decompose ntawm qhov kub thiab txias, yog li qhov kub thiab txias yuav tsum tau tswj thaum lub sij hawm distillation los yog cua sov. Nws tuaj yeem soluble hauv cov kuab tshuaj organic xws li ethanol thiab ether, tab sis tsis nyob hauv dej. Solubility hauv dej yog tsawg heev, feem ntau tsawg dua 1%. Nws muaj volatility siab thiab qis boiling point, yog li nws muaj peev xwm evaporate ntawm qis kub. Thaum lub sij hawm evaporation txheej txheem, ob daim ntawv cog lus nyob rau hauv nws cov qauv molecular yuav hloov pauv, tsim cov khoom sib txawv aroma. Nyob rau hauv tej yam kev mob xws li lub teeb, kub, thiab oxygen, nws yog tsis ruaj tsis khov thiab nquag oxidation, polymerization, thiab lwm yam tshuaj, ua rau nws deterioration. Yog li ntawd, yuav tsum tau saib xyuas kom tsis txhob muaj tshav ntuj ncaj qha, qhov kub thiab txias, thiab kev sib cuag nrog cov pa oxygen thaum khaws cia thiab siv. Nws yog ib yam khoom cais los ntawm cov paj sage thiab muaj cov tshuaj tua kab mob thiab cytotoxic. Dav siv los ua tus neeg haus luam yeeb flavoring; Hauv kab lis kev cai adipocytes, nws tuaj yeem txhawb kev rog rog thiab txo qhov ntim ntawm adipocytes, thiab tuaj yeem siv los ua tus neeg sawv cev poob phaus; Perilla lactone tuaj yeem tiv thaiv kev mob qog noj ntshav ntawm daim tawv nqaij thiab tuaj yeem siv los ua tus neeg sawv cev tanning.
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Tshuaj Formula |
C16H26O2 |
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Exact Mass |
250 |
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Molecular Luj |
250 |
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m/z |
250 (100.0%), 251 (17.3%), 252 (1.4%) |
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Elemental Analysis |
C, 76.75; H, 10.47; O, 12.78 |
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Perilla frutescens lactone, tseem hu ua decahydrotetramethylnaphthofuranone, muaj cov mis mos molecular ntawm C16H26O2 thiab molecular hnyav ntawm kwv yees li 250.38 g / mol. Nws yog ib qho dawb los yog tawm dawb crystalline hmoov nrog lub zog amber aroma, muaj zog diffusion, thiab ntev - tsw. Perilla lactone yog insoluble hauv dej, tab sis soluble hauv cov kuab tshuaj organic xws li ethanol. Nws lub npe tshuaj yog decahydroxy{12}}3a, 6,6,9a-tetramethylnaphtho (2,1b) furan-2 (1h) - ib qho, thiab nws tus lej CAS npe yog 564-20-5.
Perilla lactone feem ntau yog muab rho tawm los ntawm cov paj ntawm Salvia sclarea, tshwj xeeb tshaj yog cov nyom Perilla hlob nyob rau hauv qhov ntiav toj roob hauv pes ntawm sab qaum teb Shaanxi. Vim nws qhov tshwj xeeb kub, av noo, thiab qhov siab, nws muaj cov ntsiab lus ester siab thiab ntshiab aroma. Txoj kev extraction muaj xws li chav distillation, thiab lwm yam.
Daim ntawv thov teb
Perilla frutescens lactone tau siv dav hauv ntau qhov chaw vim nws qhov tshwj xeeb aroma thiab lom lom.
Khoom noj khoom haus kev lag luam: Raws li ib tug seasoning los txhim kho lub sensory nyhuv ntawm cov zaub mov, nws yuav siv tau nyob rau hauv cov khoom noj uas muaj qab zib seasonings los txhim kho olfactory kev. Hauv kev lag luam kas fes, ntxiv ib qho me me ntawm perilla lactone tuaj yeem ua rau muaj qhov iab ntawm kas fes thiab txhim kho nws cov nyhuv refreshing.
Kev lag luam luam yeeb: Raws li tus neeg sawv cev flavoring, nws npog cov coarse impurities nyob rau hauv luam yeeb, txhim kho aroma, thiab muab luam yeeb ib tug qab ntxiag aroma.
Kev lag luam txuj lom:Sclareolideyog siv los tsim cov khoom siv ntuj tsim khoom, xws li ambergris ether, thiab yog ib qho tseem ceeb raw khoom rau cov tshuaj tsw qab thiab tshuaj pleev ib ce.
Cov khoom poob phaus: pab txo cov rog hauv lub cev thiab txhim kho qhov zoo ntawm cov nqaij ntshiv tsis muaj lub plawv dhia.
Kev lag luam kev zoo nkauj: Nws muaj antioxidant, tiv thaiv -inflammatory thiab antibacterial teebmeem, thiab yog dav siv nyob rau hauv cov khoom tu tawv nqaij, daim npog qhov ncauj, essence thiab lwm yam khoom.
Kev siv tshuaj kho mob
Perilla frutescens lactone tau qhia qhov tseem ceeb ntawm daim ntawv thov ntawm cov tshuaj.
Kev tiv thaiv kab mob: Nws muaj cov tshuaj tua kab mob zoo tiv thaiv Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, thiab Enterococcus faecalis.
Cov nyhuv Anticancer: Hauv kev kho mob qog noj ntshav, perilla lactone txhim kho gemcitabine induced cell tuag los ntawm kev kho NICD thiab Gli1 txoj hauv kev hauv gemcitabine resistant human pancreatic cancer, qhia lub peev xwm ua tshuaj tshiab rau gemcitabine resistant pancreatic cancer ua ke nrog gemcitabine.
Kev ua si lom neeg
Perilla frutescens lactone muaj ntau yam kev ua haujlwm lom neeg, ua rau nws siv dav hauv kev lag luam kev zoo nkauj.
Antioxidant nyhuv: Nws tuaj yeem cuam tshuam cov dawb radicals, txo oxidative kev puas tsuaj, thiab pab cov tawv nqaij tswj lub cev hluas thiab noj qab nyob zoo.
Anti-inflammatory nyhuv: Inhibits zus tau tej cov inflammatory yam, alleviates daim tawv nqaij o cov tsos mob, thiab txhawb cov tawv nqaij rov qab.
Antibacterial nyhuv: zoo inhibits cov kab mob loj hlob, txo cov pob txuv tsim, thiab ua kom daim tawv nqaij huv si thiab noj qab nyob zoo.
Txhim kho daim tawv nqaij barrier muaj nuj nqi: Txhim kho daim tawv nqaij muaj peev xwm moisturizing, tiv thaiv kom tsis txhob ya raws, thiab ua kom daim tawv nqaij moisturizing.
Regulating daim tawv nqaij oil secretion: txo cov teeb meem xws li oiliness thiab enlarged pores.
Tam sim no, cov txheej txheem tshuaj synthesis feem ntau yog siv los ua kesclareolideHauv Suav teb, uas yuav tsum tau oxidation ntawm coriolol nrog oxidant poov tshuaj permanganate. Hauv cov txheej txheem no, kev siv ntau cov oxidants thiab catalysts yuav ua rau muaj kev puas tsuaj loj rau ib puag ncig, thiab cov tshuaj synthesis ntawm coriolide yog siv rau hauv cov zaub mov, tab sis nws cov purity tsis siab txaus, thiab nws yog siv rau hauv cov tshuaj pleev ib ce, thiab cov tshuaj tsw qab yog yooj yim cuam tshuam.
Lub hom phiaj ntawm txoj kev no yog los muab ib txoj hauv kev rau biosynthesis ntawm coriolide uas tuaj yeem daws cov teeb meem ntawm ib puag ncig tsis zoo, cov kauj ruam nyuaj thiab kev nyab xeeb qis hauv cov txheej txheem ntawm cov tshuaj synthesis ntawm coriolide. Txhawm rau kom ua tiav lub hom phiaj saum toj no, cov txheej txheem kev siv tshuab tau txais los ntawm cov qauv no yog:
Noj cov poov xab kab lis kev cai nruab nrab thiab ntxiv 3% ~ 8% ntawm coriol cawv thiab 4% ~ 10% ntawm Cryptococcus albicans protoplast kua rau cov poov xab kab lis kev cai nruab nrab kom tau qhov sib tov;
Muab cov sib tov tso rau hauv lub khob ntim, thiab tom qab ntawd ferment hauv lub shaker ntawm 23-28℃thiab 140 ~ 180 r / min rau 10 hnub kom tau txais coriolactone.
Tus nqi ph ntawm cov poov xab kab lis kev cai nruab nrab yog 6.0.
Tween 80 nrog ib qho loj ntawm 1.5% ~ 4% kuj ntxiv rau cov poov xab kab lis kev cai nruab nrab.
Lub teeb dawb Cryptococcus cerevisiae tau hloov los ntawm ultraviolet lub teeb rau 3 mus rau 4 feeb.
Txoj kev no siv txoj kev hloov microbial, siv basil cawv raws li tus sclareolid, thiab siv lub teeb dawb Cryptococcus cerevisiae los hloov nws los tsim basil lactone, uas daws cov teeb meem ntawm unfriendly ib puag ncig, cumbersome cov kauj ruam thiab tsis tshua muaj kev ruaj ntseg nyob rau hauv cov txheej txheem ntawm tshuaj synthesis ntawm basil lactone, thiab muab ib tug tshiab txoj kev rau cov synthesis ntawm basil lactone.
Hom kev siv tshwj xeeb:
Piv txwv 1:
1) Siv cov poov xab kab lis kev cai nruab nrab thiab ntxiv 3% ntawm caryol cawv thiab 6% ntawm Cryptococcus albicans protoplast kua rau cov poov xab kab lis kev cai nruab nrab kom tau qhov sib tov;
2) Muab cov sib tov tso rau hauv lub khob ntim, thiab tom qab ntawd ferment hauv lub shaker ntawm 25℃thiab 140 r / min rau 10 hnub kom tau txais coriolide.
Piv txwv 2:
1) Noj cov poov xab kab lis kev cai nruab nrab nrog tus nqi ph ntawm 6.0 thiab ntxiv 5% caryol, 1.5% tween 80, thiab 4% protoplast kua ntawm Cryptococcus albicans mutated los ntawm ultraviolet lub teeb rau 3 feeb kom tau qhov sib tov;
2) Muab cov sib tov tso rau hauv lub khob ntim, thiab tom qab ntawd ferment hauv lub shaker ntawm 23℃thiab 160 r / min rau 10 hnub kom tau txais coriolide.
Piv txwv 3:
1) Siv cov poov xab kab lis kev cai nruab nrab nrog tus nqi ph ntawm 6.0 thiab ntxiv 8% ntawm cov poov xab kab lis kev cai nruab nrab ntawm coriol, 3% ntawm tween 80, thiab 8% ntawm cov kua protoplast ntawm Cryptococcus albicans hloov los ntawm ultraviolet lub teeb rau 4 feeb kom tau qhov sib tov;
2) Muab cov sib tov tso rau hauv lub khob ntim, thiab tom qab ntawd ferment hauv lub shaker ntawm 26℃thiab 150 r / min rau 10 hnub kom tau txais coriolide.
Piv txwv 4:
1) Siv cov poov xab kab lis kev cai nruab nrab nrog tus nqi ph ntawm 6.0 thiab ntxiv 6% ntawm perilla cawv, 4% ntawm tween 80 thiab 10% ntawm cov kua protoplast ntawm Cryptococcus albicans mutated los ntawm ultraviolet lub teeb rau 3.5 min kom tau qhov sib tov;
2) Muab cov sib tov tso rau hauv lub khob ntim, thiab tom qab ntawd ferment hauv lub shaker ntawm 28℃thiab 180 r / min rau 10 hnub kom tau txais coriolide.
Lub invention xaiv ib hom nrog siab tawm los ntawm perilla lactone los ntawm kev hloov ntawm Cryptococcus albicans los ntawm ultraviolet rays. Raws li txoj kev npaj hauv Piv txwv 4, cov txiaj ntsig ntawm coriolide yog qhov siab tshaj plaws, 35.2g / l. Ob hom kab mob uas muaj txiaj ntsig zoo ntawm perilla lactone tau txais los ntawm UV mutagenesis ntawm Cryptococcus albicans rau 3 ~ 4 min, thiab cov txiaj ntsig yog 18.2% siab dua li ntawm thawj hom.
Lub invention muaj feem xyuam rau ib txoj kev rau biosynthesis ntawmsclareolide, uas siv cov poov xab kab lis kev cai nruab nrab thiab ntxiv 3% - 8% caryophyllol thiab 4% - 10% ntawm Cryptococcus albicans protoplast kua ntawm cov poov xab kab lis kev cai nruab nrab raws li tau txais cov sib tov; Muab cov sib tov tso rau hauv lub khob ntim, thiab tom qab ntawd ferment hauv lub shaker ntawm 23 - 28 degree, 140 ~ 180 r / min rau 10 hnub kom tau txais coriolactone. Lub invention siv txoj kev hloov microbial, siv coriol cawv ua lub substrate, thiab siv lub teeb dawb cryptococcus hloov nws los npaj coriolide, uas daws cov teeb meem ntawm unfriendly ib puag ncig, cumbersome cov kauj ruam thiab tsis tshua muaj kev nyab xeeb nyob rau hauv cov txheej txheem ntawm tshuaj synthesis ntawm coriolide, thiab muab ib tug tshiab txoj kev rau cov synthesis ntawm coriolide.
Cov khoom siv tshuaj lom neeg ntawmSclareolide(fragrant perilla lactone) tuaj yeem ua tiav raws li hauv qab no:
I. Molecular Structure thiab Basic Properties
Sclareolide yog sesquiterpene lactone compound nrog cov qauv molecular C₁₆H₂₆O₂, thiab nws qhov hnyav molecular yog kwv yees li 250.38. Nws cov qauv muaj kaum-hydroxy-naphthalenone skeleton thiab muaj plaub lub chaw chiral (3aR, 5aS, 9aS, 9bR). Qhov no stereoconfiguration endows nws nrog tshwj xeeb tshuaj stability. Cov khoom sib xyaw ua ke yog dawb rau tawm -dawb crystalline hmoov nyob rau hauv chav tsev kub, nrog lub melting point ntawm 124-126 degree, ib tug kwv yees ntawm boiling point ntawm 321.4 degree, thiab ib tug ceev ntawm kwv yees li 1.009 g / cm³ (25 degree), qhia nws siab thermal stability thiab nruab nrab ceev.
II. Solubility thiab Solvent Compatibility
Lub solubility ntawm sclareolide qhia tau hais tias ib tug tseem ceeb polarity - nyob ntawm tus cwj pwm. Nws pom zoo solubility zoo nyob rau hauv uas tsis yog{2}}polar los yog weakly polar organic solvents, xws li ethanol, dimethyl sulfoxide (DMSO), thiab methanol, nrog ib tug concentration txog li 50 mg / mL (199.69 mM); Nws yog me ntsis soluble hauv chloroform. Txawm li cas los xij, nws cov solubility hauv dej yog qhov tsawg heev (tsuas yog 10 mg / L ntawm 25 degree), uas txwv nws txoj kev thov ncaj qha hauv cov dej hauv dej. Cov cuab yeej no tuaj yeem txhim kho los ntawm kev siv cov surfactants lossis tshuaj hloov kho.
III. Chemical Stability thiab Reactivity
Sclareolide nthuav tawm cov khoom siv tshuaj ruaj khov nyob rau hauv ib puag ncig kev cia khoom (kaw, qhuav, hauv chav sov), tab sis nws yuav tsum tau zam los ntawm cov oxidants muaj zog lossis huab cua pH. Lub nplhaib lactone ntawm cov khoom sib xyaw no tuaj yeem raug hydrolysis nyob rau hauv cov kua qaub, tsim cov hydroxy acid derivatives; nyob rau hauv ib puag ncig alkaline, nws yuav raug hloov pauv ntawm cov qauv los ntawm kev qhib -kaw mechanism. Tsis tas li ntawd, qhov sib xyaw no yog qhov nkag siab rau lub teeb thiab lub sijhawm ntev tuaj yeem ua rau degradation, yog li nws raug pom zoo kom khaws cia rau hauv qhov chaw tsaus. Nws cov thermal stability tso cai rau kev tswj cov txheej txheem kev ncaj ncees thaum lub sij hawm siab -kub distillation txheej txheem (xws li thaum rho tawm los ntawm cov nroj tsuag).
IV. Cov pab pawg ua haujlwm thiab muaj peev xwm tshwm sim
Lub nplhaib lactone nyob rau hauv cov molecule yog cov pab pawg neeg ua haujlwm zoo tshaj plaws ntawm Sclareolide thiab tuaj yeem koom nrog ntau yam tshuaj lom neeg:
Kev txo cov tshuaj tiv thaiv: Raws li qhov kev txiav txim ntawm lub catalyst, lub nplhaib lactone tuaj yeem raug txo mus rau ib lub qauv diol, tsim cov derivatives nrog cov kev ua ub no sib txawv.
Ester pauv cov tshuaj tiv thaiv: Los ntawm kev ua haujlwm nrog cov cawv, cov tshuaj ester derivatives tuaj yeem ua ke, uas yog siv rau kev sib xyaw tshuaj tsw qab lossis hloov tshuaj.
Nplhaib ntxiv cov tshuaj tiv thaiv: Nyob rau hauv cov xwm txheej tshwj xeeb, lub nplhaib lactone tuaj yeem koom nrog hauv Diels-Alder cov tshuaj tiv thaiv los tsim cov txheej txheem cyclic ntau dua.
Cov tshuaj tiv thaiv no muab lub hauv paus theoretical rau kev hloov kho tshuaj ntawm Sclareolide, txhawb nqa nws cov kev siv ntau yam hauv kev ua tshuaj tsw qab thiab tshuaj.
V. Lub cev muaj zog thiab cov cwj pwm zoo
Sclareolide muaj cov yam ntxwv ntawm kev xav. Nws daim ntawv khoom nthuav tawm lub teeb woody aroma. Thaum diluted (xws li 10% isopropyl tetradecanoate tov), nws muaj peev xwm emit ib tug elegant musk -zoo li daim ntawv, nrog rau lub hauv paus sau ntawv ntawm amber thiab labdanum. Cov yam ntxwv ntawm aroma no ua rau nws yog ib qho tseem ceeb fixative nyob rau hauv siab -kum perfumes thiab tshuaj pleev ib ce, ho txhim khu lub persistence thiab complexity ntawm cov tshuaj tsw qab.
FAQ
1. Sclareolide siv rau dab tsi?
Fragrance: Sclareolide muaj cov yam ntxwv ntawm cov tshuaj tsw qab uas yog siv hauv cov tshuaj tsw qab thiab ua tus neeg sawv cev hauv ntau yam khoom. Nws pab npog qhov tsis hnov tsw ntawm lwm cov khoom xyaw hauv cov khoom. Kev Kho Plaub Hau: Sclareolide yog siv rau hauv cov tshuaj zawv plaub hau, tshuaj kho mob, thiab lwm yam khoom tu plaub hau.
2. Dab tsi yog molecule sclareolide?
Sclareolide yog sesquiterpene lactone cov khoom tsim los ntawm ntau qhov chaw cog xws li Salvia sclarea, Salvia yosgadensis, thiab luam yeeb. Nws yog ib qho zoo sib xws ntawm sclareol, cog tshuaj tua kab mob.
3. Dab tsi yog qhov solubility ntawm sclareolide?
Sclareolide muaj qhov solubility ntawm kwv yees li 0.33 mg / ml hauv 1: 2 tov ntawm DMF: PBS (pH 7.2) siv txoj kev no. Peb tsis pom zoo kom khaws cov tshuaj aqueous rau ntau tshaj ib hnub.
Cim npe nrov: Sclareolide CAS 564-20-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom