Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm uridine 5'-monophosphate cas 58-97-9 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo uridine 5'-monophosphate cas 58-97-9 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
URIDINE 5'-MONOPHOSPHATE(UMP), dawb siv lead ua hmoov, siv los ua cov tshuaj nucleic acid intermediates, khoom noj khoom haus, thiab biochemical reagents, thiab siv rau kev tsim cov uridine triphosphate, polyadenuria, fluroiron, thiab lwm yam tshuaj. Uridine acid yog phosphate ntawm uridine. Muaj peb hom uridine 2′-phosphate (2′-uridine), uridine 3′ -phosphate (3′-uridine), thiab uridine 5′-phosphate (5′- uridine.) nyob ntawm qhov chaw sib txuas. Nws feem ntau yog uridine 5′-phosphate hauv vivo. Cov ntaub ntawv qhia tau hais tias qhov kev faib ua feem ntawm cov uridine nyob rau hauv tag nrho cov nucleotides nyob rau hauv cov mis nyuj sows, txawm ua ntej - lactating, nruab nrab - lactating, los yog lig - lactating, yog hnyav, nrog rau ntau tshaj 90 % ntawm cov nqi ntawm cov tshuaj.
Tsis tas li ntawd, cov ntsiab lus nucleotide nyob rau hauv lub mis lactation lig ntawm piglets thiab sows tau muab piv, thiab nws tau pom tias ntawm tsib nucleotides, uridine yog qhov tsis txaus nyob rau hauv piglets, thaum lwm cov nucleotides tsawg los yog tsis txaus. Yog li ntawd, yog tias cov ntsiab lus nucleotide hauv npua cov kua mis sawv cev rau qhov xav tau ntawm nucleotide ntawm piglets, nws tuaj yeem xaus lus tias ntawm tsib nucleotides, piglets tsis muaj uridine ntau tshaj.
|
Tshuaj Formula |
C9H13N2O9P |
|
Exact Mass |
324 |
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Molecular Luj |
324 |
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m/z |
324 (100.0%), 325 (9.7%), 326 (1.8%) |
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Elemental Analysis |
C, 33.35; H, 4.04; N, 8.64; O, 44.42; P, 9.55 |
Melting point 202℃(rough kwv yees), ceev 1.865 ± 0.06 g / cm3 (Predicted), Cia txias - 20℃C, Solubility H2O: soluble 50 mg / mL, ntshiab, tsis muaj xim, khoom zoo, Acidity coefficient 2.5K1 (pKa) , InChIKeyDJCXFVJDGTHFX-XVFCMESISA-N , Safety statement 24/25 , WGK Germany 3 , RTECS YU8088000.
URIDINE 5'-MONOPHOSPHATE(UMP) yog ib qho tseem ceeb nucleotide derivative uas plays ntau lub luag haujlwm tseem ceeb hauv cov kab mob nyob. UMP yog tsim los ntawm uracil, ribose, thiab phosphate pawg, thiab yog ib qho tseem ceeb hauv RNA synthesis. Nws kuj yog ib qho tseem ceeb nruab nrab hauv ntau txoj hauv kev biosynthetic. Hauv qab no yog cov lus piav qhia ntxaws txog nws lub hom phiaj:
Cov ntawv thov hauv thaj chaw biomedical sciences
Cardioprotective nyhuv
Kev tshawb fawb tau pom tias UMP yog ib qho kev ua haujlwm ntawm qhov ncauj mitochondrial ATP nyob ntawm potassium channel activator. Mitochondrial ATP nyob ntawm cov poov tshuaj raws li lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob plawv, vim tias lawv qhov kev ua kom muaj peev xwm txo tau myocardial ischemia- rov qab raug mob thiab txo qhov tshwm sim ntawm arrhythmia. UMP activates cov poov tshuaj raws, nce poov tshuaj ion efflux, hyperpolarizes myocardial cell membrane, yog li txo calcium ion influx thiab txo qhov kev puas tsuaj ntawm calcium overload rau myocardial hlwb.
Tsis tas li ntawd, UMP tuaj yeem cuam tshuam qhov qhib ntawm mitochondrial permeability hloov pores, txo qhov tso tawm ntawm cytochrome C, inhibit cell apoptosis, thiab tiv thaiv cardiomyocytes. Hauv kev sim nas, kev txhaj tshuaj ntawm UMP (30 mg / kg, ib koob) tau pom cov txiaj ntsig tseem ceeb ntawm cardioprotective. UMP tuaj yeem tiv thaiv kev raug mob ischemic, txo qhov chaw myocardial infarction, thiab txhim kho kev ua haujlwm plawv. Lub caij no, UMP tseem tuaj yeem tiv thaiv qhov tshwm sim ntawm qee qhov kev tsis sib haum xeeb thiab ua kom lub plawv dhia zoo li qub. Cov txiaj ntsig no qhia tau tias UMP muaj peev xwm siv tau tus nqi hauv kev kho thiab tiv thaiv kab mob plawv.
Txhawb txoj kev loj hlob ntawm txoj hnyuv thiab txo qhov mob raws plab
UMP plays lub luag haujlwm tseem ceeb hauv kev txhim kho plab hnyuv. Kev tshawb fawb tau pom tias UMP tuaj yeem txhawb kev sib txuas ntawm CDP choline (cytidine diphosphate choline), uas yog ib qho tseem ceeb ua ntej rau phosphatidylcholine synthesis. Phosphatidylcholine yog ib qho ntawm cov khoom tseem ceeb ntawm cov cell membrane thiab tseem ceeb heev rau kev tswj nws txoj kev ncaj ncees thiab kev ua haujlwm. Hauv txoj hnyuv, UMP txhawb nqa apoptosis thiab rov ua dua tshiab ntawm plab hnyuv epithelial hlwb, uas muaj txiaj ntsig zoo rau kev loj hlob thiab kev loj hlob ntawm plab hnyuv villi. Piv txwv li, nyob rau hauv txoj kev tshawb no ntawm IPEC-J2 npua plab hnyuv epithelial hlwb, UMP (10 mM, 6 h) txhawb latest theem apoptosis ntawm hlwb.
Thaum lub qhov ncauj UMP (476 mg, ib zaug ib hnub, 10 hnub) txhawb nqa apoptosis thiab rov ua dua tshiab ntawm npua plab hnyuv villous tip epithelial hlwb, txo cov kab mob raws plab. UMP kuj tuaj yeem txhim kho kev tiv thaiv kab mob ntawm txoj hnyuv. Nucleotides yog cov khoom noj tseem ceeb rau kev loj hlob thiab kev sib txawv ntawm cov kab mob hauv plab hnyuv. Supplementing UMP tuaj yeem ua rau cov ntsiab lus ntawm intracellular nucleotides hauv txoj hnyuv, txhawb kev loj hlob thiab kev sib txawv ntawm cov hnyuv lymphocytes, txhim khu kev ua haujlwm ntawm txoj hnyuv mucosa, thiab txo qis kev cuam tshuam ntawm cov kab mob pathogenic. Tsis tas li ntawd, UMP tuaj yeem tswj hwm qhov sib npaug ntawm plab microbiota, txhawb kev loj hlob ntawm cov kab mob uas muaj txiaj ntsig zoo, inhibit qhov kev loj hlob ntawm cov kab mob phem, thiab yog li tswj lub plab noj qab haus huv.
Koom nrog hauv daim siab detoxification muaj nuj nqi
URIDINE 5'-MONOPHOSPHATEplays lub luag haujlwm tseem ceeb hauv daim siab detoxification muaj nuj nqi. Lub siab ua ke cov tshuaj lom nrog glucuronic acid los ua dej - cov metabolites soluble, uas tom qab ntawd tawm hauv lub cev. UMP yog ib qho tseem ceeb precursors rau glucuronic acid synthesis. Hauv daim siab, UMP tuaj yeem hloov mus rau hauv UDP glucuronic acid (UDPGA) los ntawm cov tshuaj tiv thaiv enzymatic. UDPGA tom qab ntawd khi nrog cov tshuaj lom los tsim glucuronide, uas tau tawm ntawm lub cev.
Yog li, cov khoom ntawm UMP ncaj qha cuam tshuam rau lub peev xwm detoxification ntawm daim siab. Vim nws lub luag haujlwm tseem ceeb hauv daim siab detoxification, UMP yog siv los kho qee cov kab mob siab. Piv txwv li, UMP tuaj yeem siv los ua cov tshuaj ntxiv rau kab mob siab los kho kab mob siab thiab txhim kho daim siab ua haujlwm. Tsis tas li ntawd, UMP tseem tuaj yeem txo qhov kev puas tsuaj rau daim siab los ntawm kev siv yeeb tshuaj - ua rau lub siab raug mob, kab mob siab cawv, thiab lwm yam. Los ntawm kev ntxiv UMP, lub peev xwm detoxification ntawm daim siab tuaj yeem txhim kho, kho thiab rov tsim dua tshiab ntawm daim siab lub hlwb tuaj yeem txhawb nqa, thiab cov kab mob ntawm daim siab tuaj yeem txhim kho.
Neuroprotection thiab txhim kho kev paub txog kev ua haujlwm
UMP muaj kev tiv thaiv hauv lub paj hlwb thiab tuaj yeem txhim kho kev txawj ntse. Kev tshawb fawb tau pom tias UMP tuaj yeem txhawb kev sib txuas ntawm CDP choline hauv lub hlwb. CDP choline yog ib qho tseem ceeb ua ntej rau kev sib txuas ntawm phosphatidylcholine, uas yog ib qho ntawm cov khoom tseem ceeb ntawm cov cell membranes.
Hauv lub hlwb, UMP (0.02-1 mmol / kg, gavage, ib koob tshuaj) tuaj yeem txhawb kev sib txuas ntawm CDP choline hauv lub hlwb ntawm cov nas tsuag xuab zeb, nce cov ntsiab lus ntawm phosphatidylcholine hauv lub hlwb, thiab txhim kho kev ua haujlwm ntawm cov paj hlwb. Ntxiv UMP tuaj yeem txhim kho kev nco thiab kev kawm muaj peev xwm. Hauv kev sim tsiaj, ntxiv UMP rau cov nas muaj hnub nyoog tuaj yeem txhim kho lawv qhov kev ua tau zoo hauv kev sim maze thiab txhim kho lawv lub peev xwm nco tau.
Neuroprotection thiab txhim kho kev paub txog kev ua haujlwm
Tsis tas li ntawd, UMP tuaj yeem txhim kho kev paub txog kev ua haujlwm ntawm Alzheimer's tus qauv nas, txo qhov tso tawm ntawm - amyloid protein, thiab txo qis cov tshuaj tiv thaiv neuroinflammatory. Cov txiaj ntsig no qhia tau tias UMP muaj peev xwm siv tau tus nqi hauv kev kho thiab tiv thaiv kab mob neurodegenerative. UMP kuj muaj kev tiv thaiv ntawm cov paj hlwb.
Nyob rau hauv tej yam kev mob ntawm hypoxia, ischemia, thiab lwm yam kev puas tsuaj, paj hlwb yog nquag mus apoptosis. UMP tuaj yeem tiv thaiv cov paj hlwb thiab txo qhov tshwm sim ntawm apoptosis los ntawm ntau txoj hauv kev. Piv txwv li, UMP tuaj yeem cuam tshuam oxidative kev ntxhov siab, txo cov khoom ntawm cov dawb radicals, thiab tiv thaiv cov txheej txheem membrane thiab kev ua haujlwm ntawm cov paj hlwb; UMP tseem tuaj yeem tswj hwm kev tso tawm thiab txhawb nqa cov neurotransmitters, tswj kev sib kis ntawm cov teeb liab neural.
Kev tiv thaiv kab mob kev tiv thaiv
UMP koom nrog hauv kev loj hlob thiab kev sib txawv ntawm lub cev tiv thaiv kab mob thiab tseem ceeb heev rau kev ua haujlwm ntawm lub cev tiv thaiv kab mob. Nucleotides yog cov khoom noj tseem ceeb rau lub cev tiv thaiv kab mob los ua ke DNA thiab RNA. Ntxiv UMP tuaj yeem ua kom cov ntsiab lus ntawm nucleotides hauv lub cev tiv thaiv kab mob, txhawb lawv txoj kev loj hlob thiab kev sib txawv, thiab txhim kho lub cev tiv thaiv kab mob. Piv txwv li, UMP tuaj yeem txhawb kev loj hlob ntawm T lymphocytes thiab B lymphocytes, txhim kho cov tshuaj tiv thaiv kab mob, thiab txhim kho kev ua haujlwm ntawm lub cev thiab lub cev tiv thaiv kab mob. UMP kuj koom nrog hauv cov kev cai ntawm cov lus teb inflammatory.
Inflammatory teb yog ib qho tseem ceeb tiv thaiv mechanism ntawm lub cev tiv thaiv kab mob kab mob thiab kev puas tsuaj, tab sis ntau inflammatory teb yuav ua rau puas tsuaj rau cov ntaub so ntswg. UMP tuaj yeem txo qhov kev puas tsuaj ntawm cov ntaub so ntswg los ntawm cov tshuaj tiv thaiv inflammatory los ntawm kev tswj cov khoom tsim thiab tso tawm cov inflammatory yam. Piv txwv li, UMP tuaj yeem tiv thaiv kev tsim tawm ntawm pro- cov kab mob inflammatory xws li qog necrosis factor - (TNF - ) thiab interleukin -6 (IL-6), thiab ua kom cov tshuaj tiv thaiv kab mob xws li interleukin-10 (IL-10), uas ua rau muaj kev cuam tshuam los tiv thaiv.
Txoj kev ntawm synthesizingURIDINE 5'-MONOPHOSPHATE(UMP) hauv chav kuaj feem ntau muaj cov tshuaj tiv thaiv kab mob, suav nrog kev sib txuas ntawm nucleotides, bases, phosphates thiab lwm yam tshuaj. Hauv qab no yog cov kauj ruam ntxaws ntxaws rau kev sib txuas UMP:
Cov kauj ruam:
ua ntej, npaj cov tshuaj uas yuav tsum tau ua. Uracil, sodium phosphate, sodium hydroxide thiab formate tau yaj hauv dej los npaj ib qho kev daws teeb meem. Cov kev daws teeb meem no yuav raug siv los ua cov khoom siv raw rau kev sib txuas ntawm ump.
Cov tshuaj uracil yog tov nrog cov tshuaj formate, thiab cov tshuaj tiv thaiv decarboxylation yog ua raws li qhov ntsuas kub thiab pH. Cov kauj ruam no yog kauj ruam tseem ceeb hauv kev sib txuas ntawm ump. Cov qauv nucleotide xav tau yog tsim los ntawm kev tshem tawm cov pawg formic acid los ntawm uracil.
phosphorylation ntawm uracil nucleotides hauv cov tshuaj tiv thaiv nrog phosphate. Hauv cov txheej txheem ntawm phosphorylation, pawg hydroxyl ntawm uracil nucleotide reacts nrog phosphate los tsim uridine phosphate. Uridine phosphate yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm ump.
Thaum lub sij hawm cov txheej txheem synthesis, cov tshuaj tsis yog siv los tswj cov pH tus nqi ntawm cov tshuaj tiv thaiv kom ruaj khov. Los ntawm kev ntxiv qhov tsis zoo, pH ntawm cov tshuaj tiv thaiv tuaj yeem hloov kho kom ntseeg tau tias qhov kev vam meej ntawm cov tshuaj tiv thaiv synthesis.
Tom qab ua tiav cov kev xav saum toj no, cov tshuaj tiv thaiv yog sib cais thiab huv si kom tau txais lub hom phiaj khoom ump. Hauv kev sib cais, impurities tuaj yeem raug tshem tawm los ntawm centrifugation thiab pom, thiab tom qab ntawd cov khoom tuaj yeem raug ntxuav los ntawm crystallization lossis ion pauv.
Thaum kawg, qhov zoo ntawm cov synthesized UMP tau kuaj pom los ntawm kev tshuaj xyuas tshuaj. Cov qauv ntawm cov khoom tuaj yeem raug lees paub los ntawm NMR thiab MS, thiab qhov purity thiab cov ntsiab lus ntawm cov khoom tuaj yeem txiav txim siab los ntawm HPLC.
khaws cov synthesized UMP rau hauv qhov chaw qhuav kom deb ntawm lub teeb rau kev siv tom ntej. Thaum siv UMP, yuav tsum tau ua raws li kev ceev faj txog kev nyab xeeb thiab kev ua haujlwm raws li qhov tsim nyog yuav tsum tau ua kom ntseeg tau.
FAQ
Dab tsi yog uridine 5 monophosphate siv rau?
Hauv kev tshawb fawb hauv hlwb, uridine monophosphate yog sivraws li ib qho yooj yim xa khoom compound rau uridine. Uridine yog lub active tivthaiv ntawm no compound.
Cim npe nrov: uridine 5'-monophosphate cas 58-97-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom