18 - glycyrhetinic acid CAS 471-53-4

{{0 {}} glycyrhetinic acidTxawm li cas los 471 {- 53-4, insolub hauv dej, soluble hauv ethanol, pyridine, thiab acetic acid. Nws yog ib qho khoom noj rau cov tshuaj thiab khoom noj. Dej cawv extract yog dav siv nyob rau hauv cov khoom qab zib thiab cov zaub mov kaus poom yog lub qab zib ntuj. Lub qab zib ntawm licorice los ntawm glycyrhrhizic acid thiab glycyrhoetinic acid. Tus qub yog ib hom ntawm triterpenoid saponin, suav rau txog li 4% ~ 5% ntawm qhov hnyav ntawm glycyrrhizic hauv paus, thiab nws cov qab zib yog 50 zaug ntawm sucrose. Glycyrrhoetinic acid yog tsim los ntawm hydrolysis ntawm glycyrhyunhizic acid kom tshem cov hmoov nplej plab, thiab nws cov tsos yog 250 zaug ntawm sucrose. Glycyrrhoetinic acid muaj cytotoxicity. Kev siv ntev ntawm glycyrhizic acid (100g / d) nyob rau hauv ntau ntau tuaj yeem ua rau bypertension thiab mob plawv hypertrophy. Cov mob kho mob yog cov sodium ion tuav thiab potassium ion excretion. Thaum muaj mob hnyav, nws tuaj yeem ua rau huab tsis muaj zog thiab ventricular fibrillation.

{{0 {}} glycyrhetinic acid, raws li cov tseem ceeb ua kom muaj cov tshuaj muaj txiaj ntsig (xws li cov qauv molecietic), uas muaj ob qho tib si corticosteroid zoo li thiab cov khoom qab zib zoo nkauj. Txij li nws sib cais thiab kev txheeb xyuas thaum ntxov xyoo pua 20, nws daim ntawv thov tau nthuav tawm ntawm cov tshuaj suav hauv nruab hnub, thiab cov tshuaj pleev txhua hnub, ua cov txheej txheem sib cuam tshuam.

Kev teb Medical: Sib tawg los ntawm kev kho mob rau kev kho mob

 

1. Anti InceMammatory thiab Kev Tiv Thaiv Kev Tiv Thaiv: Ntau - Lub Hom Phiaj Inhibition Inflammatory Rescade
Los ntawm inhibiting synthesis thiab tso tawm cov neeg kho mob kho mob xws li Prostaglandin E2, cov serotisly} κ baigring pathwility yog txo kom tsawg. Cov kev tshawb fawb soj ntsuam tau pom tias nws anti-}} ntawm hydrocortisone, tab sis tsis muaj kev pheej hmoo ntawm cov tshuaj adrenal increnal increnal. Piv txwv li:
Kev kho mob ntev: Hauv kev mob siab mob caj dab, inhibiting lub stat3 / hiS-1 pathway txo macrophage infiltration thiab unceviates koom nrog o.

 

Kev muaj kab mob: Rau cov neeg mob dermatitis, cream muaj 2%, thiab nws cov tshuab muaj cuam tshuam nrog downregulation of th2 yam tiv thaiv kab mob.
Kev tiv thaiv hauv nruab nrog cev: Hauv daim siab yog tus qauv eeshemia / Retreatment raug mob, ua ntej tuaj yeem txo cov siab lub siab Apoptosis tus lej los ntawm 32% thiab neutrophil infiltration los ntawm 45%.

2. Tshuaj tiv thaiv thiab anti {{{- qog: rov ua tus kab mob zuj zus
Antiviral Cov nyhuv: los ntawm kev sib xyaw ua ke ntawm cov khoom siv protein, nws thaiv tus kab mob siab hom mob HIV, lub voj voog kev ua npaws ntawm tus kab mob khaub thuas. Piv txwv li, nws tus nqi EC50 rau HBV yog 2.3 μ m, thiab nws muaj kev sib xyaw nrog Lamivudine tuaj yeem txhim kho cov tshuaj tua kab mob ua ke.

 

Cov Antitumnchchanism:
Cov nyhuv ncaj qha: inducing qog cond agoptosis (xws li dhau los ntawm Ros kho mob cancer mitiarweration (ic {}} μ m).

Cov teebmeem tsis ncaj: downregulate vegf qhia thiab inhibit qog angiogenesis; Txhim khu zoo 0 cell kev ua haujlwm thiab txhim kho kev tiv thaiv kev tiv thaiv kab mob.
Cov qauv kev kho kom zoo: derivatives nrog c- 11 carboriesl pab pawg raug txo los rau hydroxyl pawg tau khaws cov tub rog thaum txo cynotoxicity los ntawm 60%.

3. Kev cuam tshuam rau cov kab mob metabolic: los ntawm cov ntshav qab zib ntshav rau Lipid metabolism
Kev tswj hwm ntshav qab zib: los ntawm kev ua kom zoo nkauj

 

Tsis muaj dej ntws tawm tsam (Nafld): Inhibits The Stat3 / HIcw-1 txoj kev hauv macrophages, txo cov kev rho nyiaj, thiab txhim kho cov insulin tsis kam.

Atherosclerosis: txo qhov kev tsim cov khoom ua npuas ncauj thiab cov kev pheej hmoo ntawm cov quav hniav tsis ruaj khov los ntawm kev cuam tshuam LDL oxidation.

4. Kev kho cov kab mob tshwj xeeb: txhaws cov chaw kuaj mob
Lwm txoj kev kho rau Addison's tus kab mob: Ua ib qho hloov chaw rau DEOXCORSIVE, tab sis muaj kev sib txuas nrog cov hluav taws xob, tab sis yuav tsum tau ua ke nrog hydrocortisone kom tsis txhob muaj teeb meem.
Cholestasis Indive Mob Kab Mob: Upregulate FXR qhia, txhawb Bile acid excretion, thiab txo qis ntshav bilirubin qib los ntawm 35%.
Neuroprotection: Hauv Parkinson tus qauv kab qauv, Inhibition ntawm MPSP Induced Neuronal Apoptosis txhim kho lub cev muaj zog.

Kev Lag Luam Khoom Noj: Cov ntawv thov tshiab ntawm cov khoom xyaw ntuj muaj nuj nqi

 

1. Cov khoom qab zib muaj txiaj ntsig zoo: Ib qho kev xaiv zoo rau cov
{{0 {}} glycyrhetinic acidMuaj cov khoom qab zib 50 lub sij hawm uas ntawm sucrose, thiab nws cov calorific tus nqi tsuas yog 1/10 ntawm nws. Nyob rau hauv cov zaub mov dawb dawb, nws tau sib xyaw nrog erythritol tuaj yeem npog qhov iab thiab txhim kho cov saj tau saj. Piv txwv li, qee hom ntawm cov piam thaj dawb hauv qab zib ntxiv los ntawm 40% los ntawm kev ntxiv 0.02% glycyrrhetinic acid.
2. Cov zaub mov ua haujlwm ntxiv ntxiv: Cov txiaj ntsig kev noj qab haus huv sib xws
Antioxidant Li: Ntxiv 0.1% Glycyrrhoetinic Acid kom txuas cov khoom siv tau txuas ntxiv lub neej ntawm 25%, nrog DPPH tshiab radical txaus ntawm 89%.

 

Kev nce qib plab zom mov: los ntawm kev tswj hwm lub plab me microbiota (xws li nce cov tsos mob ntawm bifidobacteria), cov tshuaj ntsuam quav ntsej muag tau pom tias muaj 30% nce hauv plab hnyuv.
Cov kev ua kis las kis las txhawb: ua ke nrog cov ceg saw amino acids, nws tuaj yeem txo cov leeg nqaij cov leeg nqaij (CK) Tom qab 22% thiab nrawm rov qab.
3. Cov khoom noj khoom noj: Lub ntuj ua haujlwm ntawm huab cua tshiab
Daim mic muaj nuj nqis rau staphyrococcus aureus thiab eschcher coli tau 12.5 μ g / ml thiab 25 μ g / ml, feem. Hauv cov nqaij khaws cia, nws cov khoom sib xyaw nrog chitosan tuaj yeem txuas ntxiv rau lub tub yees rau lub sijhawm 3 hnub yam tsis muaj kev pheej hmoo ntawm cov khoom seem tshuaj tiv thaiv.

Cov tshuaj pleev ib ce: lub cim rau cov khoom xyaw nquag hauv kev tshawb fawb skincare

 

1. Lub ntsej muag dawb thiab cov teeb pom kev zoo: multiundionening inhibition ntawm melanin ntau lawm
Tyrosinase Inhibition: Tus nqi IC50 ntawm Glycyrrhoetinic Acid derivative glycyrrhetinic acid yog 0.8 μ m, uas yog 16 zaug uas muaj arbutin.
Melanin Thauj Thaiv: Downregulation ntawm Rab27A Protein qhia txo cov kev hloov pauv ntawm Melanosomes rau Keratinocytes.
Kev tshawb fawb txog kev kho mob: Tom qab 8 lub lis piam ntawm kev txuas ntxiv mus siv 1.5% licorice extract, Masi cov qhab nia ntawm 39.2%, thiab tsis muaj hydroquinone voos.
2. Anti Indiaratory Kho: Teeb Meem Tsim Kev Tsim Kho thiab Kev Kho Mob Me
Mob siab: Rau UV Indentive Ereethema, 2% Dipotassium Glycyrrhizate tuaj yeem qis dua tawv nqaij txias los ntawm 1.8℃thiab off rau thaj tsam los ntawm 52%.

 

Kev raug mob
Microbial txoj cai: inhibits tsim ntawm biofilm hauv Propionibacterium acnes thiab txo cov tshuaj muaj kev pheej hmoo los ntawm kev ua ke nrog cov kua qaub acidic acid.

3. Los tiv thaiv kev laus: ob lub zog ua rau cov tshuaj tiv thaiv kab mob antioxidant thiab collagen tsim dua tshiab
Dawb radical lom zem: Orac tus nqi ntawm licorice chalcone a yog 5200 μ mol te / g, uas yog 1.8 zaug ntawm vitamin C.
Collagen synthesis Stimulation: Los ua kom lub tgf - Txoj Kev Qhia Tawm, Kev Ua Yeeb Yam Ntxiv Los ntawm 40%, txhim kho Wrinkle qhov tob.
Txhim Kho Cov Ntaub Ntawv: Siv cov tshuaj pleev thaiv hnub tuaj yeem nce tus nqi SPF los ntawm 15% thiab txo UVB ntxias DNA kev puas tsuaj.

Cov Khoom Siv Txhua Hnub: Ua haujlwm ntxiv ntawm cov khoom xyaw ntuj

 

1. Qhov ncauj tu ncua: kev tiv thaiv dual
Kev kho hniav txheej txheem: Glycyrrhetinic acid tau muaj 18 hli tawm tsam streptococcus mutor, nws tuaj yeem txo qhov tshwm sim ntawm cov neeg kho hniav los ntawm 37%.
Kev Noj Qab Haus Huv Cov pos hniav: Ntxiv 0.5% Glycyrhetinic acid rau cov tshuaj txhuam hniav los ntawm 41%, thiab nws cov tshuab cuam tshuam nrog inhibiting IL-6 tso tawm.

2. Kev tu tus kheej: maj mam tshem tawm thiab tiv thaiv daim tawv nqaij
Cov tshuaj zawv plaub hau: Los daws cov thawv qhia daus nyiaj, cov roj ntau lawm ntawm cov plaub hau plaub hau yog txo los ntawm 31%, thiab tsis muaj qhov kev xav qhuav thiab nruj.

Daim ntawv thov ntawm da dej gel: thaum ua ke nrog oat pectin, nws tuaj yeem txo qhov kev txob txob ntawm surfactants thiab luv lub sijhawm ntawm daim tawv nqaij erythema los ntawm 50%.

Glycyrrhoetinic acid, nrog nws cov qauv molecular ntau thiab ntau- hom phiaj sib txuas ntawm kev nqis tes ua ke thiab thev naus laus zis. Nrog kev nce qib ntawm cov qauv txheej txheem biology thiab cov khoom siv thev naus laus zis, nws daim ntawv thov kev siv thev naus laus zis yuav txuas ntxiv mus ntxiv, muab cov kev nyab xeeb dua rau tib neeg kev noj qab haus huv.

Ib txoj kev npaj ntawm{{0 {}} glycyrhetinic acid:

Noj 140g ntawm glycyrhizic acid hmoov (glycyrhrhizic acid cov ntsiab lus, distact ntawm 100℃rau ntawm cov dej tsis muaj zog kom tau 115% 20%; Tom qab tsoo cov extract qhuav, noj 100g, ntxiv 300ml ntawm acetic acid, muaj qhov kub thiab txias rau 98 ~ 103 degree, thiab hnov ​​mob rau 2 teev. Tom qab cov hydrolysis thiab acetylation ua tiav, txias rau chav tsev kub, thiab tom qab ntawd ntxuav nrog eteticol, thiab tom qab ntawd, ntxuav cov kua roj ntsha, thiab tom qab ntawd, ntxuav cov kua roj av, thiab tom qab ntawd, ntxuav tawm ntawm etetyllglycyrrhetinic acid, nrog kev coj dawb huv ntawm 88.2% (HPLC).

Noj 20g ntawm acetylglycyrrhetinic acid, ntxiv 300ml ntawm sodium hydrocyf, thiab qhuav rau ntawm 100℃kom tau 17.8g ntawm crude Glycyrrhoetinic acid, purity 92.9% (HPLC), thiab tom qab ntawd ethanol ntawm qhov hnyav glycyrrhetinic acid tau ntxiv nrog ua kom cov pa roj teeb ua kom zoo dua. Tom qab Reflux decolorization, cov filtrate yog lim. Tom qab ethanol tau rov zoo, cov khoom tau sib cais tawm, thiab 16.4g ntawm glycyrrhoetinic acid yog lim, nrog txoj kev purity ntawm 98.2% (txoj kev needralization). Txhawm rau huv si, siv 95% ethanol los kho peb zaug kom tau txais glycyrrhetinic kua qaub nrog purity of 98% (HPLC). Tag nrho cov impurity peak tsis ntau tshaj 2%, thiab ib qho Ipurity Peak tsis ntau tshaj 0.7%, uas txhua yam kev ua raws li European pharapacopoeia tus qauv.

1. AdrireCortical cov tshuaj hormones - zoo li cov nyhuv:
A Cov Mineralocorticoid Cov nyhob:
Rau cov neeg noj qab haus huv thiab ntau yam tsiaj, glycyrhoetinic acid tuaj yeem txhawb kev nce ntawm sodium, dej ua kom muaj zog, thiab cov dej tawm hws, uas qhia tias muaj kev phom sij. Thaum cov neeg mob uas muaj cov khoom siv ob zaug yog kho nrog 40mg ntawm hydrocortisone intramuscularly rau kev saib xyuas subcutanely rau kev kho subcutaneously rau txhua hnub, yuav muaj kev sib luag thiab cov electrolyte yuav khaws cia hauv seem. Txawm li cas los xij, yog tias hydrocortisone yog nres thiab tsuas yog glycyrhoetinic acid tau muab, sodium cia muaj peev xwm ploj thiab addison's Crisis yuav tshwm sim.
⑵ Gllucocorticoid cov ...
Cov qauv tshuaj ntawm{{0 {}} glycyrhetinic acidyog zoo li ntawm corticosteroids. Glycyrrhoetinic acid tseem tuaj yeem tsim cov sodium khaws cia, anti {{incammatory cuam tshuam hauv cov tsiaj nrog adrenocegortectomy thiab hypophysiectomy. Cov nyhuv ntawm 25 mg glycyrhetinic acid ntawm dej thiab sodium khaws cia hauv cov nas tau muaj zog dua li ntawm 1 mg deoxycorticicoterone. Yog li no, lub Deoxycorticosterone - Zoo li cov nyhuv ntawm glycyrrhoetinic acid tsis yog tsim los ntawm endogenous deadosterone thiab aldosteroneterousica thiab aldosterone, tab sis tej zaum yuav yog qhov xwm txheej ncaj qha. Qee tus neeg kuj tau ntseeg tias nws yog ib qho kev cuam tshuam tsis ncaj, yog li cov ntsiab lus ntawm cov tshuaj ntsuab uas muaj kev puas tsuaj rau cov tshuaj ntsuab Nws tseem raug qhia tias Glycyrrhetinic acid yuav muaj kev cuam tshuam tsuas yog ntawm cov uas tsis muaj zog adrenal cortex ua haujlwm thiab tsis tiav.

2. Anti {{- pob txha thiab anti -} imm imm ills cuam tshuam:
Glycyrrhoetinic acid muaj ov - inflammatory nyhuv zoo ib yam li ntawm cortisone lossis cortisone. Glycyrrhawinic acid muaj cov paj rwb pob granuloma, formatin {{ Glycyrrhoetinic acid muaj cov phom sij uas sim ua rau muaj kev ua txhaum cai ntawm cov nas, thiab muaj cov tshuaj tsw qab los ntawm cov ntshav ntshav lossis qe dawb hauv guinea npua. Its anti-inflammatory and anti-allergic reactions may be related to inhibition of capillary permeability, anti-histamine or reduction of cell responsiveness to stimulation.
Glycyrrhetinic acid muaj inhibitosions tshwm sim ntau yam mob o. Nws anti {- cov nyhuv hluav taws xob, tab sis muaj feem xyuam rau cov pituitary ntawm {}} Hydrocortictinic acid tuaj yeem incibrhetinic acid tuaj yeem inhibit tsim ntawm Malondesdehyde, cov kev ua haujlwm ntawm PG EnterOperoxide nyob rau hauv cov nas inducation ntawm cov protein, uas tuaj yeem txwv los ntawm exogenous arachidonic acid. Sodium glycyrhetinic acid kuj tseem txhim kho qhov tsis- glycyrhetinic acid tau immunomodulatory nyhuv rau mob mob serum kab mob hauv luav. Tsib tsib caug luav tau faib ua pab pawg kev sim thiab pab pawg. Tus luav qauv ntawm cov mob khaub lig Serum kab mob tau tsim nrog Bovine Serum Protein (BSA) raws li antigen. Yuav 18 - glycyrrhoetinic acid tau yaj hauv txiv roj roj (150mg / ml). Cov tsiaj hauv pawg sim ua 18 {{- glycyrrhoetinic acid 200mg / kg tau txhaj injentcatly rau hauv cov tsiaj. Cov pab pawg tswj tau yog intramuscularly txhaj nrog txiv roj roj. Cov txiaj ntsig los tiv thaiv BSA-1GGS nyob rau hauv cov tsiaj txhu ntawm pawg neeg tswj hwm thiab cov pab tshuaj tiv thaiv BSA, thiab nce qib siab tshaj plaws nyob rau hnub 12. Cov pab pawg sim tau ua ntau dua li pawg tswj hwm. Qhov tshwj xeeb BSA-anti-bsa complex nyob rau hauv cov pawg ntawm ob pawg tsiaj tau siab dua li qhov kev txhaj tshuaj, tab sis tsis muaj qhov sib txawv ntawm ob pawg. Kev qhuas tus nqi hauv cov pab pawg sim tau nce siab dua li ntawm pawg tswj hwm {} glycyrrhetinic acid tsis muaj kev cuam tshuam rau kev tsim ntawm CIC.

3. Cov nyhuv ntawm Digestive:
Glycyrrhoetinic acid tuaj yeem txo cov ntshav bilirubin thiab nce cov zis bilirubin excretion hauv tag nrho cov bile duct, uas muaj zog dua li glucuronolactone lossis methionine. Nws muaj zoo anti {- ulcer nyhuv ntawm pyloric ligation nas. Nws cov kev kho mob yog qhov siab.

Cim npe nrov: 18 - glycyrhetinic acid CAS 471-53-43-43-43-43-4, chaw tsim khoom, Hoobkas, yuav, nqe, loj, rau muag