Chrysophanic acidyog ib txwm tshwm sim anthraquinone organic compound, feem ntau muab rho tawm los ntawm cov hauv paus hniav thiab stems ntawm cov nroj tsuag xws li rhubarb thiab silybum marianum. Nws muaj keeb kwm ntev hauv cov tshuaj ib txwm muaj thiab muaj npe nrov rau nws cov nyhuv purgative me me, uas txo cov cem quav los ntawm kev ua kom cov kab mob colonic peristalsis. Cov kev tshawb fawb tshuaj niaj hnub no tau nthuav tawm nws cov dej num dav dav, suav nrog cov tshuaj tua kab mob tseem ceeb (tshwj xeeb tshaj yog tawm tsam dermatophytes), tshuaj tua kab mob, tiv thaiv- mob, thiab qee yam kev tiv thaiv kab mob thiab tiv thaiv- cov teebmeem loj hlob. Yog li ntawd, nws daim ntawv thov tsis txwv rau kev siv laxative. Kev tshawb fawb thiab kev loj hlob tam sim no tau tsom mus rau thaj chaw dermatology, xws li kev tshawb nrhiav nws ua cov khoom muaj nyob hauv cov tshuaj pleev xim rau cov mob xws li psoriasis, eczema, thiab ringworm. Txawm li cas los xij, qhov sib xyaw no yog irritating. Kev siv qhov ncauj yuav ua rau mob plab thiab zawv plab hnyav, thiab siv sijhawm ntev - tuaj yeem ua rau electrolyte imbalance lossis colon melanosis. Kev siv sab nraud tuaj yeem ua rau tawv nqaij kub hnyiab, liab, thiab lwm yam kev cuam tshuam. Thaum siv nws, ib tug yuav tsum nruj me ntsis raws li tus kws kho mob cov lus qhia. Tsis txhob siv sijhawm ntev - lossis siv ntau dhau. Cov poj niam cev xeeb tub, cov poj niam lactating, thiab cov neeg uas muaj lub plab hnyuv ua haujlwm tsis zoo yuav tsum siv ceev faj.
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Tshuaj Formula |
C15H10O4 |
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Exact Mass |
254 |
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Molecular Luj |
254 |
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m/z |
254 (100.0%), 255 (16.2%), 256 (1.2%) |
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Elemental Analysis |
C, 70.86; H, 3.96; O, 25.17 |
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Chrysophanic acid, raws li ib tug organic compound nrog nplua nuj lom lom ua si thiab pharmacological teebmeem, muaj ntau thiab ntau yam kev siv. Hauv qab no yog cov lus piav qhia ntxaws txog kev siv tseem ceeb ntawm emodin:
1. Antibacterial nyhuv
Rhubarb phenol muaj cov tshuaj tua kab mob tseem ceeb rau ntau yam kab mob, uas yog ib qho tseem ceeb tshaj plaws siv. Cov kab mob no suav nrog tab sis tsis txwv rau Streptococcus pneumoniae, pneumococcus, influenza bacilli, thiab cocci. Los ntawm inhibiting kev loj hlob thiab kev loj hlob ntawm cov kab mob no, emodin tuaj yeem tswj tau cov kab mob tshwm sim los ntawm lawv, yog li ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob ntsig txog. Piv txwv li, hauv kev kho cov kab mob ua pa, kab mob hauv lub cev, kab mob hauv plab thiab lwm yam kab mob, emodin tuaj yeem siv los ua cov tshuaj tua kab mob zoo. Cov nyhuv tshuaj tua kab mob no ua rau emodin muaj ntau yam ntawm daim ntawv thov kev cia siab hauv kev lag luam tshuaj.
2. hnoos thiab mob hawb pob
Rhubarb phenol kuj muaj cov txiaj ntsig ntawm kev tshem tawm hnoos thiab mob hawb pob. Nws tuaj yeem txo qhov mob ua pa, txo cov tsos mob hnoos, thiab pab txhim kho kev ua pa. Cov nyhuv no ua rau emodin muaj qee yam txiaj ntsig hauv kev kho mob ntawm cov kab mob ua pa xws li mob khaub thuas, mob ntsws, mob hawb pob, thiab lwm yam. Los ntawm inhibiting cov lus teb inflammatory ntawm cov pa mucosa, txo cov hnoos qeev thiab ua rau hnoos, emodin tuaj yeem txo cov tsos mob thiab txhim kho lawv lub neej zoo.
3. Txhawb txoj hnyuv motility
Rhubarb phenol muaj qhov cuam tshuam tseem ceeb ntawm txoj hnyuv motility. Nws tuaj yeem txhim kho txoj haujlwm peristalsis ntawm txoj hnyuv, txhawb kev zais ntawm cov kua txiv hmab txiv ntoo thiab kev zom zaub mov thiab nqus cov zaub mov. Cov nyhuv no yog qhov tseem ceeb hauv kev txhim kho cov teeb meem hauv plab hnyuv xws li cem quav thiab tsam plab. Los ntawm kev txhawb txoj hnyuv plab thiab tshem tawm cov khoom tsis zoo, emodin pab tswj kev noj qab haus huv hauv cov hnyuv thiab tiv thaiv qhov tshwm sim ntawm cov kab mob hauv plab.
Ib txoj kev npaj rau phab ntsa- rhuav tshem ntawmchrysophanic acid, cov kauj ruam yog raws li nram no:
1) Nws nyob ntawm qhov ziab thiab crushing ntawm cassia noob, sieving los ntawm 40 mesh, soaking cov hmoov nyob rau hauv ethanol, ntxiv cov khoom soaked rau hauv lub ultra- siab siab extractor, thiab extracting chrysophanol los ntawm cassia noob los ntawm ultra- siab siab thiab impinging kwj tshuab;
2) Cov extracted chrysophanol yog eluted nrog chloroform - methanol tov nrog ib tug ntim piv ntawm 20: 1 los ntawm macroporous adsorption resin, thiab cov eluate yog sau thiab concentrated nyob rau hauv txo siab kom tau cov concentrate;
3) Cov concentration yog sib cais thiab purified los ntawm siab -ceev countercurrent chromatography, siv chloroform - methanol - dej raws li ob -theem hnyav system, noj cov theem sab sauv raws li theem nyob ruaj ruaj thiab qis theem raws li theem mobile, nrog lub ntsiab cav tig ceev ntawm 800 - 1000 rpm tus nqi 2 / min, thiab - ndlwg tus nqi ntawm 2. kwj, rov qab cov reagent, thiab ziab kom tau cov khoom. Cov txheej txheem muaj qhov zoo ntawm cov qauv qis dua, kev sib cais zoo thiab tus nqi qis, thiab tuaj yeem tau txais chrysophanol nrog cov ntsiab lus siab thiab zoo.
Lub synthesis ntawm chrysophanol feem ntau yog pib los ntawm ib tug tej yam organic precursor thiab undergoes ib tug series ntawm cov tshuaj tiv thaiv, xws li acylation, txo, diazotization, hydrolysis, cyclization, thiab lwm yam., thaum kawg tau lub hom phiaj khoom chrysophanol. Noj 3-nitrophthalic acid ua cov khoom pib, txoj kev sib txuas nrog ntau cov kauj ruam tseem ceeb thiab cov tshuaj tiv thaiv.
Cov txheej txheem synthesis ntxaws thiab kev sib npaug ntawm cov tshuaj
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Kauj ruam piav qhia:
Pib los ntawm 3-nitrophthalic acid, thawj kauj ruam yog Friedel Crafts acylation cov tshuaj tiv thaiv. Friedel Crafts acylation cov tshuaj tiv thaiv yog ib qho tshuaj tiv thaiv electrophilic ntawm cov tshuaj tsw qab hydrocarbons thiab acylating reagents (xws li acyl chlorides, anhydrides, thiab lwm yam) nyob rau hauv lub xub ntiag ntawm ib tug catalyst, uas ua rau tsim ntawm aromatic ketones. Hauv cov kauj ruam no, 3-nitrophthalic acid reacts nrog ib qho tsim nyog acylation reagent los tsim cov khoom siv acylation.
Vim tsis muaj cov tshuaj tiv thaiv tshwj xeeb thiab cov tshuaj reagents, nws tsis tuaj yeem sau ncaj qha rau kev sib npaug tshuaj. Tab sis daim ntawv dav dav tuaj yeem qhia tau tias:
3-nitrophthalic acid + acylation reagent → acylation khoom
Cov lus piav qhia kauj ruam: Cov khoom acylation tom qab ntawd raug txo qis cov tshuaj tiv thaiv, txo cov pab pawg nitro mus rau ib pawg amino. Cov kauj ruam no feem ntau yog ua los ntawm kev siv cov tshuaj txo qis (xws li hydrogen, hlau catalysts, thiab lwm yam) raws li qhov tsim nyog. Tom qab txo cov tshuaj tiv thaiv, qhov nruab nrab uas muaj cov amino pawg tau txais.
Chemical equation: Ib yam li ntawd, vim tsis muaj cov tshuaj tiv thaiv tshwj xeeb thiab cov tshuaj reagents, cov tshuaj sib npaug tsis tuaj yeem sau ncaj qha. Tab sis daim ntawv dav dav tuaj yeem qhia tau tias:
Acylation khoom → amino muaj nruab nrab
Kauj ruam piav qhia: Cov nruab nrab uas muaj cov amino pawg yog ntxiv rau cov tshuaj tiv thaiv diazotization. Cov tshuaj tiv thaiv diazotization yog cov tshuaj tiv thaiv ntawm cov amino tebchaw thiab nitrous acid (los yog nws cov ntsev) nyob rau hauv acidic tej yam kev mob, uas ua rau tsim diazonium ntsev. Diazonium ntsev yog cov tshuaj tsis ruaj khov uas feem ntau siv hauv cov tshuaj hydrolysis tom qab lossis cyclization.
Chemical sib npaug: Nruab nrab muaj cov amino pawg + nitrous acid → diazonium ntsev
Cov lus piav qhia: Diazonium ntsev tau txais cov tshuaj tiv thaiv hydrolysis nyob rau hauv acidic lossis alkaline tej yam kev mob los tsim cov phenolic tebchaw. Cov kauj ruam no yog ib qho ntawm cov kauj ruam tseem ceeb hauv kev tsim cov qauv ntawm emodin.
Chemical sib npaug: diazonium ntsev → phenolic intermediate
Cov lus piav qhia: Phenolic intermediates tau txais kev cuam tshuam ntxiv cyclization los tsim cov qauv pob txha ntawm emodin. Cov tshuaj tiv thaiv cyclization feem ntau yuav tsum tau ua raws li qhov tsim nyog catalysts thiab tej yam kev mob los xyuas kom meej cov efficiency ntawm cov tshuaj tiv thaiv thiab purity ntawm cov khoom.
Chemical sib npaug: Phenolic intermediate → C15H10O4
Tom qab ua tiav thiab purification
Tom qab tau txais emodin crude, tom qab ua tiav thiab purification feem ntau yuav tsum tau txhim kho cov purity thiab tawm los ntawm cov khoom. Qhov no suav nrog txoj hauv kev xws li hnyav rho tawm, crystallization, thiab kem chromatography. Kev xaiv ntawm txoj kev tshwj xeeb nyob ntawm tus yam ntxwv ntawm txoj kev sib txuas thiab cov khoom ntawm cov khoom.
Raws li cov khoom xyaw nrog kev tiv thaiv kev laus -, rhubarb phenol tau nyiam heev rau nws daim ntawv thov hauv kev tu tawv nqaij thiab cov khoom kho mob.
Kev siv hauv cov khoom tu tawv nqaij
Ntxiv rau cov tshuaj tiv thaiv -aging cream
Cov neeg tsim khoom ntawm daim tawv nqaij tuaj yeem ntxiv rhubarb phenol ua cov khoom muaj txiaj ntsig los tiv thaiv - cov tshuaj pleev kom laus. Cov tshuaj no muaj peev xwm nkag mus tob rau hauv daim tawv nqaij, inhibit lipid peroxidation thiab txo cov ntsiab lus ntawm malondialdehyde (MDA), yog li tiv thaiv cov tawv nqaij ntawm oxidative puas.
Ntev - siv cov tshuaj nplaum uas muaj rhubarb phenol ua rau cov tawv nqaij elasticity thiab radiance, txo cov tsos ntawm wrinkles thiab kab zoo, thiab ua rau daim tawv nqaij zoo dua thiab noj qab nyob zoo.
Ntxiv rau Serums
Serums yog cov concentrated active ingredient cov khoom nyob rau hauv kev tu tawv nqaij. Ntxiv rhubarb phenol rau cov ntshav tso cai rau nws kom zoo dua absorbed rau hauv daim tawv nqaij thiab siv zog ntau dua los tiv thaiv- laus.
Serum uas muaj rhubarb phenol tuaj yeem pab txhawb rau daim tawv nqaij, txhim kho daim tawv nqaij muaj peev xwm antioxidant, tshem tawm cov dawb radicals thiab tiv thaiv kev laus ntawm daim tawv nqaij.
kev siv cov khoom kho mob
Anti-cov tshuaj tiv thaiv kev laus
Cov tuam txhab tsim khoom noj qab haus huv tuaj yeem siv rhubarb phenol ua cov khoom xyaw tseem ceeb, ua ke nrog lwm cov khoom xyaw nrog los tiv thaiv- kev laus (xws li vitamin E, vitamin C, thiab lwm yam) los ua cov tshuaj tiv thaiv - laus.
Cov tshuaj ntsiav zoo li no tuaj yeem yooj yim rau tib neeg noj txhua hnub los pab txhim kho lub cev muaj peev xwm antioxidant thiab txo qhov kev puas tsuaj los ntawm oxidative kev nyuaj siab rau lub cev, yog li ua rau cov txheej txheem laus.
Ntxiv rau Serums
Serums yog cov concentrated active ingredient cov khoom nyob rau hauv kev tu tawv nqaij. Ntxiv rhubarb phenol rau cov ntshav tso cai rau nws kom zoo dua absorbed rau hauv daim tawv nqaij thiab siv zog ntau dua los tiv thaiv- laus.
Serum uas muaj rhubarb phenol tuaj yeem pab txhawb rau daim tawv nqaij, txhim kho daim tawv nqaij muaj peev xwm antioxidant, tshem tawm cov dawb radicals thiab tiv thaiv kev laus ntawm daim tawv nqaij.
Cov xwm txheej tshwj xeeb
Ib lub npe zoo - paub txog kev tu tawv nqaij tau tshaj tawm cov tshuaj tiv thaiv kev laus - muaj rhubarb phenol. Cov qab zib tau dhau los ua kev ntsuam xyuas kev nyab xeeb thiab kev ua tau zoo thiab tau ua pov thawj los txhim kho daim tawv nqaij elasticity thiab radiance, thiab txo cov tsos ntawm wrinkles thiab kab zoo. Cov neeg siv khoom tau tshaj tawm cov tawv nqaij firmer thiab smoother uas zoo li hluas dua tom qab siv.
Lub tuam txhab nutraceutical tau tshaj tawm cov tshuaj tiv thaiv - kev laus tshuaj ntsiav uas muaj rhubarb phenol. Lub capsule tau txais kev saib xyuas dav dav thiab cov kev tshuaj xyuas zoo hauv kev ua lag luam. Cov neeg tau txais kev pab tau tshaj tawm tias tom qab noj cov tshuaj ntsiav, lawv lub cev lub peev xwm antioxidant tau txhim kho zoo thiab lawv xav tias muaj zog thiab yau dua.
Nyob rau hauv cov ntsiab lus, daim ntawv thov ntawm rhubarb phenol nyob rau hauv kev kho mob ntawm daim tawv nqaij thiab cov khoom kho mob muaj ib tug dav prospect thiab muaj peev xwm. Los ntawm kev tshawb fawb thiab kev xav tau ntxiv rau cov khoom lag luam, nws cov kev tiv thaiv kev laus - tuaj yeem siv tag nrho los pab cov neeg hluas thiab noj qab haus huv.
FAQ
1. Chrysophanic Acid yog dab tsi?
Nws yog feem ntau yog ib hom anthraquinone-raws li natural compound muab rho tawm los ntawm cov nroj tsuag xws li rhubarb thiab senna, thiab nws muaj cov yam ntxwv lom.
2. Nws lub luag haujlwm tseem ceeb thiab kev siv yog dab tsi?
Kev lig kev cai, nws tau raug siv vim nws cov tshuaj laxative, tshuaj tua kab mob (tshwj xeeb tshaj yog tshuaj tua kab mob) thiab tiv thaiv - cov khoom ua rau mob. Kev tshawb fawb niaj hnub no tseem tsom mus rau nws cov kev siv peev xwm hauv cov kab mob ntawm daim tawv nqaij (xws li psoriasis, ringworm), thiab tswj cov cell proliferation.
3. Puas muaj kev nyab xeeb rau kev siv? Cov kev phiv tshwm sim yog dab tsi?
Raws li cov khoom muaj zog, kev siv tsis raug yuav ua rau khaus. Kev siv qhov ncauj tuaj yeem ua rau mob plab, plab hnyuv loj thiab tsis txaus electrolyte; Kev siv sab nraud tuaj yeem ua rau tawv nqaij kub hnyiab thiab liab. Nws yuav tsum tau siv raws li kev cob qhia kws tshaj lij.
4. Cov kev ceev faj tseem ceeb yog dab tsi?
Cov poj niam cev xeeb tub, cov poj niam lactating, cov menyuam yaus thiab cov neeg uas muaj cov hnyuv rhiab yuav tsum tsis txhob siv nws. Tsis txhob noj nws ntev lossis ntau npaum li cas los tiv thaiv kev vam khom lossis kev puas tsuaj rau txoj hnyuv. Tham nrog kws kho mob lossis kws muag tshuaj ua ntej siv.
Cim npe nrov: Chrysophanic acid CAS 481-74-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom