Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm 3-hydroxytyramine cas 51-61-6 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 3-hydroxytyramine cas 51-61-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
3-Hydroxytyramineyog ib hom tshuaj siv los pab cov hlwb xa cov pulses, thiab nws yog ib yam khoom siv paj hlwb. Cov khoom siv hluav taws xob no feem ntau yog lub luag haujlwm rau lub hlwb kev ntshaw, kev xav, thiab kev xa cov ntaub ntawv zoo siab thiab zoo siab. Nws tseem hu ua dopamine, xa cov teeb liab ntawm cov neurons thiab tswj kev ua haujlwm hauv lub hlwb thiab hauv nruab nrab paj hlwb. Molar mass yog 153.18 g / mol. Qhov no txhais tau hais tias ib gram ntawm cov khoom molecules muaj txog 6.5 × 10 ^ 20 molecules, thiab nws qhov hnyav molecular yog me me, uas yog qhov zoo rau kev hla cov cell membrane thiab nkag mus rau sab hauv ntawm cov neurons kom ua tiav neurotransmission. Tsis tas li ntawd, nws tseem koom nrog ntau lwm cov txheej txheem physiological, xws li kev tswj cov hlab plawv, lub plab zom mov teb, lub cev tsis muaj zog thiab lub hlwb ua haujlwm, thiab lwm yam.
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Tshuaj Formula |
C8H11NO2 |
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Exact Mass |
458 |
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Molecular Luj |
459 |
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m/z |
153 (100.0%), 154 (8.7%) |
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Elemental Analysis |
C, 62.73; H, 7.24; N, 9.14; O, 20.89 |
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3-Hydroxytyraminereceptors yog qhov chaw uas khi rau daim nyias nyias thiab tau lees paub los ntawm neurotransmitter dopamine. Dopamine receptors muaj nyob rau hauv lub hauv nruab nrab lub paj hlwb (CNS) kuj muaj nyob rau hauv lub periphery. Raws li biochemical thiab pharmacological qauv, cov receptor no tau muab faib ua ob hom. Micro Friction concentration ntawm dopamine ua rau D1 dopamine receptor, uas tuaj yeem txhawb kev ua haujlwm ntawm adenylate cyclase. Phenothiazide dopamine antagonists xws li fluphenazine muaj zog heev, thiab tsuas yog namo theem yuav tsum tau inhibit qhov kev cuam tshuam ntawm dopamine D1 receptor, thaum butyryl benzene antagonists xws li haloperidol tsis tshua muaj txiaj ntsig Nws tsis muaj zog npaum li cas, thiab cov nyhuv tsuas yog pom ntawm micro waviness. Ergot nrog cov nyhuv dopamine yog ib feem agonist ntawm qaug zog D1 receptor. Ntawm qhov tsis sib xws, qhov kev txiav txim ntawm dopamine agonist ntawm namo concentration ntawm D2 receptor tuaj yeem inhibit adenylate cyclase kev ua haujlwm los ntawm lwm cov tshuaj hormones lossis neurotransmitters. Rau D2 receptors, cov teebmeem ntawm phenothiazine thiab butyrylbenzenes yog nanomolar, thiab ergot nrog cov nyhuv dopamine yog lub zog ua tiav agonist. Phenylamide antipsychotics, xws li sulpiride, raws li antagonists, muaj cov teebmeem xws li namo mus rau micromotor, tab sis lawv tsis muaj kev cuam tshuam rau D1 dopamine receptor.
2- (3,4-dihydroxyphenyl) ethylamine, tseem hu ua dopamine, yog cov organic compound uas ua lub luag haujlwm tseem ceeb hauv cov kab mob muaj sia. Nws tsis tsuas yog ua lub luag haujlwm tseem ceeb hauv lub paj hlwb, tab sis kuj nthuav tawm ntau yam kev ua ub no, nrog rau kev siv dav dav hauv kev kho mob. Cov hauv qab no yog kev tshawb fawb ntxaws txog kev ua haujlwm lom neeg ntawm 2- (3,4-dihydroxyphenyl) ethylamine
Cov mis mos molecular ntawm 2- (3,4-dihydroxyphenyl) ethylamine yog C8H11NO2, nrog rau qhov hnyav molecular ntawm 153.18 thiab CAS naj npawb ntawm 51-61-6. Nws yog nyob rau hauv daim ntawv ntawm chav tsev kub, nrog ib tug xim xws li los ntawm lub teeb xim av mus rau xim av. Lub melting point range ntawm no compound yog 218 ~ 220℃C, nrog ib tug boiling point ntawm kwv yees li 276.1℃C (kwv yees tus nqi), ib tug ceev ntawm 1.1577 (kwv yees tus nqi), thiab ib tug refractive index ntawm 1.4770 (kwv yees tus nqi). Nws muaj qee yam solubility hauv dej, tshwj xeeb tshaj yog nyob rau hauv acidic tej yam kev mob, thiab tseem tuaj yeem yaj me ntsis tom qab cua sov hauv DMSO thiab methanol.
Neurotransmitter ua haujlwm
Raws li lub ntsiab catecholamine neurotransmitter nyob rau hauv mammalian hlwb,3-Hydroxytyramineplays lub luag haujlwm tseem ceeb hauv cov paj hlwb. Nws tswj hwm ntau yam kev ua haujlwm ntawm lub cev los ntawm kev tso tawm cov cim los ntawm cov neurons thiab xa mus rau lwm cov paj hlwb, suav nrog:
(1) Kev tswj kev txav mus los: Dopamine feem ntau koom nrog hauv kev tswj cov leeg nqaij leeg, uas muaj feem cuam tshuam nrog lub paj hlwb basal ganglia. Nws tuav qhov sib npaug ntawm excitatory thiab inhibitory signals nyob rau hauv lub cev muaj zog txoj kev, kom ntseeg tau tias kev sib koom tes, raug thiab sib npaug ntawm lub cev txav. Kev tsis txaus ntawm dopamine tuaj yeem ua rau muaj kev cuam tshuam ntawm kev txav mus los xws li tshee thiab tawv.
(2) Kev txawj ntse muaj nuj nqi: Nws muaj kev cuam tshuam tseem ceeb ntawm kev paub txog lub luag haujlwm xws li kev mloog, kev nco, thiab kev muaj peev xwm kawm. Dopamine tuaj yeem txhim kho lub hlwb lub peev xwm los tsom rau lub hom phiaj cov ntaub ntawv, txhawb kev tsim thiab sib sau ua ke ntawm kev nco, thiab pab txhawb kev kawm thiab kev paub txog kev paub tshiab thiab kev txawj ntse, uas yog qhov tseem ceeb rau kev paub txog kev ua haujlwm.
(4) Kev tswj kev xav: Dopamine muaj feem cuam tshuam nrog cov lus teb ntawm kev xav xws li kev txaus siab, kev zoo siab, thiab khoom plig. Nws yog tus neeg nruab nrab tseem ceeb ntawm lub paj hlwb lub nqi zog. Thaum cov qib dopamine hauv lub hlwb nce (xws li tom qab ua tiav lub hom phiaj lossis tau txais cov lus pom zoo), tib neeg yuav hnov zoo siab thiab txaus siab, thaum nws qhov tsis txaus yuav cuam tshuam nrog kev xav tsis zoo.
(5) Kev txhawb nqa zoo: Dopamine pab cov kab mob hloov mus rau lawv qhov chaw nyob thiab txhim kho lawv txoj kev muaj sia nyob los ntawm kev txhawb nqa tus cwj pwm zoo. Nws tuaj yeem ntxiv dag zog rau kev sib txuas ntawm qee tus cwj pwm thiab nws qhov txiaj ntsig zoo, ua rau cov kab mob rov ua tus cwj pwm zoo (xws li kev noj zaub mov thiab zam kev phom sij) kom tswj tau lawv tus kheej txoj sia nyob thiab kev yug me nyuam.
(6) Kev noj zaub mov thiab kev tswj hwm endocrine: Dopamine tseem koom nrog hauv kev tswj kev qab los noj mov thiab cov kab mob endocrine. Nws tuaj yeem cuam tshuam kev noj zaub mov ntau dhau los ntawm kev tswj hwm qhov chaw pub mis hauv hypothalamus, thiab koom nrog kev tswj hwm cov tshuaj hormones xws li insulin thiab thyroid hormone, yog li cuam tshuam rau lub cev lub zog sib npaug thiab cov txheej txheem metabolic.
Kev ua haujlwm lom neeg thiab cov tshuaj pharmacological
Nyob rau hauv xyoo tas los no, ntau cov kev tshawb fawb tau qhia txog kev ua haujlwm lom neeg tseem ceeb thiab ntau yam tshuaj muaj txiaj ntsig hauv kev kho mob.
(1) Antioxidant nyhuv: Dopamine tuaj yeem tshem tawm cov dawb radicals, txo oxidative kev nyuaj siab puas tsuaj, thiab tiv thaiv cov hlwb los ntawm oxidative puas. Cov nyhuv antioxidant no tseem ceeb heev rau kev tiv thaiv thiab kho cov kab mob plawv, kab mob neurodegenerative, thiab lwm yam.
(2) Anti-inflammatory nyhuv: Los ntawm kev tswj cov inflammatory teb, dopamine yuav alleviate inflammatory kev puas tsuaj thiab txhawb kev kho mob. Cov tshuaj tiv thaiv no -cov nyhuv inflammatory muaj peev xwm siv tau rau hauv kev kho mob ntawm cov kab mob xws li mob caj dab, enteritis, thiab lwm yam.
(3) Cov nyhuv Antitumor: Dopamine tuaj yeem cuam tshuam qhov kev loj hlob thiab kev sib txawv ntawm cov qog hlwb, yog li ua kom pom qhov muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav. Nws cuam tshuam rau kev loj hlob thiab apoptosis txheej txheem ntawm cov qog hlwb los ntawm kev tswj cov kab mob hauv lub cev.
(4) Kev tiv thaiv kab mob plawv: Dopamine tuaj yeem nthuav cov hlab ntsha, txo cov ntshav siab, ua kom lub plawv dhia, thiab yog li txhim kho cov hlab plawv. Cov nyhuv no ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob plawv xws li ntshav siab, plawv tsis ua haujlwm, thiab lwm yam.
(5) Cov nyhuv Neuroprotective:
Dopamine muaj cov teebmeem neuroprotective thiab tuaj yeem txo cov kev puas hlwb hauv cov kab mob neurodegenerative xws li Parkinson's disease, Alzheimer's disease, thiab lwm yam. Nws txhim kho neural muaj nuj nqi los ntawm kev txhawb kev loj hlob thiab kho cov neurons.
Daim ntawv thov hauv kev kho mob
Vim nws muaj ntau yam kev ua ub no lom neeg thiab cov tshuaj pharmacological, 2- (3,4-dihydroxyphenyl) ethylamine muaj cov ntawv thov dav dav hauv kev lag luam tshuaj.
(1) Cov tshuaj tiv thaiv kev poob siab:
Dopamine yog ib qho tshuaj tiv thaiv kev poob siab uas tuaj yeem siv los kho ntau hom kev poob siab, suav nrog kev poob siab, kev poob siab cardiogenic, hemorrhagic shock, thiab hauv nruab nrab poob siab. Tshwj xeeb tshaj yog rau cov neeg mob lub raum tsis txaus, txo qis cov zis tawm, cov hlab ntsha tsis muaj zog, thiab cov ntshav ntim tau ntxiv lawm, qhov kev kho mob tseem ceeb ntawm dopamine tseem ceeb dua. Nws ua rau kom muaj sia nyob ntawm cov neeg mob los ntawm kev ua kom lub plawv tso zis, dilating cov hlab ntsha, thiab txhim kho microcirculation.
(2) Kev kho cov kab mob neurological:
Dopamine plays lub luag haujlwm tseem ceeb hauv kev kho cov kab mob neurological. Piv txwv li, hauv kev kho mob Parkinson tus kab mob, dopamine tuaj yeem ntxiv qhov tsis txaus ntawm dopamine hauv tus neeg mob lub cev, txhim kho cov tsos mob xws li kev txav mus los thiab cov leeg nqaij. Tsis tas li ntawd, dopamine kuj tuaj yeem siv los kho cov kab mob neurological xws li kev tsis txaus siab tsis txaus ntseeg siab (ADHD) thiab kev nyuaj siab.
(3) Kev kho mob plawv:
Dopamine muaj ntau yam kev siv hauv kev kho mob plawv. Nws tuaj yeem siv los kho cov kab mob xws li lub plawv tsis ua haujlwm, myocardial infarction, thiab arrhythmia. Dopamine tuaj yeem txo cov tsos mob thiab txhim kho lub neej zoo hauv cov neeg mob los ntawm kev ua kom lub plawv dhia, txo cov ntshav siab, thiab txhim kho cov ntshav myocardial.
(4) Kev kho mob raum:
Dopamine kuj tseem siv tau los kho cov kab mob raum. Nws txhim kho lub raum kev ua haujlwm los ntawm dilating lub raum cov hlab ntsha, ua rau lub raum ntshav txaus, thiab txhim kho glomerular pom tus nqi. Dopamine muaj qee yam kev kho mob hauv kev kho cov kab mob xws li mob raum raug mob thiab mob raum tsis ua haujlwm.
(5) Lwm yam kev siv:
Ntxiv nrog rau cov ntawv thov saum toj no, dopamine kuj tuaj yeem siv los kho cov kab mob endocrine, kab mob ua pa, thiab kab mob hauv plab. Piv txwv li, hauv kev kho mob ntshav qab zib mellitus, dopamine tuaj yeem tswj hwm kev zais cia thiab siv cov tshuaj insulin thiab txhim kho cov ntshav qab zib. Thaum kho mob hawb pob bronchial, dopamine tuaj yeem ua rau cov leeg nqaij bronchial du thiab txo cov tsos mob hawb pob. Thaum kho mob plab rwj, dopamine tuaj yeem cuam tshuam rau lub plab acid secretion thiab txhawb kev kho rwj.
Raws li ib qho tshuaj lom neeg, muaj ntau yam kev siv hluavtaws ntawm3-Hydroxytyramine. Nov yog qee txoj kev siv hluavtaws
1. Hoffmann ammonia synthesis method:
Txoj kev ua kom ntxov tshaj plaws ntawm nws yog Hoffmann ammonia synthesis method. Txoj kev tshwj xeeb yog ua kom sov resorcinol thiab potassium hydroxide txog li 150℃los tsim cov aldehydes thiab ketones, thiab tom qab ntawd distilled nrog ammonia dej kom tau cov khoom. Txawm hais tias txoj kev npaj tau yooj yim, cov txiaj ntsig tau qis thiab qhov kub thiab txias yuav tsum tau ua, yog li nws maj mam hloov los ntawm lwm txoj hauv kev zoo dua.
2. Wolff-Kishner txo txoj kev:
Wolff-Kishner txo txoj kev yog ib txoj kev txo qis ntawm ketones, uas tau siv rau kev npaj nws. Feem ntau, 4-hydroxyacetophenone yog thawj zaug npaj nrog resorcinol, tom qab ntawd txo qis rau cov cawv sib xws nrog hydrogen ammonia dej lossis sodium isopropoxide, thiab lub cev qhuav dej hauv qab alkaline los tsim cov khoom. Txoj kev no siv cov mob me me, tab sis yuav tsum tau siv lub hauv paus muaj zog, thiab yuav tsum tau them nyiaj rau kev ua haujlwm.
3.Introduction to the Wolff-Kishner txo txoj kev:
3-Hydroxytyramineyog ib qho khoom siv roj ntsha uas muaj nyob rau hauv lub paj hlwb thiab koom nrog ntau yam txheej txheem physiological xws li kev txav mus los, kev kawm thiab kev coj cwj pwm. Yog li ntawd, nws yog ib qho tseem ceeb los npaj cov khoom. Lub Wolff-Kishner txo yog ib txoj hauv kev txo cov aldehydes los yog ketones rau cov sib txuas alkyl lossis aryl compounds. Lub hauv paus ntsiab lus ntawm cov tshuaj tiv thaiv yog: thawj zaug sib tov ketone los yog aldehyde nrog ntau tshaj ammonia dej thiab sodium hydroxide los tsim cov oxime compound. Tom qab ntawd cov tau txais oxime compound yog tov nrog sodium hydroxide thiab ethylene glycol, thiab rhuab ntawm qhov kub thiab txias los ua deoxidation los tsim cov sib txuam alkyl lossis aryl compound.
Kev cuam tshuam los ntawm cov tshuaj tiv thaiv redox:
Nws muaj hydroxyl (–OH) thiab amine (–NH2) cov pab pawg ua haujlwm thiab yog cov khoom siv electrophilic. Nws tuaj yeem txais electrons lossis poob electrons, thiab koom nrog cov tshuaj tiv thaiv redox tseem ceeb hauv cov kab mob muaj sia. Nws yog interconverted nrog rau lwm cov metabolites nyob rau hauv vivo, yog hais tias nws muaj peev xwm ntxiv oxidized rau hauv dopamine los yog norepinephrine, nws kuj yuav thim rov qab los ntawm kev txo cov tshuaj tiv thaiv. Qhov sib npaug ntawm cov tshuaj tiv thaiv redox no yog tus yuam sij rau kev tswj kev ruaj ntseg thiab kev ua haujlwm ntawm cov khoom hauv vivo.
Kev khi rau receptors:
Nws tuaj yeem khi rau receptors los ua lub luag haujlwm tsom. Piv txwv li, nws tuaj yeem khi rau dopamine receptors, norepinephrine receptors lossis adrenergic receptors thiab koom nrog cov teeb liab sib xws. Nws tuaj yeem khi rau ntau yam proteins xws li tyrosine kinase, MAPK / ERK txoj hauv kev, thiab cuam tshuam rau lawv txoj haujlwm thiab kev ua haujlwm.
Hydroxylation tshwm sim:
3-Hydroxytyraminetuaj yeem ua rau cov tshuaj tiv thaiv hydroxylation nyob rau hauv qee yam mob, thiab cov tshuaj tiv thaiv hydroxylation feem ntau xav tau kev koom tes ntawm exogenous catalysts. Piv txwv li, hydrogen peroxide (H2O2) thiab catalyst hlau ion (Fe2+) tuaj yeem siv los ntxiv cov pab pawg hydroxyl ntawm cov khoom rau lub nplhaib uas muaj ntxhiab los tsim cov khoom quinone. Cov khoom no muaj feem xyuam rau kev ua haujlwm lom neeg ntawm nws.
muaj peev xwm ntawm redox cov tshuaj tiv thaiv:
Nws yog electrophilic thiab tuaj yeem ua rau cov tshuaj tiv thaiv redox. Hauv cov kab mob muaj sia, nws feem ntau yog oxidized rau qhov tseem ceeb sib npaug ntawm cov neurotransmitter dopamine, uas tuaj yeem txo qis rau norepinephrine los ntawm kev txo qis. Cov tshuaj tiv thaiv redox no yog cov txheej txheem metabolic tseem ceeb hauv cov kab mob, uas tuaj yeem ua kom ruaj khov thiab ua haujlwm ntawm cov khoom.
Nws tuaj yeem ua ke nrog lwm cov tshuaj los ua biomolecules xws li protein, DNA thiab RNA:
Hydroxytyramine tuaj yeem ua ke nrog lwm cov tshuaj los ntawm nws cov pab pawg ua haujlwm los tsim cov biomolecules tshiab, xws li cov protein, DNA thiab RNA. Hauv cov neurons, nws khi rau lwm cov neurotransmitters, enzymes thiab receptors, yog li txhawb kev sib kis ntawm neurotransmitter thiab neuromodulation. Tsis tas li ntawd, nws tuaj yeem cuam tshuam nrog cytochrome P450 enzymes, cuam tshuam nws cov metabolism thiab ua rau muaj kev cuam tshuam ntawm cov tshuaj.
FAQ
3-hydroxytyramine yog dab tsi?
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3-Hydroxytyramine, Hydrochloride yogib tug loj catecholamine neurotransmitter. 62-31-7. Purity: Ntau dua lossis sib npaug li 98%
CAS tus lej ntawm 62 31 7 yog dab tsi?
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CAS Nr .: 62-31-7 Khoom npe:Dopamine Hydrochloride - API| Lub npe tshuaj: Dopamine Hydrochloride|Pharmaffiliates.
Cim npe nrov: 3-hydroxytyramine cas 51-61-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom