5-Chlorouracilyog cov organic compound uas yog dawb rau yuav luag dawb cov hmoov nplej dawb, feem ntau ua rau muaj cov qauv me ntsis crystalline. Qhov hnyav molecular yog 146.53, yog 1820 - 81- 1, thiab cov mis nyuj molecular yog c4h3cln2o2. Lub solubility hauv dej yog 1m nh4oh: soluble ntawm 50mg / ml, thiab acidity coefficient (PKA) yog 6.77) yog 6.77 (kwv yees). Nws yog pyrimidine analogue tsuas yog siv rau kev kho mob ntawm cov qog. Nws yog hom kev tiv thaiv yeeb tshuaj metabolic. Feem ntau siv hauv kev sib xyaw nrog leucovorin. Tom qab reacting nrog uracil, xenon difluoride ua rau 5-fluorouracil. Nws kuj tseem siv tau los ua ke nrog capecitabine, uas yog nqus tau qhov ncauj thiab hloov mus rau 5-fu hauv cov ntaub so ntswg kom tau txais kev tawm tsam kev tawm tsam kev tawm tsam kev tawm tsam. Raws li cov tshuaj tiv thaiv qog xim, fluorouracil kuj tseem muaj tus nqi nyob hauv cov xwm txheej ntawm lwm cov pyrimidine derivatives. Cov tebchaw muaj ntau cov kev siv hauv kev tshawb fawb kev tshawb fawb lub neej xws li DNA cov txheej txheem kev kawm xws li cov khoom noj fluorescent xws li fluorescent dyes, pigments, thiab surfactants.
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Tshuaj Cov Qauv |
C4h3Cln2o2 |
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Muaj pes tsawg leej |
146 |
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Molecular hnyav |
147 |
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m/z |
146 (100.0%), 148 (32.0%), 147 (4.3%), 149 (1.4%) |
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Kev Ntsuam Xyuas |
C, 32.79; H, 2.06; Cl, 24.19; N, 19.12; O, 21.84 |
5-Chlorouracilyog ib tus organic compound feem ntau siv rau kev sib xyaw ntawm lwm yam tshuaj thiab tshuaj lom neeg, nrog ntau yam tshuaj.
1. Cov hluavtaws los tiv thaiv - cov tshuaj siv qog tshuaj: nws yog cov organic sib xyaw nrog cov qauv kev coj ua ntawm pyrimidine. Nws yog dav siv nyob rau hauv cov synthesis ntawm anti - Cov neeg siv cov tshuaj qog, feem ntau yog los ntawm inhibiting thymidine nucleotide cuam tshuam nrog DNA synthesis. Cov enzyme no yog ib qho ntawm cov txheej txheem tseem ceeb hauv cov txheej txheem ntawm cov txheej txheem ntawm tes, lub luag hauj lwm rau synthesizing thymidine nucleotides xav tau rau DNA. Los ntawm inhibiting txoj kev ua ntawm enzyme no, DNA synthesis yog tiv thaiv, yog li inhibiting txoj kev loj hlob thiab muaj kev loj hlob ntawm cov qog hlwb.
Hais txog kev kho mob, nws yog feem ntau yog siv rau kev kho mob qog noj ntshav, mob cancer mis, mob qog noj ntshav thiab lwm yam qog ua mob. Cov cancer no feem ntau muaj qhov siab xav rau DNA synthesis, yog li muaj peev xwm ua rau muaj kev nkag siab qog ntawm tes los ntawm kev cuam tshuam ntawm tes los ntawm cuam tshuam nrog DNA synthesis. Kev sib xyaw ua ke nrog lwm cov tshuaj tuaj yeem txhim kho lawv cov kev tua ntawm cov qog nqaij hlav thiab txuas ntxiv txhim kho txoj kev kho mob.
2. Cov khoom noj fluorouracil:
Ua si lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm cov khoom ua kom zoo nkauj. Fluorouracil yog ib qho siv dav ove - cov tshuaj siv qog ua yog los ntawm cov qog nqaij hlav los ntawm kev cuam tshuam nrog DNA synthesis. Tus txheej txheem no yog qhov tseem ceeb rau kev tswj thiab kho cov qog.
Nyob rau hauv cov txheej txheem ntawm sterthesizing fluorouracil, nws yog ib qho tsim nyog los ua ke 5Colouracil nrog cov tshuaj fluorine. Qhov kev tawm tsam no feem ntau yuav tsum tau nqa tawm hauv cov tshuaj lom neeg los ua kom muaj kev kawm tau zoo ntawm cov tshuaj tiv thaiv thiab kev coj dawb huv ntawm cov khoom. Los ntawm kev sib txuas nrog cov tshuaj fluorine, cov qauv hauv kev hloov pauv, sib sau ua ib qho kev sib txuas lus tshiab hu ua cov fluorouracil.
Fluorouracil muaj anti {{{0} Kev ua cov qog thiab tuaj yeem siv los kho ntau yam qog ntshav, xws li cancer mob cancer, mob cancer mis thiab mob plab. Nws cov kev ua tau zoo tau raug suav tau rau hauv ntau ntawm cov chaw kuaj mob thiab kho mob hauv tsev kho mob. Kev siv sib xyaw nrog lwm cov tshuaj tuaj yeem txhim kho lawv cov nyhuv ntxiv rau cov qog nqaij hlav thiab txhim kho cov nyhuv kho.
3. Cov Khoom Siv Hluav Taws Xob: Capecitabine yog qhov ncauj siv tshuaj tiv thaiv qog hauv lub cev, uas tuaj yeem npaj tau los ntawm kev sib txuas nrog cov tshuaj tsim nyog. Capecerabine yog feem ntau yog siv los kho mob cancer cancer, mob cancer mis, mob qog nqaij hlav thiab lwm yam qog ua mob.
Cov tshwm sim ntawm cov khoom no yog dab tsi?
1. Digestive System Cov Txiaj Ntsig
- Xeev siab thiab ntuav: Cov no yog cov kev phiv hluav taws xob hauv plab tshaj plaws, feem ntau tau tshaj tawm thaum ntxov ntawm kev noj tshuaj, thiab yuav maj mam ua kev kho mob.
- Kev tsis pub noj qab haus qis dua: Cov neeg mob yuav muaj kev tsis qab los vim tias muaj kev cuam tshuam ntawm kev noj tshuaj.
- Mob plab thiab raws plab: qee tus neeg mob yuav tsis xis nyob lossis raws plab nyob hauv plab, thiab mob ntshav plab lossis ntshav nqaij tawv yuav tshwm sim. Lub sijhawm no, cov tshuaj yuav tsum nres tam sim ntawd thiab cov tsos mob yuav tsum tau muab.
2. Kev phiv ntshav phiv
- Kev ua haujlwm pob txha pob txha: qhov no cov lus sib xyaw tuaj yeem cuam tshuam txog cov hlwb pob txha, ua kom tsawg cov qe ntshav, ntshav liab, thiab platelets. Qhov no tuaj yeem ua rau muaj kev pheej hmoo kis tus mob, mob ntshav, thiab los ntshav.
- Cov ntshav tsawg dua: Qhov no yog ib qho ntawm cov ntshav sab hauv 2-3 lub lis piam tom qab pib kho, thiab yuav rov qab los ua ib txwm tom qab 3-4 lub lis piam.
3. Qhov ncauj mencosa thiab cov tawv nqaij phiv
- Qhov ncauj ntawm qhov ncauj lossis ulceration: ib qho ntawm cov kev phiv tshwj xeeb ntawm cov kab ke no yog qhov ua rau muaj qhov ncauj ua rau muaj mob rwj hauv cov mob hnyav.
- Cov xim tawv nqaij: Cov neeg mob yuav hnov cov xim tawv nqaij ntawm lub ntsej muag, cov tes, thiab lwm yam chaw tom qab siv.
- Cov plaub hau poob thiab kev siv cev nqaij daim tawv: Siv tau ntev ntev yuav ua rau cov teeb meem ntawm daim tawv nqaij xws li plaub hau poob thiab dermatitis.
4. Mob siab mus
Mob siab ua haujlwm tsis pom: Nws yog metabolized hauv daim siab thiab tuaj yeem ua rau rov ua haujlwm rau lub siab. Yog li ntawd, kev soj ntsuam ntawm daim siab ua haujlwm yog tsim nyog thaum siv.
5. Cardiotoxicity
Tej yam tsis tshua muaj kev cuam tshuam: Hauv qee kis tsis tshua muaj neeg yuav ua rau cov neeg mob plawv yuav ua rau cov neeg mob plawv xws li arrhythmia, angina, lossis hloov hauv electrocardiogram. Thaum cov tshuaj tiv thaiv no tshwm sim, kev siv fluorouracil yuav tsum tau nres thiab tsim nyog kev kho mob yuav tsum tau ua.
6. Neurotoxicity
- Peripheral neuropathy: nws tuaj yeem cuam tshuam rau lub paj hlwb, ua rau peripheral neuropathy. Qee tus neeg mob yuav muaj cov tsos mob xws li kev ua tsis ncaj, loog hauv lawv txhais tes thiab txhais taw, thiab neuralgia.
- Lub sij hawm ntev Neurotoxicity: ntev siv fluorouracil yuav ua rau muaj kev lom zem ntau rau cov leeg ntshav.
7. Kev phiv hauv zos
Venous o: Thaum txhaj cov tshuaj no, cov pa hluav taws hauv zos yuav tshwm sim.
8. Lwm cov kev mob tshwm sim
- Txhim kho cov cardiotoxicity: rau cov neeg mob uas tab tom muaj kab mob xws li mob plawv caj qaum, nws cov ntawv xov xwm plawv yuav tau tshaj tawm.
- Cov tshuaj tau nce ntxiv: vim nws cov tshuaj metabolism me me, cov tshuaj no tau dhau los ntawm lub cev, thiab siv ntau dhau tuaj yeem ua rau muaj kev lom zem ntau.
Dab tsi yog qhov muag muag rau cov khoom no?
Tshuaj Yeeb Nkab Reagent
Ntau tus kws tshaj lij tshuaj lom neeg muab cov kev pabcuam muag rau5-ChlorouracilCov. Cov chaw muab khoom no feem ntau muaj cov khoom siv tshuaj lom neeg tshuaj lom neeg, nrog rau cov khoom siv hluav taws xob xws li guarpaceuticals muaj ntau cov tshuaj lom neeg cov khoom siv tshuaj ntsuam cov khoom lag luam. Koj tuaj yeem tshawb cov khoom ntawm cov platform no thiab hu rau tus xa khoom rau kev sab laj thiab yuav.
Hu ncaj qha rau cov chaw muag khoom: Qee tus neeg muag khoom yuav tshaj tawm cov khoom xa tawm ntawm lawv cov vev xaib cov vev xaib, thiab koj tuaj yeem tuaj xyuas cov vev xaib no hu rau cov neeg sab laj thiab yuav.
Kws Kho Mob Cov Tuam Txhab
Kws tsim khoom lag luam kws tshaj lij tshwj xeeb hauv kev tsim khoom thiab kev lag luam ntawm cov khoom xyaw hauv cov chaw muag tshuaj thiab cov khoom tseem ceeb rau kev yuav khoom no. Cov tuam txhab no feem ntau muaj cov zoo - nrhiav ntau lawm, thiab kev tshuaj xyuas zoo, thiab cov khoom lag luam zoo, thiab cov kev pabcuam zoo.
Cov ntaub ntawv tawm haujlwm: Qee cov tuam txhab kws tshuaj yuav tshaj tawm cov vev xaib cov vev xaib ntawm lawv lub vev xaib no thiab koj tuaj yeem tiv toj lub tuam txhab rau kev sab laj thiab yuav.
Kws Kho Mob Cov Tuam Txhab
Kev lag luam kev lag luam: kev lag luam kws nthuav dav feem ntau tuav ntau lub sijhawm ua yeeb yam, uas yog cov hauv kev zoo rau kev kawm txog kev lag luam qauv, cov khoom lag luam, thiab cov khoom yuav khoom. Koj tuaj yeem tshawb rau cov tuam txhab tshuaj uas muab cov tshuaj no ntawm kev nthuav qhia thiab muaj ntsej muag {- Kev sib txuas lus thiab kev yuav khoom nrog lawv.
Cov chaw tshawb fawb thiab tsev kawm qib siab
Qee cov chaw tshawb fawb thiab cov tsev kawm qib siab kuj tseem muaj nws cov lus nug thiab txaus siab muag rau sab nraud ntiaj teb. Cov chaw haujlwm no feem ntau muaj cov cuab yeej siv hluav taws xob siab thiab tshawb nrhiav cov cuab yeej siv hluav taws xob ntawm kev tsim cov siab siab- zoo tshuaj ntsuam xyuas tshuaj lom neeg.
Cov chaw tshawb fawb thiab tsev kawm qib siab
Kev Tshawb Fawb Kev Koom Tes: Yog tias koj yog tus kws tshawb fawb los ntawm cov chaw tshawb fawb lossis tsev kawm qib siab, koj tuaj yeem sim tsim kev sib tw ua haujlwm thiab cov tsev kawm qib siab ua kom muaj cov haujlwm tshawb fawb thiab muab cov peev txheej qhia tawm.
Kev yuav khoom ncaj qha: qee cov chaw tshawb fawb lossis cov tsev kawm qib siab tuaj yeem txais cov khoom lag luam ntawm cov neeg siv khoom ncaj qha rau cov neeg siv khoom hauv kev xav tau. Koj tuaj yeem tiv toj rau lub Tuam Txhab Tswj Xyuas Kev Tshawb Fawb lossis kuaj lub taub hau ntawm cov tsev haujlwm no rau kev sib tham thiab yuav.
Cov kev ceev faj
Cov khoom lag luam zoo: Thaum kev yuav khoom, nws yog ib qho tseem ceeb kom them sai sai rau qhov zoo ntawm cov khoom. Xaiv cov neeg xa khoom siv cov npe nrov lossis cov tuam txhab ua kom ntseeg tau tias cov khoom lag luam yuav ua tau raws cov qauv thiab cov tseev kom muaj.
Nqe thiab Lub sijhawm xa khoom: Cov nqi khoom thiab khoom xa tuaj yeem sib txawv ntawm cov chaw muag khoom sib txawv. Ua ntej kev yuav khoom, thov sib txuas lus tag nrho nrog cov khoom xa khoom lossis tuam txhab kom nkag siab cov ntaub ntawv ntxaws xws li nqi thiab khoom xa tuaj.
Cov Cai Raws Cai: Thov ua raws li txoj cai lij choj, cov cai tswj hwm, thiab cov cai thaum yuav khoom thiab siv5-ChlorouracilCov. Xyuas kom meej tias koj txoj kev yuav khoom thiab kev coj ua yog txoj cai thiab ua raws.
Cov Lus Qhia Yooj Yim thiab Tshuaj Siv Khoom Siv
5-ChlorouracilYog cov chlorinated pyrimidine compound nrog cov tshuaj noj cov mis nyuj c₄h₃cln₂o₂, muaj cov tshuaj molecular hnyav ntawm 146.53 thiab ib tug lej ntawm 1820-81-1. Nws cov tsos yog cov muaju dawb, nrog lub ntom ntom ntawm 1.61 g / cm³, lub ntsiab lus melting saum 203.9 degree, thiab ib qho ntsuas hluav taws xob ua haujlwm ntawm 1.587. Raws li cov chlorinated derivative ntawm uracil, cov chlorine atom hauv nws cov molecular hloov lub hydrogen ab at uracil, txhim kho txoj hauj lwm polarity thiab reactivity ntawm lub molecule.
Cov txheej txheem tsim khoom thiab cov kauj ruam tseem ceeb
Cov khoom tseem ceeb raw yog uracil (c₄h₄n₂o₂) thiab tshuaj lis haujlwm roj av (clot). Lub purity ntawm uracil yuav tsum muaj ntau dua los yog sib npaug rau 99% kom txo cov kev phiv. Chlorine roj yuav tsum tau qhuav (piv txwv li, los ntawm kev xav cov sulfuric acid Scruber) tshem tawm cov kev tsim ntawm hydrolysis los ntawm- cov khoom.
Cov tshuaj tiv thaiv yog nqa tawm nyob rau hauv kev mob phem. Cov kuab tshuaj uas muaj xws li dichhloromethane lossis Trichloromshane. Ulacil yog yaj nyob rau hauv cov kuab tshuaj, thiab qhuav chlorine roj yog maj mam sau. Cov tshuaj tiv thaiv kub yog tswj tau ntawm 25-40℃kom tsis txhob muaj cov chlorination ntau dhau. Thaum lub sij hawm cov tshuaj tiv thaiv, txuas ntxiv stirring yog yuav tsum ua kom ntseeg tau cov kev faib tshuaj uas muaj kev faib tawm ntawm cov chlorine roj. Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no: c₄h₄n₂o₂ + clj → c₄₄cln₂o₂ + hcl
Cov tshuaj pleev hydrogen merated fydroride (HCL) tau raug tshem tawm los ntawm nitrogen purging lossis alkali kev nqus cov khoom siv, pab txhawb cov tshuaj tiv thaiv kev coj ua.
Tom qab cov tshuaj tiv thaiv, sib xyaw sib xyaw inegoes nqus nqus nqus nqus nqus tsev kom tshem tawm cov kuab tshuaj, thiab cov seem yog cov dej txias kom tshem tawm uracil thiab inorganic ntsev. Cov khoom lag luam nyoos yog kev ua kom huv ntxiv los ntawm recrystallization, siv tshuaj ethanol- cov dej sib tov (ntim piv 3: 1) raws li cov kuab tshuaj. Lub recrystallization kub yog tswj tau ntawm 60 - 70 Degree, thiab tom qab txias, dawb} zoo li muaju ua pa nag. Cov khoom siv huv yuav tsum tau ua lub tshuab qhuav los ntawm 50℃kom txog thaum lub cev hnyav tau ua tiav, nrog qhov kawg purity mus txog 99%.
Lub cev muaj kev ua kom tau pom los ntawm qhov siab - Kev ua kua chromatography (HPLC), cov qauv molc) tau lees paub los ntawm ¹h NMR. Tus qauv tswj hwm tseem ceeb muaj xws li: Purity ntau dua los yog sib npaug ntawm 99% ,302 degree, thiab impurity tsawg dua los yog sib npaug rau 0.1%.
Kev ua kom zoo ntawm kev lag luam - nplai ntau lawm
Nruam Nruam Reactor Tsim
Nyob rau hauv loj - nplai ntau lawm, tubular tshuab reactor tau siv kom ua tiav kev tawm tsam roj av thiab uracil daws, txhim kho cov neeg siv cov neeg hloov chaw ua haujlwm. Tus reactor tau nruab nrog lub txias txias kauj los tswj qhov kub ntawm 30 ± 2 degree, zam kev tsim kom muaj los ntawm- cov khoom (xws li dichlorouracil).
Hnyav Rov Qab System System
Cov kuab tshuaj distilled tau qhuav los ntawm molecular sieves thiab rov ua dua tshiab, nrog tus nqi rov qab ntawm ntau dua lossis sib npaug rau 95%, txo cov nqi ntau lawm. Chav dej kho roj siv cov alkaline kua tsuag tshuaj tsuag ntauwd yog paub tseeb tias cov emrission kev tiv thaiv yog <10 ppm, ntsib ib puag ncig kev tiv thaiv kev tiv thaiv.
Kev Tswj Automation
Lub plc system tau siv los saib xyuas lub siab, kub thiab tshuaj chlorine txaus rau hauv lub raj tiv thaiv lub sijhawm. Cov kev tsis tseem ceeb tau txuas nrog thaum muaj xwm txheej ceev - tawm cov khoom siv los xyuas kom muaj kev nyab xeeb ntau. Piv txwv li, thaum cov tshuaj chlorine roj ntws tau txawv txav, lub kaw lus cia li nres nres cov khoom noj thiab pib cov nitrogen purge program.
Cov chaw thov thiab kev xav tau kev lag luam
Tshuaj Txha
Raws li qhov tseem ceeb hauv nruab nrab rau cov synthesis ntawm anti {{0} Dub cov tshuaj qog), zoo li xyoo 5-ntiaj teb yog kwv yees li 200 tons. Nws derivative, 5-chloro-6- chloromethyl) uracil, yog siv los npaj cov methylation inhibitors, nrog tus nqi lag luam ntawm 48,600 yuan / tuj.
Kev Tshawb Fawb Reagents
Siv los ntawm cov tsev kawm qib siab thiab tshawb nrhiav cov vev xaib rau nucleic acid tshuaj tshawb nrhiav, xws li tshawb xyuas cov nyhuv ntawm chloro {}} uracil ntawm DNA repllicide fault. Siab - purity reagents (ntau dua lossis sib npaug ntawm 9,5%) raug nqi kwv yees li 1,500 yuan / kg, nrog kev muag khoom txhua xyoo ntawm ntau tshaj 50 tons.
Cov ntaub ntawv kawm txuj ci
Raws li txoj haujlwm ua haujlwm tau koom rau hauv cov tshuaj tiv thaiv copolymerization, nws yog siv los npaj cov ntaub ntawv cob muaj nrog cov qauv adsorption tshwj xeeb. Piv txwv li, lub resin tau los ntawm copolymerization nrog STRYREE muaj qhov muaj peev xwm adsorption ntawm 120 mg / g rau cov hlau hnyav (xws li PB²⁺).
Kev Nyab Xeeb Kev Nyab Xeeb thiab Kev Tiv Thaiv Kev Nyab Xeeb
Kev tiv thaiv tus kheej
Cov neeg ua haujlwm yuav tsum tau hnav cov ntsej muag roj, cov tshuaj tiv thaiv kab lom thiab nitrile. Kev kuaj mob ib txwm muaj yuav tsum tau ua, nrog kev ua kom pom tseeb ntawm kev ua pa thiab tawv nqaij tiv thaiv kev pheej hmoo.
Nkim pov tseg
Cov khoom pov tseg yog kho los ntawm oxidation (xws li nrog sodium hypochlorite) thiab tom qab ntawd nkag mus rau hauv lub biochemical system. Lub Cod tshem tawm tus nqi ntau dua lossis sib npaug ntawm 90%. Cov pa tso pa tawm yog nqus tau los ntawm ob theem ntawm alkaline tov +}}}}}}}}}}}}}}}}}}}} ill / mp / m³. Cov khoom pov tseg yog muab rau ib pawg tsim nyog rau kev siv hluav taws xob.
Cov phiaj xwm ceev
Qhov kev ua haujlwm yog nruab nrog chlorine xau dej pom kev ua kom pom lub cev (nrog kev kuaj pom ntawm 0.5 ppm) thiab cov khoom tsuag tsuag thaum muaj xwm ceev. Kev xyaum ua ntu zus. Thaum muaj kev xau, lub zog tsis zoo nyob hloov pa hluav taws xob tam sim ntawd, thiab 10% Sodium Hydium Kev daws teeb meem hydroxide yog siv rau kev nruab nrab.
Cim npe nrov: 5-Chlorouracil Case 1820-81-1, Tuam Tshoj Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, Lag Luam Wholesale, Yuav, Nqe, Hlua, Rau Muag