Gentamycin sulfate hmoovchemical formula C60H125O22N15 · H2SO4, CAS 1405-41-0. Nws yog dawb los yog zoo li dawb crystalline hmoov. Nws muaj hygroscopicity, yooj yim soluble hauv dej, insoluble hauv lipids, thiab insoluble hauv organic solvents. Nws muaj cov solubility zoo thiab tuaj yeem yaj sai sai hauv dej, tsim cov pob tshab los yog me ntsis turbid tov uas tuaj yeem hydrolyzed rau hauv ammonia thiab urea, yog li nws cov toxicity yog tib yam li urea. Nws tuaj yeem yaj hauv lwm cov kuab tshuaj, xws li methanol thiab ethanol. Lub solubility nyob ntawm qhov hnyav thiab kub. Nyob rau hauv dej, solubility yog siab, mus txog 100 mg / mL. Thaum lub solubility tshaj saturation, crystals yuav precipitated. Tus nqi pH feem ntau nyob hauv thaj tsam alkaline, kwv yees li 7.5 txog 8.5. Qhov no ua rau nws ruaj khov hauv vitro thiab hauv vivo. Nws muaj qee yam kev ruaj ntseg nyob rau hauv qhuav, tsaus, thiab tsis kub kub. Txawm li cas los xij, nws yooj yim dua rau lub teeb, cua sov, thiab av noo, thiab nws yooj yim rau decomposition thiab tsis ua haujlwm. Yog li ntawd, nws tau ceeb toom kom tswj xyuas cov xwm txheej tsim nyog kom ntseeg tau tias nws zoo. Gentamicin Sulfate (Gentamycin Sulfate) yog tshuaj tua kab mob dav siv hauv kev kho mob, nrog rau dav -spectrum antibacterial kev ua haujlwm. Nws belongs rau Aminoglycoside, uas tuaj yeem cuam tshuam kev loj hlob ntawm Gram{25}} cov kab mob zoo thiab cov kab mob Gram-negative, thiab tseem muaj qee yam tshuaj tua kab mob rau qee hom tshuaj tiv thaiv xws li pneumococcus thiab Haemophilus influenzae.
|
Tshuaj Formula |
C60H127N15O26S |
|
Exact Mass |
1507 |
|
Molecular Luj |
1507 |
|
m/z |
1506 (100.0%), 1508 (20.7%), 1507 (64.9%) |
|
Elemental Analysis |
C, 47.83; H, 8.50; N, 13.94; O, 27.61; S, 2.13 |
|
|
|
Clinically, nws yog tsuas yog siv rau kev ua pa ib ntsuj av, plab hnyuv ib ntsuj av, biliary ib ntsuj av, urogenital system, daim tawv nqaij thiab cov nqaij mos kab mob los yog cov kab mob hauv zos tshwm sim los ntawm gram{0}}cov kab mob tsis zoo. Cov khoom no yog siv los kho qhov muag kab mob. Tsis tas li ntawd, kev siv gentamycin sulfate hauv tsev kho tsiaj.
1) Nqaij qaib:
Compound gentamicin soluble hmoov tau siv los kho cov nqaij qaib colibacillosis, nrog kev kho tus nqi ntawm 95% thiab tus txheeb ze qhov hnyav nce ntawm 98.05%, uas yog qhov zoo dua li streptomycin sulfate thiab doxycycline. Los ntawm kev sim tshuaj rhiab heev, nws tau pom tias gentamycin sulfate tau rhiab heev rau Haemophilus paragallinarum, thiab cov nyhuv kho tau raug, nrog tus nqi kho mob siab txog 98%.
2) npua:
Cov menyuam yug tshiab tau txhaj tshuaj gentamicin sulfate los ntawm gavage, 2mL txhua lub sijhawm, thiab tau soj ntsuam tas li rau 21 hnub. Qhov tshwm sim ntawm kev mob raws plab hauv piglets yog 8.61%, uas yog qis dua 29.43% hauv pawg tswj hwm, qhia tias gentamicin sulfate muaj txiaj ntsig zoo rau kev tiv thaiv thiab kho mob raws plab hauv piglets thaum muaj hnub nyoog 21 hnub.
3) Cov khoom siv:
Gentamycin sulfate ua ke nrog rboGMCSF tau siv los kho nyuj tus mob mastitis, thiab tus nqi kho yog 50%, uas yog qhov zoo dua li lwm pawg tswj hwm. Gentamicin sulfate qhov ncauj gel antidiarrheal tus neeg sawv cev (8 mg / kg) tau siv los kho mob raws plab calves thiab yaks. Tus nqi siv tau yog 87.5%, thiab tus nqi kho yog 75%. Tom qab kev kho mob, cov ntsiab lus ntawm Ca2 + thiab cov ntshav albumin (ALB) nyob rau hauv cov ntshav ntawm raws plab plab mog thiab yaks rov qab mus rau qhov qub.
4) Lwm yam tsiaj:
Gentamycin sulfate ua ke nrog Buzhong Yiqi Pill tau siv los ntsuas qhov kev kho mob ntawm cov kab mob raws plab ntawm tus po tsis muaj peev xwm ntawm tus dev. Cov txiaj ntsig tau pom tias tus nqi kho tau yog 87.5%. Tom qab kev kho mob, cov qe ntshav dawb, cov qe ntshav liab thiab cov qe ntshav liab tau rov zoo sai, thiab cov txiaj ntsig tau raug ntau dua li ntawm pawg neeg dawb huv.
Gentamicin sulfate yog ib qho dav -spectrum aminoglycoside tshuaj tua kab mob uas feem ntau siv tshuaj tua kab mob los ntawm inhibiting cov kab mob protein synthesis, thiab muaj kev cuam tshuam zoo rau ntau yam kab mob Gram tsis zoo thiab zoo.
Antibacterial mechanism
Nws lub ntsiab antibacterial mechanism yog cuam tshuam nrog cov kab mob protein synthesis los ntawm kev khi rau cov kab mob ribosomes, yog li inhibiting kab mob loj hlob thiab kev loj hlob. Cov txheej txheem ntawm kev ua haujlwm no ua rau nws muaj zog tiv thaiv kab mob tiv thaiv ntau yam kab mob, tshwj xeeb tshaj yog tiv thaiv kab mob Gram tsis zoo.
Daim ntawv thov kev kho mob
1. Kab mob plab hnyuv
Nws muaj ntau yam kev siv hauv kev kho mob plab hnyuv. Nws tuaj yeem cuam tshuam cov kab mob rhiab heev hauv txoj hnyuv, xws li Escherichia coli, Klebsiella pneumoniae, thiab lwm yam, yog li txo cov tsos mob xws li plab hnyuv thiab raws plab. Rau cov kab mob plab hnyuv loj xws li kab mob dysentery, gentamicin sulfate kuj yog ib qho ntawm cov tshuaj uas siv los kho.
2. Kab mob ua pa
Nws kuj tseem tuaj yeem siv los kho cov kab mob ua pa los ntawm cov kab mob rhiab heev, xws li mob ntsws, mob ntsws, thiab lwm yam. Nws pab cov neeg mob rov qab ua haujlwm ua pa los ntawm inhibiting cov kab mob loj hlob hauv txoj kev ua pa, txo cov tsos mob xws li mob thiab hnoos.
3. Cov kab mob tso zis
Cov kab mob tso zis yog lwm qhov chaw thov tseem ceeb. Nws tuaj yeem kho cov kab mob urinary zoo xws li urethritis, cystitis, pyelonephritis, thiab lwm yam los ntawm cov kab mob rhiab heev. Los ntawm inhibiting kev loj hlob ntawm cov kab mob nyob rau hauv lub urinary system, txo cov tsos mob xws li mob thiab urinary mob, thiab txhawb cov neeg mob rov qab.
4. Kab mob ntawm daim tawv nqaij thiab cov nqaij mos
Nws kuj tau pom tias muaj txiaj ntsig zoo hauv kev kho mob ntawm daim tawv nqaij thiab cov ntaub so ntswg mos. Nws tuaj yeem siv los kho cov kab mob ntawm daim tawv nqaij los ntawm cov kab mob rhiab heev, xws li pustules, boils, abscesses, thiab lwm yam. Los ntawm inhibiting cov kab mob loj hlob ntawm daim tawv nqaij thiab cov nqaij mos, txo cov tsos mob xws li mob thiab mob, thiab txhawb kev kho thiab kho ntawm daim tawv nqaij.
5. Kab mob plab
Kab mob plab yog ib qho ntawm cov kab mob loj, uas ua lub luag haujlwm tseem ceeb hauv kev kho mob plab. Nws tuaj yeem siv los kho kab mob plab xws li peritonitis thiab plab abscess tshwm sim los ntawm cov kab mob rhiab heev. Los ntawm inhibiting kev loj hlob ntawm cov kab mob hauv lub plab kab noj hniav, txo cov tsos mob xws li mob thiab mob, txhawb kev daws teeb meem ntawm plab o thiab kho cov ntaub so ntswg.
6. Kab mob biliary ib ntsuj av
Kab mob biliary yog ib yam kab mob sib kis nyob rau hauv cov kab mob biliary, thiab nws kuj qhia tau hais tias muaj txiaj ntsig zoo hauv kev kho kab mob biliary. Nws tuaj yeem siv los kho cov kab mob biliary xws li cholecystitis thiab cholangitis los ntawm cov kab mob rhiab heev. Los ntawm inhibiting kev loj hlob ntawm cov kab mob nyob rau hauv lub biliary ib ntsuj av, txo cov tsos mob xws li o thiab mob, thiab txhawb lub rov qab ntawm lub biliary system.
7. Central paj hlwb kab mob
Nws kuj tseem siv tau los kho cov kab mob hauv nruab nrab ntawm lub paj hlwb xws li mob meningitis, ventricular o, thiab lwm yam. Nws pab cov neeg mob rov qab ua haujlwm ntawm lub paj hlwb los ntawm inhibiting kev loj hlob ntawm cov kab mob hauv nruab nrab paj hlwb, txo cov tsos mob xws li mob thiab lub hlwb edema. Thaum tsim nyog, nws tseem tuaj yeem siv los ua cov tshuaj ntxiv rau kev txhaj tshuaj intrathecal, ncaj qha ua haujlwm ntawm lub paj hlwb hauv nruab nrab los txhim kho kev kho mob.
8. Cov kab mob qhov muag
Gentamicin sulfate qhov muag tee kuj tsim nyog rau kev kho qhov muag kab mob los ntawm cov kab mob rhiab heev, xws li conjunctivitis, keratitis, thiab lwm yam. Nws txhawb kev kho thiab kho cov ntaub so ntswg ntawm qhov muag los ntawm inhibiting kev loj hlob ntawm cov kab mob hauv lub qhov muag, txo cov tsos mob xws li mob qhov muag thiab mob. Thaum siv gentamicin sulfate qhov muag tee, nws yog ib qho tseem ceeb kom tsis txhob muaj kab mob thiab kis kab mob, thiab ua raws li tus kws kho mob cov lus qhia rau kev siv tshuaj nruj me ntsis.
Adjuvant kho cov nyhuv ntawm gentamicin sulfate
Ntxiv nrog rau cov kev kho mob saum toj no, nws kuj tseem siv tau los ua cov tshuaj pab kho mob rau kev kho mob ntawm ntau yam kab mob. Piv txwv li, nyob rau hauv kev kho mob ntawm cov kab mob loj xws li neonatal sepsis thiab sepsis, nws tuaj yeem ua ke nrog lwm cov tshuaj tua kab mob los txhim kho kev kho mob. Tsis tas li ntawd, nws tseem tuaj yeem siv rau kev npaj ua ntej kev phais txoj hnyuv, los ntawm inhibiting cov kab mob loj hlob hauv txoj hnyuv thiab txo qhov kev pheej hmoo ntawm kev kis kab mob tom qab phais.
Txoj kev npaj ntawmGentamycin sulfate hmoovsuav nrog cov kauj ruam hauv qab no:
Gentamicin xuab zeb spores tau muab tso rau ntawm qhov nruab nrab slant rau kab lis kev cai ntawm 36℃rau 10 hnub. Gentamicin spores tau txais tom qab kab lis kev cai slant;
Cov gentamicin spores tau los ntawm cov kab lis kev cai slant nyob rau hauv kauj ruam 1) yog kab lis kev cai nyob rau hauv ib lub khob cawv. Tus nqi nkag ntawm cov spores kab lis kev cai nyob rau hauv lub khob cawv yog: 0.25cm2 ntawm cov spores slant yog khawb rau hauv lub khob co co, kab lis kev cai kub yog 36 degree, kab lis kev cai lub sij hawm yog 42 teev, thiab gentamicin shake flask mycelia yog tau;
Muab cov gentamicin shake flask mycelia tau nyob rau hauv kauj ruam 2) ntawm cov noob kab lis kev cai nruab nrab rau cov noob kab lis kev cai, thiab cov noob kab lis kev cai input tus nqi yog: Gentamicin shake flask mycelia yog txhaj rau hauv lub shake flask noob raws li ob txhiab ntawm qhov ntim ntawm cov noob kab lis kev cai nruab nrab, kab lis kev cai kub yog 36 degree, thiab kab lis kev cai lub sij hawm yog 48 teev kom tau txais kab lis kev cai.
Muab cov gentamicin noob kab lis kev cai tau nyob rau hauv kauj ruam 3) nyob rau hauv lub propagation tank rau nthuav kab lis kev cai. Cov noob kab lis kev cai gentamicin yog tau los ntawm kev ntxiv 20% ntawm qhov nthuav dav nruab nrab ntim, kab lis kev cai kub yog 36 degree, thiab kab lis kev cai lub sij hawm yog 42 teev;
Muab gentamicin propagation kab lis kev cai tau nyob rau hauv kauj ruam 4) nyob rau hauv lub fermentation nruab nrab rau fermentation. Tus nqi ntawm gentamicin propagation kab lis kev cai yog 20% ntawm qhov ntim ntawm fermentation nruab nrab, fermentation kub yog 34 degree, thiab lub sij hawm fermentation yog 120 teev kom tau gentamicin fermentation khoom;
Cov khoom gentamicin fermentation tau nyob rau hauv kauj ruam 5) yog acidified rau pH nqi ntawm 2 - 3 kom tau gentamicin acidified tov; Acidizing kev kho mob yog ua nrog hydrochloric acid nrog concentration ntawm 30%, thiab kho pH 2 ~ 3;
Neutralize cov gentamicin acidizing tov tau nyob rau hauv kauj ruam 6) kom tau gentamicin tov nrog pH nqi ntawm 6.8; Kev kho neutralization yog nqa tawm nrog 40% sodium hydroxide, thiab pH raug kho rau 6.8;
Cov tshuaj gentamicin tau txais hauv qib 7) yog kho nrog 732 resin kom tau txais cov tshuaj adsorbed gentamicin; 732 resin siv rau kev kho adsorption yog 001 × 7 Muaj zog acidic styrene cation txauv resin;
Tshem tawm Ca2+, Mg2+, Cl‑ 1 los ntawm cov tshuaj adsorbed gentamicin tau txais nyob rau hauv kauj ruam 8) nyob rau hauv kem kom tau cov ion tshem tawm gentamicin tov; Kem tshem tawm Ca2+, Mg2+thiab Cl‑1 yog Φ 1m siab 2m kem;
Tom qab dhau cov ion tshem tawm cov tshuaj gentamicin uas tau txais nyob rau hauv kauj ruam 9) los ntawm saturated resin, soj ntsuam nws nrog ammonia dej nrog ib tug loj feem pua ntawm 4.5% kom tau gentamicin analytic tov; Cov saturated resin hais txog cov resin tau los ntawm adsorbing 80000 units ntawm gentamicin ib milliliter ntawm resin;
Decolorize cov tshuaj gentamicin tau nyob rau hauv kauj ruam 10) nrog 711 resin kom tau gentamicin decolorization tov; 711 resin siv rau kev kho decolorization yog qhov yooj yim styrene anion txauv resin;
Concentrate cov gentamicin decoloring tov tau nyob rau hauv kauj ruam 11) nrog ib zaj duab xis kom tau gentamicin concentrated tov; Tus nqi concentration yog 500L / h, thiab qhov concentration yog 1/7 ntawm qhov qub;
Ntxiv cov concentrated gentamicin tov tau nyob rau hauv kauj ruam 12) rau hauv sulfuric acid los npaj gentamicin sulfate; Cov concentration ntawm sulfuric acid yog 98%, kho rau pH 5.3;
Cov gentamicin sulfate tau nyob rau hauv kauj ruam 13) yog tshuaj tsuag qhuav kom tau gentamicin sulfate tiav cov khoom. Cov tshuaj tsuag kom qhuav yog: inlet cua kub 130 degree, qhov hluav taws xob cua kub 85 degree, thiab tsuag ceev 100 L / h.
faq ua
gentamicin sulfate siv rau dab tsi?
Vim li cas cov tshuaj no thiaj li muab tshuaj? Tshuaj pleev gentamicin yog siv rau cov neeg laus thiab menyuam yaus hnub nyoog 1 xyoos thiab laus duakho cov kab mob ntawm daim tawv nqaij los ntawm qee cov kab mob. Topical gentamicin yog nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua tshuaj tua kab mob. Nws ua haujlwm los ntawm kev tua cov kab mob uas ua rau muaj kab mob.
Cov kab mob dab tsi uas yog gentamicin tau muab rau?
Nws yuav tsum tau qhia raws li tus neeg mob lub hnub nyoog, cov tsos mob, cov cim qhia ntawm kev nthuav qhia, thiab cov qauv tshuaj tiv thaiv kab mob hauv zos los txhim kho qhov tshwm sim ntawm kev kho mob zoo hauvCov kab mob septicemia, meningitis, kab mob urinary ib ntsuj av, kab mob plab hnyuv, thiab cov ntaub so ntswg mos..
Kev faib tawm ntawm gentamicin sulfate yog dab tsi?
J01GB03 - gentamicin ; belongs rau chav kawm ntawmLwm cov aminoglycosides. Siv rau hauv kev kho mob ntawm cov kab mob.
Puas yog gentamicin sulfate zoo li neosporin?
Cim npe nrov: gentamycin sulfate hmoov cas 1405-41-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom