Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam ntawm 99.9% Txais tos rau kev lag luam wholesale ntau qhov zoo heev 99.9% Cov hmoov zoo liidocaine hmoov 137-58-6 Kev Muag Khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Lub npe tshuaj lom neeg ntawmlidocainePuas yog n {- diylaminoacetyl {{}}} 2,6-xylidine. N- (2,6-2 Methylphenyl) -2- (Diethylamino) Acetamide Hydrochloride Monohydrate yog siv tau.99.9% Kev ntshiab Lidocaine Powdeyog cov tshuaj loog hauv zos nrog cov ntawv thov uas dav. Ntxiv rau nws cov tshuaj tiv thaiv cov khoom, Lidocaine tseem muaj ntau yam khoom siv lub cev, uas tseem ceeb heev rau kev ua haujlwm thiab ua haujlwm zoo ntawm Lidocaine hauv kev npaj thiab cov ntaub ntawv thov. Lub solubility hauv dej yog qhov tseem ceeb, ncav 6g / l. Txawm li cas los xij, hauv cov kuab tshuaj organic xws li ethanol, methanol, thiab acetone, Lidocaine muaj kev txom nyem sudubility. Cov xeeb ceem no cuam tshuam rau cov solubility thiab ruaj khov ntawm Lidocaine nyob rau hauv cov nqa khoom sib txawv xaiv thaum lub sijhawm npaj ntawm kev tsim qauv. Nws yog lub loog hauv cheeb tsam dav siv los daws qhov mob thaum phais cov hniav, kho hniav, cov txheej txheem ntawm daim tawv nqaij, thiab lwm yam txheej txheem. Ntxiv rau kev siv tshuaj loog, Lidocaine kuj tau pom tias muaj ntau yam kev kho mob thiab tsis yog kev siv kev kho mob.
|
Morphological |
hmoov |
|
Acidity Coefficient (PKA) |
PKA 7.88 (h2o) (kwv yees) |
|
Solubility ethanol |
4 mg / ml |
|
Chaw Cia Khoom |
Khw ntawm RT |
|
Flash point |
9 kev kawm |
|
Xim |
Dawb rau me ntsis daj |
Lidocaine Hmoov Coa
Thaum siv Lidocaine, peb yuav tsum xav txog txhua yam nws cov tshuaj tiv thaiv cov khoom, uas yuav pab peb nkag siab zoo dua thiab siv nws. Cov hauv qab no yog cov ncauj lus kom ntxaws ntawm txhua cov tshuaj tiv thaiv ntawm Lidocaine:
99.9% Cov hmoov dawb huv lidocainebelongs rau amine compounds thiab thiaj li tshwm sim alkaline hauv kev daws. Lidocaine molecules muaj ob qhov yooj yim nitrogen atoms uas tuaj yeem lees txais cov protons kom tsim cov ntsev. Hauv dej, cov ntsev liidocaine tau yooj yim soluble thiab muaj cov khoom siv hluav taws xob muaj zog. Thaum Lidocaine ua ke nrog cov muaj zog acids muaj zog, nws tuaj yeem tsim hydrochloride, uas yog cov txheej txheem ib txwm siv rau kev npaj cov tshuaj loog lidocaine.
Lidocaine molecules muaj cov qauv kev coj ua ntawm methylene thiab benzene rings, thiab kev hloov pauv ntawm lawv, thiab hloov pauv ntawm lawv tau muab txoj kev ua kom zoo. Nyob rau hauv lub cev, lidocaine feem ntau raug txo rau nws cov metabolites xws li monoethylglycinxlide (megx) thiab glycinxlide (GX). Cov metabolites no muaj cov chaw ua tshuaj pharmacological sib txawv thiab tuaj yeem cuam tshuam rau Bioavailability thiab efficacy ntawm lidocaine hauv vivo.
Lidocaine muaj qhov zoo thermal stability. Tom qab ob peb lub hlis ntawm cia ntawm chav tsev kub, yuav tsis muaj kev txiav txim siab tsis zoo. Hauv qhov kub thiab huab cua huab cua thiab huab cua noo ib puag ncig, Lidocaine tej zaum yuav decompose, ua kom txo qis hauv nws cov nyhuv tshuaj kom tsawg. Yog li ntawd, peb yuav tsum tau them sai sai kom tswj cov mob zoo thaum khaws thiab siv lidocaine.
Kev ua xua rau Lidocaine yog qhov muaj tsawg heev, tab sis lawv tsis tuaj yeem ua tiav tag nrho. Yog tias ib qho tshwm sim ib qho tshwm sim, xws li ua pa, ua pa, pob khaus, Lidocaine yuav tsum tau nres tam sim ntawd thiab nrhiav kev pab kho mob tam sim ntawd thiab nrhiav kev pab kho mob tam sim ntawd.
Lidocaine undergoes metabolism thiab kev hloov pauv hauv lub cev, nrog rau cov pathsetolism feem ntau suav nrog n {{demetylation thiab hydroxylation tshua muaj nyob rau hauv daim siab. Qhov hloov dua tshiab cov khoom lag luam Megx thiab GX muaj cov khoom siv pharchar cov chaw ua si thiab tuaj yeem siv ua cov ntsuas rau cov metabolaine metabolism. Qhov kev hloov dua siab tshiab muaj qhov cuam tshuam tseem ceeb ntawm kev ua tau zoo thiab kev ua siab ntev ntawm lidocaine.
Kev phiv
Lidocaine HmoovYog dav siv hauv kev tshawb fawb, tab sis nws kuj tseem tuaj yeem ua rau muaj kev phiv tshuaj, uas muaj ntau yam xws li lub paj hlwb, cov hlab ntshav, thiab kev ua xua. Cov hauv qab no yuav qhia tau raws li nws cov kev mob tshwm sim sib xws thiab txoj kev kho mob.
Kev phiv los ntawm kev mob neurological
Cov tsos mob tshwm sim
Lidocaine tej zaum yuav muaj kev cuam tshuam rau hauv nruab nrab ntawm cov hlab ntsha, thaum xub thawj ua rau lub qhov ncauj thiab tus nplaig, xiav kev hais lus, thiab hais lus slurred. Raws li cov koob tshuaj tiv thaiv lossis cov qib kev sib tw tsis txaus, cov tsos mob hnyav xws li tsis tswm, ploj, kev mob siab, thiab ua rau muaj kev ntxhov siab.
Muaj Mechanism
Lidocaine blocks hlab ntsha excitation thiab conduction los ntawm inhibiting sodium ion raws cov hlab ntaws membrane. Thaum cov yeeb tshuaj tau tshwm sim hauv kev tshaj lossis ua yuam kev nkag mus rau cov hlab ntshav, cov nyhuv nyob hauv plawv av tsis muaj zog, ua rau cov tsos mob saum toj no.
Txoj Kev Kho
Cov tsos mob me, koj tuaj yeem so thiab saib. Zam kev tsav tsheb lossis kev ua haujlwm tshuab.
Rau cov tsos mob hnyav, cov tshuaj yuav tsum nres tam sim ntawd thiab anticonvulsant tshuaj (xws li diazepam) thiab kev ua pa txhawb kev kho mob yuav tsum muab.
Thaum qaug dab peg tshwm sim, luv - ua yeeb yam budlicurates lossis cov leeg raugle tuaj yeem tswj hwm tau tias muaj kev sib zog.
Kev mob plawv kev phiv
Cov tsos mob tshwm sim
Lidocaine yuav ua rau cov arhythmias xws li Bradycardia, hypotension, atrioventricular thaiv thiab Sinus ntes. Thaum siv cov koob tshuaj tiv thaiv loj, nws kuj tseem yuav ua rau lub neej - Kev phom sij xws li ventricular fibrillation thiab mob plawv.
Muaj Mechanism
Lidocaine muaj qhov ncaj ncees Inhibitions ntawm myocardial cell thiab tuaj yeem txo cov pab pawg ua haujlwm myocardial thiab cov tso zis kev kho mob plawv. Lub caij no, cov tshuaj yuav so cov leeg vascular du cov leeg, ua rau ib qho kev txo qis ntawm cov ntshav siab.
Txoj Kev Kho
Nres cov tshuaj tam sim ntawd thiab ze saib lub electrocardoriogram thiab cov ntshav siab.
Thaum muaj Bradycardia lossis atrioventricular thaiv, Atropine lossis isoProtereren tuaj yeem muab rau kev kho mob.
Kev tsim txom hnyav arhythmia yuav tsum siv cov pacemakers lossis defibrillation.
Thaum cov ntshav siab nqus dej, incygen inalation xav tau, acidosis yuav raug muab kho, thiab ntshav siab {{| cov tshuaj yuav tsum siv.
Kev tsis haum
Cov tsos mob tshwm sim
Kev ua xua yuav tshwm sim li pob, khaus, angiofa, nws yuav txawm ua pa sab nraud, nws yuav ua pa tawm sab nraud.
Muaj Mechanism
Lidocaine ua xua muaj hom rau hom kuv xav tsis thoob thiab muaj kev kho mob los ntawm ige. Cov tshuaj lossis lawv cov metabolites, raws li haptens, sib txuas nrog cov protein nyob rau hauv lub cev los tsim lub cev, txhawb nqa lub cev los tsim cov tshuaj tiv thaiv kab mob ige tshwj xeeb. Thaum raug cov tshuaj ib zaug ntxiv, iige khi rau mast cov hlwb thiab basophils, tso cov neeg sib raug zoo xws li cov tsos mob ntawm kev ua xua.
Txoj Kev Kho
Tam sim ntawd ua haujlwm noj tshuaj thiab muab anti {- Kev kho kom haum, xws li siv tshuaj antiistamines zoo li Loratadine thiab Cetirhloride.
Tej kev tsis haum tshuaj loj yuav tsum tau txhaj tshuaj tiv thaiv mob glucorticoids (xws li dexamethasone) thiab epinephrine.
Khaws cov pa uas tsis ua haujlwm. Yog tias tsim nyog, ua tracheal anteridation lossis tracheotomy.
Cov tshuaj hauv zos
Cov tsos mob tshwm sim
Thaum Lidocaine siv sab nraud, cov tsos mob xws li Erherhema, khaus, tawg, diring, diring, diring, dir Cov tsos mob no feem ntau yog me me thiab luv - nyob thiab muaj peev xwm ib txwm nyob hauv ob peb feeb lossis teev.
Muaj Mechanism
Lidocaine yog khaus rau cov nqaij tawv nqaij hauv zos thiab cov tawv nqaij hauv plab thiab tej zaum yuav ua rau muaj cov lus teb mob. Tsis tas li ntawd, ntau dhau kev siv tshuaj tiv thaiv kev mob siab lossis kev txhaj tshuaj tiv thaiv tsis raug tej zaum tseem yuav siv zog ua rau muaj kev ntxhov siab hauv lub cev.
Txoj Kev Kho
Cov tsos mob tuaj yeem pom tau. Zam kev khawb thiab kub compresses.
Rau cov tsos mob hnyav, lub zos no txias txias tuaj yeem siv thiab tshuaj tiv thaiv cream (xws li hydrocortisone cream) tuaj yeem siv.
Txhim kho cov txheej txheem txhaj tshuaj los txo cov tshuaj ntawm cov tshuaj mus rau cov ntaub so ntswg hauv zos.
Lwm cov kev mob tshwm sim
Cov tsos mob ntawm lub plab zom mov
Lidocaine yuav ua rau cov tsos mob xws li xeev siab thiab ntuav, uas yuav cuam tshuam nrog kev voos ntawm txoj hlab plab lossis kev cuam tshuam ntawm nruab nrab ntawm cov yeeb tshuaj.
Cuam tshuam rau lub zeem muag thiab hnov lus
Ntev - sijhawm lossis siv ntau dhau ntawm Lidocaine tuaj yeem ua rau cov kev mob tshwm sim xws li qhov muag tsis pom kev thiab hnov tsis hnov lus.
Txoj Kev Kho
Xeev siab thiab ntuav tuaj yeem kho nrog cov tshuaj tiv thaiv (xws li Metoclopramide).
Qhov muag plooj plooj thiab tsis hnov lus yuav tsum muaj kev kho mob sai. Yog tias tsim nyog, hloov mus rau lwm yam tshuaj.
Qhov kev tshawb nrhiav ntawm Lidocaine yog qhov tseem ceeb ntawm kev ua kom loog ntawm kev ua haujlwm, thiab txoj kev txhim kho cov tswv yim ntawm cov kws tshawb fawb kev paub.
Kev tshawb nrhiav thaum ntxov thiab tshuaj lom neeg
Qhov kev tshawb pom ntawm Lidocaine pib los ntawm kev kawm ntawm cov qauv tshuaj ntawm cov alkaloid gramine. Thaum cov kws tshawb fawb tau zoo sib xws ntawm isogarmine, lawv pom tias nws muaj cov nyhuv anesthetic nyhuv. Qhov kev tshawb pom qhov kev tshawb pom qhov no ua rau txuas ntxiv cov lus sib xyaw ua ke los ntawm Stockholm University tau ua tiav, tso lub hauv paus rau kev tshawb fawb tom ntej.
Patents thiab cov txheej txheem ua lag luam
Tom qab synthesis ntawm Lidocaine, Lundauth qhia tau ua cov chaw muag tshuaj ntawm Karolinska thiab tom qab ntawd xa cov chaw lag luam Swedish Astra astra AB. Lub tuam txhab tau pib Lidocaine mus rau kev ua lag luam nyob rau hauv lub npe lag luam "xylocaine" xyoo 1948, khij nws txoj hauj lwm nkag rau hauv daim ntawv thov cov chaw soj ntsuam. Hauv tib lub xyoo, lof teg ua tiav nws tus kws kho mob tsis txaus ntseeg "Lidocaine: Ib qho khoom siv hluavtaws tshiab", txhawb kev lees paub ntawm cov tshuaj.
Kuaj xyuas cov txiaj ntsig thiab cov ntawv thov dav
Lidocaine has rapidly become one of the preferred drugs for local anesthesia due to its rapid onset and long-lasting effect. Nws yog siv rau ntau qhov xwm txheej zoo li Infiltration Tshuaj loog, thaiv cov tshuaj loog thiab ua kom loog, thiab muaj kev nyab xeeb tsawg thiab muaj kev nyab xeeb. Txij li xyoo 1949, Lidocaine tau muaj dav txhawb nqa ntawm lub ntsuas loj loj. Nws tsis tau tsuas yog siv dav hauv kev phais mob tab sis kuj maj mam maj mam txuas mus rau tom teb ntawm arrhythmia kho. Xyoo 1963, Lidocaine tau siv los kho ventricular arhythmias tau tshwm sim los ntawm kev mob siab rau kev tiv thaiv thiab kho cov tshuaj sai venhythmias.
Kev tshawb fawb tawg thiab kev cuam tshuam txuas ntxiv
Qhov kev tshawb pom ntawm Lidocaine yog tus qauv ntawm kev tshawb fawb sib txuam ntawm kev ua haujlwm ntawm Chemistry thiab tshuaj. Nws tsis tsuas yog daws cov kev quav ntawm cov tshuaj loog ib txwm muaj xws li yeeb tshuaj ua yeeb yam, tab sis kuj txhim kho kev ua kom zoo nkauj thiab kev nyab xeeb los ntawm kev ua kom zoo. Txog rau hnub tim, Lidocaine tseem yog cov tshuaj tseem ceeb hauv kev ua yeeb yaj kiab hauv zos. Nws cov derivatives thiab txhim kho cov ntaub ntawv kho mob (xws li aerosols thiab gels) kom tshwm sim, txuas ntxiv nthuav cov kev siv ntawm chaw khom.
Lub ntsiab
Los ntawm kev tawm tsam ntawm isomer ntawm Luteinine mus rau synthesis thiab kev ua lag luam ntawm Lidocaine, tus txheej txheem no qhia txog kev sib txuas thiab kev paub txog kev tshawb fawb txog kev tshawb fawb. Lub hnub yug ntawm Lidocaine tsis tsuas yog txhawb kev txhim kho kev tshuaj loog, tab sis kuj tseem ua cov kev tshoov siab cov tshuaj thiab kev txhim kho tshwj xeeb. Nws cov xwm txheej uas yog ib qho kev tshuaj loog hauv zos ib puag ncig tsis yooj yim los ua kom tiav rau hnub no.
Cim npe nrov: 99.9% Lub Neej Lidocaine Hmoov Li 137-58-6, Cov Chaw Tsim Khoom, Chaw Tsim Tshuaj, Hoobkas, Muag Khoom Ntaus, Yuav Khoom, Ntaus, Rau Muag