Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm sapropterin dihydrochloride hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) hmoov) yog tias hmoov zoo li 69056-38-8 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale mag cov khoom zoo sapropterin dihydrochloride hmoov yog li 69056-38-8 Kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Tus lej ntawmSapRopterin Dihydrocoride Hmoovyog 69056-38-8, tus lej EineCs yog 663-669-3, cov mis molecular yog c9h17Cl2n5o3, thiab txoj kev molecular hnyav yog 314.17. Feem ntau nthuav tawm raws li ib tug dawb kom tawm dawb powdery khoom. Nws muaj cov solubility siab, tshwj xeeb tshaj yog nyob rau hauv cov kev mob anaerobic, nrog solubility ntawm 19.60-20,40 mg / ml. Kev daws teeb meem yog qhia meej me ntsis turbid, tsis muaj daj ntseg daj. Cov dej ua kom zoo no ua rau cov nqus dej nqus thiab siv ntawm cov chaw sib txuas hauv cov kab ke ntau dua. Raws li Chloractanine Hydroxylase, nws tuaj yeem txhawb kev siv cov roj av phenylalanine, ua kom pom cov tsos mob neurological phenylalanine thiab txhim kho cov tsos mob neurological hauv cov neeg mob. Yog li ntawd, nws yog siv los kho phenylketonuria, tshwj xeeb tshaj yog rau Bh4 reactive PKU PKU cov neeg mob PKU, muaj cov teebmeem loj. Raws li ib qho tseem ceeb biochemical reagent reagent thiab cov tshuaj ua ntej cov ntawv thov hauv kev tshawb fawb tshuaj. Nws tuaj yeem siv rau synthesizing tshiab cov tshuaj lwg tshiab, kuaj xyuas cov tshuaj siv tshuaj, ntsuas kev ua tau zoo tshuaj, thiab lwm yam. Los ntawm kev kawm cov tshuaj no, peb tuaj yeem tau txais kev nkag siab tob ntawm cov qauv thiab ua haujlwm ntawm cov enzymes uas muaj feem xyuam nrog kab mob tshwm sim thiab kev loj hlob.
|
Tshuaj Cov Qauv |
C9H15N5O3 |
|
Muaj pes tsawg leej |
241.12 |
|
Molecular hnyav |
241.25 |
|
m/z |
241.12 (100.0%), 242.12 (9.7%), 242.11 (1.8%) |
|
Kev Ntsuam Xyuas |
C, 44.81; H, 6.27; N, 29.03; O, 19.9 |
Cov ntaub ntawv muaj feem ntawm sapropterin dihydrochloride. Sulfasalazine thiab nws cov metanolites thiab mesalazine yog aromazes yog inhomanine ntawm cov enzymes uas hnoos tau txheeb xyuas cov biosynthesis ntawm Cofaction Tetrahydrobiopterin. Kev cuam tshuam ntawm tetrahydrobiopterin metabolism tau piav qhia rau qee qhov txiaj ntsig thiab kev phom sij ntawm Sulfasalazine, thiab txuas ntxiv rau cov tshuaj tshiab thiab txhim kho cov tshuaj.
SapRopterin Dihydrocoride HmoovMuaj ntau lub zog tseem ceeb hauv kev tshawb fawb kev tshawb fawb. Raws li cov cuab yeej biochemical, nws yog dav siv nyob rau hauv ntau yam ntawm lub neej kev kawm thiab kev tshawb fawb txog kev kho mob.
1. Kev kho mob ntawm phenylketonuria (pku)
Phenylketonuria yog ib tug kab mob caj ces tshwm sim los ntawm qhov tsis muaj peev xwm ntawm cov neeg mob phenylalanine, uas yog cov melylalanine thiab nws cov metabolites tsis tuaj yeem hloov pauv hauv lub cev thiab ua rau muaj kev puas tsuaj ntawm neurological.
SapRopterin hydrochloride, raws li ib tug cofactor ntawm Phenylalanine Hydroxylase, yog nce cov mob phenylalanine qib thiab txhim kho cov tsos mob neurological hauv cov neeg mob. Yog li ntawd, sapropterin hydrochloride yog siv los kho phenylketonuria, tshwj xeeb tshaj yog rau Bh4 reactive PKU PKU cov neeg mob, muaj kev ua tau zoo PKU.
2. Kev kho mob ntawm TetrahyDRobiopterin Qhov tsis txaus (Bh4d)
TetrahyDrobiopterin Qhov tseeb yog qhov tsis tshua muaj caj ces los ntawm kev ua yeeb yam ntawm hydroxyles, thiab lwm yam), ua rau cov tsos mob hydroxyles, thiab lwm yam.
SapRopterin hydrochloride, raws li ib qho exogenous tetrahydrobiopterin ntxiv, rov qab ua cov haujlwm ntawm cov tsos mob uas cuam tshuam, thiab txhim kho cov tsos mob cov tsos mob. Yog li ntawd, sapropterin hydrochloride yog ib qho tshuaj zoo rau kev kho tetrahydrobiopterin tsis txaus.
3. Neuroprotective effect
Kev tshawb fawb tau pom tias Sapropterin Hydrochloride muaj cov teebmeem neuroprotrotive. Nws tuaj yeem nce cov synthesis thiab tso tawm ntawm nitric oxide nyob rau hauv lub hlwb, txhim kho cov hlab ntsha ntawm cov ntshav hlab ntsha, thiab tiv thaiv neurons ua haujlwm ntawm kev puas tsuaj xws li hypoxia thiab ischemia. Ib qho ntxiv, Sampropterin Hydroporide tuaj yeem txhawb nqa cov cuab yeej thiab tso tawm ntawm neurotransmitters, tswj txoj haujlwm ntawm lub paj hlwb.
4. Antioxidant nyhuv
SapRopterin hydrochloride kuj muaj qee qhov khoom antioxidant. Nws tuaj yeem tshem tawm cov tshuaj tiv thaiv kev phom sij xws li cov tshuaj tiv thaiv dawb thiab cov tshuaj pejthides hauv lub cev, txo cov oxidative kev puas tsuaj rau cov hlwb. Qhov no yog qhov tseem ceeb rau kev tiv thaiv thiab kho cov kab mob ntsig txog oxidative kev ntxhov siab.
Pharmacological daim ntawv thov
1. Kev tshawb fawb yeeb tshuaj
SapRopterin hydrochloride, raws li ib qho tseem ceeb biochemical reagent thiab cov tshuaj ua ntej cov ntawv thov hauv kev tshawb fawb hauv tshuaj. Nws tuaj yeem siv rau synthesizing tshiab cov tshuaj lwg tshiab, kuaj xyuas cov tshuaj siv tshuaj, ntsuas kev ua tau zoo tshuaj, thiab lwm yam. Los ntawm kev kawm sapropterin hydrochloride, peb tuaj yeem tau txais kev nkag siab tob ntawm cov qauv thiab ua haujlwm ntawm cov kev ua tau zoo li ntawm kab mob tshwm sim thiab kev loj hlob.
2. Kev tshawb tshuaj metabolism hauv yeeb tshuaj
SapRopterin Hydrochloride tseem siv tau rau cov tshuaj tshawb xyuas tshuaj metabolism. Nws tuaj yeem ua kev sojntsuam molecule rau kev saib xyuas cov txheej txheem metabolic, metabolites, thiab cov kev cuam tshuam ntawm cov tshuaj thiab cov enzymes hauv lub cev. Qhov no yog qhov tseem ceeb rau kev ua kom zoo rau cov qauv tshuaj, txhim kho kev ua tau tshuaj tshuaj, thiab txo cov tshuaj phiv.
1. Cov Khoom Noj Khoom Haus
Txawm yogSapRopterin Dihydrocoride HmoovFeem ntau siv los kho cov kab mob tshwj xeeb, nws kuj tseem siv tau los ua cov khoom noj muaj txiaj ntsig hauv qee qhov xwm txheej. Piv txwv li, hauv qee tus neeg mob nrog cov tshuaj muaj kab mob caj ces, thaum synthesisdrobiopterin hauv lub cev tsis txaus, sapropterin hydrochloride tuaj yeem pab txhawb kom tau raws li lub cev xav tau.
2. Kev Tshawb Fawb Cov Cuab Yeej
Nws tseem siv tau siv los ua kev tshawb fawb hauv biochemistry thiab molecular biology kev tshawb fawb. Nws tuaj yeem siv los kawm cov qauv thiab cov kev ua haujlwm ntawm cov txheej txheem cuam tshuam, thiab cov qauv molecular ntawm cov kab mob tshwm sim thiab kev txhim kho. Los ntawm kev siv sapropterin hydrochloride yog kev sojntsuam lossis cim rau kev tshawb fawb, kev ua haujlwm ntawm kev ua haujlwm thiab kev ua haujlwm ntawm ntau yam phenomena tuaj yeem raug qhia tawm.
Ntxiv rau cov hom phiaj saum toj no, nws muaj ntau yam ntawm daim ntawv thov tus nqi yog cov cuab yeej tshawb nrhiav hauv ntau daim teb xws li biochemistry, kev txhim kho kev ua haujlwm ntawm kev tsim kho pob zeb thiab tshuaj ntsuam.
Kev Tshawb Fawb Biochemical
1. Kev tshawb fawb ntawm enzymatic cov tshuaj tiv thaiv
Nws yog ib qho kev tshawb fawb ntawm ntau cov enzymes tseem ceeb, suav nrog kev tshawb fawb cenylalanys (PACH), ittrate tshwj xeeb, thiab Cofactor vam txog ntawm cov enzymes no. Los ntawm kev hloov pauv ntawm sapropterin hydroporide, hloov cov txheej txheem enzyme tuaj yeem pom, pom kev sib cuam tshuam kev sib txuam ntawm cov enzymes thiab co yam.
2. MeteeColic Txoj Kev Ntsuam Xyuas Kev Kawm Pej Xeem
Koom nrog txoj kev metabolic ntawm cov amino acids xws li Phenyylalanine thiab Tyrosine. Hauv kev tshawb fawb, feem ntau nws yog feem ntau siv los kawm cov txheej txheem kev tswj hwm ntawm cov kev tswj hwm metabolism ntawm cov kev sib tw metabolism ntawm cov kev sib tw metabolic ntawm cov kab mob metabolism, thiab cov tshuab ntawm cov kab mob metabolic. Los ntawm IsoTope labeling, metabolomics, thiab lwm txoj kev, nws muaj peev xwm taug qab cov kev khiav tawm, muab cov ntaub ntawv tseem ceeb rau kev nkag siab tobic.
Kev Tshawb Fawb Molecular Biology
1. Cov piv txwv qhia thiab cov kev cai
Tsis muaj cov koom haum nrog ntau yam kab mob metholic metabolic, qhov tshwm sim ntawm uas feem ntau muaj feem cuam tshuam rau kev hloov pauv lossis kev sib txawv ntawm cov noob. Hauv Molecular Biology kev tshawb fawb,SapRopterin Dihydrocoride HmoovFeem ntau siv los kawm cov qauv hais tawm, cov kev tswj hwm kev cai, thiab kev sib raug zoo ntawm cov noob thiab cov phenotypes ntawm cov noob. Los ntawm cov tswv yim xws li noob caj noob dua, gene kev cuam tshuam rau noob tuaj yeem pom, pom nws cov kab mob caj ces hauv genetic met.
2. Protein qauv thiab muaj nuj nqi
Raws li Cofactor ntawm enzymes, tus khi nrog enzyme protein yog qhov tseem ceeb rau kev ua haujlwm catalytic ntawm enzymes. Hauv kev tshawb fawb ntawm cov qauv protein thiab muaj nuj nqi, nws feem ntau siv los tshawb xyuas cov qauv siv los ntawm cov chaw sib dhos, thiab qhov cuam tshuam ntawm kev khi ntawm enzyme kev ua. Los ntawm kev siv cov qauv txheej txheem biology xws li x- duab sib xyaw ua ke, muab cov ntaub ntawv tseem ceeb ntawm kev nkag siab tob txog lub tshuab catalynism ntawm cov enzymes.
Kev Tsim Tshuaj Tshuaj thiab Kev Ntsuam Xyuas
1. Cov hom yeeb tshuaj
Raws li ib qho tshuaj rau kev kho cov kab mob metabolic, nws lub hom phiaj yog cov enzymes tseem ceeb hauv kev muaj peev xwm ntawm cov hlua metabolism. Hauv kev tsim kev tshuaj, nws feem ntau siv los ua tus qauv sib txuas los yog kev sojntsuam molecule kom pom cov hom tshuaj tshiab lossis siv tau qhov ua tau zoo ntawm cov hom phiaj. Los ntawm kev tsim cov qauv ua qauv ntawm cov hom protein thiab sapropterin hydrochloride, cov hom phiaj tuaj yeem kwv yees, muab kev tseem ceeb rau kev tsim tshuaj.
2. Tshuaj Ntsuam Xyuas thiab Tshuaj Ntsuam Xyuas
Raws li cov tshuaj uas muaj kev paub txog kev cuam tshuam, nws lub cev pharmacologism ntawm kev nqis tes ua yog tseeb thiab sib txawv. Hauv kev tshuaj ntsuam xyuas thiab tshuaj ntsuam xyuas, feem ntau nws yog siv cov tshuaj uas tswj tau zoo lossis kev siv tshuaj los ntsuas kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj tshiab. Los ntawm kev sib piv sib txawv ntawm cov tshuaj tshiab nrog rau hauv cov kev sim vitro lossis cov tsiaj txhu muaj peev xwm thiab thov kev txiav txim siab ua kom tau txais kev txiav txim siab tshiab.
Nws kuj tseem tuaj yeem siv rau hauv cov liaj teb xws li kev tshawb fawb ntawm tes thiab xovtooj ntawm biology. Hauv kev coj noj coj ua ntawm tes, nws tuaj yeem ua ib qho ntawm cov tseem ceeb rau kev loj hlob ntawm tes thiab metabolism; Hauv kev tshawb fawb Biology, nws tuaj yeem siv los kawm cov txheej txheem ntawm cov amino actake thiab siv cov txheej txheem kev tswj hwm ntawm cov kev coj noj coj ua ntawm cov kab mob cellular.
Hais txog synthesis txoj kev ntawm 2 {-}}}}}} HydroxyRimid) yuav yog qhov sib txawv me ntsis ntawm Sapropterin yuav txawv me ntsis thiab tsis yog hais ncaj qha rau raws li "tetrahydrododimidimidididation") thiab cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib npaug rau nws hloov dua siab tshiab rauSapRopterin Dihydrocoride Hmoov, vim qhov sib txawv hauv kev sim tshuaj, cov txheej txheem muaj txiaj ntsig zoo, cov qauv hauv qab no yog cov ntsiab cai hypothetical ntawm cov ntsiab cai ntawm cov organic synthesis.
Txheej txheem cej luam ntawm cov kev xwm txheej
Cov synthesis ntawm 2 - amino-} HydroxyRimid) -4- (2 ' Vim tias qhov tsis raug ntawm cov ntsiab lus synthesis thiab tshuaj lom neeg sib npaug li 2000 lo lus, Kuv yuav qhia cov ntsiab lus tseem ceeb ntawm txhua kauj ruam.
Cov kauj ruam synthesis thiab tshuaj sib txig sib luag (hypothetical)
Kauj ruam 1: Xaiv cov ntaub ntawv pib tsim nyog, xws li cov lus sib xyaw uas muaj cov phenol rings thiab cov pab pawg amino Cov ntaub ntawv raw no yuav xav tau los ntawm kev yuav khoom lag luam lossis ua ntej synthesis.
Kauj Ruam 2: Ua ke sib txuas ua ke muaj cov phenol rings nrog cov laj kab ke nrog cov tshuaj tiv thaiv monscich (xws li cov tshuaj tiv thaiv mansich (xws li cov teeb meem sib txawv) los tsim cov qauv sib txawv. Cov kauj ruam no yuav xav tau ib qho kev sib xyaw thiab cov kuab tshuaj uas tsim nyog.
Piv txwv ntawm kev sib npaug tshuaj (hypothetical):
Phenolic tebchaw + hydroxycarbonyl Tebchaw → Intermediates
Kauj Ruam 3: Ua pab pawg ua haujlwm ntxiv rau cov pab pawg sib txuas, xws li txo qis, oxidation, etc. Cov kauj ruam no yuav koom nrog ntau yam kev tawm tsam, txhua qhov xav tau kev tswj kom haum thiab reagent ntau.
Kauj Ruam 4: Hloov cov nruab nrab mus rau hauv lub hom phiaj txuas los ntawm kev sib txuas lus sib txuas lus. Qhov no feem ntau yog ib kauj ruam tseem ceeb uas yuav tsum tau xaiv Cyclization tsim nyog tshuaj thiab cov xwm txheej. Cov tshuaj tiv thaiv kev sib xyaw ua ke yuav muaj cov cua sov, catalysts, lossis muaj zog acid / puag mob.
Piv txwv ntawm kev sib npaug tshuaj (hypothetical):
Nruab Nrab → 2 {- Am1 {6 - Hydroxyethyl) -5 - Hydroxyethyl) -5,6,8-TetrahyDrodipyrimidine
Kauj Ruam 5: Purify lub hom phiaj sib txuas los ntawm kem chromatography, recrystallization, lossis lwm yam tswv yim ua kom huv si kom tshem tawm impurities. Lub lim haum sib txuas yuav tsum tau ua kom dhau los ua tus yam ntxwv, xws li NMR, IR, MS, thiab lwm yam, kom paub meej tias nws cov qauv.
Kauj Ruam 6 (hypothetical): Yog tias lub hom phiaj sib txuas tsis yog sapropterin nws tus kheej, tab sis nws analog, cov kauj ruam kev hloov pauv ntxiv yuav tsum muaj. Txawm li cas los xij, rau qhov ncaj qha synthesis ntawm saptopterin hydrochloride, nws yog feem ntau tsis yog yuav tsum tau pib los ntawm cov ntawv foob hais los saum toj no. Tab sis rau kev ua tiav ntawm cov lus teb, peb tuaj yeem xav tias muaj ib kauj ruam los hloov lub hom phiaj sib txuas ua ke rau sapropterin, ua raws li cov kua qaub kom tau nws cov ntsev hydrochloride.
Tshuaj piv txwv zoo (kev ua piv txwv zoo (hypothetical):
Lub Hom Phiaj Txuas → sapropterin + hcl → sapropterin hydrochloride
Nws yuav tsum raug sau tseg tias cov txheej txheem hloov tshiab sib xws thiab feem ntau cov synthemes synthemes thiab feem ntau tsis tau pib ua ke}}}}}}}}}}}}}}}}}}}}}}}}}}}} -5,6,7,8-tetrahydrododimidimidation.
Ib qho ntxiv, vim txoj haujlwm tseem ceeb ntawm sapropterin hauv cov kab mob muaj sia, thiab cov synthesis feem ntau yog ua tib zoo siv thiab ua kom zoo. Hauv qab no yog qhov tseeb tiag tiag txhawb nqa ntawm nws cov synthesis txoj kev, txawm hais tias nws tseem tsis tuaj yeem mus nthuav dav rau txhua qhov kev tshuaj lom neeg tshuaj lom neeg thiab cov tswv yim.
Txheej txheem cej luam ntawm cov kev xwm txheej
1. Kev npaj ua haujlwm tseem ceeb
Cov synthesis ntawm sapropterin feem ntau pib nrog ib lossis ntau qhov yooj yim sib xyaw, uas tau xa mus rau cov tebchaw prefursor. Cov lus teb no ua ntej yuav suav nrog cov lwg me me xws li Rings Functional xws li pawg ib ncig, cov pab pawg amino, pab pawg hydroxyl, thiab carbonyl pawg. Los ntawm cov organic cov organic xws li acylation, alkylation, txo, oxidation, thiab lwm yam.
2. Tsim ntawm cov tseem ceeb intermediates
Thaum lub sij hawm synthesis cov txheej txheem, cov lej tseem ceeb ntawm cov neeg nruab nrab yog tsim, uas ua haujlwm rau choj ntawm cov khoom pib thiab cov khoom lag luam. Kev xaiv thiab tsim qauv ntawm cov intermediales yog qhov tseem ceeb rau kev ua tiav ntawm tag nrho cov xwm txheej hluavtaws. Piv txwv li, nws yuav tsim nyog los ua qhov tshwj xeeb tetrahydropyridine lossis pyridine nplhaib qauv qauv, Daim duab spengler cov tshuaj tiv thaiv, lossis lwm yam kev sib tw sib txawv.
3. Kev tswj hwm kev tswj hwm
SapRopterin yog qhov sib xyaw nrog cov kev tswj hwm tshwj xeeb, yog li cov txheej txheem kev coj ua kom ntseeg tau tias cov khoom siv hluav taws xob thiab cov khoom lag luam nrog cov khoom siv raug. Qhov no feem ntau cuam tshuam nrog chiral catalysts, chiral reagents, lossis asymmetric squinesis cov nyom.
4. Kev ua haujlwm thiab ua kom huv
Qhov kev sib cav sib ceg sapropterin xav tau kom yauv ua tiav {{0} Taug kev kom tshem tawm cov impurities thiab txhim kho cov kev coj dawb huv ntawm cov khoom. These steps may include extraction, washing, drying, crystallization, column chromatography, etc. The purified Sapropterin needs further structural characterization to confirm its chemical structure and purity.
5. Hloov mus rau Sapropterin Hydrochloride
Lub Lim Kom huv Sapropterin tuaj yeem hloov mus rau hauv nws cov ntawv hydrochloride los ntawm reacoting nrog hydrochloric acid. Cov kauj ruam no feem ntau cuam tshuam nrog sapropterin nyob rau hauv ib qho kev daws teeb meem hydrochloric kom paub tseeb tias kev tsim cov sapropterin hydrochloride ntsev.
6. Tswj zoo thiab ruaj khov
Thaum kawg, cov synthesis ntawm E yuav tsum tau kev tswj hwm zoo thiab kev ruaj khov los xyuas kom ntseeg tau tiasSapRopterin Dihydrocoride HmoovUa tau raws li cov qauv muag tshuaj thiab tuaj yeem tswj ruaj khov thaum lub sijhawm cia thiab siv. Cov kev xeem no suav nrog cov ntsiab lus kev txiav txim siab, kuaj xyuas microbior tsis muaj microbi, thiab lwm yam.
Cim npe nrov: SapRopterin Dihydrocoride Hmoov Li 69056-38-8, Cov Neeg Tsim Khoom, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Chaw Muag Khoom, Yuav, Nqe, Ntau, Rau Muag