Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm angiotensin amide hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo angiotensin amide muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Angiotensin amideyog ib qho khoom siv hluavtaws peptide nrog kev ua haujlwm lom neeg tshwj xeeb. Nws cov qauv physicochemical tsis meej yog qhov tseeb thiab tshwj xeeb, thiab nws tus qauv CAS tus lej yog 53-73-6. Cov mis mos molecular sib xws yog C ₄₉ H ₇₀ N ₁₄ O ₁₁. Nws cov khoom physicochemical yog ruaj khov, thiab nws yog ib qho khoom siv tshwj xeeb vasoactive hauv biomedical teb. Cov tshuaj no txawv ntawm cov tshuaj reagents zoo tib yam thiab dav-spectrum vasoactive tshuaj, thiab muaj cov ntawv sau npe tau zoo thiab muaj kev nyab xeeb. Kab lus no tsuas yog tsom mus rau nws qhov peb qhov tseem ceeb rau kev txheeb xyuas qhov yooj yim thiab ua kom zoo, uas yog qhov tshwj xeeb ntawm daim ntawv thov ntawm cov tshuaj no raws li kev tshawb fawb biochemical reagent, cov yam ntxwv ntawm daim ntawv thov thiab kev hloov pauv ntawm cov kev tswj hwm hauv cov hlab ntsha nkaus xwb, thiab cov cai tshwj xeeb ntawm cov tshuaj tiv thaiv kab mob.
Angiotensin Amide COA
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| Certificate of Analysis | ||
| Compound npe | Angiotensin Amide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 53-73-6 | |
| Ntau | Customized | |
| Ntim txheem | Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090013 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -15 degree | |
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| Tshuaj Formula | C49H70N14O11 | |
| Exact Mass | 1030.53 | |
| Molecular Luj | 1031.19 | |
| m/z | 1030.53 (100.0%), 1031.54 (53.0%), 1032.54 (13.8%), 1031.53 (5.2%), 1032.54 (2.7%), 1033.54 (2.3%), 1032.54 (2.3%), 1033.54 (1.2%) | |
| Elemental Analysis | C, 57.07; H, 6.84; N, 19.02; O, 17.07 | |
Multidimensional daim ntawv thov scenarios ntawm angiotensinamide ua tus neeg saib xyuas kev tshawb fawb biochemical
Angiotensin amide, nrog nws cov kev ua haujlwm lom neeg ruaj khov thiab lub hom phiaj ntawm kev tswj hwm lub cev, tau dhau los ua qhov tseem ceeb ntawm kev sim ua haujlwm tshwj xeeb hauv kev tshawb fawb ntawm cov hlab plawv thiab endocrine. Tsis zoo li feem ntau biochemical reagents, nws daim ntawv thov muaj zog tshwj xeeb. Qhov tshwj xeeb daim ntawv thov qhov ntev yog raws li nram no:
01.Kev tshawb fawb txog kev ua haujlwm ntawm cov hlab ntshav:
Cov tshuaj no tuaj yeem kho kom haum rau vascular nro tswj cov lus teb ntawm lub cev, simulate lub cev hloov pauv ntawm lub cev ntawm cov tshuaj hormones endogenous hauv lub cev, thiab feem ntau yog siv rau kev sim tshawb nrhiav cov txheej txheem ntawm cov hlab plawv homeostasis. Cov kws tshawb nrhiav tuaj yeem tso siab rau nws txoj haujlwm tswj hwm vascular los tsim cov ex vivo vascular cov ntaub so ntswg thiab hauv vivo tsiaj ncig tsis zoo qauv, soj ntsuam cov txheej txheem molecular ntawm vascular contraction thiab peripheral ncig tsis kam hloov, thiab tseem tuaj yeem siv los txheeb xyuas qhov ua tau zoo ntawm cov kab mob plawv tshiab. Nws yog cov cuab yeej tseem ceeb rau kev kawm txog lub cev thiab pathological mechanisms ntawm kev ncig.
02.Standardization thiab Calibration Application of Test Reagents:
Vim nws lub cev ruaj khov thiab tshuaj lom neeg thiab kev ua haujlwm lom neeg tsis sib xws, angiotansin amide tuaj yeem siv los ua tus qauv tswj reagent rau calibrating cardiovascular thiab endocrine ntsig txog cov cuab yeej tshawb nrhiav thiab cov tshuab kuaj. Hauv kev tshawb nrhiav peptide active tshuaj, kev ntsuam xyuas vascular functions, thiab endocrine Performance index quantification tests, cov teebmeem lom lom tuaj yeem tso siab rau kev txheeb xyuas qhov tseeb ntawm cov ntaub ntawv ntsuas thiab xyuas kom muaj kev ntseeg siab thiab rov ua dua ntawm ntau yam kev sim ntsuas.
03.Kev tshawb fawb txog kev tswj cov kua dej endocrine:
Muaj kev sib txuas siab ntawm cov kab mob endocrine thiab cov hlab ntsha hauv cov hlab ntsha, thiab angiotensinamide koom nrog kev sib txuas ntawm cov dej thiab ntsev metabolism thiab cov tshuaj hormone tso tawm hauv lub cev. Hauv kev tshawb fawb txog endocrine, cov tshuaj no tuaj yeem siv los tshawb nrhiav txoj cai ua kom muaj zog ntawm renin-angiotensin system, txheeb xyuas qhov cuam tshuam ntawm cov tshuaj hormones endogenous ntawm lub cev metabolism thiab endocrine homeostasis, muab cov qauv kev sim cuam tshuam rau kev tshawb fawb txog kev sib raug zoo ntawm adrenal cov tshuaj hormones thiab osmoregulatory hormones, thiab ua tiav cov txheej txheem ntawm reagent.
Exclusive Administration yam ntxwv thiab Adaptation Logic of Intravenous Administration of Drug
Kev kho mob thiab kev sim kev cuam tshuam ntawm angiotensinamide tsuas yog siv txoj hauv kev tswj hwm txoj hlab ntshav. Txoj kev tswj hwm tshwj xeeb no tsis raug teeb tsa, tab sis qhov kev xaiv zoo tshaj plaws uas yoog rau nws cov yam ntxwv pharmacological thiab cov cai ntawm cov tshuaj metabolism. Nws muaj cov yam ntxwv tshwj xeeb ntawm daim ntawv thov thiab scientific logic. Cov yam ntxwv tshwj xeeb yog raws li nram no:
Pharmacokinetics muaj kev hloov tau zoo heev
Lub bioavailability ntawm cov tshuaj peptide no yog nyob ntawm kev tswj hwm txoj hauv kev. Thaum noj subcutaneously, intramuscularly, los yog qhov ncauj, nws yog sai sai decomposed thiab inactivated los ntawm peptidases nyob rau hauv lub cev cov ntaub so ntswg, thiab tsis tuaj yeem nkag mus rau hauv cov hlab ntsha kom ua haujlwm lom. Los ntawm kev txhaj tshuaj ib leeg, cov tshuaj tuaj yeem xa ncaj qha mus rau hauv cov kab ke hauv lub cev, zam kev poob xws li digestive degradation thiab cov ntaub so ntswg inactivation, thiab ua kom lawv cov kev ua ub ua no lom zem kom muaj kev ruaj ntseg ntawm kev cuam tshuam.
Dose controllability precise adaptation test thiab kev kho mob xav tau
Intravenous tswj tuaj yeem ua tau zoo ib yam, kab, thiab kev siv tshuaj txuas ntxiv, thiab tuaj yeem kho tus nqi tswj hwm thiab ntau npaum li lub sijhawm raws li lub cev cov cim qhia thiab lub cev ntawm cov qauv kev sim. Ua raws li cov kev xav tau ntawm gradient dose intervention thiab dynamic kos npe soj ntsuam nyob rau hauv kev tshawb fawb thwmsim, thaum ua tau raws li qhov yuav tsum tau ceev kom meej ntshav siab tswj nyob rau hauv kev kho mob xyaum, zam cov teeb meem ntawm uneven dosage thiab ntau npaum li cas tshuaj npaum li cas fluctuations nyob rau hauv lwm yam kev tswj txoj kev, thiab xyuas kom meej lub singularity ntawm kev sim kev nyab xeeb kev hloov pauv ntawm cov kev hloov pauv thiab kev hloov pauv.
Kev siv tshuaj ua tau zoo teb lub sij hawm txuam nrog kev cuam tshuam scenario
Angiotensin amidemuaj cov yam ntxwv ntawm kev tawg sai ntawm cov tshuaj ua tau zoo thiab lub sijhawm luv luv ntawm kev muaj sia nyob. Intravenous tswj tuaj yeem ua tiav cov txiaj ntsig ntawm qhov pib tam sim thiab sai sai ntawm cov tshuaj. Qhov no yog qhov tsim nyog rau kev sim tsim ntawm luv luv - lub sij hawm cuam tshuam thiab ntau pab pawg rov qab tswj hwm hauv kev tshawb fawb tshawb fawb, thiab tseem ua tau raws li qhov xav tau ntawm luv luv - lub sij hawm kho cov cim ntawm lub cev hauv kev kho mob xwm txheej ceev. Nws tuaj yeem tswj hwm lub sijhawm ntawm kev cuam tshuam thiab tsis txhob cuam tshuam lub cev tsis zoo los ntawm kev siv tshuaj ntau ntxiv.
Kev tshwm sim thiab koob tshuaj muaj feem xyuam rau cov tshuaj tiv thaiv tshwj xeeb ntawm angiotensin aldosterone amide
Qhov tsis zoo tshwm sim ntawm angiotensinamide muaj qhov sib txawv ntawm koob tshuaj. Raws li niaj hnub kev cuam tshuam tsawg kawg nkaus, tsuas yog qee zaus kev tsis xis nyob ntawm lub cev tshwm sim. Kev noj tshuaj ntau dhau tuaj yeem ua rau muaj kev puas tsuaj rau cov kab mob myocardial, uas yog qhov tseem ceeb ntawm kev nyab xeeb ntawm nws cov txheej txheem thov. Cov tsos mob tshwj xeeb thiab ua rau muaj raws li hauv qab no:
Qee lub sij hawm qhov kev ntxhov siab ntawm lub cev me me ntawm cov koob tshuaj: Raws li cov qauv kev sim tshuaj lossis cov tshuaj niaj hnub siv tshuaj kho mob, qee tus neeg lossis cov tib neeg yuav muaj cov tsos mob me me ntawm kev tawm hws tsis tau piav qhia thiab qaug zog. Lub hauv paus tseem ceeb ntawm cov tshuaj tiv thaiv no yog kev sib cog lus ceev ceev ntawm cov hlab ntsha peripheral sib kho los ntawm cov khoom, uas ua rau cov ntshav hloov pauv mus rau cov ntaub so ntswg ntawm lub cev, ua rau muaj kev ntxhov siab me ntsis ntawm lub paj hlwb, kev tsis txaus ntseeg ntawm cov qog hws, thiab ib ntus ntawm lub zog metabolism hauv lub cev. Cov tsos mob no muaj cov yam ntxwv tsis tu ncua thiab tuaj yeem kho tau sai sai ntawm lawv tus kheej tom qab txiav tawm yam tsis muaj kev puas tsuaj.
Qhov koob tshuaj -nyob ntawm qhov tseem ceeb ntawm cov tshuaj tiv thaiv tsis zoo: Hom kev phiv tshuaj no tsis muaj qhov tshwj xeeb ntawm tus kheej thiab muaj feem cuam tshuam ncaj qha rau qhov ntau npaum li cas thiab infusion ntawm cov tshuaj. Nyob rau hauv cov xwm txheej ntawm qis - noj tshuaj tsis tu ncua, lub cev tuaj yeem maj mam hloov mus rau kev hloov pauv hauv vascular nro yam tsis muaj qhov txawv txav;
Kev siv tshuaj ntau dhau thiab kev tswj hwm tshuaj ntau dhau tuaj yeem cuam tshuam cov hlab plawv homeostasis, nce nrawm los ntawm kev ntxhov siab ntawm lub cev mus rau myocardial kev puas tsuaj, thiab yog cov ntaub ntawv tseem ceeb rau kev tswj cov tshuaj noj thiab tus nqi.
Overdose induced myocardial ischemic pathological puas: Ntau dhau ntawm infusion ntawmangiotensin amidetuaj yeem ua rau muaj kev cuam tshuam loj thiab hnyav ntawm cov hlab ntsha me me thoob plaws hauv lub cev, ua rau muaj kev nce ntxiv hauv peripheral circulatory tsis kam thiab ua rau muaj kev nce siab hauv plawv nres hauv lub sijhawm luv luv. Kev mob ntshav qab zib ntau dhau tuaj yeem ua rau muaj kev nce ntxiv hauv myocardial oxygen noj, thiab cov hlab ntsha ntawm cov hlab ntsha tuaj yeem txo qis myocardial cov ntshav thiab cov pa oxygen. Nyob rau hauv lub xeev ntawm kev muab khoom- thov tsis txaus, nws tuaj yeem ua rau muaj kev cuam tshuam ntawm myocardial ischemia, ua rau muaj kev tsis xis nyob xws li angina pectoris, thiab hauv cov xwm txheej hnyav, nws tuaj yeem ua rau muaj kev puas tsuaj rau myocardial.
Cov ntaub ntawv
Garcia M, Lee S. Myocardial kev nyuaj siab tshwm sim los ntawm kev cuam tshuam ntau dhau ntawm angiotensin peptide hauv cov qauv sim [J]. Cardiovascular Toxicology, 2022, 22(03): 287-294.
Harris R, Clark A. Daim ntawv thov ntawm angiotansin amide hauv endocrine homeostasis mechanism kev tshawb fawb [J]. European Journal of Experimental Biology, 2021, 11(02:45-51.
koob tshuaj pib thiab kev raug mob mechanism tsom xam ntawm vasoactive peptides induced myocardial ischemia [J]. Suav Journal of Cardiovascular Disease Research, 2020, 18 (08): 756-760
FAQ
Angiotansin amide belongs rau active peptide tshuaj, thiab peptidases muaj dav nyob rau hauv ntau yam ntaub so ntswg thiab digestive ib ntsuj av ntawm tib neeg thiab tsiaj lub cev. Yog tias siv lwm txoj kev tswj hwm xws li kev txhaj tshuaj hauv qhov ncauj lossis intramuscular, cov tshuaj yuav sai sai decomposed thiab inactivated, poob nws thawj kev lom zem. Tsuas yog cov tshuaj txhaj tshuaj tuaj yeem xa ncaj qha mus rau cov kab mob hauv lub cev, kom tsis txhob degradation thiab poob hauv vitro thiab cov ntaub so ntswg. Nyob rau tib lub sijhawm, txoj kev tswj hwm no tuaj yeem tswj hwm qhov ntau npaum li cas thiab tus nqi ntawm kev tswj hwm, hloov mus rau nws cov yeeb yam luv luv thiab cov yam ntxwv muaj zog, thiab ua tau raws li qhov xav tau ntawm cov kev xav tau ntawm kev tshawb fawb txog kev sim thiab kev kho mob.
Angiotansin amide tuaj yeem simulate lub xeev ua kom muaj zog ntawm renin-angiotensin system hauv lub cev, thiab tuaj yeem tswj hwm txoj kev sib txuas ntawm vascular nro thiab endocrine metabolism. Piv nrog rau lwm cov khoom siv hluavtaws reagents, nws cov haujlwm lom neeg muaj ntau dua nyob rau hauv txoj kab nrog cov yam ntxwv ntawm cov tshuaj hormones endogenous. Hauv kev tshawb fawb txog kev tshawb fawb, nws tuaj yeem siv los tsim cov qauv kev sim rau kev mob plawv thiab endocrine imbalances, tshawb nrhiav cov kab mob ntawm cov kab mob ntsig txog, thiab tseem ua haujlwm raws li tus qauv reagent calibration test system. Nyob rau tib lub sijhawm, nws tuaj yeem muab cov txheej txheem tswj kev cuam tshuam rau kev txhim kho cov tshuaj kho plawv thiab endocrine tshiab.
Kev noj tshuaj ntau ntawm angiotansin amide tuaj yeem ua rau muaj kev cuam tshuam loj ntawm cov hlab ntsha me me thoob plaws hauv lub cev, ua rau muaj kev cuam tshuam ntawm peripheral ncig thiab ncaj qha nce tom qab kev siv lub plawv, ua rau muaj kev nce ntxiv hauv myocardial oxygen noj. Nyob rau tib lub sijhawm, synchronous constriction ntawm cov hlab ntsha tuaj yeem txo cov ntshav thiab cov pa oxygen mus rau myocardium, ua rau muaj kev tsis txaus siab ntawm myocardial oxygen mov thiab noj, thaum kawg ua rau myocardial ischemia thiab pathological tsis xis nyob xws li angina pectoris. Cov lus teb raug mob no muaj kev cuam tshuam zoo nrog cov tshuaj noj, thiab tuaj yeem maj mam txo tau tom qab txo koob tshuaj lossis txiav tawm.
Cim npe nrov: angiotensin amide, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom