Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam benzobarbital ua 744-80-9 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo benzobarbital CAS 744-80-9 cia muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Zaj tshaj tawm
Cov tshuaj no txwv tsis pub muag, thiab peb lub vev xaib tsuas saib tau cov ntaub ntawv yooj yim. Peb tsis muag tshuaj ntawm no!
Lub Kaum Hlis 28, 2025
Benzobarbital, cov tshuaj organic, cov qauv molecular: c19h16n2o4. Cov tsos yog dawb crystalline hmoov nrog iab iab; Yuav luag Insoluble hauv dej, me ntsis soluble hauv 95% ethanol, soluble hauv ether, thiab yooj yim soluble hauv chloroform. Phenobarbital muaj cov nyhuv sedative. Nws cov tshuaj tiav tiav tuaj yeem siv rau kev kho mob. Txawm li cas los xij, lub tuam txhab cov khoom lag luam yog cov khoom siv tshuaj lom neeg muaj kuab lom, uas tsuas yog siv rau kev tshawb fawb thiab txwv tsis pub lwm lub hom phiaj.
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Tshuaj Cov Qauv |
C19H16N2O4 |
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Muaj pes tsawg leej |
336 |
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Molecular hnyav |
336 |
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m/z |
336 (100.0%), 337 (20.5%), 338 (2.0%) |
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Kev Ntsuam Xyuas |
C, 67.85; H, 4.80; N, 8.33; O, 19.03 |
Cov ntawv thov loj ntawm Benzobarbital muaj cov chaw muag tshuaj, tshwj xeeb yog cov tshuaj tiv thaiv tshuaj.
Nws yog ib qho kev ua haujlwm ntawm barbiturates uas muaj sedative, hypnotic, anticonvulsant, thiab antiepileptic cuam tshuam. Txawm hais tias Benzobarbitalital nws tus kheej yuav tsis yog cov kev siv benbarurates feem ntau (xws li phualocalbital, uas yog cov khoom siv tau zoo dua lossis siv hauv kev ua yeeb yam lossis kev tshawb fawb.
Ib qho ntxiv, Benzobarbital kuj tseem siv tau ua preursor lossis nruab nrab rau kev sib tw hauv kev ntsuas tshuaj, raws li cov kev sib txuas lus zoo sib xws thiab ua haujlwm pab cuam pab neeg.
Xyoo 1857, Tus Kws Kho Mob British tsim thawj cov tshuaj tiv thaiv potassium bromide. Ua ntej sivBenzobarbital, Bromide yog tib cov tshuaj antiepileptic, tab sis bromide ua rau dermatitis thiab kev phiv los ntawm kev puas hlwb. Bromine yog cov khoom siv nquag ntawm cov potassium bromide. Cov kev sib tw transmembrane thauj ntawm bromide ions ua rau hyperpolarization ntawm cov kev tawm tsam ntawm cov hlab ntsha thiab inhibiting tawm ntawm epileptiform. Lub antierepiltic nyhuv ntawm bromine yog feem ntau ntawm neuronal expitation. Qhov tshwm sim ntawm kev sib deev dav hlau.
Xyoo 1912, phenobarbital pib siv rau hauv kev kho mob ntawm epilsis. Vim nws meej anti - epileptic nyhuv thiab qis toxicity dua bromide, nws tau siv dav dav siv. Txawm li cas los xij, hauv cov txheej txheem ntawm kev tshawb pom thiab chaw kuaj mob ntawm phenobarbital, nws yog tag nrho ntawm cov lus dab neeg! Nws yog npe tom qab Vajtswv; Nws tuaj yeem kho tau tus mob vwm; Nws yog feem ntau cuam tshuam nrog kev tuag ntawm kev tuag; Thiab nws tau muab yug rau kev tsim tsa ntawm "Kev Tsim Kho Kev Tsim Txiaj" (GMP) uas tam sim no siv tau hauv kev lag luam kws tshuaj.
Muaj ib hmos nyob rau xyoo 1864, lub German Chemper Bayer (Bayer, ua kev zoo siab rau cov neeg nyob hauv lub moos Barbara, seev cev Txawm hais tias boardbituric acid yuav ua rau lub chav kawm tshiab loj tshiab ntawm cov kab teb uas hu ua barbiturates, Bayer pom tsis muaj tshuaj siv rau nws thiab shelved nws.
Txog thaum xyoo 1903, German Chemists Fischer thiab Merlin tau pom tias tus nqi kho mob ntawmBenzobarbitalCov. Lawv pom tias cov synthesized diethyl barbituric acid yuav ua rau cov dev tsaug zog sai sai; Yog li benbituric acid los ua tshuaj yuav pw. Xyoo 1904, tuam txhab Bayer tso Diethyl Barbital rau kev ua lag luam, thiab lub npe khoom tau Veronal (Flora). Tom qab ntawd, nws tau pom tias barciturate tuaj yeem siv ua kev tshuaj zoo thiab muaj kev nyab xeeb rau kev kho mob vwm; Bariturate yog ib qho ntawm cov derivatives tau los ntawm kev hloov barbituric acid ntawm C5 txoj haujlwm, thiab cov ntawv cog lus ntev (xws li kev sib tw ua haujlwm ntev dua (xws li qhov ua kom muaj zog tab sis luv luv; hloov chaw los ntawm lub nplhaib Benzene (xws li phenobarbital) muaj cov txiaj ntsig anticonvulsant; O ntawm C2 hloov pauv los ntawm cov lus hauv vaj (xws li thiopiner) ua rau cov rog ua kua, thiab cov khoom siv roj ntsha yuav siv sij hawm tam sim ntawd, tab sis lub sijhawm txij nkawm yog luv heev.
Mus txog xyoo 1903, German Chemists Fischer thiab Merlin tau pom tias tus nqi kho mob ntawm Barbiturates. Lawv pom tias cov synthesized diethyl barbituric acid yuav ua rau cov dev tsaug zog sai sai; Yog li benbituric acid los ua tshuaj yuav pw. Xyoo 1904, tuam txhab Bayer tso Diethyl Barbital rau kev ua lag luam, thiab lub npe khoom tau Veronal (Flora). Tom qab ntawd, nws tau pom tias barciturate tuaj yeem siv ua kev tshuaj zoo thiab muaj kev nyab xeeb rau kev kho mob vwm; Bariturate yog ib qho ntawm cov derivatives tau los ntawm kev hloov barbituric acid ntawm C5 txoj haujlwm, thiab cov ntawv cog lus ntev (xws li kev sib tw ua haujlwm ntev dua (xws li qhov ua kom muaj zog tab sis luv luv; hloov chaw los ntawm lub nplhaib Benzene (xws li phenobarbital) muaj cov txiaj ntsig anticonvulsant; O ntawm C2 hloov pauv los ntawm cov lus hauv vaj (xws li thiopiner) ua rau cov rog ua kua, thiab cov khoom siv roj ntsha yuav siv sij hawm tam sim ntawd, tab sis lub sijhawm txij nkawm yog luv heev.
Cov kev tshawb fawb tau pom tias cov barbiturates tuaj yeem inhibit ib {{0} {{1} -} nkauj tawm ntawm lub hlwb, thiab tawm tsam kev tawm tsam txawv txawv uas ua rau qaug dab peg. Phenobarbital kuj tau pom los txo cov Jaundice, uas tuaj yeem kho cov neeg neonatal neonundice; Tom qab siv phenobarbital, nws tuaj yeem ntxias cov tshuaj siv tshuaj {} metabolizing enzymes hauv daim siab ntawm bilirubin nyob rau hauv cov ntshav, yog li ntawd jaundice mus.
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Txawm li cas los xij, lub Chratred Chemara yeeb tshuaj no tsis yog "wrest siv tshuaj" raws li keeb kwm pom. Nws muaj ntau cov kev phiv tshuaj, feem ntau yog suav nrog kev ua tsaug thiab muaj qee qhov kev hloov pauv, thiab muaj kev hloov pauv ntev rau kev ua haujlwm los tswj hwm qhov ua tau zoo; Nyob rau tib lub sijhawm, nws lub siab tau zoo yog ze rau cov tshuaj lom neeg lom zem. Yog tias koj tsis ceev faj, qhov koob tshuaj yuav dhau ntawm koob tshuaj kho thiab ncav cuag cov koob tshuaj tuag. Qee lub sij hawm overdose los yog noj nrog cawv tej zaum yuav tuag. Qhov no yog qhov ua rau muaj kev tuag ntawm tus neeg nyiam Asmeskas tus neeg ua yeeb yam marilyn monroe. Tab sis tom qab yuav luag ib puas xyoo, phenobarbital tseem muaj kev lag luam heev, thiab ib qho ntawm nws cov chaw ntxim nyiam, tshwj xeeb tshaj yog rau kev tsim cov teb chaws, yog nws tus nqi qis.
Phenobarbital tseem pab txhawb rau kev sib tsoo thaum ntxov thiab tsis ncaj rau cov qauv tsim thiab tsim tsa "kev tsim kho kom zoo nyob hauv cov chaw muag tshuaj.
Thaum lub Kaum Ob Hlis 1940, Winthrop Tshuaj tsis muaj zog tsim ib pob ntawm sulfathiazole ntsiav tshuaj tov nrog phenobarbital {} mg; Raws li cov tshuaj uas ib txwm siv los kho tus kab mob, sulfathiazole feem ntau yog noj nyob rau hauv koob tshuaj ntau vim nws cov tshuaj lom tsawg. Qhov kev sib tsoo no tom qab tau ua ntau pua tus neeg tuag.
Kev tshawb nrhiav FDA pom tias phenobarbital tau muab sib xyaw ua ke ntawm wintrep cov ntsiav tshuaj, thiab cov kab ntau lawm, tshwj xeeb tshaj yog cov khoom siv ntau lawm, tshwj xeeb tshaj yog cov khoom siv ntau lawm, tshwj xeeb tshaj yog kev sib hloov pauv. Thaum lub tuam txhab nrhiav tau tias cov tshuaj no tau ua paug, nws txawm qeeb rau ntau tshaj peb lub hlis ua ntej yuav siv tshuaj tsis sib xws los ntawm kev ua lag luam. Winthrop qhov tsis zoo tshuaj xyuas cov kab ke, qhov tsis tau qhia qhov xwm txheej rau FDA raws sijhawm, thiab rov qab pom cov khoom tsis huv tom qab nws tau pom zoo sai sai tom qab nws tau pom tias yog vim li cas thiaj raug rau cov laj thawj rau qhov kev raug mob no.
Qhov kev sib tsoo no ua rau Asmeskas cov zaub mov thiab tshuaj kho kev txiav txim siab los daws qhov chaw ua yeeb yam ntawm Winthrop Sulfathiazole ntsiav tshuaj "xyoo 1962. Kev tswj hwm" Kev Tsim Kho Kom Zoo "(GMP). Yog li ntawd, phenobarbital indirectly txhawb kev tawm tsam cov tshuajBenzobarbitalsiab thiab tswj.
Raws li ib qho kev tawm tsam ntawm sedobarbitalbital, cov tshuaj no muaj qee lub peev xwm rau kev thov thiab kev tsim kho cov tshuaj lom tsawg, kev mob tshwm sim tsawg, thiab ntau npaum li cas. Cov hauv qab no yog cov ncauj lus kom ntxaws ntxaws ntawm nws txoj kev txhim kho tom ntej:
Kev Tshawb Nrhiav Kev Lag Luam
Kev kho mob xav tau rau kev tsis txaus ntseeg neurological
Raws li lub nruab nrab ntawm lub ntsej muag ua kom huv, nws tuaj yeem siv los kho cov tsos mob xws li kev xav tsis zoo, epileptic qaug dab peg, thiab insomnia. Nrog lub nrawm nrawm ntawm lub neej niaj hnub no thiab nce siab ntawm kev muaj mob hlwb, thiab kev thov rau cov sedatives no tas li. Tshwj xeeb tshaj yog nyob rau hauv kev kho ntawm qee hom kev qaug dab peg, nws ua lub luag haujlwm tseem ceeb. Nrog rau hauv - qhov tob ntawm cov kab mob kev kho mob xws li cov kev kho mob tshwm sim los ntawm kev kho mob kho mob, yog li txhim kho kev kho mob zoo thiab kev ua haujlwm zoo ntawm cov neeg mob.
Qhov kev thov ntawm kev laus zej zog
Nrog rau kev siv zog ntawm cov pej xeem kev laus laus, qhov kev thov rau kev kho mob ntawm cov laus nce zuj zus ib hnub. Cov pej xeem cov neeg laus yog cov ua rau muaj kev phom sij thiab pw tsis tsaug zog, yog li cov neeg ua lag luam muaj kev lag luam dav hauv cov pej xeem. Ib qho ntxiv, cov neeg laus neeg muaj peev xwm tsis zoo rau cov tshuaj, thiab lawv cov kev phiv loj thiab ntau dua kev kho cov tshuaj rau cov neeg laus.
Qhov sib txawv ntawm kev ua lag luam xav tau ntawm kev lag luam hauv tsev thiab txawv teb chaws
Muaj cov sib txawv ntawm cov tshuaj no ntawm cov teb chaws sib txawv thiab cov cheeb tsam. Hauv qee lub tebchaws tsim khoom, vim yog qhov zoo - nrhiav cov kev kho mob thiab kev tsim tshuaj kev siv tshuaj kho siab rau cov sedatives tshiab yog qhov siab. Hauv qee lub tebchaws thiab cov cheeb tsam tsim kho, vim muaj kev lag luam tsawg thiab kev kho mob me me, qhov xav tau rau Sedatives yuav yog tsawg. Tab sis nrog kev txhim kho kev lag luam thiab kev txhim kho cov qauv kev kho mob, qhov xav tau rau cov neeg sedatives nyob rau hauv cov cheeb tsam no yuav tsum nce ntxiv.
Kev ua thev naus laus zis thiab kev hloov tshiab
Synthesis technology thiab txheej txheem txheej txheem txheej txheem
Nrog kev nce qib ntawm kev siv hluavtaws ntawm tes hluavtaws thiab tsim qauv txheej txheem, nws txoj kev ua tau zoo thiab kev nyab xeeb tau ntxiv lawm. Los ntawm kev ua kom zoo tshaj plaws cov synthesis txoj kev thiab txhim kho ntau ntau lawm, cov nqi tsim ntawm cov tshuaj no tuaj yeem txo, ua rau nws nyiam dua thiab pheej yig. Lub caij no, kev tsim kho tshiab hauv cov txheej txheem tsim tau kuj tseem tuaj yeem txhim kho nws cov kev cuam tshuam thiab txhim kho cov kev sib raug zoo, thiab txhim kho cov neeg mob kev ua kom ua tau zoo thiab lub neej zoo.
Tshawb nrhiav thiab kev txhim kho ntawm ntev {{0} ua yeeb yam thiab txhawb nqa {{tso zis
Cov kev tshawb fawb thiab kev loj hlob ntawm kev ntev {{0} ua yeeb yam thiab txhawb nqa cov qauv tsim qauv nws yuav dhau los ua ib qho tseem ceeb. Ntev ua yeeb yam thiab txhawb nqa - tso cov formulations tuaj yeem nthuav tawm cov tshuaj, txo cov tshuaj kho mob rau cov neeg mob. Ntxiv rau, ntev - ua yeeb yam thiab txhawb nqa cov yeeb tshuaj thiab kev txhim kho ntawm cov kev tsis sib haum xeeb, yog li kev txhim kho lawv cov kev ua tau zoo thiab kev nyab xeeb.
Cov tshuaj tshiab txuas ntxiv tawm
Nrog rau kev tshwm sim txuas ntxiv ntawm cov tshuaj tshiab, nws yuav raug siv ntau ua kev kho mob ntxiv. Tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas tsis teb zoo rau txoj kev kho, nws tuaj yeem siv ua lwm txoj kev siv tshuaj lossis ib feem ntawm kev kho cov tshuaj sib xyaw. Nyob rau tib lub sijhawm, kev txhim kho cov tshuaj tshiab kuj tseem tuaj yeem muab qhov chaw thov thiab nthuav dav, txhawb kev txhim kho txuas ntxiv ntawm kev ua lag luam no.
Cim npe nrov: Benzobarbital CAS WEBE 744-80-9, Cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, loj, loj, rau muag