Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg uas ntshiab tetracaine cas 94-24-6 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo ntshiab tetracaine cas 94-24-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Tetracaine ntshiabyog ib qho tshuaj loog muaj zog hauv zos muaj npe nrov rau nws cov mucosal penetrability zoo heev, ua rau nws yog qhov kev xaiv tseem ceeb rau ntau yam kev siv tshuaj loog hauv lub cev, suav nrog kev siv ophthalmic, qhov ntswg, thiab laryngeal. Nws qhov pib ntawm qhov kev txiav txim yog qhov nrawm, muab cov teebmeem analgesic tam sim ntawd thaum thov rau qhov chaw mucosal. Tetracaine feem ntau nthuav tawm raws li cov xim dawb mus rau daj daj crystalline hmoov, yam ntxwv los ntawm cov ntsiab lus siab melting thiab boiling, qhia txog nws cov qauv crystalline ruaj khov. Nws pom cov dej tsis zoo solubility, nrog rau kev solubility tsuas yog kwv yees li 5 mg / mL hauv dej, thiab muaj pKa tus nqi ntawm 8.6. Qhov xwm txheej no txhais tau hais tias tetracaine nyiam ionized nyob rau hauv ib puag ncig acidic, uas tuaj yeem txo nws cov tshuaj loog hauv zos, raws li daim ntawv un- ionized yuav tsum tau ua rau cov paj hlwb nkag mus thiab thaiv. Yog li ntawd, kev zam nruj heev ntawm acidic tej yam kev mob yog qhov tseem ceeb thaum lub sij hawm tsim, npaj, thiab cia tetracaine- muaj cov khoom los khaws nws cov tshuaj loog. Thaum nws cov aqueous solubility yog txwv, tetracaine qhia tau zoo solubility nyob rau hauv ntau yam organic solvents, ib yam khoom uas cuam tshuam nws formulation tswv yim thiab daim ntawv thov profiles. Cov yam ntxwv physicochemical txawv no{10}}xws li solubility, pKa, thiab ruaj khov- cuam tshuam ncaj qha rau nws cov kev ua tau zoo, kev ua tau zoo, thiab kev nyab xeeb ntawm cov chaw kho mob thiab kev tshawb fawb sib txawv, yuav tsum tau ua tib zoo saib xyuas thiab kev tswj kom muaj nuj nqis hauv nws txoj kev siv thiab kev tsim kho.
Cov khoom siv roj ntsha:
Cytotoxicity:
Tetracaine ntshiabmuaj qee yam ntawm cytotoxicity thiab tuaj yeem ua rau cell tuag lossis puas. Kev tshawb fawb tau pom tias Tetracaine ua rau cell tuag los ntawm inhibiting cell membrane sodium channels.
Bioreactivity:
Tetracaine feem ntau yog metabolized los ntawm daim siab hauv lub cev, tsim cov metabolites nquag xws li p-aminobenzoic acid, diethylamine ether, N-ethyl-p-hydroxybenzamide, thiab lwm yam. Cov metabolites no muaj feem cuam tshuam nrog kev siv tshuaj, tshuaj lom, thiab lwm yam.
Therapeutic nyhuv:
Tetracaine tuaj yeem siv tshuaj loog hauv zos xws li qhov muag, pob ntseg, qhov ncauj, qhov ntswg, thiab tawv nqaij. Nws cov txheej txheem ntawm kev ua haujlwm yog los tiv thaiv kev sib kis ntawm cov paj hlwb thiab thaiv kev sib kis ntawm cov cim mob.
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Tshuaj Formula |
C15H24N2O2 |
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Exact Mass |
264 |
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Molecular Luj |
264 |
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m/z |
264 (100.0%), 265 (16.2%), 266 (1.2%) |
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Elemental Analysis |
C, 68.15; H, 9.15; N, 10.60; O, 12.10 |
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Ntshiab tetracaineyog ib hom tshuaj, feem ntau suav nrog ntxiv -cov ntaub thaiv npog, thaiv cov hlab membranous, cov hlab ntsha tsis zoo, cov hlab ntsha txuas ntxiv thiab qee qhov tshuaj loog. Nws lub cev muaj zog yog odorless, me ntsis iab saj thiab loog ntawm tus nplaig. Soluble nyob rau hauv dej, soluble nyob rau hauv ethanol, insoluble nyob rau hauv ether los yog benzene, nrog aromatic theem nrab amine qauv.
Tetracaine yog ib qho tshuaj loog hauv zos uas xaiv inhibits sodium ion channels hauv cov neurons, yog li ua rau cov neurons tsis tuaj yeem xa cov paj hlwb ntau. Nws cov txheej txheem ntawm kev ua haujlwm zoo ib yam li cov tshuaj loog hauv zos xws li lidocaine thiab procaine, tab sis nws lub sijhawm ntev dua. Piv nrog Novocain thiab Benzocaine, Tetracaine muaj lub sijhawm ntev ntawm kev ua, uas tuaj yeem kav ntev txog 2 txog 4 teev. Piv nrog rau Dibucaine, nws muaj lub sijhawm luv luv ntawm kev ua, xws li 20 feeb mus rau ib teev.
Zoo sib xws
Qhov kev nyab xeeb noj ntawmNtshiab tetracaineNws txawv nyob ntawm txoj kev siv thiab tus neeg mob tus mob. Cov hauv qab no yog qhov kev nyab xeeb ntau npaum li cas muab raws li kev siv sib txawv:
1. Epidural thaiv:
- Feem ntau siv cov kev daws teeb meem nrog cov concentration ntawm 0.15% mus rau 0.3%.
- Thaum siv ua ke nrog lidocaine, qhov siab tshaj plaws yog 0.3%.
- Cov koob tshuaj uas nquag siv yog 4050mg, thiab qhov siab tshaj plaws koob tshuaj yog 80mg (tseem muaj cov ntaub ntawv qhia tias ntau npaum li cas ntawm 6080mg, tab sis ntawm no peb siv ntau qhov kev txwv txwv ntawm 80mg).
2. Subarachnoid thaiv:
- Ib qho kev sib xyaw uas siv ntau yog tsim los ntawm kev sib xyaw 1ml ntawm 1% lidocaine hydrochloride nrog 1ml ntawm 10% qabzib thiab 1ml ntawm 3% ephedrine hydrochloride.
- Cov koob tshuaj nquag siv yog 10mg, qhov txwv koob yog 15mg, thiab qhov siab tshaj plaws yog 20mg.
Neural conduction thaiv:
Ib qho kev daws teeb meem uas feem ntau siv nrog cov concentration ntau ntawm 0.1% txog 0.2%.
Qhov ntau npaum li cas yog 40-50mg, thiab qhov siab tshaj plaws yog 100mg.
Mucosal nto anesthesia:
Ib qho kev daws teeb meem uas feem ntau siv nrog qhov concentration ntawm 1%.
Ophthalmology siv 1% isotonic tov, thaum otolaryngology siv 1% mus rau 2% tov.
Ib koob tshuaj feem ntau yog 40mg.
Txhawm rau kom tsis txhob oxidation ntawm cov khoom, cov kev ntsuas hauv qab no tuaj yeem ua:
1. Cia ib puag ncig:
- Xaiv qhov chaw txias, qhuav, thiab qhov chaw tsaus, vim qhov kub thiab txias, av noo, thiab lub teeb tuaj yeem ua kom cov txheej txheem oxidation ntawm cov tshuaj.
- Xyuas kom meej tias qhov kub thiab av noo nyob rau hauv qhov chaw cia yog tswj nyob rau hauv ib qho chaw tsim nyog, nrog rau qhov pom zoo kom kub tsis tshaj 25℃thiab av noo nyob rau hauv qis qis.
2. Ntim thiab sealing:
- Siv cov khoom ntim nrog cov pa oxygen thaiv cov khoom, xws li cov hnab ntawv aluminium, lub hnab nqus tsev, thiab lwm yam, kom txo qis kev sib cuag ntawm cov tshuaj thiab cov pa oxygen.
- Thaum lub sij hawm ntim cov txheej txheem, xyuas kom zoo sealing kom tsis txhob muaj cua nkag mus rau sab hauv ntawm lub ntim. Rau cov pob khoom uas twb tau qhib lawm, lawv yuav tsum tau siv kom sai li sai tau thiab tsis txhob raug huab cua ntev.
3.Nitrogen tiv thaiv: Thaum lub sij hawm ntim cov txheej txheem, inert gases xws li nitrogen tuaj yeem muab ntim los hloov cov pa hauv lub ntim, yog li txo qhov kev pheej hmoo ntawm cov tshuaj oxidation.
4.Tsis txhob sib cuag nrog lwm yam tshuaj: Thaum khaws cia, tsis txhob sib cuag nrog cov tshuaj oxidizing xws li cov kua qaub muaj zog, cov hauv paus, cov hlau hnyav ions, thiab lwm yam, vim tias cov tshuaj no tuaj yeem ua kom cov txheej txheem oxidation ntawm cov tshuaj.
Tshawb xyuas cov khoom khaws cia tsis tu ncua kom saib seb lawv cov xim, tsw, thiab daim ntawv hloov pauv. Yog tias pom muaj cov tsos mob txawv txav, xws li tsaus xim, tsim cov ntxhiab tsw, thiab lwm yam, kev siv yuav tsum tau nres tam sim ntawd thiab kev sab laj kev tshaj lij yuav tsum tau nrhiav.
Ua raws li cov kev taw qhia kev tshaj lij: Thaum khaws cia thiab siv, ua raws li cov lus qhia ntawm cov kws tshaj lij kom ntseeg tau tias kev ua haujlwm ua tau raws li cov yam ntxwv thiab cov kev xav tau ntawm cov tshuaj.
Raws li ib qho tshuaj loog hauv zos, nws cov khoom siv tshuaj muaj zog yog qhov ruaj khov, tab sis nws tseem tuaj yeem cuam tshuam nrog qee yam tshuaj nyob rau hauv cov xwm txheej tshwj xeeb. Cov hauv qab no yog cov hom tshuaj uas yuav hnov mob nrog nws thiab lawv cov lus piav qhia txog:
Oxidizing tus neeg sawv cev
Cov oxidants muaj zog xws li poov tshuaj permanganate thiab hydrogen peroxide tuaj yeem ua kom cov txheej txheem oxidation ntawm cov tshuaj, ua rau cov tshuaj degradation lossis tsis ua haujlwm. Yog li ntawd, kev sib cuag ncaj qha nrog cov oxidants yuav tsum tau zam thaum lub sij hawm cia thiab siv.
Cov tshuaj acidic thiab alkaline
Nws tuaj yeem raug cov tshuaj tiv thaiv hydrolysis nyob rau hauv cov kua qaub los yog muaj zog alkali ib puag ncig, tsim cov kua qaub los yog cov ntsev yooj yim, yog li cuam tshuam rau nws cov tshuaj loog. Yog li ntawd, yuav tsum raug zam ntawm cov khoom mus rau huab pH ib puag ncig.
Heavy hlau ions
Qee cov hlau hnyav ions, xws li tooj liab thiab hlau, tuaj yeem ua rau muaj kev cuam tshuam nrog nws, tsim cov dej tsis sib haum. Qhov no tsis tsuas yog txo cov purity ntawm cov tshuaj, tab sis kuj yuav cuam tshuam rau nws cov tshuaj loog. Yog li ntawd, cov ntsiab lus hlau hnyav hauv cov khoom siv raw yuav tsum tau tswj nruj me ntsis thaum npaj thiab siv.
Thaum sib xyaw nrog lwm cov tshuaj, kev sib cuam tshuam ntawm cov tshuaj yuav tshwm sim. Piv txwv li, qee yam tshuaj tua kab mob, tshuaj tua kab mob, thiab lwm yam yuav muaj kev phiv los yog txo lawv cov tshuaj loog. Yog li ntawd, thaum siv cov tshuaj no, cov kws kho mob lossis kws muag tshuaj yuav tsum tau sab laj kom tsis txhob siv ib txhij los yog cuam tshuam nrog lwm cov tshuaj.
Lub koom haum lom neeg
Hauv kev siv vivo, nws yuav hnov mob nrog enzymes, proteins, thiab lwm yam hauv cov ntaub so ntswg lom, ua rau cov tshuaj metabolism thiab tso tawm. Cov tshuaj tiv thaiv no feem ntau yog cov txheej txheem tsim nyog rau cov tshuaj los ua kom lawv cov txiaj ntsig zoo hauv lub cev, tab sis nws kuj tuaj yeem ua rau qee qhov tsis zoo. Yog li ntawd, thaum siv nws rau tshuaj loog, yuav tsum tau ua tib zoo saib xyuas rau tus neeg mob cov tshuaj tiv thaiv thiab yuav tsum tau kho raws li xav tau.
Cov kev mob tshwm sim ntawm cov tshuaj no yog dab tsi?
Kev siv cov tshuaj no feem ntau yog txwv tsis pub lossis tsis pom zoo hauv cov xwm txheej hauv qab no:
Tus neeg mob
ua xua
Yog tias cov neeg mob ua xua rau lidocaine lossis nws cov khoom siv, kev siv yuav ua rau muaj kev fab tshuaj hnyav xws li ua pa nyuaj, anaphylactic shock, thiab lwm yam, yog li nws yog contraindicated.
Mob plawv mob hnyav: Rau cov neeg mob uas mob plawv mob hnyav, xws li mob arrhythmia, plawv tsis ua hauj lwm, thiab lwm yam, siv nws yuav ua rau lub nra hnyav rau lub plawv thiab ua rau mob hnyav, yog li nws feem ntau tsis pom zoo siv nws.
Lub siab thiab lub raum tsis ua haujlwm
Cov neeg mob uas mob siab heev thiab lub raum tsis ua haujlwm muaj peev xwm txo cov tshuaj metabolism thiab tshem tawm, thiab kev siv cov tshuaj no tuaj yeem ua rau cov tshuaj tsub zuj zuj, ua rau muaj kev pheej hmoo ntawm cov tshuaj lom. Yog li ntawd, nws yuav tsum tau ua tsis taus.
Myasthenia gravis
Kev siv cov tshuaj no hauv cov neeg mob uas muaj myasthenia gravis tuaj yeem cuam tshuam rau kev ua haujlwm ntawm lub paj hlwb thiab ua rau cov tsos mob myasthenia ua rau tsis zoo, yog li nws tsis pom zoo.
Txoj kev siv tshuaj loog tshwj xeeb
Feem ntau nws tsis yog siv rau infiltration anesthesia, intravenous txhaj, los yog intravenous drip. Qhov no yog vim nws qhov nqus tau nrawm heev. Yog tias nws nkag mus rau hauv cov hlab ntsha thiab qhov ntau npaum li cas, nws yuav ua rau muaj kev phom sij loj xws li kiv taub hau, ua daus no, coma, thiab ua pa tsis ua haujlwm.
Kev sib cuam tshuam tshuaj: Yog tias nws siv tib lub sijhawm nrog lwm cov tshuaj yuav ua rau muaj kev cuam tshuam, txo cov tshuaj loog ua haujlwm, lossis ua rau muaj kev pheej hmoo ntawm kev tsis zoo, ces nws yuav tsum zam rau qee qhov xwm txheej.
Cov pejxeem tshwj xeeb:
Cov menyuam yaus, cov neeg laus, cov neeg tsis muaj zog, tsis muaj zaub mov noj, thiab tshaib plab yog qhov ua rau muaj tshuaj lom thiab yuav tsum tau siv ceev faj thiab ua kom zoo.
Cov poj niam cev xeeb tub uas siv cov tshuaj no yuav muaj kev cuam tshuam tsis zoo rau tus menyuam hauv plab, yog li nws yuav tsum tau txwv.
Kev raug mob ntawm daim tawv nqaij los yog mucosal:
Kev ceev faj tshwj xeeb yuav tsum tau siv thaum siv cov tshuaj no nyob rau hauv cov cheeb tsam uas muaj cov tawv nqaij hnyav los yog mucosal deg puas tsuaj los yog kab mob, vim tias cov tshuaj yuav nqus tau sai heev los ntawm qhov chaw puas, ua rau muaj kev pheej hmoo ntawm cov tshuaj lom.
Cim npe nrov: ntshiab tetracaine cas 94-24-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom