Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm carbasalate calcium hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo carbasalate calcium rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Carbasalate calcium, molecular mis C10H14CaN2O5, CAS 5749-67-7, yog ib tug derivative ntawm aspirin tsim los ntawm complexation ntawm calcium acetylsalicylate nrog urea. Cov yam ntxwv metabolic thiab cov tshuaj pharmacological zoo ib yam li cov tshuaj aspirin. Nyob rau hauv dej, carbapenem calcium hydrolyzes los tsim acetylsalicylic acid, uas zoo muaj antipyretic, analgesic, anti-inflammatory, thiab aggregation inhibiting teebmeem. Nws tuaj yeem kho kub taub hau thiab mob hauv cov nqaij qaib thiab tsiaj txhu. Thaum kho cov kab mob avian xws li avian influenza thiab lub raum o, nws tuaj yeem siv los ua tshuaj ntxiv. Siv rau kub taub hau, mob, thiab mob tshwm sim los ntawm ntau yam laj thawj. Nws kuj tseem siv tau rau lub raum o thiab urate deposition hauv qaib. Nws tuaj yeem txo cov tsos mob ntawm qhov tsis paub ua npaws siab hauv npua, mob khaub thuas qaib, kab mob atypical Newcastle, kis kab mob bursitis, kab mob bronchitis, thiab lwm yam, thiab muaj kev pab kho mob.
Peb cov khoom
Carbalate calcium, raws li ib tug chelate ntawm calcium acetylsalicylate thiab urea, occupies ib tug tseem ceeb txoj hauj lwm nyob rau hauv ob qho tib si tib neeg thiab tsiaj kev noj qab haus huv teb vim nws tshwj xeeb tshuaj qauv thiab pharmacological zog. Nws cov mis molecular yog C10H14CaN2O5, nrog rau qhov hnyav molecular ntawm 458.43 thiab CAS naj npawb ntawm 5749-67-7. Txij li thaum nws tshwm sim nyob rau hauv lub xyoo pua 20th, carbapenem calcium tau dhau los ua dav siv tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob thoob ntiaj teb los ntawm kev ua kom zoo dua qub ntawm cov ntaub ntawv ntau npaum thiab kev tswj hwm txoj kev.
Chemical Essence thiab Metabolic yam ntxwv
1. Cov qauv tshuaj thiab hydrolysis mechanism
Carbasalate calciumyog tsim los ntawm complexation cov tshuaj tiv thaiv ntawm acetylsalicylic acid calcium (aspirin calcium) thiab urea, uas endows nws nrog nws cov dej solubility. Tom qab kev tswj hwm qhov ncauj, carbapenem calcium sai sai hydrolyzes rau hauv acetylsalicylic acid (aspirin) thiab urea hauv plab hnyuv, siab, thiab ntshav. Acetylsalicylic acid yog ntxiv metabolized rau hauv salicylates, uas ua rau cov tshuaj muaj txiaj ntsig zoo. Cov txheej txheem hydrolysis ua raws li ob chav qhib qauv, nrog rau kev sib txuas ntawm 65% -90% ntawm salicylate thiab plasma protein. Nws yog feem ntau metabolized los ntawm lub siab mus rau hauv salicylic acid thiab glucuronic acid complexes, nrog ib tug me me npaum li cas oxidized rau gentian acid, uas yog thaum kawg excreted los ntawm ob lub raum.
2. Pharmacokinetic zoo
Kev nqus tau zoo: Cov ntshav siab tshaj plaws ntawm acetylsalicylic acid tau mus txog 20 feeb tom qab kev tswj hwm qhov ncauj, thiab qhov siab tshaj plaws ntawm salicylic acid tau mus txog 1 teev.Qhov bioavailability yog li 6.7% siab dua li cov tshuaj aspirin.
Kev faib tawm cov yam ntxwv: Tshaj tawm dav hauv cov ntaub so ntswg thoob plaws lub cev, nrog rau cov ntshav plasma protein ruaj khov, ua kom ntseeg tau ntev - ua haujlwm tau ntev.
Ib nrab ntawm lub neej muaj zog: Kev tshem tawm ib nrab- lub neej nce ntxiv nrog koob tshuaj, nrog ib nrab ntawm - lub neej li ntawm 15-20 feeb ntawm cov koob tshuaj qis thiab ob peb teev ntawm cov koob tshuaj siab, txhawb kev hloov pauv hloov pauv.
3. Metabolic kev nyab xeeb
Raws li lub hom phiaj kev ntsuam xyuas tsiaj kev nyab xeeb ua los ntawm Tuam Tshoj Agricultural University, tsis muaj kev cuam tshuam tsis zoo tau pom ntawm 6 zaug ntawm cov tshuaj pom zoo, qhia tias nws txoj hauv kev metabolic zoo thiab nyab xeeb. Cov kev sim tsiaj tau pom tias carbapenem calcium tuaj yeem degraded tag nrho rau hauv cov tshuaj aspirin hauv cov qaib, tsis muaj cov tshuaj seem, ua raws li cov zaub mov tsiaj noj cov qauv.
Clinical daim ntawv thov thiab kho mechanism
1. Tib neeg kev kho mob
(1) Antipyretic, analgesic, tiv thaiv -inflammatory
Indications: Nws yog dav siv nyob rau hauv kev kho mob ntawm ntau yam ua npaws thiab mob cov tsos mob, xws li kub taub hau los ntawm ib tug mob khaub thuas thiab mob npaws, mob me mus rau nruab nrab mob xws li mob taub hau, toothache, neuralgia, mob nqaij thiab mob khaub thuas, raws li zoo raws li kev kho mob ntawm rheumatic thiab rheumatoid mob caj dab kom kho thiab sib koom tes.
Anti-inflammatory: Nws xaiv inhibits kev ua ntawm cyclooxygenase-2 (COX-2) enzyme, uas yog ze ze rau cov inflammatory teb. Los ntawm inhibiting COX-2, nws txo qhov kev tso tawm ntawm cov tshuaj kho mob xws li prostaglandins thiab leukotrienes, yog li txo cov plaub yam kev mob tshwm sim: liab, o, kub thiab mob.
Kev sib piv ntawm cov teebmeem kev kho mob: Kev sim tshuaj ntsuam xyuas pom tau tias tom qab kev tswj hwm qhov ncauj ntawm carbasalate calcium, plasma salicylate concentration nce sai, ncav cuag qhov siab tshaj plaws ntawm 72.2 μ g / ml hauv ib teev. Piv nrog rau cov tshuaj aspirin li niaj zaus, uas yuav siv sij hawm ob teev kom ncav cuag qhov siab tshaj plaws ntawm 67.7 μ g / ml, carbasalate calcium muaj qhov pib sai dua, kev ua tau zoo dua qub thiab siab dua cov ntshav plasma concentration, thiab cov txiaj ntsig kho mob tseem ceeb dua.
Mechanism ntawm kev ua:
Antipyretic: Nws exerts antipyretic nyhuv los ntawm tshwj xeeb inhibiting synthesis thiab tso tawm ntawm prostaglandin E2 (PGE2) nyob rau hauv hypothalamic thermoregulatory chaw. Qhov kev txwv no tuaj yeem kho lub cev thermoregulatory teeb tsa rov qab mus rau qhov qub, yog li nthuav cov hlab ntsha peripheral, ua rau cov ntshav ntws ntawm cov tawv nqaij thiab hws caj pas, thiab txhawb cov cua sov kom txo tau lub cev kub.
Analgesia: Nws thaiv cov synthesis ntawm prostaglandins hauv peripheral mob receptors. Prostaglandins yog cov tshuaj kho mob tseem ceeb uas tuaj yeem ua rau mob receptors. Los ntawm kev txo lawv cov ntsiab lus, cov tshuaj tuaj yeem txo qhov mob inflammatory, tshwj xeeb tshaj yog rau cov mob dull mob xws li mob leeg, neuralgia thiab mob khaub thuas, nrog rau cov teebmeem tseem ceeb thiab kav ntev.
(2) Antithrombotic tsim
Mechanism: Nws exerts antithrombotic nyhuv los ntawm inhibiting cov kev ua ntawm cyclooxygenase-1 (COX-1) enzyme nyob rau hauv platelets. Qhov inhibition no tuaj yeem txo cov synthesis ntawm thromboxane A2 (TXA2) hauv platelets. TXA2 yog ib qho muaj zog platelet aggregating tus neeg saib xyuas thiab vasoconstrictor, yog li txo nws cov ntsiab lus tuaj yeem txo qhov kev pheej hmoo ntawm platelet aggregation thiab tiv thaiv thrombosis.
Daim ntawv thov: Nws yog siv rau kev kho mob ntawm cov kab mob thrombotic, nrog rau kev tawm tsam tsis ntev los no, mob myocardial infarction, thiab tom qab phais mob thrombosis (xws li orthopedic, cardiovascular thiab plab hnyuv). Nws yog feem ntau siv ua ke nrog cov tshuaj anticoagulant (xws li warfarin, clopidogrel) los txhim kho cov nyhuv antithrombotic, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev pheej hmoo ntawm thrombosis xws li cov neeg laus, cov neeg mob ntshav siab thiab ntshav qab zib.
2. Tsiaj kev noj qab haus huv teb
(1) Indication extension
Nqaij qaib: Nws yog tsuas yog siv rau kev kho mob kub taub hau los ntawm cov kab mob xws li avian influenza, Newcastle kab mob thiab kis kab mob bursitis hauv qaib, ducks, geese thiab lwm yam nqaij qaib. Nws tuaj yeem txo lub cev kub ntawm cov nqaij qaib mob, txo cov tsos mob xws li kev puas siab puas ntsws thiab tsis qab los noj mov, thiab tib lub sij hawm txo qis raum o thiab urate deposition los ntawm kab mob los yog siv tshuaj, tiv thaiv lub raum ua haujlwm.
Tsiaj txhu: Nws yog siv rau kev kho mob ntawm cov kab mob thiab kab mob hauv npua, nyuj, yaj thiab lwm yam tsiaj nyeg, xws li tsis muaj npe kub taub hau, kab mob pob ntseg xiav, pleuropneumonia, streptococosis, thiab lwm yam. Nws tuaj yeem txo qis cov tshuaj tiv thaiv kab mob ntawm cov tsiaj nyeg mob, txo cov tsos mob xws li kub taub hau, hnoos, mob plab thiab sib koom ua ke.
Cov txiaj ntsig dav dav: Raws li tsuas yog qhov ncauj tshuaj tua kab mob thiab tshuaj tua kab mob tau pom zoo rau cov tsiaj txhu los ntawm European Pharmacopoeia thiab Tuam Tshoj Ministry of Agriculture, carbasalate calcium muaj cov txiaj ntsig zoo: dej solubility zoo, yooj yim rau yaj hauv dej haus thiab pub, yooj yim rau pab pawg tshuaj; tsis muaj tshuaj nyob hauv cov khoom tsiaj (nqaij, qe, mis nyuj), nyab xeeb rau tib neeg noj; tsis xav tau lub sij hawm tshem tawm, uas zoo heev pab txhawb kev yug me nyuam thiab ntau lawm.
(2) Kev txheeb xyuas qhov ua tau zoo
Qaib antipyretic test: Kev tshawb fawb los ntawm College of Veterinary Medicine ntawm Tuam Tshoj Agricultural University qhia tau hais tias siab thiab nruab nrab koob tshuaj carbasalate calcium yuav txo tau lub cev kub siab ntawm cov qaib induced los ntawm endotoxin, thiab cov nyhuv antipyretic yog sai thiab kav ntev, uas yog zoo dua li ntawm metamizole sodium (ib hom tshuaj tiv thaiv kab mob rau cov tsiaj txhu), thiab tsis muaj kev phiv tshuaj.
Pig anti-kev kuaj mob: Ib daim ntawv tshawb fawb los ntawm Huazhong Agricultural University qhia tias soluble carbasalate calcium hmoov tuaj yeem txo cov tsos mob ntawm kev mob caj dab hauv npua (xws li kev sib koom tes o, mob thiab txav tsis zoo), txo qis qis qis ntawm cov npua mob, txhawb kev rov ua haujlwm ntawm kev sib koom ua ke, thiab tus nqi zoo yog ntau dua 85%, uas yog tsim los ntawm kev kho mob ntau yam.
(3) Kev siv tshuaj
Nqaij qaib haus dej: Rau qaib, ducks, geese thiab lwm yam nqaij qaib, ntxiv 50-100g ntawm carbasalate calcium ib tuj ntawm cov dej haus, do tusyees kom yaj tag, thiab siv tsis tu ncua rau 3-5 hnub; Tsis tas li ntawd, suav cov tshuaj noj txhua hnub raws li 20-40mg ib kg ntawm lub cev hnyav, faib ua ob zaug hauv ib hnub, thiab sib tov rau hauv cov dej haus dawb, uas tuaj yeem hloov kho kom haum raws li qhov hnyav ntawm tus kab mob.
Cov tsiaj txhu sib xyaw: Rau cov npua loj hlob thiab fattening, ntxiv 1-2g ntawm carbasalate calcium rau ib tug npua txhua lub sij hawm, ob zaug ib hnub twg, sib tov rau hauv cov zaub mov noj; rau piglets, xam qhov ntau npaum li cas raws li 20-40mg ib kg ntawm lub cev hnyav, sib tov rau hauv pub los yog yaj nyob rau hauv dej sov rau lub qhov ncauj noj, ib hnub twg, thiab siv tsis tu ncua rau 3-5 hnub.
Kev Tswj Xyuas Kev Nyab Xeeb thiab Kev Tsis Pom Zoo
1. Tej yam tshwm sim tsis zoo
Gastrointestinal reactions: xeev siab, ntuav, mob plab sab sauv (nrog rau qhov tshwm sim ntawm kwv yees li 15% -30%), kev siv tshuaj ntau yuav ua rau mob plab lossis mob plab.
Kev tsis haum tshuaj: bronchospasm hawb pob (xws li 2% -5%), pob liab liab, urticaria.
Lwm yam: Hematuria, kiv taub hau, mob siab (tsis tshua muaj).
2. Kev tiv thaiv thiab tswj kev pheej hmoo
Kev txwv koob tshuaj: kev kho mob antipyretic yuav tsum tsis pub tshaj 3 hnub, kev kho mob analgesic yuav tsum tsis pub tshaj 5 hnub, thiab tsis pub ntau tshaj 4 zaug hauv 24 teev.
Taboos of drug interactions:
Tsis txhob sib xyaw nrog cov tshuaj tiv thaiv kab mob (xws li sodium bicarbonate) thiab lwm yam NSAIDs (xws li ibuprofen) txhawm rau tiv thaiv kev txo qis hauv cov tshuaj ntshav los yog muaj kev pheej hmoo ntawm cov los ntshav hauv plab.
Ceev faj thaum siv cov tshuaj tiv thaiv coagulants (xws li warfarin) thiab saib xyuas kev ua haujlwm coagulation.
Kev saib xyuas pej xeem tshwj xeeb:
Cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm yuav tsum tau kho qhov ntau npaum li cas thiab tsis tu ncua kuaj lub siab enzymes thiab creatinine.
Cov neeg mob hawb pob yuav tsum tau kuaj cov tshuaj aspirin ua ntej siv.
Cov tshuaj tiv thaiv thiab kev sib raug zoo Taboos
1. Contraindications rau hauv vitro compatibility
Cov tshuaj alkaline xws li sodium bicarbonate, tshuaj iodine, tshuaj calcium ntxiv, thiab vitamin D tuaj yeem ua rau cov tshuaj salicylic acid tsis ua haujlwm.
Protein binding kev sib tw: Thaum siv ua ke nrog cov tshuaj penicillin thiab sulfonamide, qhov ua tau zoo yuav cuam tshuam los ntawm kev sib tw rau cov chaw sib txuas ntawm cov plasma protein.
2. Kev sib cuam tshuam hauv lub cev
Pharmacokinetic teebmeem:
Cov tshuaj tua kab mob xws li ranitidine thiab omeprazole tuaj yeem txo qis tus nqi pH hauv plab thiab ncua kev sib cais thiab nqus ntawm carbapenem calcium.
Ethanol tuaj yeem ua kom cov permeability ntawm plab hnyuv mucosa thiab ua rau muaj kev pheej hmoo los ntshav.
Pharmacodynamic synergy:
Kev siv ua ke nrog cov tshuaj tua kab mob penicillin tuaj yeem txhim kho cov kab mob tua kab mob thiab tsim nyog rau kev kho mob ntawm cov kab mob hauv cov tsiaj nyeg thiab nqaij qaib.
Kev siv ua ke nrog cov tshuaj tiv thaiv kab mob xws li Radix Isatidis thiab Astragalus polysaccharides tuaj yeem txo cov tsos mob ntawm tus kab mob.
Txoj kev txhim kho yav tom ntej thiab cov teeb meem
1. Kev tshawb fawb thiab kev tsim cov qauv tshiab
Extended release formulation: Extending drug action time and txo dosing zaus los ntawm microencapsulation technology.
Targeted drug delivery system: siv nanocarriers xa cov tshuaj mus rau qhov chaw ntawm o nyob rau hauv lub hom phiaj, txo cov kev tsis zoo tshwm sim.
2. Kev tswj tshuaj tiv thaiv
Kev sib xyaw ua ke kev kho lub tswv yim: Tshawb nrhiav cov txiaj ntsig sib koom ua ke nrog COX-2 inhibitors thiab cov tshuaj suav tshuaj suav tshuaj tiv thaiv kab mob kom ncua kev txhim kho cov tshuaj tiv thaiv.
Kev siv tshuaj kho kom zoo dua qub: Tsim kom muaj ib qho kev noj tshuaj rau tus kheej raws li cov tshuaj pharmacokinetics kom tsis txhob siv sijhawm ntev - lub sij hawm qis - siv koob tshuaj.
3. Kev tswj hwm kev tswj hwm thoob ntiaj teb
Standardization: Txhawb kev sib nrig sib paub ntawm cov qauv zoo raucarbasalate calciumnyob rau hauv International Pharmocopoeia, thiab pab txhawb kev lag luam thoob ntiaj teb.
Kev saib xyuas cov khoom seem: Txhim kho cov txheej txheem tshawb nrhiav cov salicylate residues hauv cov khoom noj uas tau los ntawm cov tsiaj los xyuas kom muaj kev nyab xeeb ntawm cov zaub mov.
Kabapilin calcium tau dhau los ua cov tshuaj tseem ceeb hauv kev ua kom muaj tshuaj tua kab mob, tshuaj tua kab mob, thiab tiv thaiv - mob vim nws cov qauv tshuaj tshwj xeeb, cov khoom siv tshuaj muaj txiaj ntsig zoo, thiab ntau yam kev tshuaj xyuas. Los ntawm tib neeg kev noj qab haus huv mus rau tsiaj noj qab haus huv, nws daim ntawv thov scenarios tau nthuav dav tas li, tab sis kev tswj hwm kev nyab xeeb thiab kev siv tshuaj muaj txiaj ntsig tseem ceeb.
FAQ
Carbasalate calcium yog dab tsi?
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Carbasalate calcium yogcalcium -urea chelate ntawm aspirin(Ib yam tsis muaj. 70260) uas muaj tshuaj tua kab mob, tiv thaiv- mob, thiab tshuaj tua kab mob.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm carbasalate calcium?
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Nyob rau hauv cov ntsiab lus, lub mechanism ntawm carbasalate calcium yog multifaceted, nrog rau covinhibition ntawm COX enzymes, txo qis ntawm prostaglandin synthesis, thiab cov teebmeem antiplatelet. Nws formulation nrog calcium tsis tsuas yog pab txhawb kev nqus sai, tab sis kuj txo cov kev mob tshwm sim ntawm plab hnyuv.
Cim npe nrov: carbasalate calcium, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom