Halofuginone hydobromide, tseem hu ua HF, yog qhov sib xyaw nrog cov tshuaj noj tshuaj c16hbrn3o} Kuv tus cwj pwm me me yog} Nws yog cov pyridine, nrog rau ib lub pyridine thiab ib sab acetone saw hlau, tsim lub stereoconformation {}} Cov tshuaj dawb uas yog insolub sulfoxide (DMOPS) {9}℃thiab 8℃kom tsis txhob Kev txiav txim siab tsis ua hauj lwm . Yog cov khoom siv tshuaj lom neeg tau txais txiaj ntsig zoo los ntawm Dichro
Peb Cov Khoom
Halofuginone hydobromide, raws li ib qho kev sib xyaw ua ke tawm los ntawm cov tshuaj suav suav thiab kev kho mob dav dav, thiab cov khoom lag luam dav dav vim nws cov tshuaj lom neeg thiab kev siv tshuaj lom neeg .
{{01. Cov Tshuaj Siv Rau Cov Tshuaj Tivti Coccidiosis
Nws yog cov tshuaj tseem ceeb rau kev tiv thaiv thiab tswj ntawm kev ua liaj ua teb nqaij qaib thiab cov khoom siv tsis sib haum xeeb, nrog rau {}} Nws cov cim tshwj xeeb nyob rau hauv:
Thaiv cov kis tau tus kis: inhibiting tshem tawm cov hnab qe tom qab noj tshuaj (tsuas yog rau kev pheej hmoo rov ua si .
Tsis muaj tus neeg hla dej Kuj: tsis zoo li cov mankoccidial muaj xws li monsinomycin, uas muaj sib txawv los ncua kev txhim kho ntawm {}}
Kev Tshaj Tawm Kev Loj Hlob: Ntxiv2.72-5.44 g /}}}}}}} {% thiab pub hloov ua tau zoo los ntawm 8% {}}%.
Cov ntaub ntawv thov cov chaw kuaj mob:
EU kev pom zoo: hauv 2024, European Commissed tshaj 2024/23/23/23/23/231
Cov Qauv Suav: Kev Tshaj Tawm Kev Ua Si Hauv Zej Zog tias qhov kev sib ntxiv ntawm cov nqaij qaib pub yog 3 mg / kg, nrog rau kev nyab xeeb ntawm tsiaj cov zaub mov.
2. Adjuvant kev kho rau Taylor tus kab mob
Nyob rau hauv ruminant tsiaj xws li cov nyuj thiab yaj, lwm yam tshuaj (xws li kev kho mob me me los ua ke los ntawm kev kho tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev kho mob tsiaj los ntawm kev txhim kho tsiaj los txog 85% .
{{0 {}} cov tswv yim synergistic rau kev kho kho
Feem ntau siv ua ke nrog cov tshuaj hauv qab no los nthuav cov tshuaj tua kab mob:
Methylsalicylic acid anid bacitracin: txhim kho cov kab mob gram zoo thiab siv los tiv thaiv Necrotizing Enteritis hauv qaib {}}}
Rosha o: synergistically anti coccidiosis, txo cov tshuaj noj ib leeg tshuaj, thiab txo kev pheej hmoo txaus ntshai {}}
Bacitracin Zinc: Txhawb nqa cov hnyuv loj microbiota sib npaug thiab txhim kho cov khoom noj equility {}}
Kev siv kev txwv:
Txwv tsis pub siv hauv kev tso cov hens thiab waterfowl (xws li ducks thiab geese) los tiv thaiv cov zaub mov seem los ntawm kev ua zaub mov noj los ntawm cov zaub mov saw hlau .
Lom rau ntses thiab dej tsiaj, yuav tsum tau siv kom deb ntawm cov chaw dej .
Kev tshawb nrhiav hauv thaj teb cov tshuaj: los ntawm kev tawm tsam rau cov qog los tiv thaiv
1.} tej zaum yuav kho cov tshuaj rau osteoarthritis (OA)
Kev ncua kev ua haujlwm ntawm OA los ntawm kev ua tiav ob qho tib si:
Inhibition ntawm tgf - teeb tsa txoj hauv kev: txo cov hlab ntsha
Kev thaiv cov prolyl Trna synthetase: inhibits hom kuv synthe kev txhaj tshuaj (o}}) hauv nas oa qauv {}}
Cov Kev Kawm Ua Ntej:
Nyob rau hauv kev sib hloov pauv ntawm kev sib pauv ntawm kev pib ua si (Aclt) nas ua rau muaj cov lej me me thiab 00% rov qab ntawm cov proteoglycan cov ntsiab lus rau qib ib txwm muaj.
2.} Lub hom phiaj tshiab rau qog txoj kev kho mob qog
Inhibiting cov qog nqaij hlav los ntawm kev tswj hwm ntawm NPF2 txoj kev:
Downregulation ntawm nrf2 protein qhia: hauv esophageal Cancer (KYSE70) thiab mob ntsws, ntsig txog kev txhawb nqa kev tiv thaiv kev ua haujlwm.
Kev txhim kho kev siv tshuaj kho mob rhiab: ua ke nrog cisnergistically inhibit cov qog ua ke, 30% {% hauv pawg monotherapy) .
Mechanism ntawm Kev Ua:
Kev sib tw khi mus rau lub hnab looj tes proline ntawm proline protein synthesis incorporation (ic} {{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{.
3.} Cov tswv yim cuam tshuam rau cov kab mob fibrotic
Hauv cov kab mob xws li cov kab mob sclerosis thiab pulmonary feelition tau pom tias muaj kev cuam tshuam ntawm cov khoom siv rau cov roj av Cov kab mob .
Muaj cov khoom siv muaj ntau yam raws li cov khoom siv raw tshuaj raw
{{{01. tus yuam sij nruab nrab hauv cov organic synthesis
Tus qauv tseem ceeb ntawm nws quinazolinone ua rauHalofuginone hydobromideIb tug prefursor rau synthesizing ntau yam bioactive molecules:
Cov tshuaj surthesis: Siv rau kev npaj cov tshuaj tiv thaiv antimalarial, tshuaj tiv thaiv qog siv tshuaj, thiab cov tshuaj tiv thaiv cov tshuaj tiv thaiv kab mob.
Cov ntaub ntawv kawm txuj ci: raws li monomer rau kev ua haujlwm polymers, nws yog siv los npaj cov ntaub ntawv photoluminescent lossis sensors .
{{02. cov qauv tshuaj hauv cov tshuaj analytical
Vim nws cov tshuaj ruaj khov, nws yog siv los ua:
Calibration txheem rau kev ua kua chromatography (HPLC): Siv rau kev ntsuas kom muaj nuj nqis ntawm cov qauv sib xyaw nrog cov qauv zoo sib xws.
Cov ntaub ntawv siv rau cov roj teeb huab tais (MS): Pawg Spectrometry tawg siv los pab hauv kev txheeb xyuas ntawm Quinazolinone teb chaws .
Qhov kev tshawb pom ntawm HaloFuginone hydrobromamide yog ib qho kev txhim kho ntawm cov khoom siv chemiska, thiab nws cov txheej txheem niaj hnub kos duab thiab kev ua haujlwm ntawm kev ua.
Lub keeb kwm ntawm Changshan ua cov tshuaj suav ib txwm muaj los kho cov neeg ua haujlwm "Shennes}} lom zem ntawm Febrifugene, xws li ntuav kev loj thiab lub siab hloov kho kom muaj cov kws tshawb fawb kev hloov kho tshiab thaum khaws cov kev ua si lom zem thaum khaws cov haujlwm {}}
Nyob rau hauv lub xyoo 1960, Asmeskas lub tuam txhab Cyanamid (tom qab sib xyaw ua ke rau cov neeg ua haujlwm sib dhos thiab cov pa hluav taws xob ua ke
Cov ntaub ntawv lom: Qhov ncauj koob ntawm LD ₅₀ hauv cov nas yog 25 mg / kg .}}}}}} 4}}
Kev txhim kho hauv palatability: txawm hais tias tseem muaj teeb meem ntawm cov neeg txom nyem lub Palatability (15% {% txo qis hauv tsiaj cov ntawv thov loj.
Nyob rau hauv 1991, Haloketone hydrobromide (lub npe luam tawm stenolol) tau pom zoo los ntawm peb qhov kev hloov pauv ntawm lub chaw ua lag luam los ntawm kev ua lag luam .
Qhov tshwj xeeb ntawm tus nqi ntawm haloketones nyob hauv lawv cov hom phiaj ntau ntawm kev nqis tes ua:
Anti coccidiosis ua si:
Inhibit lub nucleic acid synthesis ntawm cov microscoridia thiab schizonts, thiab thaiv cov kev nthuav dav ua kom muaj zog {}}
MIC rau 6 hom ntawm Eimeria, suav nrog Eimeria Tenella thiab Eimeria toxin, yog} {} {} {{.
Anti o thiab anti fibrosis:
Raws li ATP cov neeg sib tw inhibitor ntawm prolyl Trna synthetase (K}}}}}}} synagen hom kuv collagen hom {}}
Los ntawm inhibiting tgf - kev qhia txoj hauv kev uas tau pom tias muaj kev cuam tshuam rau pob txha hauv pob txha caj qaum, thiab kev ncua cov qe ntshav hauv nas OA {4 4}}
Antitumor muaj peev xwm:
Hauv cov kev sim vito qhia tau tias nws cov IC ₅₀ tawm tsam esophageal Cancer (KYSE70) thiab mob ntsws
Ua ke nrog cisplatin,Halofuginone hydobromidetuaj yeem synergistically inhibit qog kev loj hlob thiab nce cov qog ntim cov nqi txo los ntawm 40% piv rau mooderapy.
Cim npe nrov: HaloGinone hydobromide, cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag