Chlorpromazine hydrochloride, Molecular Cov Qauv Molecular C17H191s · HCL, CAS 69-09-0, dawb lossis milly dawb crystalline hmoov. Melting taw tes 179-180℃(194-196 degree) Nws yooj yim soluble hauv dej, ethanol, thiab chloroform, tab sis tsis nyob hauv ether thiab benzene. Nws muaj hygroscopicity, nrog pH ntawm 5% hauv cov kua aqueous thiab 4-5. Nws yog me ntsis smelly, iab heev. Nyob rau hauv cov kev ua pa, cov tshuaj aqueous ntawm chlrprromazine hydrochloride cov khoom pov thawj tsis muaj zog acidity (pH kwv yees li 3-4). Cov khoom lag luam no yog siv rau oxidation thiab yuav maj mam tig liab dawb xim av hauv huab cua lossis tshav ntuj. Nws yog khaws cia rau hauv qhov chaw txias. Shaanxi ua tiav Chem Tech Co., Ltd. tsim cov khoom lag luam no rau kev kuaj thiab raug txwv los ntawm lwm cov kev siv.
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Tshuaj Cov Qauv |
C17H20Cl2n2s |
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Muaj pes tsawg leej |
354 |
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Molecular hnyav |
355 |
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m/z |
354 (100.0%), 356 (63.9%), 355 (18.4%), 357 (11.8%), 358 (10.2%), 356 (4.5%), 358 (2.9%), 359 (1.9%), 356 (1.6%), 358 (1.0%) |
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Kev Ntsuam Xyuas |
C, 57.47; H, 5.67; Cl, 19.95; N, 7.88; S, 9.02 |
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Hauv Vivo kawm:
Chlorpromazine (3,10,20,40 thiab 60 μ m) Txo lub ncov tam sim no ntawm Hnav1.7 hauv kev thaj chaw siab, nrog IC50 ntawm 25.9 μ MAN M. Lub Roob IC50 ntawm 253. Chlorpromazine (25 μ m) Nws muaj kev siv cov nyhuv nyob ruaj khov rau ntawm hnav1.7 tam sim no. Chlorpromazine blocks Hnav1.7 Channel thiab yog ywj siab ntawm Calmodulin. Chlorpromazine thaiv cov xov hluav taws xob cov tshuaj potassium chansium, thiab tus nqi IC50 yog 21.6 μ MAN M HMAN M. HAN M. HILL COefficient yog 1.11. Chlorpromazine (1,10100 μ m) Cov tshuaj Pereg Potassium channel qhia tawm hauv Xenopus Oocytes tau thaiv hauv qhov chaw siab. Chlorpromazine thaiv cov xov hluav taws xob cov poov xab channel nyob rau hauv lub xeev actived.
Hauv kev kawm vitro:
Chlorpromazine (2 mg / kg, IP) -}}}} urnivalal tsis txaus ntseeg thiab lub caij nyoog li cas nyob rau hauv nas. Chlorpromazine (1 lossis 5 mg / kg, Kuv tuaj yeem tiv thaiv Ketamine (Ket) los ntawm nce δ {qhov kev nce qib nruab nrab ntawm lub hyperspectal band.
Synthesis ntawmchlorpromazine hydrochloride:
1. Lub nplhaib loj tau npaj los ntawm Ullmann cov tshuaj tiv thaiv nrog o- Txoj Kev Siv Cua sov los npaj 2-carboxyl-3-diphenyl-3-Diphenyl-3-Dipherylamine; Tom qab decarboxylation ntawm qhov kub, nws yog fused nrog sulfur mus rau cyclically synthesize 2-chlorophenylthiazine.
2. Sab saw hlua tau npaj los ntawm cov cawv cua sov nrog dej haus dej nrog cov slotylamine nyob rau hauv muaj 1-chloro-3-dimethyloraminopring.
3. Lub nplhaib hws ntawm lub nplhaib loj thiab sab tes yog nqa tawm nrog cov neeg sawv cev hydrocorod, thiab tau txais chlorpromazine yog sterication nrog hydrogen chloride roj kom tau chlorpromazin hydrochloride.
Nws yog tshuaj tiv thaiv tshuaj antipsychotic. Ntawm no yog cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib txig sib luag ntawm cov kev ntsuas hluav taws xob synthesis:
Kauj ruam 1: Kev npaj Dimetylaniline
1. Rov qab nitroxylene nrog zinc hmoov thiab mloog zoo li hydrochloric acid.
C6H4(Ch3)2(Tsis muaj2) {{+ 6 hcl + 6 zn → c6H4(Ch3)2Naj2 + 2H2O + 6 ZNCL2
2. Lim cov tshuaj tiv thaiv sib xyaw thiab sau cov txiaj ntsig dimethylaniline.
Kauj ruam 2: Kev npaj Dimethyl Aminomethyl - penothiazine
1. Rov qab ua rau dimethylandaniline nrog 2,3-Hauromopropanane.
C6H4(Ch3)2Naj2 + (Ch2)2Tus br2 → C6H4(Ch3)2N (ch2)2Tus br2
2. Distill kom tau dimethyl aminomethyl - Phenothomezine.
Kauj ruam 3: Kev npaj ntawm cov khoom
1. Rov qab ua rau dimethyl aminomethyl -} Phenothomezine nrog chloroacetone.
C6H4(Ch3)2N (ch2)2Tus br2 + Ch3Cooj2Cl → c6H4(Ch3)2N (ch2)2Ch2Cooj3 + HBR
2. Ntxiv sodium hydroxide daws thiab lim kom tshem tawm impurities los ntawm kev daws.
3. Cov khoom acidification tau hloov mus rau hauv chlorpromazin hydrochloride siv hydrochloric acid.
C6H4(Ch3)2N (ch2)2Ch2Cooj3+ Hc → c6H4(Ch3)2N (ch2)2Ch2Cooj3· HCL
Thaum kawg, chlorpromazin hydrochloride tau txais.
Nws yuav tsum raug sau tseg tias cov qauv synthesis saum toj no tsuas yog ib lub chaw ntsuas kev sib cav sib ceg, thiab kev ua haujlwm tiag tiag vim muaj kev sim lossis lwm yam. Thaum ua kev sim, thov nruj me ntsis ua raws kev nyab xeeb ntawm kev nyab xeeb thiab tsim qauv thiab ua kom cov kev sim ua kom zoo raws li qee yam.
Nws ua tus sawv cev ntawm Phenothiazine Tshuaj tiv thaiv kab mob, tau dhau los ua kev noj tshuaj hauv lub hlwb thiab kev kho mob hauv tsev kho mob txij li xyoo 1950. Nws ua kom muaj ntau yam ntawm cov tshuaj pharetorological los ntawm thaiv dopamine receptors, serotonin receptors, m {} hom acetylcholine receptors, thiab alpha adrenergic receptors.
1. Cov tsos mob zoo tswj cov schizophrenia
Nws muaj cov teebmeem tseem ceeb ntawm cov tsos mob zoo xws li kev txaus siab, nyob tsis tswm, tsis muaj kev cuam tshuam, thiab kev coj cwj pwm, thiab kev coj tus cwj pwm ploj hauv schizophrenia. Nws cov tshuab kev ua yog los thaiv Dopamine D ₂ receptors hauv midbrain Limbic system thiab madbrain Cortex txoj hauv kev. Cov kev tshawb fawb soj ntsuam tau pom tias nyob rau hauv kev kho mob ntawm theem kev kho mob schivenia, nce txog ntawm 2500-6 Rau cov neeg mob refactory, intramuscular lossis kev txhaj tshuaj ntawm kev tsim nyog tuaj yeem ua tiav tau sai dua kev haus dej haus kom ntau dua. Piv txwv li, tom qab muaj kev cuam tshuam los ntawm 25-50mg, cov neeg mob tuaj yeem muaj cov teebmeem sedative li ntawm 30 feeb.
2. Kev xav ruaj khov hauv kev ua yeeb yam
Thaum lub sij hawm manic theem ntawm bipolar puas tsuaj, los ntawm inhibiting dopaminergic neurotransmission, tus neeg mob lub siab xav txog lub siab. Ib qho kev kawm multicenter uas muaj kev cuam tshuam 200 tus neeg mob uas muaj kev puas siab puas ntsws bipolar uas pom tias kev sib xyaw ua kechlorpromazine hydrochloride(300-400mg ib hnub) thiab Lithium ntsev txo lub bipolar disorder nplai (BAST) tau los ntawm cov pab pawg lithium ntsev ib leeg (P<0.01). Its sedative effect can help patients restore their sleep rhythm and create conditions for subsequent psychological treatment.
3. Adjervant kev kho rau lwm cov kev puas hlwb
Rau cov organic kev puas siab ntsws (xws li kev tsis ncaj ncees rau kev puas hlwb Piv txwv li, hauv cov neeg mob uas muaj cov neeg mob hauv qab kev raug mob lub hlwb, qis dua chlorpromazine tuaj yeem ua rau lub sijhawm delirium los ntawm 2-3 hnub thiab txo qhov kev pheej hmoo ntawm tus kheej raug mob.
Tshwj xeeb kho cov xwm txheej tshwj xeeb: cov ntawv thov sib txawv ntawm antiemetic rau cov khoom siv hibernation
Qhov kev daws teeb meem kawg rau kev ua kom tawv ncauj
Nws cov nyhuv antiemetic tau ua tiav los ntawm kev siv tshuaj qis dua (Ct), Nws muaj cov teebmeem tseem ceeb ntawm cov hom ntuav ntawm cov ntuav:
Tshuaj tsis pom kev: Cov tshuaj tiv thaiv mob hnyav los ntawm cov tshuaj kho mob (xws li Cisplatin) tuaj yeem txhim kho thaum ua tiav thaum ua ke nrog 5-HT3 releptor antagonists (xws li Ondansetron).
Ua kom muaj kev ntuav tawm: Hauv cov neeg mob uas muaj raum tsis ua haujlwm, Chlorpromazine HCL tuaj yeem txo qis zaus ntawm kev ntuav ntawm ntuav ntawm ntuav ntawm 5-8 zaug ib hnub, txhim kho cov khoom noj muaj txiaj ntsig zoo.
Tej Tshuaj Pauv Xeeb: Rau cov neeg ua haujlwm tawv ncauj ua tsis muaj tshuaj tiv thaiv hluav taws xob, nws tuaj yeem txo cov poj niam cev xeeb tub, tab sis nruj kev soj ntsuam ntawm kev nyab xeeb ntawm plab yog qhov tsim nyog.
Saib xyuas: ntuav vim kev mob tau hnov mob tsis zoo raws li nws cuam tshuam nrog vestibular system.
2. Kev rhuav tshem kev kho mob rau stubborn hiccups
Hiccup kav ntev dua 48 teev yog txhais ua HICCUCUP, feem ntau pom hauv kev ncua, mob hlab ntsha tawg, lossis cov mob plab zom mov. Los ntawm thaiv cov hiccup chaw nyob hauv Modulla oblongata, lub hiCcup Cessation tus nqi tau ncav cuag 80% hauv 30 feeb tom qab kev sib xyaw ntawm 25-50mg.
Kev tshawb fawb txog ntawm 50 qhov kev ncua ntawv hiccup neeg mob pom tias qhov kev rov muaj dua li 24% tsuas yog 15%, qis dua li ntawm chlorpromazine (35% kev rov ua dua).
3. Lub synergistic nyhuv ntawm tsawg -} kev ua kom sov thiab khoom siv hibernation
Nyob rau hauv phais mob plawv, chl / kg) ua ke nrog lub cev sib xyaw ua ke "-36 degrees Piv txwv li, nyob rau hauv kev phais rau Aortic Dissection, Fibernation hibernation tuaj yeem txo cov pa oxygen tau los ntawm 30% thiab txhim kho qhov ua tiav ntawm kev phais mob.
1. Syergistic nyhuv nrog analgesics
Tuaj yeem txhim kho cov txiaj ntsig zoo ntawm cov tshuaj opioid, tshwj xeeb tshaj yog tsim nyog rau cov neeg mob uas mob mob hnyav rau hauv tus mob cancer thaum kawg. Lub tshuab siv hluav taws xob suav nrog:
Kev thaiv cov dopamine receptors txo cov kev mob tshwm sim ntawm xeev siab thiab ntuav los ntawm cov tshuaj opioid.
Inhibit lub excitusability ntawm tus txha caj qaum dorsal horn neurons thiab nce qhov kev mob ntsuas.
Kev tshawb nrhiav kev tshawb fawb tau pom tias kev sib xyaw ua kechlorpromazine hydrochloride(25-50mg / hnub) thiab morphine (30-60mg / hnub) tuaj yeem nce qhov mob tus nqi ntawm 70%, thaum txo cov tshuaj morphine ntau dua los ntawm 30%.
3. Kev ceev faj ua ke nrog cov tshuaj antihypertensive
Nws alpha adrenergic recenor thaiv cov yuav ua rau orthitic hypotension, thiab cov tshuaj antiyperensive xws li diuretics thiab ace inhibitors.
Piv txwv li, hauv cov neeg mob uas muaj kev kub ntxhov, yog tias nws yog qhov tsim nyog los tswj cov tshuaj tiv thaiv kev puas hlwb, thiab cov ntshav siab hloov yuav tsum tau saib xyuas kom zoo.
4. Kev cuam tshuam nrog tshuaj anticholiceergic
Cov kev cuam tshuam anticholmifygicgic cuam tshuam ntawm chlorpromazine hcl (xws li qhuav qhov ncauj thiab quav tawv) tuaj yeem txhim kho cov tshuaj antichinergic xws li atrochinergic xws li atrochine, ua rau muaj kev cuam tshuam loj. Hauv cov neeg laus neeg mob, kev kho kev kho kom muaj kev ntsuas kev pheej hmoo rov qab piv thiab saib xyuas cov suab siab thiab lub suab quav yog tias tsim nyog.
Lub molecular qauv tsom xam ntawmchlorpromazine hydrochlorideyog ib qho kev tshawb fawb ua haujlwm heev. Los ntawm kev txheeb xyuas nws cov qauv molecular, ib tus tuaj yeem nkag siab txog nws lub cev thiab tshuaj lom neeg, nrog rau nws cov kev ua ntawm tib neeg lub cev.
1. Molecular formula thiab molecular hnyav ntawm chlorpromazin hydrochloride
Cov mis molecular ntawm chlorpromazin hydrochloride yog C17h191SHen · Hydr, nrog tus txheeb ze sib npaug ntawm 355.33 da. Ntawm lawv, C raug sawv cev carbon, h sawv cev rau cov hydrogen, n sawv cev rau cov tshuaj nitrogen, s sawv cev sawv cev, thiab hcrocoric acid.
2. Molecular qauv ntawm chlorpromazin hydrochloride
Cov qauv molecular ntawm chlorpromazin hydrochloride yog tsim ntawm ntau cov atoms, suav nrog ob lub benzene rings, ib pawg pyrimidine, thiab ib pawg neeg pthopenyl nrho pawg. Cov pab pawg no tau kaw kom nruj rau hauv lawv cov qauv molecular thiab txuas ua ke los ntawm kev sib txuas lus.
3. Tshuaj lom neeg ntawm Chlorpromazin Hydrochloride:
Chlorpromazin hydrochloride yog ib qho tshuaj nrog ntau yam tshuaj xws li kev ua kom loog, tshuaj tiv thaiv, thiab anti ua xua. Nws muaj cov solubility siab nyob rau hauv dej thiab tuaj yeem yauv ua kev ntxhov siab thiab kev hloov pauv nrog kev hloov pauv ntawm tus nqi PH. Piv txwv li, nyob rau hauv cov xwm txheej acidic, chlorpromazine tuaj yeem ua rau protonated los tsim cationic cundromrazin hydrochloride. Nyob rau hauv Alkaline cov xwm txheej, chlorpromazine yog deprotonated rau hauv daim ntawv ntawm radicals dawb. Tsis tas li ntawd, chlorpromazine kuj muaj qee yam toxicity thiab voos, thiab nws yuav tsum tau siv nyob rau hauv kev taw qhia ntawm cov kws kho mob.
4. Cov qauv thiab kev ua ntawm Chlorpromazin Hydrochloride:
Vim muaj cov pab pawg sib txawv hauv cov qauv molecular ntawm chlorpromazin hydrochloride, nws muaj cov tshuaj lom neeg nyuaj thiab ntau yam cuam tshuam. Nws yog feem ntau ntseeg hais tias cov antipsychhotic cuam tshuam ntawm chlorpromazin hydrochloride yog ua tiav los ntawm kev ua haujlwm ntawm dopamine receptors hauv nruab nrab ntawm cov leeg ntshav nruab nrab. Nws khi rau cov neurotransmitter dopamine, yog li daws cov tsos mob tshwm sim hauv cov neeg mob muaj cov neeg mob hlwb. Lub caij no, chlorpromazine tseem tuaj yeem cuam tshuam cov metabolism thiab tso tawm lwm cov neurotransmitters, xws li serotonin thiab acetylcholine.
Cim npe nrov: Chlorpromazine Hydrochloride Hmoov Cas 69-0, Tus neeg muab khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, rau muag