Chlortetracycline hmoovyog cov tshuaj tiv thaiv tetraciotic, uas yog cov qauv siv cov tshuaj tsw qab los ntawm cov xim av los ntawm xim av daj los ntawm xim av xim av lossis xim dub, uas muaj feem xyuam rau nws cov duab tshaj tawm .}}}}}}}}}} Cov khoom poob qis ua rau nws muaj qhov tsis txaus ntseeg nrog cov hlau tsis muaj hlau ions (xws li ca ⁺, mg ⁺ ⁺), txo nws cov ntshav, yog li nws tuaj yeem ua rau cov ntshav, tshwj xeeb yog hauv plab hnyuv siab ib yam li daim siab thiab raum thiab .
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
Peb Cov Khoom
Chlortetracycline +. coa
1. solubility
Lub solubility ntawm chlorotetracline muaj cov yam ntxwv tseem ceeb:
Kev ntxhov siab heev hauv dej: lub solubility hauv dej ntshiab (0}} 86g / ml ntawm 28 degree), tab sis solable vloride tov).
Ib nrab soluble hauv cov kuab tshuaj muaj zog:Chlortetracycline hmoovhydrochloride daim ntawv yog soluble me ntsis hauv methanol, dej, thiab yuav luag tsis muaj acetone, ether, chloroform, etc .
PHOOG: Kev sib txawv Isomerization yog nquag tshwm sim nyob rau hauv acidic tej yam kev mob (pH {2-6} Ib qho yooj yim rau lub kaum tawm thiab daim ntawv lub cev qhuav dej nyob rau hauv cov acidic acidic ib puag ncig (Ph<2); In alkaline conditions (pH>7), nws nrawm thiab poob qis (xws li ib nrab-lub neej ntawm tsuas yog 3. 5 teev nyob rau pH 9.8).
{{0 {}} melting taw tes thiab boiling taw tes
Melting taw tes: {168-169℃(decomposition (decomposition), nthuav tawm cov khoom kub dog dig thaum dej, thiab tsim cov khoom dub {}}
BOARDING NTA: the theoretical kwv yees tus nqi yog 821. 1 degree, tab sis qhov nyuaj kom ncav cuag qhov kub no vim qhov kev txiav txim siab tawm.
{{03. ntom thiab tsis muaj zog index
Ntws: 1 {.} 7g / cm / cm/00 (crystalline xeev), siab dua li cov qauv organic, vim nws cov qauv molecular.
Cov ntsiab lus tsis zoo: kwv yees li 1 .}}}}}}}} (kwv yees tus nqi), muaj peev xwm siv tau rau kev sim siab huv.
4. kua qaub cov khoom
Chlorotetracline yog ib qho kev sib txuas amphoteric:
Alkaline pab pawg: pawg dimethylamino
Cov pab pawg acidicylrameslmethanethanethanethanethanethanethanethanethanethanethanete thiab tuaj yeem tso cov prodity thiab tuaj yeem tso cov protons kom tsim cov acions .
Cov ntsev tsim: Los ntawm kev rov ua kom sov nrog cov kua qaub lossis hauv qab no xws li ntsev hydrochloride tuaj yeem tsim tawm . Piv txwv:
Chlortetracline hydrochloride: ua los ntawm rau-relorotetcline nrog hydrochloric acid, thiab yog ib qho kev siv tsim me ntsis .
Chlortetracline calcium: tsim los ntawm raucotetracline nrog cov ntsev ntxiv thiab tuaj yeem tso cov khoom xyaw hauv lub plab acid .
5.} thermal ruaj khov thiab photosensitivity
Thermal stability: nyob rau hauv ib puag ncig qhuav, xws li kub siab dua li 5 xyoos rau 5 teev nws muaj tsawg kawg yog 5% .
Rhiab heev rau lub teeb: Thaum raug rau lub teeb, cov xim tsaus nti thiab cov khoom ua kom muaj kev ua kom zoo dua qub lub raj mis los yog txhuas ntawv ci ntim) .
6. molecular qauv thiab kev teeb tsa kev teeb tsa kev teeb tsa
Cov qauv molecular ntawm chlorotetracline yog c ₂₂ h ₂₂ h ₂ ₂ h ₂ ₂ o ₈ ₈, nrog lub cev hnyav ntawm {} nws cov qauv suav nrog:
Tetracycline Core Tub ntxhais: muaj ntawm plaub tus fused rings (a, b, c, d), nws yog tus qauv tseem ceeb rau {}}
Cov pab pawg ua haujlwm:
{6- Txoj Haujlwm Methyl (Enhances Methylial Dagential) .
7- Txoj Haujlwm Chlorine Atom (txhim kho cov kab mob gram zoo) .
{{04- dimethylamino (ib qho tseem ceeb khi cov chaw rau ribosomes).
Polyhydroxyl thiab carboryl pab pawg (koom nrog hydrogen bonding tsim, ruaj ruaj molecular conformation) {}}}}
Cov txheej txheem synthesis ntawmChlortetracycline hmoov(Aureomycin) feem ntau suav nrog kev siv tshuaj lom neeg thiab tshuaj kho hluav taws xob yog cov txheej txheem hluav taws xob ntawm kev lag luam. Cov lus qhia ntxaws ntxaws ntawm cov lus qhia ntxaws ntxaws ntawm cov qauv:
Kev Raug Mob Rau Fais Fab Kev Lag Luam: Cov Technology Core ntawm Kev Lag Luam Ntau Lawm
Kev txheeb xyuas cov txheej txheem kev siv hluav taws xob siv streforyciens raws li kev tsim cov khoom siv, thiab ua tiav cov txheej txheem txaus tuaj yeem faib ua cov kauj ruam tseem ceeb hauv qab no:
Kev yug me nyuam ntawm cov kab mob sib txawv thiab ua kom zoo dua ntawm cov kab lis kev cai media
Kev Xaiv Xaiv: Kev Ntsuas Xyuas Nyiaj Txiag Heev los ntawm Kev Xaiv Ntuj Ceg, siv cov kab mob caj ces, siv cov khoom siv caj ces thiab nce cov txiaj ntsig ntawm cov khoom lag luam metabolic {}
Kab lis kev cai nruab nrab hauv nruab nrab: Qhov nruab nrab fermentation yuav tsum muaj cov roj carbon ntau (xws li malite acid), xws li cov tshuaj txhuam hniav (xws li cov ceg ntoo zoo nkauj (xws li cov roj nplaum thiab cov pa roj ntsha chlorotetracline, uas tuaj yeem txhawb los ntawm kev ntxiv sodium chloride lossis ammonium chloride {}}
Fermentation Txheej Txheem Tswj
Fermentation tej yam: kub tswj tau ntawm 28-30℃{}}}}}}}} {.
Cov Kev Tswj Xyuas Cov Me Nyuam: Los ntawm kev ntxiv cov tshuaj tiv thaiv neeg tsis suav nrog cov kab lis kev cai no ua rau muaj kev sib tw nrog cov tshuaj lis kev sib txuas lus ntxiv, yog li cov tshuaj sib tw ntxiv rau cov tshuaj condorine, yog li kev coj ua fermorine, yog li kev coj ua fermentation los ua tetraccline .
Cov Khoom Tawm Extraction thiab Kev Siv Kom Huv
Dag Zog Txheej Txheem:
Tom qab acidification (p p {4.5-5.0) ntawm fermentation broth, chlorotetectates raws li cov kua qaub dawb thiab sib cais los ntawm kev lim}
01
Cov kuab tshuaj rho tawm:
Siv qhov sib txawv hauv kev sib txawv ntawm cov solubility ntawm vlorotetracline hauv cov sib txawv ntawm PH thiab cov kuab tshuaj thiab lub pentyl acetate yog siv rau extraction .
02
Ion kev sib pauv qauv:
Chlortetralcline yog adsorbed los ntawm anion sib pauv resin thiab ntxiv kom huv si los ntawm kev ntxuav methanol lossis ethanol .
03
Crystallization txheej txheem:
Tom qab cov khoom nyoos yog yaj thiab salted (xws li fydrochloride los ntawm kev tswj qhov kub thiab txias kom tau txais kev ua siab loj chlorotetcline.
04
Tshuaj Lom Neeg Hluav Taws Xob: Qauv Hloov Kho thiab Kev Npaj Ua Khoom Noj
Kev siv tshuaj lom hluav taws xob hluav taws xob feem ntau yog siv los npaj cov tshuaj chlorotetralcline los yog ua kom zoo dua lawv cov khoom hloov kho {}}}}}}}} txoj hauv kev:
Palladium catalyzed hydrogenation cov tshuaj tiv thaiv hydrogenation
Cov tshuaj tiv thaiv hydrogracleceve uas yog cov khoom siv ntawm kev ua haujlwm ntawm hydrogenation, tab sis cov chaw ua haujlwm tau siv rau kev lag luam tshawb nrhiav tsis muaj ntau lawm {}
Daim Ntawv Thov Kev Ua Yeeb Yam: Cov Qauv Tshuaj Lom Zem Muaj txiaj ntsig zoo rau hauv Kev Npaj Ua Tshuaj Zoo Tshaj Plaws.
Ceev faj rau cov khoom siv
请替换当前内容 Tsis txhob nce lub voos xwmfab ntse rau saum qab nthab uas tsis muaj lub thawv ntim khoom khov kho tsis txaus los txhim kho lub teeb lub teeb mus rau saum qab nthab;.
Tsis txhob siv cov kab xev ob npaug rau txuas cov panels rau plua plav, noo, wallinished ntoo, pob zeb ruaj khov lossis pob zeb ruaj khov los yog}
Tsis txhob siv cov kab xev ob npaug rau txuas cov panels rau plua plav, noo, wallinished ntoo, pob zeb ruaj khov lossis pob zeb ruaj khov los yog}
Cov khoom lag luam tsis yog dej tsis huv, thov tsis txhob ntxuav lossis sib cuag nrog dej;
Tsis txhob cia menyuam yaus tsis muaj cov neeg laus saib xyuas cov khoom no ib leeg, menyuam yuav tsum tsis txhob tso ib leeg nrog cov khoom lag luam, kev pheej hmoo ntawm choking .
Tsis tu ncua xyuas cov ntsia hlau xoob, cov khoom tawg lossis hloov cov khoom uas tau ua tib zoo, thov ua raws li phau ntawv qhia ua kom tsis txhob muaj kev puas tsuaj tsis tsim nyog.
Kev tshawb nrhiav tag nrho cov kev sib tw zoo nkauj tag nrho
Kev Tshawb Fawb Kev Kawm: txawm tias cov kab mob hluavtaws zoo nkauj, cov kws tshawb fawb tseem ceeb los ntawm cov khoom siv ntawm cov kev txwv ntawm cov kev txwv 1, {4- butanediol .
Kev sib tw thiab qhov tseem ceeb: tag nrho cov teeb meem synthesis muaj teeb meem ntawm cov qauv kev sib raug zoo, tab sis nws txoj kev vam meej yuav ua rau cov qauv tsim tawm tshiab.
Txuj Ci Kev Loj Hlob
Metabolic engineering thiab hluavtaws biology:
Los ntawm kev siv cov gene tab tom muaj kev kawm sib dhos thiab txhim kho cov qauv ntawm CTCOt, ntau dhau ntawm peb cov qauv CTCP tuaj yeem tsim cov khoom lag luam loj chlortetralcline los ntawm 15 g / l rau 25 . 9 g / l.
Cov txheej txheem ntsuab hluavtaws:
Txhim kho cov txheej txheem muaj sia nyob thiab muaj kuab paug qias neeg, xws li siv cov khoom siv tshuaj lom neeg tsis sib xws?
Koom Tes Ua Si Lub Tswv Yim:
By regulating the metabolic network of Streptomyces coelicolor, the co production of chlorotetracycline and other tetracycline antibiotics (such as tetracycline and oxytetacycline) can be achieved, improving resource utilization efficiency. For example, when chlorine suppressants are added to the culture medium, Streptomyces coelicolor can switch to synthesizing TetRacycline .
Tshuaj Ntsuam Xyuas Tshuaj thiab Kev Tswj Xyuas Zoo
Daim Ntawv Thov: Kev Txiav Txim Siab ntawm Chlortetracline hydrochloride cov ntsiab lus hauv compound cleartetralcline glycerol .
Mob:
Chromatographic Pob: Autima C18 Kem (4 {{}}}} 6mm × 250mm, 5 μ m).
Mobile theem: methanol -0.01 mol / l nah ₂ po ₄ daws (364) .
Kev Tshawb Pom Wavelength: 355nm .
Linear ntau: {{{85.56-513.36} μ g / ml (r {{1}.
Rov qab tus nqi: 100 {. 23%, Rsd =1.34%.
Lub hauv paus ntsiab lus: RECATCUMBUMBLECALBALCALE RECTION ntawm Tris (2,2 '- potassium tshuaj tua kab mob (Oven)
Rhiab:
TetRacycline: 1 {{4 4}} × 0 ⁻⁷ 10-1.0}}}} 10 ⁻⁵ g / ml.
Chlorotetralcline: 4 {{4 4}}} 0 × 10}-1.0}}} 10 ⁻⁵ g / ml.
OxytetyCline: 1 {{{4 4}} × 0 ⁻⁷ 10-1.0}}}} 10 ⁻⁵ g / ml.
Kev nrhiav kom tsis pub muaj: Chlaticetralcline yog 1 .} × 0 ⁻⁸ 10 - n=3).
Cov Ntsiab Lus Kev Txiav Txim Siab: Cov ntsiab lus txiav txim los ntawm HPLC Txujcub yuav tsum yog nruab nrab ntawm 90% thiab 110% ntawm tus nqi ....
Impurity tswj: nws yog ib qho tsim nyog los tshawb xyuas cov impurities xws li tetracycline thiab isomers, nrog tag nrho cov impurity tsis dhau 2%.
Tus lej ntawm cov ntsiav tshuaj yuav tsum tau ua kom tau raws li cov chaw muag tshuaj (xws li 30 feeb tsawg dua lossis sib npaug nrog 75%).
Lub chaw qhuav:Chlortetracycline hmoovtuaj yeem nyob ruaj khov rau lub sijhawm ntev rau hauv lub xeev qhuav (xws li khaws cia ntawm 20℃rau 3 xyoos tsis muaj dab tsi lwj rau hauv potency).
Cov nyhuv av noo: Tom qab kev nqus dej noo yog qhov tshwm sim, tsim kom muaj kev sib tw thiab khaws cia .
Kev tswj qhov kub thiab txias: Nws raug nquahu kom khaws ntawm qhov kub ntawm 2-8 kev kawm kom tsis txhob muaj kev puas tsuaj rau cov qauv siv lead ua).
Lub teeb zam kev xav tau: Siv cov ntim opaque los tiv thaiv cov duab thaij duab tshwm sim los ntawm lub teeb kis .
Cim npe nrov: Chlyetracline Hmoov, Cov Khoom Siv, Chaw Tsim Tshuaj, Hoobkas, Lag Luam Wholesale, Yuav, Nqe, Hlua, Rau Muag