Chlortetracline hydrochlorideyog lub fydrochloride daim ntawv ntawm chlorotetracline, nrog rau lub npe tshuaj 7 {{} {{{} (Detethylamino) -1-4,5a, 6,11,12A-Octahydro-3,10,12,12,12,12,11-penthyl-1,11-dioxo-2-tetrabengengenide hydrochloride. Nws molecular mis yog c22h2n2n2n2o8, CAS 64-72-2, thiab molecular hnyav yog 515.34. Golden daj rau daj crystalline hmoov, tsw ntxhiab, iab. Nws cov qauv tseem ceeb suav nrog plaub hau tib lub cev pob txha (A, B, C, DOWNSHY Atom thiab 4 pab pawg ua haujlwm yog cov haujlwm tseem ceeb rau cov haujlwm tua kab mob. Soluble me ntsis hauv dej (50 mg / ml / mL soluble hauv 1 m naoh), soluble hauv hydroxide lossis carbonate alkali. Yuav luag Insoluble nyob rau hauv tsis-polar organic cov kuab tshuaj xws li acetone, thiab lwm yam ricketions, thiab ntau fab xwm meem, mypsofasma, myCooLasma, MyCocetes, thiab Protozoa; Mas siv rau cov kab mob sib deev uas tiv taus pneumillin, xws li mob ntsws thiab staphylopasma sawb, amoesbic dysentery, thiab lwm yam.
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
Peb Cov Khoom
Chlortetracycline +. coa
Tshuaj tua kab mob
Chlortetracline hydrochlorideTshwj xeeb khi rau cov kab mob rau cov kab mob 30s ribosomal subunit, inhibiting txoj sia ntawm aminokev mus rau ribosomes thiab yog li thaiv cov protein synthesis.
Nws cov tshuaj tua hluav taws tau npog:
Gram Bateria: Staphylococcus aureus, streptococcus pyogenes, pneumococcus, thiab lwm yam.
Gram tsis zoo bateria: Pasteurella, Haemophilus influenza, neSisseria Gonorrheae, thiab lwm yam.
Atypical pathogens: myCoplasma, chlamydia, rickettsia, methanogens, thiab lwm yam.
Piv txwv li Mol tus nqi:
Staphylococcus aureus: 0.292 mg / l
Streptococcus Pyogenes: 0.098 mg / l
Pneumococcus: 0.15 mg / l
Soj ntsuam inditions
Tsiaj Raug Kab:
Phacine pa tub rog sensdrome (PRDC), weaned piglet raws plab raws plab.
Tus kab mob ua pa ua pa (CRD) thiab avian cholera hauv nqaij qaib.
Aquaculture: Vibrio kab mob thiab streptococcal muaj mob hauv ntses.
Tib neeg kis tau:
Cov tawv nqaij thiab cov tshuaj txhuam cov nqaij mos mos (xws li impetigo, me nyuam me).
O ntawm pob ntseg, qhov ntswg thiab caj pas (xws li mob laryngitis, feem ntau kho nrog dexamethasone sib xyaw nrog tshuaj tsuag).
Chlamydia trachomatis kev sib deev.
Txoj Kev Kho Mob
Ua ke nrog Tylosin: ua tiav cov nyhuv ordegactrial antibacterial ", cov khoom siv FIC ntawm MySeplaspa (mg) yog 0.5-0.75, uas tuaj yeem txo cov tshuaj tiv thaiv thiab luv dua kev kho mob.
Ua ke nrog dexamethasone: Siv rau tshuaj tsuag kev kho mob ntawm cov laryngitis kom txo tau cov tshuaj tiv thaiv.
Chlorotetracline hydrochloride, uas yog ib tus sawv cev tshuaj ntawm tetracycologics npog cov khoom siv tshuaj tua kab mob ntau yam li tshuaj tua kab mob, cov tshuaj tua kab mob, thiab tiv thaiv.
Nws khi tshwj xeeb rau lub 30s ribosomal subunit, thaiv nkag mus rau hauv lub xaib ntawm lub ribosome, yog li inhibiting peptide saw elongation thiab protein synthesis. Nws cov khoom siv tshuaj tiv thaiv yog lub sijhawm- Nyob ze, thiab nws yog qhov tsim nyog los tswj hwm cov tshuaj tsis muaj nyob rau hauv kev txiav txim siab tua bateria. Ib qho ntxiv, cov tshuaj tuaj yeem nkag mus hauv tes ntawm lub ntsej muag, khi rau 50s subbanes, cuam tshuam nrog peptidyl hloov kev ua haujlwm peptide. Qhov no dual lub hom phiaj kev ua ntawm kev ua muab nws cov tshuaj tiv thaiv kab mob siab (xws li tus mob Staphyncus) thiab Gramophia Pathogens xws li myocydia, chlamydia, thiab rickettsia.
Pharmaconinetics: Tsawg ntawm qhov nqus dej thiab cov ntaub so ntswg faib khoom
Kev nqus tau: Qhov ncauj Bioavailability yog li 50% - 70%, tseem ceeb heev los ntawm cov zaub mov. Kev noj zaub mov muaj roj muaj peev xwm ncua cov pa roj plab, txo cov tshuaj chwv nrog cov pa roj plab, yog li txo tus nqi; Cov khoom noj lossis cov tshuaj muaj xws li cov roj ntsha li hluav taws xob, magnesium, xws li cov tshuaj tiv thaiv hydrochloride, txo cov khoom nqus ntawm ntau dua 50%.
Kev faib tawm: cov tshuaj tau faib cov ntaub so ntswg thoob plaws lub cev, tshwj xeeb hauv cov plab hnyuv siab raum, cov raum tshwj xeeb, thiab lub ntsws uas muaj siab. Nws tuaj yeem nkag mus rau hauv cov menyuam hauv plab los ntawm cov txheej txheem ntawm kev placental lossis raug zais rau hauv niam mis. Nws cov khoom ntim pom ntawm kev faib tawm (VD) yog 1.5-2.0 L / KG, nrog cov protein khi ntawm kwv yees li 35%, feem ntau yog khi rau cov ntshav albumin.
Cov metabolism: daim siab yog lub ntsiab metabolic site, tsim cov metabolites hauv cov neeg me me los ntawm hydroxylation thiab demethylation. Qee cov metabolites tau tawm los ntawm bile los ua cov hepatic txoj hnyuv.
Excretion: Txog 40% ntawm cov tshuaj tau tawm hauv nws daim ntawv qub los ntawm ob lub raum, thiab 20% {30% yog ua tiav hauv daim ntawv ntawm cov metabolites. Ib nrab-lub neej (t ₁ / ₂) yog 6-8 teev, thiab nws yog ntev txog 10-12 teev nyob rau hauv rooj plaub ntawm lub raum tsis txaus.
Tshuaj Yeeb Tshuaj thiab Kev Txwv Txwv: Hla Kev Tiv Thaiv thiab Kuaj Xyuas Cov Kev Sib Tw
Kev siv ntev dav dav tau coj mus rau qhov nce loj hauv Babs tsis kam lees tus nqi, thiab nws cov cuab yeej tiv thaiv feem ntau suav nrog:
Kev nqus cov twj ua haujlwm effex of Efflex
Ribosomal tiv thaiv protein: Tetm cov protein khi rau ribosomes, tiv thaiv cov tshuaj los ntawm cov chaw sib khi thiab nce mic los ntawm 8-32 zaug.
Enzyme hloov kho tsis tau: Qee cov leeg ua cov acetyltransferases thiab phosphotdases, uas inactivate tshuaj.
Tam sim no, cov nqi tiv thaiv ntawm Streptomycin Hydrochloride Airerus yog 60%}}}}}, uas txwv nws txoj haujlwm ua ib qho tshuaj ua ntej. Tam sim no feem ntau yog siv rau cov me me rau cov kev sib deev lossis kev kho kom haum.
Chlortetracline hydrochlorideMuaj cov nyhuv ceev ceev rau feem ntau gram bateria (mic tsawg dua los yog sib npaug ntawm 0.5 μ tsawg dua lossis sib npaug lossis sib npaug ntawm 2 μ G / ML), tshwj xeeb yog tsim rau:
Kev ua pa tawm ua pa tawm: kho mob hauv zej zog - Nrhiav kev mob ntsws tshwm sim los ntawm beta lactam tshuaj tua kab mob, tuaj yeem txhim kho kev ua tau zoo.
Cov tawv nqaij thiab cov tshuaj txhuam hniav muag: tus nqi kho kom zoo rau kev kho cov pustules thiab folliculisit a {{} {tsis kam) yog tshaj 85%.
Atypical pathogen proction: raws li cov tshuaj kho mob siab rau myCoplasma kev mob ntsws, chav kho mob yog feem ntau yog 10-14 hnub.
Cov Kev Tso Cai Tshwj Xeeb:
Calcium ion cov cab kuj muaj nuj nqi: los ntawm chelating calcium ions, nws inhibits qhov kev tso tawm platelet ua kom muaj txiaj ntsig zoo thiab siv los tiv thaiv kom tsis txhob muaj cov hnoos qeev.
Kev tshawb fawb hauv xov tooj ntawm tes: Ua kev sojntsuam fluorescent kom lo cim npe, saib cov kev hloov pauv ntawm cov calcium tawm tsam thaum lub condtoptosis.
Chlortetracline hydrochloride, raws li ib qho ntawm thawj lub tetraccocline tshuaj tua kab mob, tau dhau los ntawm kev ua haujlwm zoo nyob rau hauv nws cov txheej txheem kev lag luam dominated thiab ntxiv los ntawm kev tshuaj lom neeg tshuaj lom neeg.
Tshuaj Lom Neeg Hluav Taws Xob Hluav Taws Xob: Kuaj Kev Tshawb Fawb thiab Kev Loj Hlob
Cov tshuaj lom hluav taws xob siv hluav taws xob siv cov tshuaj tua kab mob ntuj thaum pib cov khoom lag luam los npaj chloramphenicol hydrochloral los ntawm kev hloov kho qauv txheej txheem. Nws yog tsuas yog siv rau kev kuaj nrhiav thiab kev txhim kho ntawm high- tus nqi derivatives xws li Minocycline thiab doxycycline thiab doxycycline.
Pib cov khoom siv: OxytTraccline yog siv ua cov khoom siv raw, thiab nws cov pab pawg 6-metyl muab cov chaw rau cov khoom siv tom ntej.
Chlorination reagents: phosphorus trichloride (pocl α) lossis thentyl chloride (xws li dichhloromethane) los tsim 7-chlorinated derivatives.
Cov tshuaj tiv thaiv: kev tswj kom kub ntawm 0-5 degree, cov tshuaj tiv thaiv lub sijhawm 6-8 teev, thiab chlorine atom hloov dua 90%.
Reagent Xaiv: Sodium nyob rau hauv: Sodium nyob rau hauv (Nanh ₂ (Nanh ₂) lossis sodium hydride (Nah) yog siv los tshem tawm cov pab pawg 6-methyl thiab tsim cov Streptomycin lub cev.
Cov kev hloov pauv: los ntawm E2 tshem tawm mechanism, methyl thiab nyob ze hydrogen atoms yog syjugistically tshem tawm oblugated oblig qauv.
Cov thev naus laus zis thev naus laus zis: Cov khoom lag luam yog ua kom huv (ethanol dej system) lossis kem chromatography (Ethyl acetate roj av ethet ethingate ethet exution ethetate ethet ething), nrog kev coj dawb huv ntawm 99%.
Cov tshuaj tiv thaiv kev hloov kho tshiab: Rho tawm DAWB hauv ethanol, maj mam ntxiv cov kua qaub (PH 1-2) Dropwise, thiab do ntawm chav tsev kub rau 2 teev.
Crystallization tswj: indass crystallization yog tiav los ntawm gradient cua txias (5℃/ h) kom zam dhau brystal thiab txo qis hauv bioavailability.
Kev Lag Luam Tiam
Xov Xwm Kev Lag Luam:
Ntsuab synthesis technology:
Ib pab neeg tsim tsa Nano crystalline cellulose / hydroxyapatite comprotomycin hydrochloride (adsorption muaj peev xwm ntawm 120 mg / g) rau kev kho dej kom zoo thiab khoom noj rov qab.
Koom Tes Ua Si Lub Tswv Yim:
Los ntawm kev siv cov tshuab ua lag luam metabolic los hloov cov Deptomyces Aeditorces, cov sib koom ua ke ntawm cov tshuaj tiv thaiv thiab TetRacycline tuaj yeem ua tiav, ua rau muaj 30% nce rau hauv cov peev txheej siv tau ua haujlwm.
Kev tswj ntse heev:
Ai Algorithms Ua kom zoo ua cov pa oxygen thiab cov khoom noj pub mov ntxiv los ntawm 15% thiab cov khoom lag luam kom nruj ntau dua li ntawm 98%.
Txoj kev muaj roj ntsha fermentation txheej txheem, nrog nws tus nqi ua tau zoo thiab ntsuas cov thev naus laus zis rau cov khoom siv chloramphenicol hydrochloride; Cov hauv paus ntsiab lus ntawm cov hluavtaws hluavtaws ua si ib lub luag haujlwm IRREplacesable txoj haujlwm hauv kev txhim kho thiab kev tshawb fawb txheej txheem ntawm kev ua haujlwm. Nyob rau hauv lub neej yav tom ntej, nrog kev sib xyaw ua ke ntawm cov hluavtaws biology thiab Green Chemistry, cov tshuaj ntsuab ntawm cov tshuaj tiv thaiv hydrochloride, muab cov tshuaj tiv thaiv loj rau cov tshuaj tua kab thoob ntiaj teb.
Cim npe nrov: Chlaletracline hydrochloride, tus lwm tus neeg, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag