Cladribine HmoovYog cov tshuaj lom neeg uas tshwm sim ua cov hmoov dawb lossis tawm me ntsis hauv dimethyl sulfoxide, me ntsis soluble hauv methanol, thiab yuav luag Inetoluble hauv Acetonitrile. Cladrribine yog cov chlorinated purine nucleotide analogue uas tuaj yeem cuam tshuam DNA synthesis thiab kho.
Nws ua rau Adenosine Deaminase, thaiv kev kho cov DNA puas lawm, interhibits DNA methylation, thiab muaj anti lymphoma kev ua si. Nws tuaj yeem ntxias cov kev tsub zuj zuj ntawm DNA strand tawg thiab tom qab qhib lub qog sepressor gene p53 hauv LymphocStes, yog li nthuav tawm cytotoxic cuam tshuam. Nws kuj tseem ua rau immunomodulatory los ntawm kev tswj hwm qee qhov kev tiv thaiv kab mob hauv kev tiv thaiv kab mob thiab tswj hwm amyloard beta autophagy. Nws muaj cov teebmeem tseem ceeb ntawm cov tawv nqaij ntawm cov leeg ntshav plab thiab tuaj yeem nthuav tawm cov sijhawm kho tiav tag nrho. Lub caij no, nws tseem muaj qee yam kev kho mob rau lwm yam Lymphomas thiab cov mob leukemia.
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Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
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Khoom npe |
Cladribine Hmoov |
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Khoom Yam |
Hmoov |
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Khoom Siv Purity |
100g / 1kg / thiab lwm yam. |
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Khoom daim ntawv |
Organic Synthesis |
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CDP CDP CD COG COULD
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Cladribine Hmoov, raws li ib qho tshuaj lom neeg tseem ceeb, muaj ntau yam ntawm daim ntawv thov muaj nuj nqis hauv kev kho mob. Cov hauv qab no yuav piav ntau ntxiv rau nws lub hom phiaj los ntawm ntau yam:
Kho cov ntshav system cov kab mob
Cladrribine yog thawj - kab qauv kev kho mob rau cov leeg ntawm tes leukemia (HCL). Cov plaub hau ntawm tes leukemia yog qhov tsis tshua muaj mob Lymphocytic muaj cov kab mob plaub hau hauv hlwb pob txha thiab pob txha. Cov hlwb cov plaub hau muaj cov cim morphological thiab immunochenotypic yam ntxwv thiab tsis teb zoo rau cov tshuaj kho tshuaj kho tshuaj. Clavubine tau ua tiav cov hom phiaj kho los ntawm kev cuam tshuam DNA synthesis thiab kho, inducing apoptosis ntawm cov plaub hau hlwb. Cov feem ntau siv cov tshuaj ntawm cov lus qhia meej hauv kev kho mob ntawm tes leukemia yog 0.09Mg / KG / D, tswj tsis tu ncua rau 24 teev rau 7 hnub. Ntau cov kev tshawb fawb pom tau pom tias tus nqi Ib qho ntxiv, kev ua tau zoo ntawm cov lus qhia ntawm tes loukemia yog ntev}}} i}} thip kev kho tom qab tau txais kev kho mob. Thaum lub sijhawm kho mob, nws yog ib qho tsim nyog los saib xyuas tus neeg mob cov kev ntsuas cov ntshav niaj hnub thiab kuaj pom kom zoo li cov pob txha caj pas. Nyob rau tib lub sijhawm, cov kev ua mob los tiv thaiv kev sib kis tau yuav tsum tau muab rau cov neeg mob uas tau kis tus kabmob.
Mantle cell lymphoma
Cladribine HmoovYuav siv tau rau thawj {- kab thiab thib ob}! kev kho mob ntawm mantle cell liymphoma (Mcl). Mantle cell lymphoma yog hom hodgkin lymphin tsis muaj txiaj ntsig los ntawm kev pom zoo thiab kev txhim kho. Cladribine exerts anti -} Cov txiaj ntsig qog ua los ntawm kev ua haujlwm ntawm cov qog nqaij hlav thiab hais txog xov tooj ntawm tes. Thaum kho cov mantle cell lymphoma, clarithromycin feem ntau siv hauv kev sib xyaw nrog lwm cov tshuaj siv tshuaj kho kom txhim kho kev kho mob. Piv txwv li, RC Regimen (ua kom sib txuas nrog cov ntsiab lus meej thiab rituximab) tuaj yeem siv rau kev kho mob ntawm kev hloov pauv thiab refractory b}} cell qog ntshav. Cov koob tshuaj ntawm Claromyncin yog 5mg / (m · D), muab tshuaj tivthaiv rau 2 teev rau 5 hnub sib law liag. Rituximab yog monoclonal antibody hom phiaj CD20 wb tuaj yeem tua tau tshwj xeeb b {}} cell liymphadic hlwb. Kev sib xyaw ua ke ntawm Claraimab tuaj yeem ua exert synergicist anti -} cov qog ua si thiab txhim kho kev kho mob kho mob. Ntau qhov kev tshawb fawb tau pom tau pom tias kev sib xyaw ua ke ntawm kev kho cov mantle cell liymmidoma, nrog kev teb cov lus qhia tiav thiab ib nrab ntawm cov neeg mob. Nyob rau tib lub sijhawm, kev nyab xeeb ntawm cov txheej txheem no kuj yog qhov zoo, thiab cov kev sib raug zoo yog tswj tau. Txawm li cas los xij, vim muaj heterogeneity thiab refractory cell liyymmoma, qee cov neeg mob yuav yog cov neeg mob los kho cov kev xaiv xws li lub ntsiab lus yooj yim.
Cladribine is one of the important drugs in salvage chemotherapy regimens for refractory/relapsed acute myeloid leukemia (AML). AML is a malignant clonal disease originating from bone marrow hematopoietic stem cells, characterized by high heterogeneity and refractory nature. Cladribine exerts anti-tumor effects by inhibiting the proliferation of leukemia cells and inducing cell apoptosis. When treating refractory/recurrent AML, cladribine is often used in combination with other chemotherapy drugs to improve treatment efficacy. For example, the CLAG regimen (clarithromycin, cytarabine, and granulocyte colony-stimulating factor) can be used for the treatment of relapsed and refractory AML. The dose of clarithromycin is 5mg/(m ² · d), administered intravenously for 2 hours for 5 consecutive days; Cytarabine 1-2g/(m ² · d), intravenous infusion for 4 hours, to be used 2 hours after clarithromycin, for 5 consecutive days; Granulocyte colony-stimulating factor 5 μ g/(Kg · d), subcutaneous injection (S.C.) or intravenous drip, qd, 24 hours before the infusion of clarithromycin, when WBC>20 × 10 ⁹ / l, g {- CSF thiab ClaraTromycin yuav tsum tau siv ua ke rau 6 hnub sib law liag. Lub clag regimen txhim kho kev tawm tsam kev tawm tsam kev tawm tsam kev siv tshuaj noj, tshwj xeeb tshaj yog cov neeg mob uas muaj cov lus teb tsis zoo rau kev kho mob tsoosotherapy.
Fahrenheit Macroglobulinemia & lwm yam tsawg kawg hematological malignancies
Cladrrribine kuj tseem siv tau rau kev kho fahrenheit macroglobulinemia (WM). WM yog qhov qis -}}}}}}}}}}}}}}}} agraphed los ntawm lymphoPlasmictes, cim los ntawm kev nce qib ntawm Monoclonal immunogulin m (IGM) hauv cov ntshav dej. Cladribine exerts anti - Cov txiaj ntsig qog mis los ntawm kev ua haujlwm ntawm WM thiab Inducing Cell Apoptosis. Txawm li cas los xij, piv nrog cov leeg ntawm tes ntawm cov leeg ntshav qab nyuj Tsis tas li ntawd, cov ntsiab lus meej kuj tseem siv tau rau kev kho mob hemativa, thiab lwm yam ntawm cov kab mob ntawm cov kab mob no xav tau kev tshawb fawb ntxiv thiab pov thawj.
Daim Ntawv Thov Hauv Kev Tshawb Fawb Txog Kev Tshawb Fawb
Qhov kev xaiv tau zoo ntawm kev lom zem heev ntawm cov ntsiab lus nyuaj rau lymphocytes ua rau nws yog qhov cuab yeej tseem ceeb rau kev kawm Lympphocyte muaj nuj nqi. Thaum kawm qhov kev sib tw, kev sib txawv, thiab muaj nuj nqi ntawm t hlwb thiab clariciaromycytes ntawm lymphocyte cuam tshuam thiab nws cuam tshuam rau kev sib txawv ntawm tes. Los ntawm kev sib piv cov phenotypic hloov thiab cytokine tso zais ntawm cov lymphocytes kho nrog cov yam ntxwv sib txawv ntawm cov kab mob lymphocyocytes nyob rau hauv lub xeev sib txawv thiab cov xeev pathological. Thaum kawm lub tshuab Apoptosis ntawm lymphocytes, clavulanic acid tuaj yeem siv los ua ib tus neeg sawv cev rau qhov tsis tuaj yeem. Kev kawm txog txoj kev teeb tsa thiab kev hais tawm ntawm Apoptosis cov protein thiab muab cov tshuaj lom molecularis thiab muab lub hauv paus motoretosis thiab muab lub hauv paus rau kev kho mob ntawm Lymphocyte ntsig txog cov kab mob.
Daim ntawv thov hauv kev tshawb fawb immunological
Cladrrubine kuj muaj qee cov ntawv thov hauv kev kawm txog autoimmune kab mob. Thaum kawm cov pathogenesis ntawm autoimmune cov kab mob xws li ntau yam sclerosis (ms), clarithromycin tuaj yeem siv los tswj kev tiv thaiv kev tiv thaiv kab mob. Vim tias muaj kab mob sclerosis ua tus kab mob autoimmune, tus neeg mob tiv thaiv kab mob autakune tawm tsam lub myelin sheath ntawm nruab nrab ntawm cov leeg hlwb. Cladrribine tuaj yeem simulate cov nyhuv ntawm kev kho cov qauv sclerosis hauv cov qauv tsiaj los ntawm kev tiv thaiv kab mob ntawm cov hlab ntsha. Los ntawm kev kawm cov kev hloov pauv ntawm cov kab mob, tsis muaj zog ntawm cov tsiaj muaj kab mob xws li, peb tuaj yeem tau txais kev nyuaj siab rau cov tsiaj thiab cov hau kev tshiab. Tsis tas li ntawd, cov kab mob yooj yim kuj tseem siv tau lwm cov kab mob autoimmune xws li rheumatoid erethematus, thiab lwm yam peev xwm hauv kev tiv thaiv kev tiv thaiv kab mob thiab kho kab mob autoimmune.
Clavudine tuaj yeem cuam tshuam nrog DNA synthesis thiab ntxias cell enpoptosis, yog li nws muaj cov ntawv thov ntawm tes thiab kev tshawb fawb hauv xov tooj cua thiab kev tshawb fawb hauv xov tooj cua. Thaum kawm cov txheej txheem ntawm kev sib tw ntawm tes, clarithromycin tuaj yeem siv los kho cov cell thiab soj ntsuam nws cov nyhuv ntawm kev ua voj voog ntawm tes. Los ntawm kev hloov kho cov kev hloov pauv ntawm cov kev faib tawm ntawm tes los ntawm cov kev qhia ntawm lub xov tooj ntawm tes, nws muaj peev xwm qhia cov molecular me ntsis kev cuam tshuam rau kev voj voog ntawm tes. Thaum kawm cov apoptotic signaling txoj kev, cov ntsiab lus meej tuaj yeem siv los ua tus neeg sawv cev rau qhov tsis tuaj yeem ua ntej. Los ntawm kev tshawb pom cov lus qhia thiab kev ua si hloov ntawm Apoptosis muaj cov protein thiab bclase cov ntaub ntawv kev hloov pauv ntawm cov txheej txheem kev tswj hwm cov txheej txheem kev tswj hwm cov txheej txheem ntawm xov tooj ntawm tes.
Daim Ntawv Thov hauv Kev Tshawb Fawb Cell Biology
Cladribine HmoovYuav inhibit DNA synthesis thiab kho, thiab yog li ntawd muaj cov ntawv thov hauv DNA kev puas tsuaj thiab kev tshawb fawb. Thaum kawm cov txheej txheem ntawm DNA kev puas tsuaj teb, Clarithromycin tuaj yeem siv los kho cov cell thiab ua rau muaj kev puas tsuaj DNA. Los ntawm kev tshawb pom DNA cov cim kev puas tsuaj xws li kev tsim GAMMA H2X Foci thiab kev teb ntawm DNA kev puas tsuaj, thiab cov kev cai tswj hwm kev puas tsuaj, tuaj yeem kawm. Tsis tas li ntawd, cov qauv yooj yim kuj tseem siv tau los kawm txog kev sib raug zoo ntawm DNA kev puas tsuaj thiab cov txheej txheem biological xws li cell lub voj voos ntes. Los ntawm kev siv lwm yam DNA tus neeg sawv cev lossis kho cov neeg tsis muaj peev xwm ua ke, peb tuaj yeem nkag siab ntxiv ntawm DNA kev txiav txim siab rau cov teb thiab kev tiv thaiv qog.
Cim npe nrov: Cladrribine Hmoov, Tuam Tshoj Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, Lag Luam Wholesale, Yuav, Nqe, Hlua, Rau Muag