Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub ntau tshaj plaws thiab cov neeg muag khoom ntawm coluracetam ntxiv hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo coluracetam ntxiv rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Coluracetam Ntxiv(MKC-231, BCI-540) yog ib qho tshiab choline absorption enhancer, teej tug mus rau Sitan class derivatives. Nws lub npe tshuaj yog N - (2,3-dimethyl-5,6,7,8-tetrahydrofurano [2,3-B] quinolin-4-yl) -2- (2-oxopyrrolidin-1-yl) acetamide. Nws zoo nkaus li cov hmoov dawb crystalline nrog cov solubility ntawm ntau dua los yog sib npaug rau 20mg / mL hauv DMSO thiab yog insoluble hauv dej thiab ethanol. Nws cuam tshuam nrog cov txheej txheem siab choline uptake (HACU), uas yog tus nqi txwv cov kauj ruam hauv kev sib txuas ntawm cov neurotransmitter acetylcholine los ntawm kev nqus cov choline rau hauv cov neurons.Koala Xitan tuaj yeem nce HACU tus nqi, tso cai rau ntau choline coj mus rau hauv cov neurons, yog li ua kom muaj kev ua haujlwm ntawm cholinergitive neurons, ua rau nws lub hom phiaj ntawm cholinergic neurons. kev txhim kho.
Thaum cholinergic ua haujlwm tsis zoo, colchicine tuaj yeem nqa choline rau hauv cov neurons. Nyob rau hauv lub xub ntiag ntawm HACU tsis txaus vim tshuaj lom neeg puas tsuaj, nws muaj peev xwm tswj tau cholinergic muaj nuj nqi los yog kho cholinergic dysfunction kom zoo. Los ntawm kev sim tsiaj, nws tau pom tias nws tuaj yeem txhim kho qhov txo qis hauv acetylcholine cov ntsiab lus hauv hippocampus ntawm nas thiab nas, thiab txo qis kev kawm, kev nco tsis txaus, thiab kev paub tsis meej. Piv txwv li, thaum noj qhov ncauj ntawm ib koob ntawm 1-10mg / kg, nws nthuav tawm cov haujlwm hauv nas; Coluracetam (0.3-3 mg / kg, hais lus, ib zaug ib hnub, rau 11 hnub) txhim kho kev nco tsis zoo thiab hippocampal acetylcholine noj vim yog AF64A hauv cov nas; Coluracetam (1-3 mg / kg, hais lus, ib zaug ib hnub, 8 hnub) txhim kho kev txawj ntse thiab kev kawm tsis zoo hauv cov nas, nrog rau pab txhim kho cerebral ntshav ncig thiab tswj kev ua haujlwm neurotransmitter. Nws yog siv los kho mob plab hnyuv, los ntshav, mob ntshav qab zib, thiab lwm yam kab mob.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab tshuaj txhaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
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Cov ntaub ntawv ntxiv ntawm chemical compound:
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Coluracetam Ntxiv COA
Coluracetam Ntxiv(MKC-231), raws li cov tshuaj tshiab kev paub txog kev txawj ntse, tau nyiam cov neeg nyiam nyob hauv thaj chaw ntawm neuroscience thiab kev txhim kho tshuaj nyob rau xyoo tas los no. Hauv qab no yog cov lus piav qhia ntxaws txog nws cov kev siv:
Pharmacological teebmeem
Hauv kev sim nas thiab nas, Coluracetam tau pom tias muaj peev xwm txhim kho kev kawm tsis taus, nco tsis txaus, thiab kev paub tsis meej. Piv txwv li, hauv AF64A induced nas qauv ntawm kev nco tsis zoo, kev tswj qhov ncauj ntawm Coluracetam ntawm ib koob ntawm 0.3-3mg / kg ib hnub ib zaug rau 11 hnub tuaj yeem txhim kho kev nco tsis zoo thiab hippocampal acetylcholine noj hauv cov nas. AF64A tuaj yeem cuam tshuam cov kab mob cholinergic, ua rau txo qis hauv qib acetylcholine thiab tom qab ntawd cuam tshuam rau kev kawm thiab kev nco muaj peev xwm. Coluracetam txhim kho kev nco txog teeb meem tshwm sim los ntawm AF64A los ntawm kev koom tes hauv cov txheej txheem siab choline uptake (HACU), nce synaptic uptake ntawm choline thiab txhawb acetylcholine synthesis. Hauv cov qauv nas ntawm kev paub tsis meej thiab kev kawm tsis taus, Coluracetam kuj tau pom tias muaj kev txhim kho thaum siv qhov ncauj ntawm koob tshuaj 1-3 mg / kg ib hnub ib zaug rau 8 hnub. Acetylcholine plays lub luag haujlwm tseem ceeb hauv kev kawm thiab kev nco, thiab Coluracetam nce qib acetylcholine, txhim kho cov ntaub ntawv xa mus ntawm neural synapses, thiab pab txhim kho kev kawm thiab kev nco muaj peev xwm.
Pharmacological teebmeem ntawm kev paub txog kev ua haujlwm
Coluracetam Ntxivtej zaum yuav muaj kev cuam tshuam zoo rau ob qho tib si ua haujlwm nco thiab ntev - lub sijhawm nco. Los ntawm nws txoj kev txhim kho ntawm AF64A induced ua hauj lwm nco tsis txaus nyob rau hauv nas thiab kev paub tsis meej nyob rau hauv nas (uas yuav koom nrog ntau hom kev nco), nws yuav ua lub luag hauj lwm nyob rau hauv ntau theem ntawm lub cim xeeb tsim los ntawm regulating cholinergic system. Lub cim xeeb ua haujlwm feem ntau suav nrog kev khaws cia ib ntus thiab tswj cov ntaub ntawv, thaum lub sijhawm ntev - lub sijhawm nco suav nrog lub sijhawm ntev - khaws cia thiab khaws cov ntaub ntawv. Coluracetam tsub kom cov synthesis thiab tso tawm ntawm acetylcholine, uas tej zaum yuav cuam tshuam rau lub neural circuits thiab synaptic plasticity txuam nrog cov nco hom, yog li kev txhim kho ntau hom kev nco muaj nuj nqi Lub ntsiab mechanism ntawm kev txiav txim ntawm Coluracetam yog ua kom cov uptake ntawm choline los ntawm neural synapses los ntawm kev koom nrog hauv HACU txheej txheem. HACU yog tus nqi txwv cov kauj ruam hauv kev sib txuas ntawm cov neurotransmitter acetylcholine los ntawm kev nqus choline rau hauv cov neurons. Kev nce HACU tus nqi tuaj yeem txhim kho cov haujlwm ntawm cholinergic neurons. Hauv cov kab mob xws li Alzheimer's kab mob, cholinergic system puas lawm thiab qib acetylcholine txo qis, ua rau kev paub tsis meej. Coluracetam txhim kho txoj haujlwm ntawm cholinergic system thiab txhim kho kev txawj ntse los ntawm kev nce choline uptake thiab synthesis.
Nyob rau hauv tus qauv ntawm cerebral ischemia-reperfusion raug mob, Coluracetam tuaj yeem txo cov paj hlwb infarction ntim thiab neuronal apoptosis, thiab txhim kho neurological deficits. Cerebral ischemia-reperfusion raug mob tuaj yeem ua rau muaj ntau yam kev puas tsuaj xws li oxidative stress, inflammatory teb, thiab cell apoptosis hauv neurons. Coluracetam tuaj yeem tsim cov teebmeem neuroprotective los ntawm cov txheej txheem xws li antioxidant, tiv thaiv -inflammatory, thiab anti apoptotic teebmeem. Piv txwv li, nws yuav tshem tawm cov dawb radicals thiab txo lawv cov kev puas tsuaj rau cov neurons; Inhibit inflammatory teb thiab alleviate cov tshuaj lom los ntawm inflammatory yam ntawm neurons; Txo qhov kev qhia ntawm apoptosis ntsig txog cov proteins thiab inhibit cov txheej txheem ntawm neuronal apoptosis. Hauv cov qauv kab mob neurodegenerative xws li Alzheimer's kab mob, Coluracetam tuaj yeem ua rau muaj kev tiv thaiv neuroprotective los ntawm kev txhim kho cholinergic system muaj nuj nqi thiab txo cov neuronal puas. Cov neeg mob uas muaj Alzheimer's tus kab mob muaj kev poob ntawm cholinergic neurons thiab txo qis ntawm acetylcholine hauv lub hlwb, nrog rau kev puas hlwb thiab kev tuag. Coluracetam tsub kom cov synthesis thiab tso tawm ntawm acetylcholine, txhim kho cholinergic system muaj nuj nqi, thiab pab tswj lub cev kev ua si ntawm neurons. Tsis tas li ntawd, nws cov nyhuv neuroprotective tuaj yeem ua rau qeeb ntawm cov kab mob neurodegenerative thiab tiv thaiv cov neurons los ntawm kev puas tsuaj ntxiv.
Neuroprotective pharmacological cuam tshuam
Cov txheej txheem neuroprotective ntawm Coluracetam tuaj yeem koom nrog ntau yam. Nyob rau hauv cov nqe lus ntawm kev ua antioxidant, nws yuav ua rau kom cov kev ua ntawm intracellular antioxidant enzymes xws li superoxide dismutase (SOD), glutathione peroxidase (GSH Px), thiab lwm yam., tshem tawm ntau dawb radicals nyob rau hauv lub cev thiab txo oxidative kev nyuaj siab puas rau neurons. Nyob rau hauv cov nqe lus ntawm kev tiv thaiv - inflammatory teebmeem, nws yuav inhibit qhov ua rau ntawm inflammatory signaling txoj kev, txo cov tsim thiab tso tawm ntawm inflammatory yam xws li qog necrosis factor - (TNF - ), interleukin-1 (IL-1 ), thiab lwm yam., li no alleviating cov tshuaj lom los ntawm inflammatory cov tshuaj tiv thaiv ntawm neurons. Hais txog kev tiv thaiv apoptosis, nws tuaj yeem tswj hwm qhov kev qhia ntawm apoptosis ntsig txog cov proteins, xws li inhibiting kev qhia ntawm pro apoptotic protein Bax thiab nce kev qhia ntawm anti apoptotic protein Bcl-2, yog li inhibiting txheej txheem ntawm neuronal apoptosis.
Coluracetam tuaj yeem pab txhim kho lub paj hlwb. Txawm hais tias muaj kev tshawb fawb me me ntawm cov ncauj lus no, nws cov txiaj ntsig tshuaj kho mob tag nrho qhia tias kev ua haujlwm ntawm lub paj hlwb zoo yog qhov tseem ceeb rau kev tswj hwm kev ua haujlwm ntawm lub paj hlwb. Cerebral ntshav ncig tsis zoo tuaj yeem ua rau neuronal hypoxia thiab kev noj zaub mov tsis txaus, uas cuam tshuam rau kev sib txuas thiab tso tawm cov neurotransmitters thiab kev sib kis ntawm cov ntaub ntawv ntawm cov neurons. Coluracetam tuaj yeem txhim kho cerebral ntshav ncig los ntawm kev tswj hwm endothelial cell muaj nuj nqi, txhim kho hemorheology, thiab lwm yam. Piv txwv li, nws tuaj yeem txhawb kev tso tawm ntawm nitric oxide (NO) los ntawm cov hlwb endothelial, uas muaj cov nyhuv vasodilatory, yog li ua rau cov ntshav ntws hauv hlwb thiab ua kom cov pa oxygen txaus thiab cov khoom noj rau cov neurons.
Pharmacological teebmeem ntawm cerebral ntshav ncig thiab neurotransmitter tswj
Ntxiv rau nws cov txiaj ntsig ntawm acetylcholine, Coluracetam kuj tseem tuaj yeem tswj hwm cov haujlwm ntawm lwm cov neurotransmitters. Neurotransmitters koom tes nrog ib leeg hauv lub paj hlwb, sib koom ua ke tswj ntau yam kev xav ntawm lub cev thiab lub hlwb. Coluracetam tuaj yeem tswj cov qib neurotransmitter los ntawm kev cuam tshuam cov synthesis, tso tawm, rov ua dua, thiab cov metabolism ntawm cov neurotransmitters. Piv txwv li, nws yuav cuam tshuam rau kev ua haujlwm ntawm neurotransmitters xws li glutamate thiab gamma aminobutyric acid (GABA). Glutamate yog qhov tseem ceeb tshaj plaws excitatory neurotransmitter nyob rau hauv nruab nrab paj hlwb, thaum GABA yog lub ntsiab inhibitory neurotransmitter. Qhov sib npaug ntawm lawv yog qhov tseem ceeb rau kev tswj hwm kev ua haujlwm ntawm lub paj hlwb. Coluracetam tswj cov kev ua ntawm cov neurotransmitters, pab tswj kev sib npaug ntawm cov neurotransmitter system thiab ntxiv dag zog rau kev ua haujlwm ntawm lub paj hlwb.
Coluracetam tuaj yeem siv tshuaj tiv thaiv kev ntxhov siab thiab tiv thaiv kev ntxhov siab los ntawm kev ua kom muaj zog ntawm cov neurotransmitters xws li serotonin thiab dopamine hauv synaptic cleft. Serotonin thiab dopamine yog cov neurotransmitters ze ze rau kev tswj kev xav, thiab lawv cov qib txawv txav cuam tshuam nrog qhov tshwm sim ntawm cov kab mob xws li kev nyuaj siab thiab kev ntxhov siab. Coluracetam txhawb nqa choline uptake, uas tuaj yeem cuam tshuam ncaj qha rau cov metabolism thiab tso tawm cov neurotransmitters. Tsis tas li ntawd, nws tseem tuaj yeem cuam tshuam rau neural plasticity, txhawb kev loj hlob ntawm neurons thiab tsim cov synapses, txhim kho kev ua haujlwm ntawm neural circuits, thiab yog li txo cov tsos mob ntawm kev nyuaj siab thiab kev ntxhov siab. Piv nrog rau qee cov tshuaj tiv thaiv kev ntxhov siab thiab tshuaj tiv thaiv kev ntxhov siab, Coluracetam yuav muaj qhov tshwj xeeb zoo. Cov tshuaj antidepressant thiab tshuaj tiv thaiv kev ntxhov siab uas twb muaj lawm yuav muaj teeb meem xws li pib qeeb thiab ntau yam kev mob tshwm sim. Coluracetam, raws li cov tshuaj tshiab, tej zaum yuav muaj qhov sib txawv ntawm kev ua los ntawm cov tshuaj uas twb muaj lawm, nrog rau lub sijhawm pib sai dua thiab muaj kev phiv tsawg dua. Txawm li cas los xij, tam sim no xav tau kev tshawb fawb soj ntsuam ntau ntxiv txhawm rau txheeb xyuas nws cov txiaj ntsig thiab kev nyab xeeb hauv tib neeg.
Pharmacological teebmeem ntawm antioxidant kev nyuaj siab
Coluracetam Ntxivtej zaum yuav muaj peev xwm tshem tawm cov dawb radicals, uas yog ib qho tseem ceeb ua rau oxidative kev nyuaj siab. Nyob rau hauv cov txheej txheem ntawm cov kab mob neurological thiab raug mob, ntau cov dawb radicals raug tsim, xws li superoxide anions, hydroxyl radicals, thiab lwm yam. Cov dawb radicals no tawm tsam cov cell membrane, proteins, DNA thiab lwm yam biomolecules ntawm neurons, ua rau neuronal puas thiab tuag. Coluracetam tuaj yeem cuam tshuam nrog qee pawg hauv nws cov qauv tshuaj kom tshem tawm cov dawb radicals, yog li txo qhov kev puas tsuaj ntawm cov dawb radicals rau neurons. Nws kuj tseem tuaj yeem ua rau cov tshuaj tiv thaiv kab mob hauv lub cev xws li SOD, GSH Px, thiab lwm yam. SOD tuaj yeem cuam tshuam cov superoxide anions rau hauv hydrogen peroxide thiab oxygen, thaum GSH Px tuaj yeem txo cov hydrogen peroxide rau dej, yog li txo oxidative kev nyuaj siab rau cov hlwb. Coluracetam txhim kho lub peev xwm tiv thaiv antioxidant ntawm cov hlwb thiab tiv thaiv cov neurons los ntawm oxidative kev nyuaj siab los ntawm kev ua kom cov haujlwm ntawm cov enzymes antioxidant.
Coluracetam nthuav tawm ib qho kev xaiv zoo rau cov neeg nrhiav kev paub txog kev txawj ntse, tshwj xeeb hauv kev nco, ua kom pom tseeb, thiab mus ob peb vas. Thaum cov pov thawj kev tshawb fawb tseem nyob ua ntej, nws cov txheej txheem tshwj xeeb ntawm kev ua thiab cov tshuaj lom neeg tsawg ua rau nws muaj kev xaiv nrov ntawm cov neeg nyiam nootropic.
Txawm li cas los xij, cov neeg siv yuav tsum mus cuag Coluracetam nrog ceev faj:
Pib nrog koob tshuaj tsawg los ntsuas qhov kam rau ua.
Ua ke nrog choline qhov chaw los txo cov kev mob tshwm sim.
Tham nrog ib tus kws kho mob yog tias cev xeeb tub, laus, lossis noj tshuaj.
Raws li kev tshawb fawb txuas ntxiv mus, Coluracetam tuaj yeem txhim kho nws qhov chaw ua kom muaj kev nyab xeeb, muaj txiaj ntsig kev paub txog kev txawj ntse - lossis nthuav tawm cov ntawv thov tshiab hauv kev tiv thaiv kab mob thiab kev puas hlwb.
Chemical mechanism ntawm kev ua
Lub chemical mechanism ntawm lubcoluracetam ntxivFeem ntau yog nyob ib ncig ntawm lub siab -affinity choline uptake (HACU) txheej txheem. Nws txhim khu kev noj qab haus huv thiab kev siv choline los ntawm cov neurons, txhim kho kev ua haujlwm ntawm cholinergic neural kis tau tus mob, yog li ua rau kev paub txog kev txawj ntse thiab kev tiv thaiv neuroprotective. Lub mechanism tshwj xeeb yog raws li nram no:
Kev koom tes hauv HACU txheej txheem:HACU yog tus nqi - txwv cov kauj ruam rau choline nkag mus rau cov neurons los ua ke cov neurotransmitter acetylcholine. Coluracetam txhim khu kev ua tau zoo ntawm cov txheej txheem no, ua kom cov choline los ntawm cov hlab ntsha synapses, yog li ua kom cov synthesis ntawm acetylcholine.
Nce cholinergic neuron kev ua ub no:Acetylcholine yog ib qho tseem ceeb neurotransmitter nyob rau hauv lub hauv paus paj hlwb, koom nrog hauv kev txawj ntse xws li kev kawm, nco, thiab mloog. Coluracetam txhim kho cov haujlwm ntawm cholinergic neurons los ntawm kev ua kom cov synthesis ntawm acetylcholine, yog li txhim kho kev txawj ntse.
Restore cholinergic muaj nuj nqi:Nyob rau hauv cov xwm txheej uas cov kab mob cholinergic puas lawm (xws li hauv cov kab mob neurodegenerative zoo li Alzheimer's kab mob), Coluracetam tuaj yeem tswj lossis kho cov haujlwm cholinergic kom zoo li qub. Cov kev tshawb fawb tau pom tias nws muaj kev kho mob ntawm HACU tsis txaus los ntawm kev puas tsuaj tshuaj lom neeg, yog li txhim kho kev kawm tsis zoo, nco tsis txaus, thiab kev paub tsis meej.
Neuroprotective nyhuv:Coluracetam kuj nthuav tawm qee yam teebmeem neuroprotective. Nws tuaj yeem tiv thaiv cov neurons los ntawm kev puas tsuaj los ntawm kev tswj hwm cov haujlwm neurotransmitter thiab txhim kho cerebral ntshav ncig, yog li ncua kev loj hlob ntawm cov kab mob neurodegenerative.
Cim npe nrov: coluracetam ntxiv, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom