Shaanxi Bloom Tech Co., Ltd. yog ib qho kev paub txog cov neeg tsim khoom thiab cov chaw muag khoom ntawm cov hmoov prilocaine hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo prilocaine hmoov rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Prilocaine HmoovTxawm li cas los 721-50-50-6, molecular mis c13h20n u zoo li cov hmoov dawb dawb ntawm chav sov thiab siab. Muaj qee qhov℃ntawm granularity thiab fluidity. Lub xeev lub cev no tau txais txiaj ntsig zoo rau nws cov kev ua thiab cov tshuaj lom neeg, nws tuaj yeem sib xyaw ua ke, nws tuaj yeem hloov pauv tau yooj yim thaum lub sijhawm hloov pauv hauv lub cev. Raws li lub loog hauv zos, nws muaj cov nqi tseem ceeb hauv cov ntawv thov kev kho mob. Nws ua tiav kev tshuaj loog hauv zos thiab qhov mob nyem los ntawm kev thaiv cov hlab ntsha impulse pab, thiab yog cov tawv nqaij tsis xis nyob xws li kev kho mob meaculation. Txawm li cas los xij, nws yuav tsum raug sau tseg tias peb lub tuam txhab cov khoom lag luam tsuas yog rau kev tshawb fawb kev tshawb fawb thiab raug yuam cai txwv tsis pub siv rau lwm lub hom phiaj.
Peb Cov Khoom
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Ketoconazole Hmoov | Proilocaine Ointment |
| Khoom Yam | Hmoov | Roj pleev |
| Khoom Siv Purity | HPLC ntau dua los yog sib npaug rau 99.0% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho |
| Khoom Pob | PE / AL NTAWV NYIAJ LUB HNAB / PAPTER BOX rau hmoov ntshiab |
Tau sib kho |
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Propionacaine +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
Ketoconazole | |
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Cas Tsis tau. |
65277-42-1 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
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Lauj tsis tau. |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2028 |
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Lub tsev |
 |
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| Kuaj Tus Qauv | GB / T24768-2009 kev lag luam. Stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
|
Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E. coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib qho chaw sib khi, qhov chaw tsaus thiab qhuav ntawm-20 degrees |
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Tshuaj Cov Qauv |
C13H20N2O |
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Muaj pes tsawg leej |
220 |
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Molecular hnyav |
220 |
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m/z |
220 (100.0%), 221 (14.1%) |
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Kev Ntsuam Xyuas |
C, 70.87; H, 9.15; N, 12.72; O, 7.26 |
So
Solubility hauv dej
Prilocaine Hmoovyog yooj yim soluble hauv dej. Cov xeeb ceem no yog qhov tseem ceeb tseem ceeb rau nws daim ntawv thov hauv tshuaj. Thaum npaj dej -} Ua cov kev daws teeb meem, cov phiaj xwm yooj yim, uas yooj yim rau kev txhaj tshuaj tiv thaiv. Ntxiv mus, nws txoj kev solubility zoo nyob rau hauv kev nqus rau ntawm tib neeg lub cev, thiab siv tshuaj rau cov hlab ntshav, yog li muab cov teebmeem kev cuam tshuam.
Solubility hauv ethanol
Properionacaine yog yooj yim soluble hauv ethanol. Ethanol feem ntau siv los ua cov kuab tshuaj lossis zam hauv cov chaw muag tshuaj. Qhov zoo solubility ntawm prilocaine hauv ethanol tso cai rau nws tau sib xyaw nrog ethanol los npaj qee qhov kev npaj tshwj xeeb, xws li tinctures. Tsis tas li ntawd, Ethanol kuj tseem tuaj yeem ua cov kuab tshuaj rau kev rho tawm prilocaine thaum lub sijhawm extraction thiab lim dej ntawm cov tshuaj.
Solubility hauv lwm cov kuab tshuaj
Propionine yog soluble me ntsis hauv chloroform, tab sis tsis yooj yim soluble hauv tsis {}} polar cov kuab tshuaj xws li benzene thiab ether. Qhov sib txawv hauv solubility yog cuam tshuam nrog cov qauv molecular ntawm prilocaine thiab polarity ntawm cov kuab tshuaj. Chloroform muaj qee yam polarity, yog li nws tuaj yeem yaj tag prilocaine; Benzene thiab ether tsis yog tsis {}} polar cov qauv ntawm "solubility", cov solubility ntawm prilocaine nyob rau hauv cov kuab tshuaj no yog tsawg. Cov kev dag ntxias no yog tus yam ntxwv solubility muaj cov kev qhia tseem ceeb hauv kev sib cais, ua kom huv si, thiab tsim cov txheej txheem ntawm cov tshuaj. Piv txwv li, thaum xaiv cov kuab tshuaj rau cov tshuaj tiv thaiv yeeb tshuaj, cov kuab tshuaj uas tsim nyog tuaj yeem xaiv raws nws solubility.
Kub taw tes
Kub Cov Ntaub Ntawv
Lub boiling taw tes ntawm prilocaine nws txawv nyob rau hauv cov xwm txheej sib txawv. Ntawm 760MMHG (cov qauv ntsuas huab cua siab), nws qhov cub npau npau yog 341.6 ± 25.0 degree; Nyob rau hauv cov kev mob siab lub siab ntawm 0.13kpa, lub boiling point yog 159-162 degree. Boiling taw tes yog qhov kub ntawm uas cov kua hloov mus rau hauv cov roj, cuam tshuam los ntawm cov yam ntxwv xws li siab. Nyob rau ntawm cov qauv ntsuas cua siab, Prilocaine muaj lub siab npau npau, qhia tias nws tsis yooj yim hloov ntawm chav sov thiab siab, thiab muaj cov tshuaj ruaj khov. Nyob rau hauv cov kev mob siab qis, qhov npau npau yog txo qis, uas yuav siv nyob rau hauv qee qhov kev ua nqus dej tshwj xeeb, tuaj yeem siv cov dej sib cais ntawm cov tshuaj sib cais thiab huv ntawm cov tshuaj.
Kev sib raug zoo ntawm boiling taw tes thiab tso tshuaj
Cov ntaub ntawv Bhaub taw qhia yog qhov tseem ceeb rau kev xaiv cov sib cais kom tsim nyog thiab cov txheej txheem kom huv hauv cov txheej txheem ntau lawm. Piv txwv, yog tias nws yog qhov tsim nyog los cais prilocaine los ntawm kev sib tov, cov hau kev xws li distillation tuaj yeem siv los caisPrilocaine HmoovRaws li nws boiling taw tes sib txawv los ntawm lwm yam tshuaj. Nyob rau tib lub sijhawm, thaum lub sijhawm ua kom qhuav ntawm cov tshuaj, qhov cub npau npau kuj yuav tsum tau txiav txim siab kom tsis txhob muaj kev lom zem lossis tsis zoo ntawm cov tshuaj vim qhov kub thiab txias.
melting taw tes
Melting taw tes ntau
Lub ntsiab lus melting ntawm prilocaine yog 37-38 degree. Qhov taw tes melting yog qhov kub thiab txias ntawm qhov kev hloov pauv ntawm ib qho khoom ntawm ib lub xeev ruaj khov rau lub xeev ua kua, thiab yog lub cev tseem ceeb tas li. Qhov tseem ceeb melting point ntawm prilocaine tso cai rau nws kom yauv mus rau lub xeev kev hloov pauv raws li tib neeg lub cev kub. Hauv kev siv cov tswv yim, cov yam ntxwv no yuav cuam tshuam rau kev ruaj ntseg ntawm cov tshuaj thiab cov khoom siv khaws cia ntawm cov qauv. Piv txwv li, nyob rau hauv qhov chaw kub siab ib puag ncig, tau maj mam yaj, cuam tshuam cov tsos thiab zoo ntawm cov tshuaj.
Cov nyhuv ntawm melting point ntawm cov tshuaj
Qhov muaj kev ruaj khov ntawm melting point yog qhov tseem ceeb rau kev tswj cov tshuaj zoo. Yog hais tias lub ntsiab lus melting ntawm prilocaine hloov, nws yuav qhia tau tias muaj kev hloov pauv ntawm cov tshuaj, cov qauv siv lead ua, yog li cuam tshuam nws txoj kev ua tau zoo thiab kev nyab xeeb. Yog li ntawd, nyob rau hauv cov txheej txheem ntau lawm, nws yog ib qho tsim nyog yuav tswj kub thiab lwm yam kev mob kom ntseeg tau tias qhov muaj zog ntawm prilocaine.
Cov kws kho tshuab ntawm kev nqis tes ua yog feem ntau yog raws nws cov kev txwv cuam tshuam rau sodium ion raws cov na cov leeg ntawm cov hlab ntsha paj hlwb. Qhov kev sib kis ntawm cov hlab ntsha impulses nyob ntawm qhov qhib thiab kaw ntawm ion channel, thiab sodium i channel ua si ib tiam tseem ceeb nyob rau hauv tiam thiab kev sib kis ntawm cov hlab ntsha impulses. Propavacaine tuaj yeem khi rau cov chaw tshwj xeeb ntawm Sodium Ion raws cov lus, tiv thaiv kom lub suab sodium thiab uas muaj cov hlab ntsha tsis sib luag. Cov nyhuv thaiv no yog thim rov qab. Thaum cov tshuaj siab uas txo qis lossis yog metabolized, txoj haujlwm ntawm sodium ion raws yuav maj mam rov qab, thiab cov hlab ntshav cuam tshuam yuav tseem rov qab mus rau qhov qub. Los ntawm cov txheej txheem no, cov tshuaj pleev ua ntej no tuaj yeem tsim kom muaj kev puas tsuaj rau hauv thaj chaw hauv cheeb tsam thiab cov neeg mob kom muaj mob.
Cov yam ntxwv ntawm cov chaw ua ke
Tom qab daim ntawv thov hauv zos, nws cov txheej txheem nqus thiab metabolism cov txheej txheem muaj qee yam yam ntxwv. Thaum cov tshuaj pleev tau yog thov rau cov tawv nqaij tsis huv, cov tshuaj maj mam nyob ntawm daim tawv nqaij mus rau hauv cov ntaub so ntswg subcutally. Cov qib kev nqus tau yog cuam tshuam los ntawm ntau yam los ntawm ntau yam, suav nrog kev siv tshuaj, daim ntawv thov siv tawv, thiab lwm yam tawv nqaij. Piv txwv li, ntawm cov tawv nqaij uas tsis tau tso rau hauv cov ncej puab rau cov neeg laus (260g cream rau 3 teev, kwv yees li 5% lidocaine thiab prilocaine nqus tau. Cov metabolism ntawm prilocaine hauv lub cev yog tsuas yog nqa tawm ntawm daim siab, thiab cov metabolites yog feem ntau ua tiav los ntawm ob lub raum. Vim nws cov metabolism ceev thiab cov nyiaj tsis tshua muaj,Prilocaine Hmoovyog kev nyab xeeb. Txawm li cas los xij, ntau dhau los yog ntev - siv tej zaum tseem yuav ua rau cov lus qhia kev kho mob yog qhov tsim nyog.
Cov tshuaj tiv thaiv tsis zoo
Prilocaine, raws li kev ua kom zoo nkauj hauv nroog tshuaj loog, tau siv dav hauv cov tshuaj tua kab mob thaum xyoo 1950 thiab tau dhau los ua cov tshuaj loog, cov hlab ntsha thaiv, thiab cov kab mob epidural. Nws txwv tsis pub muaj teeb meem transduction los ntawm kev thaiv cov sodium raws, thiab raws li ib tug na /} {{} urotoxic mechanism. Txawm li cas los xij, nrog kev nthuav dav ntawm cov ntawv thov kev kho mob, qhov sib txawv thiab qhov hnyav ntawm nws cov kev phiv tau yooj yim tau pom meej.
Cov tshuaj tiv thaiv hauv zos: los ntawm kev txhawb nqa cov ntaub so ntswg puas
Tiv tauj kom tsis pub muaj cai thiab mob dermatitis
Prilocaine tuaj yeem tsis muaj hom kev cuam tshuam ntawm iv Kev Hloov Siab, ua rau khaus, khaus, thiab txawm mob ntawm qhov chaw txhaj tshuaj. Kev tshawb fawb tau pom tias qhov tshwm sim rau EMLA cream (muaj lidocaine thiab prilocaine) yog 1.2% -3.5%, nrog prilocaine ua cov khoom lag luam loj. Lub tshuab siv cuam tshuam nrog kev khi cov tshuaj molecules li haptens rau cov nqaij tawv nqaij, ua kom t
Neurological kev puas tsuaj thiab zoo nkauj tsis zoo
Kev muaj zog lossis rov qab txhaj tshuaj ntawm Prilocaine yuav ua rau muaj kev puas tsuaj axonon, ua kom loog, tingling, lossis tsawg dua qhov chaw txhaj tshuaj. Cov kev sim tsiaj tau pom tias txhaj 10% nyiaj ib ncig ntawm cov kab mob sciatic ntawm cov nas kev puas tsuaj, thiab cov qib ntawm kev puas tsuaj yog qhov sib cuam tshuam nrog kev sib raug zoo.
Cov nqaij hauv zos cov nqaij necrosis
Venous extravasation yog qhov teeb meem loj ntawm prilocaine txhaj. Nyob rau hauv rooj plaub, ib lub hlis qub menyuam raug kev txom nyem los ntawm sab laug sab laug vim kev nkag mus ntawm prilocaine ntawm cov kev lis ntshav sab nraud, yuav tsum tau ib hlis ntawm kev kho mob kom rov zoo. Tus txheej txheem yog cov tshuaj ncaj qha txhawb cov hlwb Opothelial, ua rau cov ntshav hauv cov ntshav hauv zos.
Cov Txheej Txheem Txheej Txheem: Los ntawm cov teeb meem metabolic los tso cov kuab lom
Methemoglobinemia
Prilocaine cov metabolite, alpha toluidine, tuaj yeem oxidize cov hlau sib dhos hauv hemoglobin, ua rau kev tsim cov metemoglobin (metb). Thaum lub concentration ntawm metutter ntau dua li 15%, cov neeg mob yuav tshwm sim cyanosis, mob taub hau, thiab qaug zog; Thaum cov ntsiab muag ntau dua 50%, nws yuav ua rau muaj kev ntxhov siab lossis tuag taus. Kev tshawb fawb tau pom tias tom qab ib qho kev txhaj tshuaj ntawm 10mg / kg prilocaine, lub concentration ntawm metawm tuaj yeem ncav cuag 6%, thiab cov neeg mob anemia muaj kev pheej hmoo siab dua.
Hlab plawv toxicity
Prilocaine tuaj yeem tiv thaiv sodium raws hauv myocardial cells, prolong ua kom muaj peev xwm muaj peev xwm muaj peev xwm ua tau ntev, thiab induce arrhythmia. Hauv cov ntaub ntawv kuaj mob, cov neeg mob uas tau txhaj tshuaj ntawm Bradycardia, ventricular neeg yeej, thiab txawm tias mob plawv. Tsis tas li ntawd, lub vasodilatory nyhuv ntawm cov tshuaj yuav ua rau mob hypotension, tshwj xeeb tshaj yog siv ua ke nrog cov tshuaj vasentactive.
Central Ntshav Qab Zib
Kev nqus tau ntau dhau los ntawm Prilocaine tuaj yeem tsoo los ntawm cov ntshav -}}}} barrier thiab inhibit lub nruab nrab ntawm cov leeg ntshav nruab nrab. Manifested li kiv taub hau, tinnitus, ntxhov siab, kev mob ntsws, thiab muaj mob hnyav, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj, ua pa nyuaj. Cov kev sim tsiaj tau pom tias tom qab kev txhaj tshuaj ntawm prilapaine hauv nas, kg, thiab tshuaj lom, thiab tshuaj lom, thiab faraia, thiab coma.
Cim npe nrov: Prilocaine Hmoov, Lwm tus neeg, Chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag