Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov neeg muag khoom ntawm Daidasin Hmoov CAS 486-66-8 nyob rau Suav teb. Txais tos rau kev lag luam wholesale loj zoo doasin hmoov CASEin hmoov CAS 486-66-8 kev muag khoom no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Daidzein hmoovyog dawb lossis me ntsis daj crystalline hmoov nrog ib daim ntawv crystalline tshwj xeeb. Cov mis molecular yog c15h10o4, tus txheeb ze lub cev hnyav yog li 254.24g / Mol, CAST6-66-8. Nws yog cov khoom khov kho, yog li ntawd nws yuav tsis muaj lub ntsej muag ntshiab npau npau. Ntawm qhov tsis sib xws, thaum rhuab mus rau qhov kub txaus, nws yuav tshem tawm. Cov solubility hauv cov kuab tshuaj uas sib txawv. Nws tuaj yeem yaj nyob rau qee cov kuab tshuaj organic, xws li ethanol, dimethyl sulfoxide thiab diholoromomethana. Txawm li cas los xij, lub solubility hauv dej yog qhov tsawg. Nws yog dav siv hauv kev lag luam khoom noj, tshuaj pleev ib ce, thiab cov khoom tu tawv nqaij. Nws tuaj yeem raug siv los ua cov tshuaj ntxiv xws li cov xim xim duab, cov neeg sawv cev tua kabmob, thiab cov tshuaj pleev thaiv hnub. Tsis tas li ntawd, kev sib sau ua ke kuj tseem siv los ua cov nroj tsuag kev tswj hwm kev txhim kho thiab cov tshuaj tua kab hauv thaj chaw ua liaj ua teb.
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Tshuaj Cov Qauv |
C15H10O4 |
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Muaj pes tsawg leej |
254 |
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Molecular hnyav |
254 |
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m/z |
254 (100.0%), 255 (16.2%), 256 (1.2%) |
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Kev Ntsuam Xyuas |
C, 70.86; H, 3.96; O, 25.17 |
Daidzein hmoovyog lub ntuj isoflavonoid compound, uas muaj nyob rau hauv ntau cov nroj tsuag, tshwj xeeb tshaj yog taum pauv thiab taum liab. Nws muaj ntau yam kev ua si thiab cov tshuaj papacological, yog li nws tau kawm dav thiab thov.
1.PhyestRogen: Daidzein yog cov khoom noj muaj txiaj ntsig nrog cov tshuaj estrogen thiab tuaj yeem khi rau cov tshuaj estror ntawm tib neeg lub cev. Yog li ntawd, nws yog dav siv hauv cov khoom siv kev noj qab haus huv thiab cov tshuaj rau kev tswj hwm tus poj niam, tswj cov poj niam endocrine cov nyom, thiab txhim kho pob txha ceev.
2. Antioxidants: Daidkev ua dej hiav txwv, uas tuaj yeem tshem tawm cov radicals dawb thiab txo cov oxidative kev puas tsuaj. Nws pab tiv thaiv oxidative kev cuam tshuam cov kab mob ntsig, xws li cov kab mob plawv, mob cancer thiab nurodegenerative.
3. Anti inflammatory effection: Daidain qhia qee yam tshuaj tiv thaiv thiab tuaj yeem cuam tshuam txog cov tshuaj tiv thaiv thiab ntau yam xws li prostaglandin thiab interleukin thiab interleukin thiab interleukin thiab interleukin. Qhov no ua rau nws tau hais tias nws muaj qee yam peev xwm rau cov mob ntsig txog lwm tus, xws li mob ntsws rheumatoid thiab mob plab hnyuv.
4. Kev tshawb fawb qog ua haujlwm tau qhia tias DAIDZEIN muaj qee cov txiaj ntsig ntawm cov qog ntawm cov kev ntes ntawm tes thiab kuaj mob hauv lub voj voog. Nws tau suav hais tias yog muaj peev xwm los tiv thaiv-} Cov qog nqaij hlav ntshav rau kev tiv thaiv thiab phais mob cancer, prostate cancer thiab lwm yam qog nqaij hlav.
5. Kev tiv thaiv ntawm kev noj qab haus huv Nws tuaj yeem nce cov ntshav pliaj thiab txhim kho cov ntshav ncig, yog li pab tiv thaiv kev txhim kho kev mob plawv.
6. Kev Tiv Thaiv Osteoporosis: DAIDZEIN TUAJ YEEM NTAWM COV PHOOJ YWG LOS NTAWM COV PHOOJ YWG, THIAB TSIS TXAUS SIAB RAU COV ROJ NIAM.
7.
8. Kev cuam tshuam hauv Insulin Kuj: Qee qhov kev tshawb fawb tau pom tias DAIDZEIN muaj peev xwm txhim kho cov insulin rhiab thiab tswj cov ntshav qab zib. Qhov no ua rau nws pab tau kev tswj hwm ntshav qab zib.
Ntxiv rau cov lus teb ua ke, Daidain tseem siv tau hauv kev lag luam khoom noj, tshuaj pleev ib ce, thiab tu cov khoom lag luam tawv nqaij. Nws tuaj yeem raug siv los ua cov tshuaj ntxiv xws li cov xim xim duab, cov neeg sawv cev tua kabmob, thiab cov tshuaj pleev thaiv hnub. Tsis tas li ntawd, kev sib sau ua ke kuj tseem siv los ua cov nroj tsuag kev tswj hwm kev txhim kho thiab cov tshuaj tua kab hauv thaj chaw ua liaj ua teb.
Daidzein hmoov(tannin) yog ib hom ntawm isoflavonoid ib txwm muaj nyob hauv cov nroj tsuag xws li taum pauv. Nws muaj dav thov cov kev cia siab, yog li tib neeg tau cog lus los tsim ntau yam synthesis cov qauv kom tau txais cov compound no. Cov hauv qab no yog cov ncauj lus kom ntxaws ntawm cov ntsiab lus tseem ceeb ntawm daidzein:
1. Soybean Cog Cov Extraction Txoj Kev:
Qhov feem ntau thiab feem ntau siv cov qauv yog kom rho tawm daidzein los ntawm cov nroj tsuag xws li taum pauv.
Cov txheej txheem no cuam tshuam cov kauj ruam ntawm kev sib tsoo, kev rho tawm, thiab cais cov nroj tsuag thiab ua kom huv.
Firstly, qhuav taum av yog av rau hauv cov hmoov, thiab tom qab ntawd tsau rau hauv cov kuab tshuaj xws li ethanol lossis methanol los rho dosze thiab lwm yam sib txuas.
Tom ntej no, cov extract tuaj yeem ua kom huv los ntawm cov kev qhia ua ke xws li nqus tsev, cov chromatography, thiab crystallization kom tau txais siab daidzein.
2. Tshuaj Kho Mob Hluav Taws Xob:
Ntxiv rau qhov tau muab rho tawm los ntawm cov nroj tsuag, daidzein kuj tseem tuaj yeem tau txais los ntawm cov tshuaj lom neeg tshuaj lom neeg. Cov hauv qab no yog ntau cov tshuaj synthesis feem ntau:
(1) ba ba ba jin Ketone Txuj Ci: Qhov no yog ib qho qauv classicic actualesic synthesis. Cov txheej txheem tsuas yog suav nrog cov tshuaj tiv thaiv ntawm barbaginone nrog benzyl magnesium bromide kom tau p- methoxy benzyl cawv. Tom qab ntawd, cov poov tshuaj hydroxide yog siv los hloov nws rau p ing- methoxy styrenee. Thaum kawg, Daidain thaum kawg tau txais los ntawm cov kauj ruam xws li kev cyclization thiab tsis txaus ntseeg.
(2) cyclosynthesis ntawm hydroxy phenylacic acid:
Tom qab kev sib piv, resorcinol thiab p - hydrotic acid tau siv los ua cov ntaub qhwv roj av thiab kev sib tw ntawm cov ntaub ntawv me me ntawm cov tsiaj. Cov khoom tsim tawm yog qhov siab li 43.0%, thiab qhov zoo tau ua tau raws li cov qauv chaw muag tshuaj.
Cov Kev Cai Teb Chaws
1. Cov tshuaj tiv thaiv hws:
2. Lub nplhaib kaw:
(3) o - nitrophenol synthesis txoj kev: qhov no yog ib txoj kev ntawm synthesizingDaidzein hmoovSiv o {- nitrophenol raws li pib cov khoom. Ua ntej, o - nitrophenol yog refered nrog ethyl acetate kom tau o {{3} nitro Ethyl Benzoate. Tom ntej no, los ntawm nucleophilic hloov chaw, o - nitro Ethyl Benzoate tau hloov mus rau O {}} nitrophylylacetone. Tom qab ntawd, Daidzein tuaj yeem yog synthesized los ntawm cov kauj ruam ntawm cov kauj ruam xws li txo qis, ua kom zoo nkauj, zoo nkauj tig, thiab lwm yam.
(4) Vinnation Synthesis Txoj Kev: Qhov no yog ib txoj kev ntawm daidzein synthesis siv cov ntaub ntawv yas. Ua ntej, Phenol yog refleed nrog sulfuric acid kom tau p - neneneba sulfate phenol. Tom qab ntawd, nws hloov dua siab tshiab rau hauv P {4 4}} phenol los ntawm kev kho alkaline. Tom ntej, Vinyl Sulfonate yog siv los yaig hloov pauv tau nrog p} Phenol los ua cov yas phenol Phenol. Thaum kawg, daidzein tuaj yeem ua ke los ntawm cov kauj ruam xws li kev sib deev, txo qis, acylation, thiab acetate Esterification.
3. Enzyme Txuj Ci:
Lwm txoj hauv kev rau synthesizing daidzein yog siv enzyme catalyzed kev tawm tsam. Los ntawm kev xaiv cov enzymes tsim nyog, qee cov precursors tuaj yeem hloov pauv mus rau hauv kev tso tseg. Piv txwv li, siv phenylalanine enzyme tuaj yeem hloov phenylalanine rau Coumarin, thiab tom qab ntawd Hloov CastMarin kom muaj kev sib cav sib ceg. Hom qauv no muaj qhov zoo ntawm kev ua tau zoo, kev xaiv siab, thiab ib puag ncig ua phooj ywg.
Hauv cov ntsiab lus, daidzein cov txheej txheem synthesis muaj xws li cog cov extraction, tshuaj txig hluav taws xob, thiab txoj kev enzymatic. Thaum xaiv cov qauv hluav taws xob tsim nyog xws li tus nqi, kev ua haujlwm, kev nyab xeeb, thiab ib puag ncig ua phooj ywg yuav tsum tau txiav txim siab. Tsis tas li ntawd, txhawm rau kom tau txais siab- Txoj kev purificate thiab kev ua kom tsim nyog ua kom haum thiab cais cov kauj ruam kuj tseem xav tau. Nws yuav tsum tau sau tseg tias txoj kev ntawm synthesizing DAILEin xav tau los nqa tawm hauv chav kuaj lossis kev tsim khoom siv tshuaj lom neeg thiab kev cai tswjfwm.
Keeb Kwm Kev Loj Hlob
Kev tshawb nrhiav thaum ntxov thiab kev nkag siab tshiab (thaum ntxov xyoo pua 20th-1970s)
Daidzein, raws li cov tub ntxhais tivthaiv ntawm kua isoflavones, tau yog qhov kev kawm ntawm kev tshawb fawb txij li thaum ntxov xyoo pua 20th. Xyoo 1931, cov kws tshawb fawb ua ntej cais cov kua taum ua ke los ntawm cov taum pauv. Txawm li cas los xij, vim kev txwv kev ua haujlwm, kev tshawb fawb thaum ntxov ua kom dhau ntawm kev txheeb xyuas cov qauv tshuaj. Xyoo 1950, nrog kev nce qib ntawm cov qauv chromatographic, thiab nws cov yam ntxwv zoo ib yam li ntawd, thiab nws cov qauv kev coj zoo ib yam li 254.2)
Xyoo 1970, kev kawm Epidemiological tau qhia tias tus nqi ntawm cov neeg Asian mis (cov zaub mov ua prostis) tau qis dua cov neeg Western. Nws yog kev xav tias qhov no cuam tshuam nrog kev nkag ntawm cov kua taum ooflavones. Qhov kev tshawb pom no tau coj mus rau lub sijhawm pib kev tshawb fawb ntawm kev txwv, tab sis yog cov kev ua kom tiav (txog 60% -70%), uas txwv qhov tob ntawm nws daim ntawv thov.
Cov kev sib txuas lus thev naus laus zis thiab thawj zaug kev lag luam (1980s-2000s)
Kev thev naus laus zis ua haujlwm hauv kev rho tawm thiab ua kom huv huv
Nyob rau xyoo 1980, cov lus qhia ntawm high {1} Kev ua kua roj chromatography (SFE) Piv txwv li cov kws tshawb fawb Japanese siv SFE thev naus laus zis kom ua tiav kev lag luam extraction ntawm daidzein, txhawb nws nkag mus rau hauv kev tshawb fawb kev tshawb fawb raws li lub siab {kua txiv purity khoom.
Kev soj ntsuam ntawm lub tshuaj portacologism
Xyoo 1990s, kev sim ntawm tes thiab cov qauv tsiaj tau tshwm sim ntau cov haujlwm ntawm Daidzein:
Antioxidant: Lub peev xwm los tshem tawm dawb radicals yog 10 zaug ntawm vitamin E, thiab nws tuaj yeem tiv thaiv lipid lipid peroxidation.
Phytoestrogens: los ntawm kev khi rau cov receptors estrogen (ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER / ER),
Anti {- Cancer: nws tsim kev ua kom muaj mob ntawm cov qog ntshav (MCF-7) thiab inhovits cov qog ntshav angiogenesis.
Xyoo 1997, US FDA Pom zoo tau pom zoo kua isoflavones li "kev noj haus cov cai rau kev ua lag luam ntawm kev ua lag luam ntawm kev ua lag luam ntawm daidzein.
Thaum Ntxov thov Kev Thov
Thaum ntxov 2000s, Daidzein hmoov pib siv rau:
Kws Tshuaj Kho Mob: Raws li cov khoom noj muaj zog rau kev kho tus mob menopaialal thiab osteoporosis ua ib qho kev kho mob.
Kev pab tshuaj noj qab haus huv: tsim mus rau hauv cov ntsiav tshuaj thiab cov ntsiav tshuaj, thov kom "ncua kev noj qab haus huv plawv".
Cov tshuaj pleev ib ce: ntxiv rau anti - wrinkle cream, siv nws cov khoom antioxidant kom txo cov tawv nqaij.
Txawm li cas los xij, cov khoom thaum ntxov tau txwv kev lag luam tau vim tsis muaj kev pab txhawb nqa hauv Nyij Pooj, thiab Kaus Lim Qab Teb, thiab Southeast Asia.
Ntiaj teb kev ua lag luam nthuav dav thiab muaj ntau yam kev thov (txij li xyoo 2010s)
Kev Lag Luam Loj Loj
Tom qab 2010, lub ntiaj teb kua isoflavone lag luam nthuav tawm ntawm ib xyoos ib zaug ntawm 8%. Qhov kev faib ua feem ntawm Daidzein hmoov tau nce los ntawm 25% rau xyoo 2015 mus rau 4025. Tuam Tshoj tau muaj peev xwm ua tau zoo tshaj plaws rau 60% ntawm tag nrho cov thoob ntiaj teb. Cov lag luam loj suav nrog qee pab pawg hauv Shandong thiab qee cov tuam txhab Biotechnology hauv Honan, nrog ib xyoos tawm ntawm ntau dua li 500 tons.
Cov chaw soj ntsuam cov kev tshawb fawb tau siv tau ua tau zoo
Kev tiv thaiv kab mob plawv: Kev kawm 2018 hauv kev noj haus hauv tsev kho mob muaj txiaj ntsig txhua hnub tuaj yeem ua rau muaj kev pheej hmoo qis (LDL) los ntawm 12% thiab txo qis kev pheej hmoo ntawm atherosclerosis los ntawm 18%.
Anti {- Cancer: 2021 daim ntawv tshawb fawb txog kev nkag siab cancer ntawm cov mob cancer mis rau tshuaj kho mob thiab txo cov tshuaj tiv thaiv.
Neuroproction: Cov kev sim tsiaj hauv 2023 pom tias qhov kev ua haujlwm zoo ntawm cov nas nrog Alzheimer tus qauv los ntawm kev tswj hwm lub plab microbiota.
Kev nthuav dav ntawm cov ntawv thov nthuav dav
Cov khoom noj muaj nuj nqi: ntxiv rau dej haus, kua mis nyeem, xws li qee hom hauv Nyij Pooj ", thov" ib khob ib hnub, cov pob txha muaj zog ".
Ua liaj ua teb: Raws li cov nroj tsuag kev tswj hwm kev nyab xeeb, txhawb cov qoob loo tsim kev tiv thaiv (xws li downor kuj, ntsev thiab alkali tsis kam).
Cov ntaub ntawv tshawb fawb: ua ke nrog nanomaterials, tsim cov tshuaj tua kab mob antib lossis yeeb tshuaj- tso cov nqa khoom.
Cov kev sib tw tam sim no thiab yav tom ntej
Cav
Cov qauv tsis txaus: Tsis muaj cov qauv koom kev sib koom ua ke rau cov ntsiab lus devzeenally, ua rau cov khoom tsis zoo.
Tsawg Bioavailability: tsuas yog 20% -30% yog nqus tom qab kev tswj hwm ntawm qhov ncauj, thiab cov khoom xa tuaj tshiab (xws li liposomes, nanoparticles) yuav tsum tau tsim.
Cov kev txwv kev txwv: EU tau faib cov Daidzein ua "cov zaub mov tshiab", thiab tsuas yog ua lag luam tom qab kev ntsuas kev nyab xeeb.
Yav Tom Ntej
Precision Khoom Noj: Sib txuas kev kuaj caj tshuaj los tsim cov phiaj xwm Daidashion Dayzeze (xws li rau cov neeg muaj cov kab hlau polymorphisms).
Cov Khoom Siv Ntsuab: Siv cov microbial fermentation es tsis txhob siv tshuaj lom neeg ua kom muaj kuab paug rau ib puag ncig ua ke kom ua tiav nws biosynthesis).
Hla - Bergder Kev sib koom ua ke: sib txuas nrog cov phiaj xwm kev muaj peev xwm ntawm kev zam ntawm kev siv tshuab hluav taws xob, nrawm dua tshiab kev txhim kho tshuaj.
Cim npe nrov: Daidzein hmoov li 486-66-8, cov neeg muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag