Cyprooheptadine hydrochloride Sesquihydrate, Molecular mis mis c21h24444444444444-294-29-4. Nws muaj nyob rau hauv Crystalline daim ntawv thiab feem ntau pom tias yog muaju dawb lossis cov hmoov crystalline. Nws muaj solubility nyob rau hauv dej thiab tuaj yeem yaj sai los ua pob tshab lossis me ntsis turbid daws. Nws kuj tseem tuaj yeem yaj nyob rau qee cov kuab tshuaj organic, xws li ethanol thiab acetone. Nws yog chiral compound nrog kho qhov muag kev sib hloov. Nws cov kev sib hloov tshwj xeeb ([] D) nyob ntawm qhov ntsuas cov kev mob thiab cov kuab tshuaj. Cov qauv molecular muaj cov dej ntawm crystallization molecules. Yog li ntawd, nws cov ntawv hydrate muaj cov nqi ntawm cov dej ntawm crystallization. Cov plua zog cov dej muaj zog tuaj yeem txiav txim siab los ntawm kev poob phaus lossis thermal txheeb xyuas thev naus laus zis. Nws yog cov tshuaj siv feem ntau los kho cov tsos mob xws li kev ua xua, ntuav, thiab tsis qab los noj mov. Cov lus piav qhia saum toj no tsuas yog rau kev siv dav dav, thiab cov khoom siv lub cev tshwj xeeb yuav tsum ua raws cov ntawv sau tseg lossis cov lus qhia kev sim. Thaum siv lossis tuav cycloheptadine hydrochloride sesquihydrate, ntsuas kev ntsuas yuav tsum tau ua raws li cov kev xav tau thiab kev tswj hwm, yuav tsum tau ua raws.
|
|
|
|
Tshuaj Cov Qauv |
C42h50Cl2n2o3 |
|
Muaj pes tsawg leej |
700 |
|
Molecular hnyav |
702 |
|
m/z |
700 (100.0%), 702 (63.9%), 701 (45.4%), 703 (29.0%), 704 (10.2%), 702 (7.4%), 704 (5.6%), 705 (4.6%), 702 (2.7%), 706 (1.0%) |
|
Kev Ntsuam Xyuas |
C, 71.88; H, 7.18; Cl, 10.10; N, 3.99; O, 6.84 |
Cyprooheptadine hydrochloride Sesquihydrate, raws li cov tshuaj antihistamine yeeb tshuaj, tau pom muaj tus nqi tshwj xeeb hauv kev ua xua, thiab cov kws kho mob thaum lub sij hawm 20th
Cyploheptadine hyiplororide Hemihydrate yog lub hydrochloride femihtadine, nrog cov qauv tshuaj lom neeg ntawm C21H2N · Harakes. Nws cov tub ntxhais kev nqis tes ua suav nrog:
H1 receptor antagharism: los ntawm kev sib tw thaiv cov binding ntawm histamine rau H1 receptors, thiab cov leeg mob du, yog li kev sib txuam thiab cov tsos mob ua kom tsis taus pa.
5-HT Receptor Altracist: Feem ntau ua rau 5-HTT2 receptor subtypes, inhibting serotonin deliated Vasodoricy, thiab muaj txiaj ntsig nyob rau hauv 5-holriat cov kab mob xws li migraine thiab angioedema.
Anticholinic nyhuv: kev thaiv me me ntawm m -} cholinergor feltersecretion thiab plab hnyuv ntxaij.
Appetite stimulating nyhuv: los thaiv kev hypothhalamic 5-ht receptors, nce neuropeptide y (npy) tso tawm, txhawb nqa thiab nce siab.
Cov Ntawv Qhia Tseem Ceeb thiab Kho Mob
1. Cov kab mob ua xua
(1) Urticaria
Mob caj dab, khaus, thiab kho kab kev kho yeeb yam, nws tuaj yeem hloov kho URTICARIA, nrog kho mob hnyav.
Cov Uronic Urtic: Ua ke nrog ob -}}} heev antihistamines (xws li levocetirizizine) tuaj yeem txhim kho kev ua tau zoo thiab txo qis dua kev ua tau zoo.
Hom Tshwj Xeeb: Rau refractory subtypes xws li choticergic thiab solar urticaria, anti 5-hit cuam tshuam ntawm CyProHeptadine tuaj yeem muab cov txiaj ntsig ntxiv.
(2) eczema thiab dermatitis
Ua xua yog qhov ua xua: los ntawm kev txwv tsis pub muaj kev kho mob los ntawm cov neeg nyiam liab, kev sib cais, tshwj xeeb yog haum rau cov neeg mob sib deev.
Hu rau Dermatitis: Kev npaj ua kom zoo (xws li cream) tuaj yeem ncaj qha rau hauv thaj chaw hauv zos kom txo cov tawv nqaij ua xua xws li tshuaj pleev ib ce thiab cov hlau.
Ua tsis haum rhinitis
Lub caij rhinitis: thaum ua ke nrog cov qhov ntswg corticosteroids, nws tuaj yeem txhim kho qhov mob ntawm txham, los ntswg, thiab qhov ntswg.
Perennial Rhinitis: Rau cov neeg mob nrog concomitant vasomotor rhomotor li cas, Antichholarsgic nyhuv ntawm cyproheptadine tuaj yeem txhim kho kev kho mob.
Kev ua xua rau kev ua xua
Sib koom ua ke antihistamine qhov muag poob (xws li Loratadine) tuaj yeem txo qhov muag khaus, tsis sib haum, thiab muaj kev zais cia ntxiv.
2. Cov kab mob endocrine thiab metabolic
(1) Cushing syndrome
Mechanism ntawm kev ua: los ntawm inhibiting tso rau ntawm hypothalamic corticotropin tso cov tshuaj hormones (ACTH), CORTISOL qib tau txo qis.
Cov ntaub ntawv thov tau:
Bilateral Cerrenal hyperplasia: Ua ntej - Di txoj kev siv tshuaj yeeb yaj ywm rau 24mg / hnub thiab yuav tsum tau siv ntev- siv.
Kev Kho Mob Tom Qab Kev Kho Mob Ua Ntej: Ua ke nrog Glucocorticoid hloov kev kho mob tom qab adrenalecy tuaj yeem txo qhov kev pheej hmoo ntawm cov qog pituitary.
Cov pov thawj ntawm kev kho nyhuv: ntau cov kev tshawb fawb tau qhia tias CyProheptadine tuaj yeem rov qab siv cov zis ntau dua 60%, tab sis saib xyuas yuav tsum tau them nyiaj rau-} kav dej sab nrauv.
(2) acromegaly
Mechanism ntawm kev ua: inhibits lub zais ntawm kev loj hlob muaj kev loj hlob hormone (ghrh) thiab txo cov kev tso tawm ntawm kev loj hlob muaj (GH).
Cov ntaub ntawv thov kho mob: raws li kev kho mob uas yuav raug phais lossis tsim nyog rau cov neeg mob uas tsis tuaj yeem tiv thaiv ib nrab ntawm cov analogs.
Neurogenic Anorexia thiab Qhov Nyhav Tau Txais Tsis Tau
Mechanism ntawm kev ua: los ntawm kev thaiv 5-HT2C no receptors, qab los noj mov thiab lub zog ua tau nce ntxiv.
Cov ntaub ntawv thov tau:
Ncua kev loj hlob hauv cov menyuam yaus: noj ntawm 0.25 -0.5 -0.5mg / kg / hnub, noj los txhim kho tus nqi ntawm qhov hnyav.
Cancer Cachexia: ua ke nrog medroxypeprogesterne tuaj yeem txhim kho lub qab los noj qab qab los ua noj qab haus huv.
3. Neuropychiabtencers
(1) sigraine Prophylaxis
Mechanism ntawm kev ua: los ntawm kev thaiv 5-HT2 receptors, kev ua kom muaj kev ua kom muaj tseeb ntawm lub cev neurovascular system thiab cortical diffention supression (CSD) yog inhibited.
Cov ntaub ntawv thov tau:
Kev pom zoo thaum yau: Kev Pom Zoo 2022 ntawm Kev Kho Mob thiab Kev Kho Mob ntawm cov menyuam yaus pom zoo txog 0.25-hnub, uas tuaj yeem txo cov zaus thiab kev tawm tsam hnyav.
Cov Neeg Laus Migraine: Ua ke nrog beta blockers (xws li propranolol) tuaj yeem txhim kho cov nyhuv tiv thaiv.
(2) serotonin syndrome
Mechanism ntawm kev ua: raws li 5-HTTE REEPTOR kev thaiv av, nws tuaj yeem hloov cov serotonin syndrome inducle 5-ht reptive xaiv 5-HT Reptive ເ :ັມ 5-HT Reptive 5-HT Reptive Aute
pw tsis tsaug zog tsis sib haum
Mechanism ntawm kev ua: Cov teebmeem sedative yog tsim los ntawm H1 receptor antagharism thiab anticholinium cuam tshuam.
Cov ntaub ntawv thov tau:
Insomnia: Kev siv luv luv siv (tsawg dua lossis sib npaug rau 2 lub lis piam) tuaj yeem txhim kho kev nyuaj ploj thiab pw tsaug zog tu.
Kev ntxhov siab ntsig txog kev tsis txaus ntseeg txog: ua ke siv nrog cov tshuaj tiv thaiv kev ntxhov siab xws li Olanzapine tuaj yeem txhim kho cov teebmeem sedative.
4. Lwm cov taw qhia
(1) tawm tsam kev tawm tsam kev tawm tsam kev fab tshuaj
SSRI induced kev sib deev tsis sib deev: ib nrab redored deev muaj nuj nqi los ntawm kev thaiv 5-HT2 receptors.
Chlorpromazine For Tshuaj Kho Lus Tsis Tau: Ua 5-HTTA REEPTOR txojkev tiv thaiv, nws tuaj yeem daws cov tshuaj tiv thaiv.
(2) Kev Txawj Ntsej Txom Nyem rau Cov Kab Mob Ntawm Cov Mob
Blackthorn daim tawv nqaij: Los ntawm kev txhim kho insulin tsis kam thiab txhawb keratinocyte sib txawv, nws txo cov tawv nqaij pigmentation thiab verbous hyperplasia.
Tiv thaiv necrotizing pyodotizing pyodory: los ntawm inhibiting neibripiting neutrophil chemotaxis thiab inflatory cytokine tso tawm, txo cov tawv nqaij rwj.
Ib qho ntawm cov khoom siv hluav taws xob ua kom zoo nkauj rau cycloheptadine hydrochloride sesquihydrate suav nrog cov kauj ruam hauv qab no: ''
Kev npaj ntawm acetylacetone derivatives:
Ua ntej, Benzaldehyde thiab acetone yog nucleophilic ntxiv rau tsim cov acetylacetone derivatives.
Synthesis ntawm benzidine:
Lub Aniline yog cov tshuaj tiv thaiv hws nrog tshuaj acetylacetone derivatives los tsim benzidine tsim benzidine.
Synthesis ntawm p - bromocresol:
Refore react P - cresol nrog bromine nyob rau hauv alkaline tej yam kev mob los tsim p {{1} Bromocresol.
Tiam ntawm Heterocyclic Compound:
Benzidine tau tsim kev cuam tshuam nrog p - bromophem los tsim heterocyclic compound.
Amination:
Heterocyclic compound tau aminated los tsim amino compound.
Kev npaj ntawm hydrochloride Daim Ntawv:
Thaum kawg, cov Amine compound yog reacted nrog hydrochloric acid los ua lub fydrochloride daim ntawv ntawm cycloheptadine hydrochloride Sesquihydrate.
Nov yog cov txheej txheem yooj yim ntawm cov txheej txheem hluavtaws, thiab cov txheej txheem synthesis tiag tej zaum yuav nyuaj thiab muaj lwm yam nruab nrab thiab reagents. Ib qho ntxiv, muaj lwm txoj kev sib txawv ntawm cov qauv hluavtaws sib txawv ntawm, thiab cov qauv tshwj xeeb yuav txawv nyob ntawm cov kws tshawb fawb thiab cov tuam txhab kws tshuaj.
Thov nco ntsoov tias cov ntaub ntawv saum toj no yog rau kev siv xwb. Yog tias koj xav tau kev nkag siab tob txog cov txheej txheem synthesis ntawm cyclokhloride sesquihydrate, nws raug nquahu kom sab tswv teb hauv cov teb tsim nyog. Thov ua raws li txoj cai thiab cov cai tswjfwm cuam tshuam thiab kev coj ua cov kev ua yeeb yam tshuaj lom nyob rau hauv cov kev sim uas tsim kev sim.
Solubility:
Cycloheptadine hydrochloride sesquihydrate muaj solubility zoo hauv dej. Nws kuj tseem tuaj yeem yaj nyob rau qee cov kuab tshuaj organic, xws li methhanol, ethanol, thiab chloroform.
01
Acidity thiab Alkalinity:
Cycloheptadine hydrochloride sesquihydrate yog ib qho tshuaj nyob rau hauv daim ntawv ntawm hydrochloride, yog li nws muaj acidity. Nws tuaj yeem hnov mob nrog cov alkali los ua cov ntsev ua yeeb yam.
02
Hydrolysis:
Nyob rau hauv acidic los yog alkaline tej yam kev mob, cycloheptadine hydrochloride Sesquihydrate tuaj yeem nthuav tawm cov kev siv hydrolysis. Qhov no yuav cuam tshuam nws cov kev metabolism thiab ua tau zoo hauv cov kab mob muaj sia.
03
Redox:
Cyprooheptadine hydrochloride Sesquihydratemuaj qee pab pawg oxidizable pawg thiab tuaj yeem koom nrog redox. Txawm li cas los xij, nws tus cwj pwm tshwj xeeb hauv Redox xav tau kev kawm ntxiv.
04
Cov duab:
Qee cov tshuaj thiab cov tebchaw yog rhiab rau lub teeb, thiab cycloheptadine hydrochloride sesquihydrate kuj kuj tseem muaj qee cov kws yees duab. Yog li ntawd, tshav ntuj ncaj qha yuav tsum raug zam thaum lub sijhawm cia thiab siv.
05
Nws yuav tsum tau sau tseg tias cov tshuaj tiv thaiv cov tshuaj tshaj plaws tau piav qhia saum toj no tsuas yog muaj qee yam, thiab tej zaum yuav muaj lwm cov tshuaj uas tsis tau teev tseg. Ib qho ntxiv, cov tshuaj tiv thaiv cov tshuaj feem ntau muaj feem cuam tshuam nrog cov kev mob ib puag ncig, muaj lwm qhov sib txuas, thiab muab ntau npaum li cas. Rau cov tshuaj tiv thaiv tshwj xeeb thiab tus cwj pwm, nws raug pom zoo kom tham cov ntaub ntawv tshuaj paub ntau yam lossis sab tswv hauv cov kws tshaj lij hauv cov kws tshaj lij.
Cim npe nrov: Cyproheptadine Hydrochloride Sesquihydrate CAS 41354-29-4, cov neeg muag khoom, chaw tsim khoom, lag luam, yuav khoom, rau muag