Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm dimethyl fumarate (dmf) cas 624-49-7 nyob Suav teb. Txais tos rau cov lag luam wholesale bulk zoo dimethyl fumarate (dmf) cas 624-49-7 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Dimethyl Fumarate (DMF), tseem hu ua Allomaleic dimethyl ester, feem ntau hu ua anti pwm thiab preservative tus neeg saib xyuas Makoxin 1, abbreviated li DMF. CAS 624-49-7, Molecular formula C6H8O4, dawb crystalline los yog crystalline hmoov nyob rau hauv chav tsev kub. Soluble hauv ethyl acetate, chloroform, acetone, thiab cawv, me ntsis soluble hauv ether, thiab me ntsis soluble hauv dej. DMF yog tshuaj lom. Vim nws corrosiveness thiab allergenicity rau tib neeg lub cev, kev soj ntsuam kev sim tau pom tias DMF tuaj yeem ua rau muaj kev puas tsuaj thiab ua xua rau tib neeg txoj hnyuv thiab cov kab mob hauv nruab nrog cev thaum nqus tau los ntawm txoj hlab pas; Thiab thaum cov khoom no nkag mus rau hauv daim tawv nqaij, nws tuaj yeem ua rau mob dermatitis, nrog rau khaus, khaus, liab, thiab kub hnyiab; Nws tau ua phem rau tib neeg lub cev noj qab haus huv, tshwj xeeb tshaj yog rau kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus. Dimethyl fumarate tau siv dav hauv cov khoom noj, dej haus, pub, tshuaj suav tshuaj, tshuaj pleev ib ce, ntses, nqaij, zaub, txiv hmab txiv ntoo, thiab lwm yam teb los tiv thaiv pwm, corrosion, kab, thiab freshness. Tam sim no nws tau muab cais ua cov khoom siv tsis tau thiab tsis tuaj yeem siv rau hauv cov khoom noj (xws li noodles).
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Tshuaj Formula |
C6H8O4 |
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Exact Mass |
144 |
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Molecular Luj |
144 |
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m/z |
144 (100.0%), 145 (6.5%) |
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Elemental Analysis |
C, 50.00; H, 5.60; O, 44.40 |
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Dimethyl Fumarate (DMF), raws li cov organic compound nrog cov khoom siv tshuaj tshwj xeeb, tau ua kom pom kev siv nyiaj ntau hauv ntau qhov chaw. Nws ib zaug tuav txoj haujlwm tseem ceeb hauv kev lag luam ntawm kev tiv thaiv pwm thiab tiv thaiv- corrosion vim nws cov kev ua haujlwm siab, dav -spectrum antibacterial zog, thiab tsis muaj tshuaj lom. Nyob rau tib lub sijhawm, nws kuj tau ua lub luag haujlwm tseem ceeb ua cov tshuaj kho mob ntau yam sclerosis hauv kev lag luam kws tshuaj. Txawm li cas los xij, nrog kev tshawb fawb tob zuj zus ntawm nws cov tshuaj toxicity thiab allergenicity, nws daim ntawv thov tau raug txwv me ntsis.
Muaj kev tiv thaiv pwm thiab tiv thaiv -corrosion teb
Khoom noj khoom haus los tiv thaiv pwm thiab tiv thaiv-corrosion (ib zaug siv dav, tam sim no txwv)
Kev tiv thaiv pwm pwm: Dimethyl fumarate ua tau zoo hauv kev tiv thaiv pwm ntawm qhob cij, thiab nws cov txiaj ntsig zoo tshaj li cov tshuaj tua kab mob xws li calcium propionate. Nyob rau hauv tib lub chaw cia khoom, qhob cij nrog dimethyl fumarate ntxiv tuaj yeem tswj tau cov pwm dawb rau 475 hnub, thaum lub khob cij nrog calcium propionate ntxiv tuaj yeem tswj tau nws li 16-30 hnub. Qhov no feem ntau yog vim muaj peev xwm ntawm dimethyl fumarate los tiv thaiv ntau yam pwm hauv cov khoom noj, xws li Aspergillus flavus, Aspergillus niger, Penicillium, Aspergillus oryzae, Aspergillus oryzae, thiab Fusarium graminearum, zoo txuas lub txee lub neej ntawm khob cij.
Lwm cov zaub mov los tiv thaiv pwm: Ntxiv rau cov qhob cij, dimethyl fumarate kuj tau siv los tiv thaiv pwm, tiv thaiv- corrosion, thiab khaws cia cov ntses, nqaij, zaub, txiv hmab txiv ntoo, thiab lwm yam khoom noj. Nws muaj cov nyhuv inhibitory zoo ntawm cov pwm, cov poov xab, thiab cov kab mob, uas tuaj yeem tiv thaiv cov khoom noj los ntawm kev lwj vim muaj kab mob microbial thaum khaws cia thiab kev thauj mus los. Piv txwv li, ntxiv dimethyl fumarate rau cov khoom noj nqaij tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob thiab cov pwm, txo cov khoom noj khoom haus thiab tsw ntau lawm, thiab tswj qhov tshiab thiab saj ntawm nqaij.
Mechanism ntawm kev ua: Cov tshuaj tua kab mob ntawm dimethyl fumarate nyob rau hauv nws lub xeev molecular, uas tuaj yeem nkag mus rau hauv cell membrane ntawm cov kab mob, nkag mus rau hauv lub cell, inhibit microbial cell division, thiab suppress microbial respiration los ntawm inhibiting enzyme kev ua si nyob rau hauv lub tricarboxylic acid voj voog (TCAC), hexose phosphate pathway (HMP), thiab fermenting microbial txoj kev loj hlob. kev yug me nyuam.
Pub pwm tiv thaiv
Qhov zoo ntawm cov nyhuv los tiv thaiv pwm: Dimethyl fumarate muaj cov nyhuv zoo dua los tiv thaiv pwm ntawm kev noj ntau dua acidic preservatives xws li propionate, sorbic acid, thiab benzoic acid. Hauv PDA nruab nrab uas muaj 500-800ppm, nws tuaj yeem cuam tshuam tag nrho cov pwm thiab kab mob. Ntxiv dimethyl fumarate rau pub tuaj yeem tiv thaiv cov khoom noj tsis zoo thiab kev puas tsuaj zoo los ntawm cov kab mob pwm thaum lub sij hawm cia, ua kom muaj kev noj qab haus huv ntawm cov tsiaj nyeg thiab nqaij qaib.
Daim ntawv thov txoj kev: Dimethyl fumarate feem ntau yog ntxiv rau pub rau hauv ib qho kev faib ua feem, thiab los ntawm kev sib xyaw ua ke, nws tau muab faib ua tus sib npaug hauv kev pub kom siv nws cov nyhuv los tiv thaiv pwm. Hauv kev siv cov tswv yim, nws yog ib qho tsim nyog los txiav txim siab qhov tsim nyog ntawm dimethyl fumarate raws li cov yam ntxwv xws li hom pub, qhov chaw cia, thiab lub sijhawm cia.
Lwm yam kev lag luam los tiv thaiv pwm thiab tiv thaiv- kev ntsuas corrosion
Tawv, khau, thiab textile tiv thaiv pwm:Dimethyl Fumarate (DMF)yog siv dav hauv cov khoom lag luam hauv tsev, thiab ntau cov khau khau, rooj tog tawv tawv, thiab cov khoom siv hauv tsev tau ntim rau hauv cov dej noo- cov hnab pov thawj uas muaj cov khoom xyaw no rau kev tiv thaiv pwm thiab ya raws. Nws tuaj yeem cuam tshuam kev loj hlob ntawm cov pwm ntawm cov tawv nqaij, khau, thiab textiles, tiv thaiv cov khoom los ntawm kev tsim cov ntxhiab tsw, discoloration, thiab kev puas tsuaj vim pwm, thiab ntev kev pab cuam lub neej ntawm cov khoom.
Kev tiv thaiv pwm ntawm cov khoom siv tshuaj suav tshuaj: Cov khoom siv tshuaj suav tshuaj tau yooj yim kis los ntawm pwm thaum lub sijhawm khaws cia, uas cuam tshuam rau lawv qhov zoo thiab kev ua tau zoo. Dimethyl fumarate tuaj yeem siv los tiv thaiv pwm kev kho mob ntawm cov tshuaj suav tshuaj, los ntawm inhibiting kev loj hlob ntawm pwm, tswj lub dryness thiab purity ntawm tsoos suav tshuaj, thiab xyuas kom meej stability ntawm nws zoo.
Tshuaj pleev ib ce tiv thaiv pwm: Tshuaj pleev ib ce muaj nplua nuj as-ham thiab tuaj yeem yooj yim los ua ib qho chaw yug me nyuam rau cov kab mob. Cov tshuaj tua kab mob ntawm dimethyl fumarate tuaj yeem siv rau hauv cov tshuaj pleev ib ce los tiv thaiv kev kis kab mob los ntawm cov pwm thiab cov kab mob thaum khaws cia thiab siv, ua kom muaj kev nyab xeeb thiab ua haujlwm zoo ntawm cov tshuaj pleev ib ce.
Qhov zoo ntawm kev siv cov yam ntxwv
Tsawg toxicity thiab high efficiency: Dimethyl fumarate muaj cov yam ntxwv ntawm cov tshuaj toxicity tsawg, nrog rau LD50 (qhov ncauj tswj hwm rau nas) ntawm 2240 mg / kg. Tom qab nkag mus rau tib neeg lub cev, nws sai sai dhau los ua ib qho kev tiv thaiv metabolic fumarate, nrog kev nyab xeeb siab. Nyob rau tib lub sijhawm, nws muaj qhov cuam tshuam zoo rau ntau tshaj 30 hom pwm, cov poov xab, thiab cov kab mob, ua rau nws muaj txiaj ntsig zoo los tiv thaiv pwm thiab khaws cia.
Broad spectrum antibacterial: Nws cov kab mob tua kab mob yog qhov dav, thiab nws muaj kev cuam tshuam rau ntau yam pwm, cov poov xab, thiab cov kab mob, uas ua rau nws muaj txiaj ntsig zoo hauv kev tiv thaiv pwm thiab tiv thaiv - daim ntawv thov corrosion nyob rau hauv ntau hom kev lag luam.
Dual teebmeem ntawm kev sib cuag kom tsis muaj menyuam thiab fumigation sterilization: Dimethyl fumarate muaj zog lom lom zem thiab sublimation zog, yog li nws muaj ob qhov teebmeem ntawm kev sib cuag kom tsis muaj menyuam thiab fumigation sterilization. Qhov no tso cai rau nws los tiv thaiv pwm thiab tiv thaiv- cuam tshuam corrosion nyob rau hauv ib puag ncig sib txawv, tshwj xeeb tshaj yog tsim rau cov chaw kaw lossis cov khoom ntim khoom uas yuav tsum muaj kev tiv thaiv pwm.
Kev ua kom sov zoo thiab dav pH ntau: Nws tuaj yeem siv rau hauv pH ntau ntawm 3-8 thiab muaj cov cua sov zoo, uas ua rau nws muaj kev ruaj khov los tiv thaiv pwm thiab tiv thaiv corrosion nyob rau hauv ntau qhov chaw tsim khoom thiab chaw cia khoom.
Kev kho mob teb
Kho ntau yam sclerosis
Kev siv tshuaj thiab kev siv tshuaj: Dimethyl fumarate yog ib qho kev siv dav dav siv tshuaj kho mob (DMT) qhov ncauj rau ntau yam sclerosis (MS). Nws cov kev ua tau zoo thiab kev nyab xeeb tau txais kev txhawb nqa los ntawm ntau tshaj kaum xyoo dhau los, nrog ze li 600000 tus neeg mob thoob ntiaj teb tau txais kev kho mob nrog dimethyl fumarate, ua rau nws cov tshuaj DMT nrog cov neeg mob ntau tshaj plaws thoob ntiaj teb. Cov tshuaj tau pom zoo siv nyob rau hauv Suav teb xyoo 2021 thiab suav nrog hauv daim ntawv pov hwm kho mob hauv Suav teb rau xyoo 2022, muab kev kho mob tshiab rau ntau tus neeg mob sclerosis hauv Suav teb.
Mechanism ntawm kev nqis tes ua: Dimethyl fumarate feem ntau ua rau lub cev tiv thaiv kab mob thiab kev tiv thaiv ntawm tes los ntawm kev ua kom txoj hauv kev Nrf2. Nws tuaj yeem tswj hwm cytokine kev qhia thiab kev tiv thaiv kab mob hauv lub cev, hloov lub cev tiv thaiv kab mob los ntawm pro-inflammatory mus rau anti-inflammatory, yog li txo cov inflammatory teb rau cov neeg mob uas muaj ntau yam sclerosis. Nyob rau tib lub sijhawm, nws tuaj yeem tiv thaiv oxidative kev nyuaj siab puas tsuaj, tiv thaiv neurons thiab oligodendrocytes los ntawm kev tuag, pab ncua kev loj hlob ntawm ntau yam sclerosis, thiab txo cov kab mob rov qab.
Kev ua tau zoo thiab kev nyab xeeb: Piv nrog rau lwm cov tshuaj ntawm qhov ncauj ntau yam sclerosis xws li fingolimod thiab teriflunomide, dimethyl fumarate muaj txiaj ntsig zoo dua hauv kev kho mob ntau yam kab mob sclerosis, thiab muaj qhov zoo xws li kev nyab xeeb thiab kev tiv thaiv zoo. Hais txog hematology thiab kev pheej hmoo kis tus kab mob, cov neeg mob tau txais kev kho mob nrog dimethyl fumarate tsis ua rau muaj kev pheej hmoo ntawm kev kis kab mob, thiab lymphocyte depletion hnyav heev. Nws yuav tsis ua rau lub cev tsis muaj zog tiv thaiv kab mob rau cov tshuaj tiv thaiv COVID-19, thiab yuav tsis ua rau muaj kev pheej hmoo kis mob hnyav nrog COVID-19.
Kev tswj cov xwm txheej tsis zoo: Cov kev cuam tshuam ntawm plab hnyuv thiab dej ntws tawm tuaj yeem yog cov xwm txheej tseem ceeb ntawm dimethyl fumarate, tab sis tuaj yeem tswj hwm los ntawm kev sib tham / kev kawm rau tus neeg mob, kev kho mob, thiab kev hloov pauv ntawm cov tshuaj. Piv txwv li, cov xwm txheej tsis zoo hauv plab hnyuv tuaj yeem tiv thaiv lossis txo qis los ntawm kev noj cov zaub mov, maj mam nce cov koob tshuaj rau tus qauv, kho cov tsos mob, lossis txo qis ib ntus; Redness tuaj yeem tiv thaiv lossis txo qis los ntawm kev noj nws nrog zaub mov lossis kho nws cov tsos mob (xws li tshuaj aspirin lossis tshuaj tiv thaiv kab mob).
Kev tshawb fawb Anticoagulation: Nyob rau lub Rau Hli 2023, kev tshawb fawb los ntawm Biomedical Research Institute ntawm Trinity College Dublin pom tias dimethyl fumarate (DMF) thiab lwm yam compound 4-octyl itaconic acid ester (4-OI) tuaj yeem inhibit qhov tsim ntawm hom I interferon (IFN - ), muaj kev tiv thaiv kev tiv thaiv kab mob, thiab txo cov ntaub so ntswg los ntawm kev cuam tshuam ntawm macrophage. Anticoagulant cuam tshuam. DMF tau txhim kho cov tsos mob ntawm nas thiab nce kev muaj sia nyob hauv LPS, Escherichia coli, thiab Staphylococcus aureus tus qauv kab mob. Qhov kev tshawb pom no muab kev tshawb fawb tshiab rau kev siv peev xwm ntawm dimethyl fumarate hauv cov kab mob thrombotic thiab lwm yam.
Muaj peev xwm kho tau lwm yam kab mob: Nrog rau kev tshawb fawb txuas ntxiv ntawm dimethyl fumarate, cov kws tshawb fawb tseem tab tom tshawb nrhiav nws lub peev xwm hauv kev kho mob ntawm lwm yam kab mob. Piv txwv li, kev tshawb fawb tam sim no tab tom ua hauv qee yam kab mob autoimmune, kab mob inflammatory, thiab lwm yam, vam tias yuav nrhiav tau ntau yam kev kho mob thiab muab cov neeg mob nrog ntau txoj kev kho mob.
Dimethyl fumarate yog ib qho kev sib xyaw nrog ntau yam tshuaj lom neeg thiab ntau yam kev siv. Nws siv nyob rau hauv kev lag luam kws tshuaj rau kev kho mob ntawm ntau yam sclerosis thiab lwm yam kab mob autoimmune muaj kev cia siab rau cov neeg mob, thaum nws muaj peev xwm nyob rau hauv lub polymer kev lag luam thiab lwm qhov chaw kuj qhia tau hais tias cog lus. Txawm li cas los xij, kev txhawj xeeb txog kev nyab xeeb cuam tshuam nrog DMF, tshwj xeeb tshaj yog nws lub peev xwm ua rau cov tawv nqaij rhiab heev, ua pa thiab qhov muag, thiab nws cov teebmeem carcinogenic thiab mutagenic, tsis tuaj yeem tsis quav ntsej.
Kev tswj hwm thaj chaw nyob ib puag ncig DMF qhia txog qhov xav tau los sib npaug nws cov kev siv tau zoo nrog kev tiv thaiv tib neeg kev noj qab haus huv thiab ib puag ncig. Raws li kev tshawb fawb txuas ntxiv mus, nws zoo li qhov kev nkag siab tshiab rau cov khoom thiab kev siv DMF yuav tshwm sim, nrog rau kev txhim kho kev nyab xeeb thiab lwm cov kev sib txuas uas tuaj yeem muab cov txiaj ntsig zoo sib xws yam tsis muaj kev pheej hmoo cuam tshuam. Nyob rau lub sijhawm no, kev ua raws li cov cai uas twb muaj lawm thiab kev ua raws li kev tiv thaiv kev nyab xeeb tsim nyog yog qhov tseem ceeb thaum tuav thiab siv DMF.
Cov lus nug nquag
Puas yog dimethyl fumarate yog DMT?
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Dimethyl fumarate yog ib hom kab mob hloov kho (DMT) rau active relapsing MS. Nws lub npe yog Tecfidera. Koj muab nws ua ib ntsiav tshuaj.
Dab tsi yog qhov cuam tshuam ntawm DMF?
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Dimethyl fumarate tuaj yeem ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav heev lossis tsis ploj mus:
sov, liab, khaus, los yog hlawv ntawm daim tawv nqaij.
raws plab.
xeev siab.
ntuav.
mob plab.
mob plawv.
Dab tsi yog dimethyl fumarate siv rau?
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Dimethyl fumarate yog siv los kho cov kab mob sib kis ntawm ntau yam sclerosis (MS), suav nrog kev kuaj mob cais tawm, rov qab ua dua - kab mob rov ua dua, thiab cov kab mob kis tau zoo thib ob. Cov tshuaj no yuav tsis kho MS, tab sis nws yuav ua rau qee qhov cuam tshuam tsis zoo thiab txo tus lej ntawm tus kab mob rov qab.
Cim npe nrov: Dimethyl Fumarate (dmf) CAS 624-49-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom