Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub ntau tshaj plaws thiab cov neeg muag khoom ntawm theophylline hmoov cas 58-55-9 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk siab zoo theophylline hmoov cas 58-55-9 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Tshaj tawm
Cov tshuaj no raug txwv tsis pub muag, peb lub vev xaib tsuas tuaj yeem tshawb xyuas cov ntaub ntawv yooj yim. ntawm cov tshuaj no, peb tsis muag lawv!
Kaum Ib Hlis 19, 2025
Theophylline hmoovyog ib hom methylxanthine alkaloid nrog cov tshuaj formula C₇H₈N₄O₂. Nws zoo nkaus li dawb crystalline hmoov, muaj ib tug me ntsis iab saj, yog insoluble nyob rau hauv dej (1:120) thiab ethanol, thiab yog yooj yim soluble nyob rau hauv alkaline daws. Nws yog ib yam khoom uas muaj nyob rau hauv tshuaj yej thiab kas fes, tab sis kws tshuaj -qib theophylline feem ntau yog ua los ntawm cov tshuaj.
Pharmacological teebmeem thiab kev siv:
Theophylline inhibits phosphodiesterase (PDE) thiab blocks adenosine receptors, so cov leeg du ntawm bronchi. Nws yog ib tug classic bronchodilator thiab yog siv los kho mob hawb pob, mob ntsws obstructive pulmonary disease (COPD), thiab cov me nyuam mos apnea ntxov ntxov. Nws cov teebmeem muaj xws li nthuav dav cov hlab pa, tiv thaiv - mob, thiab txhim kho diaphragm contractility.
Nco tseg:
Nws muaj cov nyhuv synergistic nrog caffeine thiab yuav tsum tsis txhob siv ua ke.
Cov neeg mob uas muaj kab mob siab thiab lub plawv tsis ua haujlwm yuav tsum tau kho lawv cov koob tshuaj.
Hom kev npaj ntau yog txhawb nqa - tso cov ntsiav tshuaj. Hmoov feem ntau yog siv nyob rau hauv lub chaw soj nstuam los yog rau kev txhim kho kev npaj tshwj xeeb.
Nws yuav tsum tau muab kaw thiab khaws cia rau hauv qhov chaw tsaus kom tsis txhob ya raws thiab decomposition.
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Tshuaj Formula |
C7H8N4O2 |
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Exact Mass |
180 |
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Molecular Luj |
180 |
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m/z |
180 (100.0%), 181 (7.6%) |
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Elemental Analysis |
C, 46.67; H, 4.48; N, 31.10; O, 17.76 |
Pharmacokinetics:
Qhov ncauj nqus tau nrawm, tab sis muaj qhov sib txawv ntawm tus kheej tseem ceeb ( cuam tshuam los ntawm lub hnub nyoog thiab lub siab enzymes ). Lub plasma ib nrab -lub neej yog kwv yees li 6-12 teev. Kev soj ntsuam cov ntshav cov tshuaj concentration yog tsim nyog (kev kho qhov rai yog nqaim: 5-20 ug / mL). Kev noj ntau dhau yuav ua rau muaj kev phom sij xws li palpitations thiab convulsions.
Kev ua haujlwm ntawmtheophylline hmoovnyob rau hauv refreshing thiab awakening lub hlwb feem ntau stems los ntawm nws cov khoom raws li ib tug central paj hlwb stimulant.
Cov hauv qab no yog cov lus piav qhia ntxaws txog kev ua haujlwm ntawm theophylline hauv kev ua kom lub siab thiab ua kom lub siab:
1. Txhawb lub hauv nruab nrab paj hlwb
Nws tuaj yeem ua ncaj qha rau hauv nruab nrab lub paj hlwb, tshwj xeeb tshaj yog qee yam neurotransmitters hauv lub hlwb, xws li dopamine thiab norepinephrine. Cov neurotransmitters no ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev mloog, kev ceeb toom, thiab kev ua siab zoo. Los ntawm kev txhawb nqa kev tso tawm ntawm cov neurotransmitters no, kev ua haujlwm ntawm lub hlwb tuaj yeem nce ntxiv, ua rau tib neeg ceeb toom thiab ceeb toom.
2. Ua kom ntau ntxiv
Vim nws lub peev xwm los txhim kho kev ua haujlwm ntawm lub hauv paus paj hlwb, nws tuaj yeem txhim kho tib neeg kev mloog thiab kev xav. Qhov no ua rau tib neeg tswj hwm kev ua tau zoo dua thaum ua cov haujlwm uas yuav tsum tau muaj siab, xws li kawm, ua haujlwm, lossis tsav tsheb.
3. Txhim kho cov tshuaj tiv thaiv ceev
Nws tseem tuaj yeem ua kom nrawm nrawm ntawm cov teeb liab neural, yog li txhim kho tib neeg cov tshuaj tiv thaiv ceev. Qhov no ua rau tib neeg tuaj yeem hnov mob sai dua thiab txhim kho lawv lub peev xwm los teb thaum ntsib cov xwm txheej tsis tau xav txog lossis xav tau kev txiav txim siab sai.
4. Txo kev qaug zog
Kev ua haujlwm ntev lossis kev kawm ntev tuaj yeem ua rau qaug zog, uas tuaj yeem pab txo qis kev qaug zog thiab rov ua kom lub hlwb muaj zog los ntawm kev txhawb nqa lub hauv paus paj hlwb. Qhov no yog qhov tseem ceeb heev rau kev txhim kho kev ua haujlwm thiab kev kawm tau zoo.
5. Txhim kho kev xav
Nws kuj tuaj yeem cuam tshuam rau tus neeg lub siab lub ntsws. Qee qhov kev tshawb fawb tau pom tias nws tuaj yeem txhim kho tib neeg lub siab lub ntsws, ua rau lawv zoo siab thiab so. Qhov no kuj muaj qee qhov txiaj ntsig zoo ntawm kev txo qhov nro thiab txhim kho kev pw tsaug zog zoo.
Theophylline hmoovtuaj yeem txhim kho tib neeg lub cev tiv thaiv kab mob, txhim kho lub cev tiv thaiv, thiab txo qhov tshwm sim ntawm cov kab mob. Nws txhim kho cov haujlwm thiab ntau ntawm lub cev tiv thaiv kab mob los ntawm kev tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, yog li txhim kho lub cev tiv thaiv kab mob.
Kev ua haujlwm ntawm theophylline hauv kev txhim kho kev tiv thaiv kab mob feem ntau tshwm sim hauv cov hauv qab no:
1. Txhawb kev ua haujlwm ntawm lub cev tiv thaiv kab mob
Tom qab nqus tau, nws tuaj yeem nkag mus rau cov ntaub so ntswg sai sai xws li cov ntshav, daim siab, thiab lub hlwb, yog li txhawb tib neeg lub cev tiv thaiv kab mob, xws li gamma Delta T-cells, tiv thaiv kev cuam tshuam ntawm cov kab mob, kab mob, thiab fungi. Lub tswv yim ntawm qhov kev txiav txim no yog los txhawb kev tso tawm ntawm interferon los ntawm T- zoo li cov hlwb, tsim "tshuaj tiv thaiv kab" rau tib neeg lub cev tiv thaiv kab mob.
2. Txhim kho lub cev tiv thaiv kab mob muaj peev xwm tiv taus
Raws li kev tshawb fawb los ntawm Brigham thiab Women's Hospital ntawm Harvard University, ntev - haus ntau tshaj 5 khob tshuaj yej ib hnub twg muaj txiaj ntsig zoo rau kev tiv thaiv kab mob sib kis thiab txhim kho kev tiv thaiv kab mob. Qhov no qhia tau hais tias kev noj cov tshuaj no txaus los txhim kho lub cev muaj peev xwm tiv thaiv kab mob tshwj xeeb.
3. Synergistic nyhuv nrog tshuaj yej polyphenols
Cov tshuaj yej polyphenols hauv tshuaj yej kuj tseem yog yam tseem ceeb hauv kev txhim kho kev tiv thaiv. Tshuaj yej polyphenols muaj antioxidant zog thiab tuaj yeem txhim kho lub cev tiv thaiv kab mob. Tib lub sijhawm, tshuaj yej polyphenols kuj muaj cov tshuaj tua kab mob, xws li inhibiting Staphylococcus, Escherichia coli, Bacillus subtilis, thiab lwm yam., ntxiv kev tiv thaiv lub cev los ntawm kev kis kab mob.
4. Anti inflammatory thiab immunomodulatory teebmeem
Nyob rau hauv xyoo tas los no, nrog rau hauv - kev tshawb fawb tob ntawm nws cov tshuaj pharmacological, nws tau pom tias cov tshuaj no tsawg muaj cov tshuaj tiv thaiv -inflammatory thiab immunomodulatory teebmeem. Qhov no ntxiv txhim kho cov xwm txheej ntawm cov tshuaj hauv kev kho mob ntawm cov kab mob ua pa thiab tej zaum yuav muaj peev xwm kho tau rau lwm yam kab mob tiv thaiv kab mob.
5. Txhawb txoj hnyuv
Theophylline thiab lwm yam khoom hauv tshuaj yej, xws li cellulose, tuaj yeem txhawb txoj hnyuv peristalsis thiab txhim kho txoj hnyuv. Kev noj qab haus huv ntawm plab hnyuv muaj feem cuam tshuam nrog lub cev tiv thaiv kab mob, yog li ntawd, kev noj qab haus huv txoj hnyuv indirectly txhim kho lub cev tiv thaiv kab mob.
6. Cov teebmeem Antioxidant
Nws kuj muaj qee yam antioxidant nyhuv, uas tuaj yeem tshem tawm cov dawb radicals hauv lub cev, tiv thaiv kev puas tsuaj ntawm tes thiab kev laus. Dawb radicals yog ib qho ntawm cov tseem ceeb ua rau kev puas tsuaj ntawm tes thiab kev laus. Yog li ntawd, cov nyhuv antioxidant ntawm theophylline pab tiv thaiv cov hlwb thiab tswj kev tiv thaiv kab mob hauv lub cev.
Theophylline tau pib muab rho tawm los ntawm tshuaj yej thiab tshuaj ntsuam xyuas los ntawm German biologist Albrecht Kossel.
Emil Fischer thiab Lorenz Ach tau piav qhia txog cov txheej txheem tshuaj synthesis pib los ntawm 1,3-dimethyluric acid.
Lwm tus kws tshawb fawb German Wilhelm Traube tau qhia ib txoj hauv kev tshiab rau kev sib xyaw theophylline - Traube purine synthesis method.
Theophylline yog thawj zaug siv kho mob raws li diuretic. Nees nkaum xyoo tom qab, theophylline tau xub tshaj tawm tias yog kev kho mob hawb pob.
Cov tshuaj no tau tsim rau hauv cov tshuaj phoov Theostat 20 thiab Theostat 80.
Nws tau ua rau hauv ib ntsiav tshuaj hu ua Quibron.
Ua ntej, hauv txoj kev sib xyaw no, peb npaj theophylline los ntawm 1,3-dimethyl-4-amino-5-formamide uracil ua cov khoom pib los ntawm kev ua haujlwm nrog sodium hydroxide. Cov hauv qab no yog cov kauj ruam ntxaws ntxaws thiab sib npaug ntawm cov tshuaj sib npaug:
- Ua ntej, maj mam ntxiv 1,3-dimethyl-4-amino-5-formamide uracil rau cov tshuaj sodium hydroxide.
-React ntawm 90-95℃thiab do cov sib tov kom tag nrho react.
-Thaum cov txheej txheem tshuaj tiv thaiv, 1,3-dimethyl-4-amino-5-formamidomyrimidine reacts nrog sodium hydroxide los ua theophylline. Qhov ua tau tshuaj sib npaug rau cov tshuaj tiv thaiv yog raws li nram no:
1,3-dimethyl-4-amino-5-formamidomyluracil + NaOH → C7H8N4O2+ lwm yam khoom
- Txias cov tshuaj tiv thaiv sib tov rau hauv chav tsev kub, qhov twg cov theophylline crude yuav tau txais.
- Dissolve theophylline crude nyob rau hauv dej kub thiab maj mam txias rau hauv chav tsev kub los txhawb lub recrystallization ntawm theophylline.
- Lim kom tau txais cov khoom siv theophylline recrystallized.
-Ua cov tshuaj recrystallized theophylline los ntawm cov kab hluav taws xob qhib kom tshem tawm cov impurities thiab txhim kho cov khoom purity.
- Sau cov tshuaj theophylline uas tau decolorized los ntawm cov pa roj carbon activated, crystallize los yog qhuav nws dua, thiab thaum kawg tau txais cov khoom siab tshaj -purity theophylline.
Los ntawm cov kauj ruam saum toj no, peb ua tiav synthesizedtheophylline hmoovthiab tau txais siab -purity theophylline cov khoom los ntawm cov dej kub recrystallization thiab activated carbon decolorization. Cov txheej txheem ntawm cov dej kub recrystallization tuaj yeem txhim kho qhov purity ntawm cov khoom, thaum qhib cov pa roj carbon decolorization ntxiv purifies cov khoom los ntawm adsorbing impurities. Kev ua haujlwm zoo thiab kev tswj hwm ntawm cov kauj ruam no ua kom zoo thiab purity ntawm cov khoom kawg.
Theophylline, ua ib qho tseem ceeb alkaloid compound, muaj ntau yam kev siv hauv tshuaj thiab lwm yam. Kev tsim thiab kev ua kom zoo ntawm cov txheej txheem synthesis no muab txoj hauv kev ua tau zoo rau kev npaj tau zoo ntawm theophylline.
Zoo li lwm yam methylated xanthine derivatives.
Theophylline tau pom tias thaiv TGF beta kev sib kho los ntawm cAMP PKA, yog li inhibiting kev hloov ntawm lub ntsws fibroblasts rau myofibroblasts hauv COPD thiab mob hawb pob, thiab suppressing COL1 mRNA encoding collagen.
(1)
Kev sib tw uas tsis yog xaiv phosphodiesterase inhibitors tuaj yeem nce qib hauv cov cell ntawm cyclic adenosine monophosphate (cAMP), qhib cAMP dependent protein kinase (PKA), inhibit TNF - - mediated teebmeem, suppress leukotriene synthesis, alleviate inflammatory and innate immunity.
(2)
Tsis yog xaiv adenosine receptor antagonists yuav luag sib npaug antagonize A1, A2, thiab A3 receptors, uas piav qhia lawv ntau yam cuam tshuam rau lub plawv.
Nws tau raug pom tias theophylline tuaj yeem thim rov qab steroid insensitivity nyob rau hauv kev soj ntsuam soj ntsuam ntawm cov neeg haus luam yeeb uas muaj mob ntsws obstructive pulmonary kab mob thiab mob hawb pob (kev haus luam yeeb yog ib yam mob uas ua rau oxidative kev nyuaj siab) los ntawm ib tug ntshiab ywj siab mechanism. Theophylline tuaj yeem kho qhov txo qis ntawm HDAC (histone deacetylase) los ntawm oxidative stress (ie cell apoptosis). Tsis tas li ntawd, theophylline tau pom tias ncaj qha qhib HDAC2. Corticosteroids kaw cov lus teb inflammatory los ntawm kev thaiv cov kev qhia ntawm cov neeg kho mob inflammatory los ntawm histone deacetylation, uas yog kho los ntawm histone deacetylase-2 (HDAC2). Thaum deacetylated, DNA tau rov ntim dua, ua rau thaj tsam txhawb nqa ntawm cov noob caj ces tsis tuaj yeem siv rau kev khi cov ntaub ntawv xws li NF - κ B, uas pib ua haujlwm inflammatory. Cov kev tshawb fawb tsis ntev los no tau pom tias oxidative kev ntxhov siab cuam tshuam nrog cov pa luam yeeb tuaj yeem cuam tshuam cov haujlwm ntawm HDAC2, yog li thaiv cov teebmeem ntawm corticosteroids.
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