DMAE Bitartrate Hmoov, tshuaj lom neeg lub npe 2-dimethylamine ether (+) bitartrate ntsev (dmao), yog ib qho compound nrog molecular formula c8h17no7 thiab CAS 5988-51-2. Nws yog dawb rau me ntsis daj crystalline khoom. Nws feem ntau muaj nyob rau hauv daim ntawv ntawm crystalline hmoov lossis muaju. DMAE Bitartrate muaj cov ntxhiab tsw me me me, tab sis feem ntau nws tsis emit ib qho ntxhiab tsw zoo. Muaj solubility zoo. Nws muaj cov solubility siab hauv dej thiab yog soluble hauv dej thiab dej cawv cov kuab tshuaj xws li ethanol thiab methanol. Nws kuj tseem tuaj yeem hnov cov kua qaub, hauv paus, thiab cov kuab tshuaj organic. Nws solubility nce nrog nce kub. Ib qho ntxiv, nws tseem muaj cov thermal thiab tshuaj ruaj khov ruaj khov, ua rau nws tsis tshua muaj kev piam sij thiab oxidation. Nws yog chiral compound nrog kho qhov muag omotical. Nws qhov sib txig zoo isomer yog sau npe li (+) bitartrate ntsev. Qhov no compound tuaj yeem deflect polarized teeb dhau los ntawm nws. Nws muaj cov ntawv thov dav dav hauv cov haujlwm xws li tshuaj, biochemistry, thiab molecular biology, thiab yog ib qho tseem ceeb. Nyob rau tib lub sijhawm, cov kab sib txuas no tseem tuaj yeem siv los ua ke lwm cov chaw muag tshuaj thiab hluav taws xob.
|
Tshuaj Cov Qauv |
C8h17No7 |
|
Muaj pes tsawg leej |
239 |
|
Molecular hnyav |
239 |
|
m/z |
239 (100.0%), 240 (8.7%), 241(1.4%) |
|
Kev Ntsuam Xyuas |
C, 40.17; H, 7.16; N, 5.86; O, 46.82 |
|
|
|
Dimethyl Amino Ethyl Bittertrate (CAS naj npawb 5988-51-2) yog cov organic sib xyaw ua ke los ntawm kev ua yeeb yam tshuaj lom neeg tsim los ntawm DimethylaminoThand thiab bitartrate. Nws cov mis molecular yog c ₈ h ₁₇ tsis ₇, thiab nws txoj hnyav molecular yog 239.22. Nws cov hmoov dawb dawb, tawv acidity (pH 3.2-3.8), siab solubility (soluble hauv dej
1. Adjessvant kev kho rau cov kab mob neurodegenerative
DimethylaminoThancol tartrate muaj cov teeb meem tseem ceeb nyob rau hauv daim teb neuroprotection, thiab nws cov core tshuab sib xws muaj:
Alzheimer tus kab mob (Ad): Raws li cholinergic prefeor, dimethylaminoolol tarrate tuaj yeem nkag mus rau cov ntshav siab, txhawb kev ua haujlwm acetylcholine, thiab txhim kho kev ua haujlwm zoo nkauj. Cov kev tshawb fawb soj ntsuam tau pom tias nyob rau hauv cov neeg mob me uas muaj qhov sib xyaw mini) thiab cov lej chole) thiab cov ntsiab lus chole) thiab 20% yog 40% ntau dua li pawg monotherapital.
Ncua lub cev muaj zog muaj teeb meem (TDS): Los ntawm kev tswj hwm Dopamine recitor rhiab tuaj yeem txo qis cov neeg mob. Nyob rau hauv 200 cov neeg mob nrog TDDS, tom qab 12 lub lis piam ntawm cov tshuaj tsis tu ncua (lub hom phiaj) txo ntawm 18,3 cov ntsiab lus, nrog tus nqi ntawm 76%.
2. Kev cuam tshuam rau cov menyuam cov kab mob ntsig txog
Enceis nyob rau hauv cov menyuam yaus:DMAE Bitartrate HmoovTxo ib hmos tso zis tawm los ntawm kev ua kom lub taub hau ntawm cov ntsaum ntawm cov tshuaj tiv thaiv kab mob (ADH). Hauv 150 cov menyuam hnub nyoog 5-12 nrog enuresis, kev sib xyaw ua ke ntawm desmopressin tsawg tus nqi ntawm 35% mus rau qhov kev rov ua tiav los ntawm 50% tom qab 4 lub lim tiam ntawm kev kho.
Saib xyuas qhov tsis txaus ntseeg hyperactivity tsis meej (ADHD) rau cov menyuam yaus: Ua ib qho khoom siv gammutyric acid (gama) acculator, dimethylaminotanol tartrate tuaj yeem txhim kho kev tsis txaus siab. Hauv 80 tus menyuam nrog ADHD, tom qab 8 lub lis piam ntawm cov tshuaj, cov qhab nia tag nrho ntawm cov txiaj ntsig ntawm methylphenid, tab sis qhov tshwm sim txo qis ntawm 30%.
3. Kev tswj hwm ntawm cov metabolic syndrome
DimethylaminoThantanol tarottering protaberes rog metabolism los ntawm kev ua kom lub acepifering activerctive receptor (ppp -):
Tsis muaj dej cawv filty (NAFLDLD): hauv 120 NAFLD cov neeg mob, thiab ntsuas los ntawm kev kho mob rau daim siab rog (alt, eth, ast).
Kev Kho Mob Ntshav Qab Zib Hom 2: DetethylaminoThantanol Hydrogen Tartrate tuaj yeem txhim kho cov insulin rhiab. Hauv 60 cov neeg mob uas muaj cov tshuaj txhuam ntshav qab zib hom 2, tom qab mmol / l, thiab glycosylated hemoglobin (HBA1C) txo ntawm 7.8% rau 7.1%.
4. Lub tsev muag tshuaj paub thiab cov stabilizers
Enhanced solubility: In poorly soluble drug formulations such as certain antibiotics and anti-tumor drugs, dimethylaminoethanol tartrate can increase drug solubility by forming soluble salts or complexes. Piv txwv li, thaum ua ke nrog lub meejmalcy, nws solubility nce los ntawm 2.5 zaug, ua rau nws yooj yim dua los npaj kev txhaj tshuaj ntau.
Kev Ruaj Ntseg Ua Kom Zoo: Hauv cov qauv muaj cov ntawv cog lus estrugs (dimethylaminoolol tartrate tuaj yeem inhibit hydrolysis muaj kev cuam tshuam. Kev sim cov ntaub ntawv qhia tau hais tias qhov sib ntxiv ntawm 1% dimethylaminotanol bitretrate rau kev txo qis hauv cov kev ntsuas cov khoom xyaw cov khoom siv ua kom tsis txhob muaj.
1. Kev Noj Qab Haus Huv Fortifiers
Khoom Noj Khoom Haus Txhawb Khoom Noj Khoom Haus:DMAE Bitartrate HmoovRaws li cov choline coline prefeor tuaj yeem txhim kho kev tawm dag zog. Tom qab ntxiv ntxiv nrog DetethylaminoThancol bitartrate (300 mg / min rau 56 ml / min, thiab cov ntshav lactate tsawg dua li 25% tom qab kev tawm dag zog.
Cov zaub mov muaj txiaj ntsig zoo: Nyob rau hauv teb rau cov teeb meem ntawm cov nqaij muaj kuab laus hauv cov neeg laus, dimethylaminool tartrate tuaj yeem siv ua lwm txoj hauv kev ntxiv. Ntawm 100 laus cov neeg hnub nyoog 65 thiab siab dua, tom qab kev ntsuas txuas ntxiv rau kev ntsuas 6 lub hli, thiab cov ntsiab lus tsim kho kom zoo dua li 65%.
2. Acidity txoj cai thiab tsw txhim kho
Dej Haus Kev Lag Luam: Cov khoom siv acidic me ntsis ntawm dimethylas tartrate ua rau nws muaj qhov zoo tshaj plaws acidity regulator. Ntxiv 0.2% -0.5% rau cov kua txiv txiv ntoo tuaj yeem tswj cov nqi PH ntawm 3.5-4.0 thiab txhim kho cov txiv hmab txiv ntoo tsw. Piv txwv li, qee hom kua txiv kab ntxwv nce ntxiv nws cov neeg tau txais kev pab tau ntsuam xyuas los ntawm 7.5 ntsiab lus los ntawm kev ntxiv DetethylaminoVol tartrate.
Cov Khoom Muag Ci: Hauv Ncuav Qab Zib Ua, dimethylaminoThanol tartrate tuaj yeem hloov qee cov ntaub qhwv thiab txhim kho lub khob noom cookie. Qhov kev sim qhia tau pom tias ntxiv 0.3% qhob cij ua rau 10% nce ntxiv hauv ntim thiab ntau cov qauv sab hauv sab hauv.
3. Corrosion thiab Oxidation Kuj
Nqaij yees: DethylaminoThancol tartrate recid oxidation los ntawm chelating hlau ions. Nyob rau hauv lub tub yees kev khaws cia nqaij npuas, ntxiv 0.1% DetethylaminoThancol tartrate tuaj yeem txo tus nqi tbars los ntawm 3 hnub.
Roj kom ruaj khov: Ntxiv 0.05% DetethylaminoThaum cov roj tuaj yeem txo cov roj nrawm ntawm 60 degree, txhim kho cov roj ruaj khov.
Cosmetics research and development: from anti-aging to skin repair
1. Anti Laus Aing Cov Khaub Ncaws
Collagen Synthesis tshaj tawm txoj cai: DetethylaminoThancol tarotes {}} (tgf {{1}- Hauv cov kev sim vito pom tias 0.5% concentration ntawm dimethylasethanol tartrate tuaj yeem nce collagen tso tawm los ntawm 30%.
Dawb radical lom zem: lub qauv hydroxyl ntawm DimethylasTancol tartrate tuaj yeem neutralize cov actions (O ₂⁻) thiab hydroxyl radicals (· Oh). Nyob rau hauv dpph radical scavennging kev sim, nws cov nqi IC50 yog 12.5 μ G / ML, uas tau zoo dua rau cov vitamin C (IC {}} 【G / ML).
2. Kev kho kom tawv nqaij
Txo cov dej tsis sib xws
Kev txhim kho kev khiav dej ntawm stratum Corneum: dimethylaminotanol tartrate tuaj yeem txhawb nqa cov hluav taws xob ntawm ntuj tua neeg (NMF). Nyob rau hauv ib tug qauv tawv nqaij qhuav, 0.5% concentration ntawm dimethylasethanol tartrate tuaj yeem nce cov ntsiab lus noo noo ntawm stratum Corneum ntawm 20%.
3. Kev tu plaub hau
Tiv thaiv kev txiav plaub hau:DMAE Bitartrate HmoovTxo cov khoom lag luam ntawm dihydrotestosterone (AHT) los ntawm inhibiting qhov kev ua ntawm 5 - reductase, yog li unceviating Androdicing Alopecia. Ntawm 60 tus txiv neej cov plaub hau poob, daim ntawv thov hauv zos ntawm kev daws teeb meem rau 6 lub hlis nce cov plaub hau ceev los ntawm 15 cov strands / cm ², nrog tus nqi ntawm 70%.
Cov plaub hau Lus Tshaj Tawm: DetethylaminoVolol tartrate tuaj yeem kho cov tawv nqaij me me. Hauv Electron microscopy soj ntsuam, plaub hau kho nrog 0.2% DetethylaminoTANTANTHANTHANOLOL cov txheej txheem plaub hau ntau dua thiab 30% nce rau hauv qhov chaw mos.
1. Cog Kev Loj Hlob Regulators
Kev Nyab Xeeb Kev Nyuaj Siab: DetethylaminoVolol tartrate tuaj yeem tsim cov ntoo uas muaj cov protein cuam tshuam. Nyob rau hauv kev ntxhov siab uas muaj kev ntxhov siab, cov txheeb ze cov ntsiab lus ntawm cov nplej nplooj txau nrog 0.1 hli dimetyloosen tartrate nce los ntawm 20%.
Bas kev txhim kho: hauv lws suav sau qoob, foliar txau ntawm 0.05% dimethylas tuaj yeem nce cov nroj tsuag ib leeg tawm los ntawm 1.5%.
2. Cov khoom noj khoom haus tsiaj ntxiv
Kev ua kom zoo ntawm kev noj khoom haus: Ntxiv 0.1% Detethylamino Ces Ua Rau Cov Neeg Ua Si Ua Rau Cov Neeg Ua Si ntawm 8% thiab qhov hnyav txhua hnub los ntawm 10%.
Kev tiv thaiv kab mob: Ntxiv 0.05% DetethylaminoVeShanol bitartrate mus rau cov tshuaj tiv thaiv kab mob los ntawm 20% thiab txo cov kab mob sib txuam los ntawm 15%.
Kev Siv Khoom Siv: Los ntawm catalytic synthesis rau kev kho ib puag ncig
1. Organic synthesis catalyst
Esterification cov tshuaj tiv thaiv: dimethylaminoolol tartrate li ib theem hloov catalyst catalyst ntawm cov dej cawv thiab cov roj carboxylic acids. Hauv kev sim ntawm synthesizing ethyl acetate, ntxiv 1% dimethylaminoT lub sijhawm uas muaj hnub nyoog 6 teev mus rau 25% rau 92%.
Kev sib sau ua ke cov kev cai: hauv polyurethane synthesis, detethylaminool tittrate tuaj yeem siv los ua cov kab sib txuas tau faib cov molecular qhov hnyav faib ntawm cov polymer. Qhov kev sim ua tau pom tias ntxiv 0.5% polyurethane elasteane elasteane Elastomer nce lub zog tensile los ntawm 15% thiab elongation thaum muaj 20%.
2. Kev kho cov hlau sib txawv
Rust inibitor: dimethylaminoThancol tartrate tuaj yeem tsim cov yeeb yaj kiab tiv thaiv ntawm cov hlau chaw, inhibiting corrosion. Hauv cov tshuaj ntsev kuaj, cov qauv corrosion ntawm cov hlau me me kho nrog dimethylasethanol tartrate tau txo los ntawm 60%.
Tu tus neeg saib xyuas: dimethylaminotanol tartrate tuaj yeem zom cov hlau oxides. Nyob rau hauv kev tu tooj liab, ib 0.5% cov kev daws teeb meem tuaj yeem tshem tawm cov oxide txheej hauv 5 feeb, txo qhov chaw ntawm 30%.
3. Kev tiv thaiv ib puag ncig kev kho mob
Hnyav hlau adsorption: Biochar ua haujlwm nrog Detethylasethancol tartrate muaj qhov muaj peev xwm xaiv adsorption muaj cov txheej ions (PB ²). Ntawm ph {=5}, qhov siab tshaj plaws adsorption muaj peev xwm ncav cuag 150 mg / g, uas yog plaub zaug siab dua li ntawm unmodified biochar.
Wastewater kev txiav txim siab: dimethylaminotanol tartrate tuaj yeem tshem tawm cov pigments los ntawm zas nqaij wastewater los ntawm flocculation. Thaum kho cov methylenater zam kev daws teeb meem tuaj yeem ua tiav qhov kev tshem tawm cov chromaticity chromaticity ntawm 90% thiab ib tus lej tshem tawm tus nqi ntawm 65%.
DMAE Bitartrate yog qhov nruab nrab tseem ceeb hauv synthic synthesis. Nws muaj cov tshuaj ruaj khov thiab biocompatibility, thiab yog dav siv nyob rau hauv cov tshuaj, doges, ethinganol hydrogy thiab ethylene cawv nrog tartaric acid.
Cov txheej txheem tshwj xeeb ntawm cov qauv saum toj no yog raws li hauv qab no:
Npaj cov khoom siv raw: dimethylamine, ethylene cawv, tartaric acid.
Sib tov dimethylamine nrog ethylene cawv thiab do tusyees.
Dissolve tartaric acid nyob rau ib tus nqi tsim nyog ntawm cov kuab tshuaj, xws li methanol lossis ethanol, los tsim cov tshuaj tartaric acid.
Ua kom sov qhov sib xyaw ntawm ethylene cawv thiab dimethylamine rau ib qho kub, feem ntau yog siv tshuaj kub.
Maj mam ntxiv Tartaric acid daws rau cov cua sov sib tov ntawm ethylene cawv thiab dimethylamine, thiab do tusyees.
Tom qab ib lub sijhawm ntawm lub sijhawm, feem ntau nws yuav siv sijhawm ntau teev kom ua tiav cov kev xav tau hloov siab dua.
Los ntawm kev siv sib cais thiab cov hau kev ua kom huv, xws li rho tawm, distillation, thiab lwm yam, lub hom phiaj khoom dimethylas yog tau.
Tom qab ua tiav cov kauj ruam saum toj no, cov sib piv tshuaj lom neeg muaj raws li hauv qab no:
Dimethylamine reacts nrog ethylene cawv los tsim n, n - dimethylethangamine:
Ch2{{0 {}} ch - huag + (ch3)2Nh → (ch3)2Ch - nh - - ch3
N. n {- dimethylethanbon reacts nrog tartaric acid los tsim dimethylogen tartrate:
(Ch3)2Ch - nh - - ch3 + Hoooc - cheh - ch2- cooh → (ch3) 2Ch - nh - - ch2- ch2- cooh + (ch3)2Naj4+
Qhov kev tiv thaiv tag nrho cov tshuaj tiv thaiv yog:
Ch 2= ch - huag + (ch3)2Nh + hoooc - cheh - ch2- cooh → (ch3)2Ch - nh - - ch2- ch2- cooh + (ch3)2Naj4+
Thaum lub sij hawm cov txheej txheem kev tshuaj tiv thaiv, dimethylamine muaj kev ua haujlwm siab thiab muaj kev cuam tshuam nrog ethylene cawv. Lub caij no, tartaric acid muaj ob pab pawg neeg ywj siab, uas yog carroxyl, thiab tuaj yeem yo yi inggroks nrog n, n - dimethylethangy. Yog li ntawd, nws yog ib qho tsim nyog los tswj cov tshuaj tiv thaiv kev mob thiab cov txheeb ze ntawm cov pab pawg ua haujlwm kom ntseeg tau tias cov khoom lag luam, dimethylaminoolol tartrate.
TankSylival rau kev tsim lub tank, muaj lub tshuab ua kom txias rau sab nraum lub taub hau txias, nrog rau tus pas nrig txias Kev tswj hwm kev ceev ceev Chute yog muab nrog slider, sab saum toj ntawm slider yog muab nrog cov hlau nplaum sib txuas, uas txhim kho cov khoom siv txav mus los ntawm cov xov hlau, thiab txo cov khoom siv ua haujlwm thiab txo cov nqi ua haujlwm ntawm cov lag luam.
Nyob rau hauv qhov tseeb ntau lawm ntawmDMAE Bitartrate HmoovCov khoom lag luam, cov ketstallization feem ntau siv los do thiab lub tsho muaj cov dej txias kom tsis tu ncua cov khoom kub ntawm cov khoom lag luam, kom cov khoom lag luam txuas ntxiv nag.
Thaum cov KetStallization muaj nyob rau hauv kev siv, qhov loj me ntawm Detethylamol tartrate cov khoom yuav tsis tuaj yeem hloov kho nyob rau hauv cov txheej txheem crystallization. Txhawm rau tsim cov khoom lag luam nrog cov xim sib txawv, nws yog qhov tsim nyog rau nruab Crystallization kettles nrog cov kev hloov pauv sib xyaw, uas tsis tsim nyog rau cov khoom lag luam nrog cov zis me me. Nws yog qhov tsim nyog los nruab ntau cov kettles, ua rau cov khoom siv khib nyiab, vim tias lub plab zom mov, vim tias lub plab zom zaws, lub neej ntawm kev tu, lub dimethylolization tartrate yuav lo rau sab hauv phab ntsa ntawm lub phab ntsa crystallization.
Cim npe nrov: DMAE Bitartrate Cov hmoov uas 5988-51-2, cov neeg tsim khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav khoom, rau muag