Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub ntau tshaj plaws thiab cov neeg muag khoom ntawm cov tshuaj aspirin ntshiab cas 50-78-2 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo siab ntshiab aspirin hmoov cas 50-78-2 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pure Aspirin Hmoov, tseem hu ua Acetylsalicylic acid, Molecular formula C9H8O4, CAS 50-78-2. Aspirin feem ntau yog nyob rau hauv daim ntawv ntawm cov muaju dawb los yog crystalline hmoov. Aspirin crystals nrog siab purity yog nyob rau hauv daim ntawv ntawm cov hlaws dai, tej zaum kuj tsim flakes los yog ntsiav tshuaj. Nws yog ib hom tshuaj uas siv ntau tshaj -lub khw muag tshuaj. Vim nws cov qauv molecular tshwj xeeb, cov tshuaj aspirin tsis yooj yim rau volatilize ntawm chav tsev kub. Nws muaj ib qho℃ntawm solubility. Nws tuaj yeem yaj hauv dej, tab sis nws cov solubility tsawg, tsuas yog 1 mus rau 2 grams ntawm cov tshuaj aspirin yaj ib 100 milliliters dej. Txawm li cas los xij, cov tshuaj aspirin muaj ntau dua solubility hauv cov kuab tshuaj organic xws li ethanol, chloroform, thiab acetone. Nws yog ib qho tsis muaj zog acid. Hauv cov tshuaj aqueous, nws yuav me ntsis acidify thiab txo tus nqi pH. Nws cov qauv yog tsim los ntawm benzene nplhaib, ester pawg, thiab pawg carboxyl. Aspirin siv lead ua qauv belongs rau Orthorhombic siv lead ua, nrog rau cov cell tsis thiab Lattice tas li. Nws muaj anti-inflammatory, analgesic, thiab antipyretic teebmeem.
Lub npe tshuaj yog 2-(ACETYLOXY)-BENZOIC ACID. Basic acetylsalicylic acid yog ib qho yooj yim rau hydrolyze, tab sis cov carboxyl acid tsis muaj zog txaus (ester hydrolysis nyob rau hauv muaj zog acidic tej yam kev mob). Nws cov tshuaj tuaj yeem maj mam hydrolyzed, thiab nws feem ntau yog npaj rau hauv ntsev kom tiv thaiv hydrolysis. Kuj tseem hu ua aspirin (ASA), yog ib hom tshuaj salicylic acid, feem ntau yog siv los ua tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob, kuj tuaj yeem siv los kho qee yam kab mob.
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Tshuaj Formula |
C9H8O4 |
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Exact Mass |
180.04 |
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Molecular Luj |
180.16 |
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m/z |
180.04 (100.0%), 181.05 (9.7%) |
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Elemental Analysis |
C, 60.00; H, 4.48; O, 35.52 |
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Melting Point |
134-136 ° C (lit.) |
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Boiling Point |
272.96 ° C (kwv yees kwv yees) |
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Qhov ntom |
1.35 |
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Refractive Index |
1.4500 (kwv yees) |
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Flash Point |
250℃C |
| Kev cia khoom | 2-8 degree |
| Solubility | Solubility hauv dej 10 mg / mL ntawm 37 degree |
| Acidity Coefficient (pKa) | 3.5 (ntawm 25 degree) |
| Dej Solubility | 3.3 g/L (20 ºC) |
Txoj kev acetylation tshuaj tiv thaiv
C7H6O3+ (CH3CO)2O → C9H8O4+ CH3COOH
Qhov hnyav kwv yees li 10 grams salicylic acid rau hauv cov hlab ntsha huv.
Ntxiv rau qhov tsim nyog ntawm glacial acetic acid kom yaj salicylic acid. Nws tuaj yeem nqa tawm hauv qab nplawm kom nrawm nrawm nrawm.
Ntxiv ob peb tee ntawm phosphoric acid ua ib qho catalyst. Phosphoric acid pab txhawb cov tshuaj tiv thaiv.
Ntsuas tus nqi tsim nyog ntawm anhydrous acetic acid thiab glacial acetic acid cais, thiab sib tov rau hauv lwm lub khob huv si. Qhov no yog qhov reactant ntawm cov tshuaj tiv thaiv acetylation.
Maj mam tso cov reactants ntawm acetylation cov tshuaj tiv thaiv rau hauv cov tshuaj tiv thaiv ntim uas muaj salicylic acid. Tib lub sijhawm siv lub tshuab nplawm los yog sib nqus stirrer kom do thiab sib tov, cia cov reactants tuaj rau hauv kev sib cuag.
Qhov sib tov feem ntau yuav tsum tau khaws cia ntawm qhov kub thiab txias. Cov hlab ntsha cov tshuaj tiv thaiv tuaj yeem muab tso rau hauv da dej dej khov lossis da dej txias kom tswj tau qhov kub thiab txias.
Txuas ntxiv stirring thiab sib tov nyob rau hauv txias txias kom tiav cov tshuaj tiv thaiv. Nws feem ntau yuav siv li 30 feeb.
Tom qab cov tshuaj tiv thaiv tiav lawm, cais cov tshuaj aspirin uas tau tsim los ntawm qhov sib tov. Extraction tuaj yeem nqa tawm los ntawm cov khoom siv lim dej xws li cov ntaub lim dej lossis funnels.
Ntxuav cov tshuaj aspirin sib cais nrog cov dej tsim nyog kom tshem tawm cov impurities. Thaum kawg, muab rho tawm nrog dej distilled kom ntxiv purify aspirin.
Analgesic thiab Antipyretic (Pain Reliever thiab Fever Reducer)
- Mechanism: Aspirin inhibits cov synthesis ntawm prostaglandins (PGs), uas muaj kev koom tes nyob rau hauv mob kev nkag siab thiab kub taub hau tswj.
- Daim ntawv thov: Nws yog siv los txo qhov mob me me mus rau nruab nrab, nrog rau mob taub hau, mob leeg, mob hniav, mob khaub thuas, thiab mob pob qij txha. Nws kuj tseem txo qis kub taub hau hauv cov neeg mob khaub thuas, mob khaub thuas, lossis lwm yam kab mob.
Anti-inflammatory thiab Anti-rheumatic
- Mechanism: Los ntawm inhibiting PG synthesis, aspirin txo qhov mob thiab o.
- Daim ntawv thov: Nws yog thawj zaug - kho kab mob rau cov mob xws li mob caj dab rheumatoid thiab mob rheumatic kub taub hau. Nws txhim kho cov tsos mob sai sai hauv cov neeg mob no, suav nrog mob pob qij txha, o, thiab txhav.
Antiplatelet thiab Antithrombotic
- Mechanism: Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1), txo kev tsim cov thromboxane A2 (TXA2), muaj zog platelet aggregator.
- Daim ntawv thov: Me me ntawm cov tshuaj aspirin yog siv los tiv thaiv cov kab mob plawv xws li myocardial infarction (lub plawv nres), mob stroke, thiab transient ischemic attacks (TIAs). Nws kuj tseem muaj txiaj ntsig zoo hauv kev tiv thaiv thrombosis (ntshav txhaws) hauv cov neeg mob uas muaj kab mob plawv, atrial fibrillation, thiab tom qab cov txheej txheem phais xws li coronary artery bypass grafting.
Kev Tiv Thaiv Kab Mob
- Kev tshawb nrhiav pom: Cov kev tshawb fawb qhia tias cov tshuaj aspirin tuaj yeem muaj tshuaj tiv thaiv kab mob qog noj ntshav, tshwj xeeb yog mob qog noj ntshav.
- Mechanism: Qhov tseeb mechanism tsis to taub tag nrho, tab sis nws ntseeg tau tias muaj kev cuam tshuam ntawm COX-2, uas yog overexpressed nyob rau hauv ntau lub qog hlwb.
Lwm Daim Ntawv Thov
- Cov Kab Mob Ocular: Aspirin tau pom tias yuav txo tau qhov kev pheej hmoo ntawm qee yam kab mob ntawm lub qhov muag, xws li hnub nyoog - ntsig txog macular degeneration thiab cataracts.
- Cov Kab Mob Neurological: Qee qhov kev tshawb fawb qhia tias cov tshuaj aspirin tuaj yeem muaj cov teebmeem neuroprotective thiab tuaj yeem txo qhov kev pheej hmoo ntawm Alzheimer's kab mob thiab dementia.
- Mob Ntshav Qab Zib: Aspirin tuaj yeem pab tiv thaiv kev mob plawv hauv cov neeg mob ntshav qab zib.
Thaum ntxov li 1853 hauv Charles, Frederick Gerhardt tau tsimPure Aspirin Hmoov(acetylated salicylic acid) los ntawm salicylic acid thiab acetic anhydride, tab sis nws ua tsis tau raws li cov neeg xav tau.
Nyob rau hauv 1897, German chemist Felix Hoffman synthesized nws dua thiab kho nws txiv nrog rheumatoid mob caj dab, nrog zoo heev.
Xyoo 1897, Bayer, Lub Tebchaws Yelemees, tau tsim cov tshuaj aspirin thawj zaug.
Aspirin tau muab tso rau hauv kev ua lag luam hauv xyoo 1898, thiab nws tau pom tias nws kuj muaj cov nyhuv anti platelet aggregation, yog li nws ua rau muaj kev txaus siab zoo dua. Aspirin thiab lwm yam salicylic acid derivatives yog yaj esterified nrog hydroxyl uas muaj cov polymers xws li polyvinyl cawv thiab cellulose acetate kom lawv siab molecular. Cov tshuaj tiv thaiv -inflammatory thiab antipyretic analgesic zog ntawm cov khoom tau txais yog ntev dua - kav ntev tshaj li cov tshuaj aspirin dawb.
Los ntawm 1899, Bayer tau muag cov tshuaj rau lub ntiaj teb raws li lub cim lag luamPure Aspirin Hmoov.
Los ntawm 2015, cov tshuaj aspirin tau siv rau 100 xyoo thiab tau dhau los ua ib qho ntawm peb cov tshuaj classic hauv keeb kwm ntawm cov tshuaj. Txog tam sim no, nws tseem yog cov tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob ntau tshaj plaws hauv ntiaj teb. Nws kuj yog ib qho kev npaj rau kev sib piv thiab tshuaj xyuas lwm yam tshuaj. Nws muaj cov nyhuv antithrombotic hauv vivo. Nws tuaj yeem cuam tshuam qhov tso tawm cov tshuaj tiv thaiv ntawm platelets thiab inhibit qhov sib sau ntawm cov platelets, uas cuam tshuam nrog kev txo qis ntawm TXA2 ntau lawm. Nws yog siv rau kev kho mob los tiv thaiv qhov pib ntawm cov kab mob plawv thiab cerebrovascular.
Antithrombotic Applications
Kev tiv thaiv kab mob cerebrovascular:
Cov tshuaj Aspirin tuaj yeem siv los tiv thaiv kev tawm tsam tsis ntev los no (TIA), lossis kev tawm tsam tsis ntev los no, uas yog qhov tsis zoo ntawm lub paj hlwb uas tshwm sim los ntawm lub paj hlwb lossis lub paj hlwb. Los ntawm inhibiting platelet aggregation, tshuaj aspirin txo qhov kev pheej hmoo ntawm cerebral infarction lossis rov ua dua ntawm cov ischemia nyob rau hauv cov neeg mob TIA.
Kev tiv thaiv ntawm myocardial infarction:
Myocardial infarction yog myocardial necrosis tshwm sim los ntawm kev mob hnyav thiab tsis tu ncua ischemia thiab hypoxia ntawm cov hlab ntsha. Aspirin, los ntawm nws cov nyhuv antiplatelet, txo qhov kev pheej hmoo ntawm cov xwm txheej hauv plawv hauv cov neeg mob uas muaj myocardial infarction.
Kev kho mob ntawm Atrial Fibrillation:
Atrial fibrillation (AF) yog ib qho mob plawv arrhythmia uas tuaj yeem ua rau muaj kev pheej hmoo ntawm thromboembolism. Kev siv tshuaj aspirin hauv cov neeg mob AF, tshwj xeeb tshaj yog thaum ua ke nrog cov tshuaj tiv thaiv coagulants, txo qhov tshwm sim ntawm cov xwm txheej thromboembolic.
Prosthetic heart valve thiab post-surgical prophylaxis:
Hauv cov neeg mob uas tau hloov lub plawv lub plawv los yog phais arteriovenous fistula, tshuaj aspirin tiv thaiv cov neeg mob los ntawm kev txo qis kev pheej hmoo ntawm kev mob ntshav qab zib.
Kev kho mob ntawm angina tsis ruaj khov:
Unstable angina yog ib qho kev nthuav qhia kev kho mob ntawm exertional ruaj khov angina thiab mob myocardial infarction thiab kev tuag tam sim ntawd. Aspirin txo qhov kev pheej hmoo ntawm cov kab mob plawv hauv cov neeg mob uas tsis ruaj khov angina los ntawm kev kho mob antiplatelet.
Cov lus nug nquag
Dab tsi yog qhov txiaj ntsig tseem ceeb ntawm siab -purity hmoov piv rau cov ntsiav tshuaj thaum siv los ua "cov khoom siv raw" rau cov tshuaj synthesis?
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Zam kom tsis txhob muaj ntau ntawm excipients thiab impurities hauv cov tshuaj. Cov excipients no tuaj yeem cuam tshuam cov txiaj ntsig, purity, thiab kev sib cais tom qab ntawm cov tshuaj tiv thaiv, thaum siab -purity hmoov tuaj yeem muab kev txiav txim siab thiab tswj tau stoichiometry thiab cov tshuaj tiv thaiv.
Vim li cas nws thiaj li muaj nqi tshwj xeeb raws li tus qauv lossis nruab nrab rau kev tsim "prodrugs"?
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Nws muaj ob qho tib si hloov pauv tau carboxyl thiab phenolic ester bonds. Carboxyl pawg tuaj yeem txuas mus rau lwm cov tshuaj molecules lossis cov pab pawg los tsim cov esters, uas tuaj yeem siv los ua cov tshuaj los txhim kho cov solubility, stability, los yog lub hom phiaj ntawm cov tshuaj qub.
Vim li cas nws cov acetylsalicylic acid qauv siv tau los ua "ion khub reagent" lossis "mobile phase additive" hauv kev tshuaj ntsuam chemistry?
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Nws cov acidic carboxyl pawg thiab cov pob txha muaj ntxhiab ua rau nws tsim cov ion rov qab ua ke nrog qee cov alkaline analytes hauv cov kua chromatography, yog li txhim kho tus cwj pwm tuav thiab ncov zoo ntawm cov analytes.
Vim li cas nws puas tau siv los ua "tus tswj kev loj hlob ntawm tsob ntoo" lossis "tus kab mob inhibitor" nyob rau hauv tsis yog - kho mob thaj chaw xws li horticulture?
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Nws tuaj yeem hydrolyzed rau hauv salicylic acid nyob rau hauv cov nroj tsuag, uas yog ib qho tseem ceeb taw qhia molecule rau cov nroj tsuag systemic acquired kuj. Qhov no ua rau nws muaj peev xwm induce nroj kab mob tsis kam, alleviate kev nyuaj siab, los yog tswj flowering.
Dab tsi tsis paub txog qhov "crystal morphology" ntawm nws cov hmoov muaj nyob rau hauv kev tsim cov tshuaj zoo tagnrho?
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Cov ntaub ntawv siv lead ua sib txawv tuaj yeem cuam tshuam rau cov flowability, compressibility, thiab compaction ntawm cov hmoov, ncaj qha txiav txim seb cov ntsiav tshuaj puas tuaj yeem ua tau zoo, seb lawv puas tuaj yeem tawg, thiab qhov tawg ntawm cov khoom xyaw nquag.
Cim npe nrov: Aspirin hmoov CAS 50-78-2, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom