Doxycycline hyclate hmoov, Kuj hu ua doxycycline hydrochloride los yog doxycycline hydrochloride, nws yog ib qho tshuaj tua kab mob tetracycline semi hluavtaws. Tshaj tawm raws li cov khoom siv crystalline xws li daj mus rau daj ntsuab. Nws cov khoom yog muag heev, tsis muaj ntxhiab, iab hauv saj, thiab muaj qee qhov℃ntawm hygroscopicity. Nws muaj cov dej solubility zoo heev. Nws solubility nyob rau hauv dej tuaj yeem ncav cuag 50mg / mL, thiab cov kua dej yaj tuaj yeem pom meej thiab daj ntsuab. Tsis tas li ntawd, nws yooj yim soluble hauv methanol, tab sis me ntsis soluble hauv ethanol thiab acetone. Cov yam ntxwv solubility no ua rau nws yooj yim los tuav thaum lub sij hawm kev npaj ntawm formulation, thaum tseem muab kev yooj yim rau nws nqus thiab tis nyob rau hauv lub cev. Vim nws cov kab mob dav dav thiab kev ua haujlwm lom neeg zoo heev, nws tau siv dav hauv kev kho mob. Wide antibacterial spectrum, zoo tiv thaiv Gram zoo cocci thiab tsis zoo bacilli. Cov nyhuv tshuaj tua kab mob yog kwv yees li 10 npaug zog dua li tetracycline, thiab nws tseem muaj txiaj ntsig zoo tiv thaiv kab mob tetracycline resistant. Feem ntau yog siv rau cov kab mob ua pa, mob ntsws, mob ntsws, thiab kab mob hauv cov zis, nws kuj tseem siv tau rau cov pob khaus, typhoid fever, thiab mycoplasma pneumonia. Raws li qhov dav -spectrum tshuaj tua kab mob thiab metalloproteinase inhibitor, nws muaj ntau yam kev siv tshuaj kho mob thiab cov teebmeem tseem ceeb. Hauv kev tshawb fawb txog kev tshawb fawb, nws kuj tau qhia txog nws cov txiaj ntsig tshwj xeeb, muab cov tswv yim tshiab thiab cov txheej txheem rau kev txhim kho cov tshuaj tshiab thiab kho kab mob.
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Tshuaj Formula |
C22H25ClN2O8 |
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Exact Mass |
480 |
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Molecular Luj |
481 |
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m/z |
480 (100.0%), 482 (32.0%), 481 (23.8%), 483 (7.6%), 482 (2.7%), 482 (1.6%) |
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Elemental Analysis |
C, 54,95; H, 5,24; lwj, 7,37; n, 5,83; ib. 26.62 Nws |
Kev siv tshuaj kho mob
Doxycycline hyclate hmoov,Kuj hu ua doxycycline hydrochloride los yog doxycycline hydrochloride, nws yog ib qho tshuaj tua kab mob tetracycline semi hluavtaws. Raws li ib tug dav -spectrum antibacterial tshuaj, nws tuav ib tug tseem ceeb txoj hauj lwm nyob rau hauv lub chaw kws tshuaj vim nws tshwj xeeb pharmacological zog thiab ntau yam kev siv.
Raws li qhov ncauj siv tau dav dav -spectrum tshuaj tua kab mob, nws yog siv los kho ntau yam kab mob los ntawm cov kab mob rhiab heev. Nws cov kab mob tua kab mob yog qhov dav, npog Gram zoo cocci thiab tsis zoo bacilli, nrog rau ntau yam kab mob xws li Mycoplasma, Chlamydia, thiab Rickettsia. Hauv kev kho mob, nws feem ntau siv los kho cov kab mob hauv qab no.
Cov kab mob ua pa, xws li mob ntsws, tonsillitis, pharyngitis, thiab lwm yam, yog tshwm sim los ntawm cov kab mob rhiab heev xws li Mycoplasma pneumoniae thiab Haemophilus influenzae. Nws tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob no, txo cov kev mob tshwm sim, thiab txhawb cov neeg mob rov zoo.
Cov kab mob urinary, xws li urethritis, cystitis, pyelonephritis, thiab lwm yam, yog tshwm sim los ntawm cov kab mob rhiab heev xws li Escherichia coli thiab Staphylococcus. Nws tuaj yeem nkag mus rau hauv cov cell membrane sai sai thiab khi rau A qhov chaw ntawm cov kab mob ribosome 30S subunit, tiv thaiv kev sib txuas ntawm cov kab mob proteins thiab ua tiav cov hom phiaj tiv thaiv kab mob.
Tsis tas li ntawd, nws tseem tuaj yeem siv los kho cov kab mob xws li typhus, Qiangchong kab mob, thiab mycoplasma pneumonia. Hauv kev xyaum ua haujlwm ntev -, nws tau pom tias cov tshuaj no yog cov tshuaj tua kab mob zoo, nrog rau cov kab mob dav dav, muaj zog tiv thaiv kab mob, ua haujlwm ntev, thiab nqus sai sai tom qab kev tswj hwm qhov ncauj. Nws yog feem ntau maj mam tawm los ntawm lub raum.
Kab mob hauv plab: xws li cholecystitis, cholangitis, thiab lwm yam, tshwm sim los ntawm cov kab mob rhiab heev xws li gram- cov kab mob tsis zoo. Nws muaj cov ntsiab lus siab hauv cov kab mob biliary, uas tuaj yeem tua cov kab mob zoo thiab txo cov tsos mob ntawm cov neeg mob.
Cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos, xws li cellulitis, carbuncle, abscess, thiab lwm yam, yog tshwm sim los ntawm cov kab mob rhiab heev xws li Staphylococcus aureus thiab Streptococcus. Nws tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob no, txo cov kev mob tshwm sim, thiab txhawb kev kho qhov txhab.
Kev tshawb fawb
Kev tshawb nrhiav tshuaj tiv thaiv qog
Nyob rau hauv xyoo tas los no, kev tshawb fawb ntau ntxiv tau pom tias cov tshuaj no muaj kev tiv thaiv -mob qog noj ntshav cell proliferation. Hauv kev tshawb fawb hauv vitro, nws tuaj yeem cuam tshuam kev loj hlob thiab kev loj hlob ntawm ntau hom qog nqaij hlav, xws li glioma hlwb, hlwb qog nqaij hlav cancer mis, thiab lwm yam. Qhov no muab cov tswv yim tshiab thiab cov txheej txheem rau kev txhim kho cov tshuaj tiv thaiv - qog nqaij hlav.
Anti-inflammatory kev tshawb fawb
Nws kuj muaj qee yam tshuaj tiv thaiv - mob. Nws muaj peev xwm inhibit collagen synthesis, proliferation, thiab migration, nrog rau inhibit inflammatory tshua tshwm sim los ntawm Lyme kab mob. Cov kev tshawb fawb no qhia tau hais tias cov tshuaj muaj peev xwm siv tau rau hauv thaj tsam ntawm kev tiv thaiv -inflammatory.
Kev tshawb nrhiav microbiological
Raws li dav dav -spectrum tshuaj tua kab mob, nws kuj tau siv dav hauv kev tshawb fawb microbiological. Nws tuaj yeem siv los tshuaj xyuas cov kab mob microbial uas nkag siab rau cov khoom lag luam, muab cov ntsiab lus tseem ceeb rau kev kawm txog cov yam ntxwv ntawm lub cev thiab cov txheej txheem metabolic ntawm cov kab mob.
Lwm yam kev siv
Tsiaj txhu
Hauv kev yug tsiaj, nws tuaj yeem siv los kho ntau yam kab mob sib kis ntawm cov tsiaj, xws li mob ntsws, mob ntsws, mob ntsws, endometritis, thiab lwm yam. Nws cov kab mob dav dav, muaj zog tiv thaiv kab mob, thiab lub sijhawm ntev ntawm kev ua haujlwm ua rau nws muaj kev thov dav dav hauv kev yug tsiaj.
Kev tiv thaiv ib puag ncig
Nws tseem tuaj yeem siv rau kev kho dej hauv thaj chaw tiv thaiv ib puag ncig. Nws tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob thiab cov algae hauv dej, thiab tiv thaiv qhov tshwm sim ntawm eutrophication hauv dej. Nyob rau tib lub sijhawm, nws kuj muaj qee yam deodorizing nyhuv, uas tuaj yeem txhim kho qhov tsw thiab xim ntawm lub cev dej.
keeb kwm ntawm kev loj hlob
Oxytetracycline hydrochloride, tseem hu ua doxycycline hydrochloride los yog doxycycline, yog thib ob - tiam tetracycline tshuaj tua kab mob. Nws txoj kev loj hlob tau ua pov thawj txog kev txawj ntse thiab kev tsim kho tshiab ntawm tib neeg hauv kev tawm tsam cov kab mob, ua rau muaj txiaj ntsig zoo hauv kev kho mob thiab kws kho tsiaj.
Xyoo 1948, Dr. Benjamin Duggar, kws kho mob cog qoob loo ntawm Cornell University hauv Tebchaws Meskas, cais thawj cov tshuaj tua kab mob tetracycline, streptomycin, los ntawm cov kab mob hauv av ntawm Streptomyces coelicolor, kos npe rau qhov pib ntawm kev tshawb fawb ntawm tetracycline tshuaj tua kab mob.
Tom qab ntawd, cov kws tshawb fawb txuas ntxiv cais oxytetracycline thiab tetracycline los ntawm av actinomycetes. Cov khoom lag luam ntuj no tau pom cov txiaj ntsig zoo ntawm cov kab mob Gram zoo thiab tsis zoo, nrog rau cov kab mob tshwm sim los ntawm intracellular mycoplasma, chlamydia, thiab rickettsia, tso lub hauv paus ruaj khov rau kev txhim kho cov tshuaj semi hluavtaws tetracycline yav tom ntej.
Xyoo 1970s thiab 1980s yog lub sijhawm kub rau kev txhim kho cov tshuaj semi hluavtaws tetracycline. Cov kws tshawb fawb tau ua tiav cov tshuaj metoprolol los ntawm halogenated thiab lub cev qhuav dej ntawm C6 txoj hauj lwm ntawm oxytetracycline, thiab ntxiv kev hloov kho nws kom tau txais doxycycline nrog kev ruaj ntseg tseem ceeb thiab kev ua haujlwm tshuaj. Qhov kev tsim kho tshiab no tsis yog tsuas yog txhim kho cov lipids solubility ntawm cov tshuaj, ua kom yooj yim rau nkag mus rau hauv cov cell membranes, tab sis kuj txhim kho nws cov kev faib tawm thiab cov nyhuv antibacterial hauv lub cev. Kev vam meej ntawm doxycycline yog ib theem tshiab ntawm kev loj hlob rau tetracycline tshuaj tua kab mob.
Nyob rau hauv 1967, nws twb officially tsim thiab sai muab tso rau hauv industrial ntau lawm. Nws cov txheej txheem tsim khoom siv oxytetracycline puag raws li cov khoom siv raw, uas tau txais los ntawm ntau yam kev cuam tshuam xws li chlorination, dehydration, hydrogenation, dawb puag hloov dua siab tshiab, thiab ntsev tsim. Ntawm lawv, kev npaj ntawm hydrochloride doxycycline dehydrate yog ib kauj ruam tseem ceeb hauv cov tshuaj tiv thaiv synthesis, uas cuam tshuam ncaj qha rau cov txiaj ntsig thiab cov ntsiab lus tsis huv ntawm cov khoom siv tshuaj raw khoom. Nrog rau kev ua kom zoo dua qub thiab txhim kho cov txheej txheem ntau lawm, ob qho tib si zoo thiab cov khoom siv tau raug txhim kho, muab kev lees paub zoo rau nws cov ntawv thov kho mob thoob plaws.
Cov lus nug nquag
Cov tshuaj doxycycline hyclate siv rau dab tsi?
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Doxycycline yog nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua tetracycline tshuaj tua kab mob. Nws ua haujlwm raukho cov kab mob los ntawm kev tiv thaiv kev loj hlob thiab kis kab mob. Nws ua haujlwm los kho pob txuv los ntawm kev tua cov kab mob uas ua rau lub qhov hws thiab txo cov roj ntsha uas ua rau pob txuv.
Puas yog doxycycline yog tshuaj tua kab mob uas muaj zog heev?
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Kev tshawb nrhiav kev kho mob dav dav tau pom tias yog doxycyclinezoo heev nyob rau hauv cov kab mob ntawm cov kab mob ua pa, nrog rau atypical pneumonias; daim tawv nqaij thiab cov nqaij mos; kab mob genitourinary xws li gonorrhea, syphilis, nonspecific urethritis, thiab prostatitis; intraabdominal kab mob vim raug mob, sepsis, los yog ...
Yuav ua li cas noj doxycycline rau kab mob sinus?
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Rau kab mob:
Cov neeg laus - 100 milligrams (mg) txhua 12 teev ntawm thawj hnub, tom qab ntawd 100 mg ib hnub ib zaug lossis 50 txog 100 mg txhua 12 teev.
Cov menyuam yaus hnub nyoog 8 xyoos lossis laus dua uas hnyav 45 kilograms (kg) lossis ntau dua-100 mg txhua 12 teev ntawm thawj hnub, tom qab ntawd 100 mg ib hnub ib zaug lossis 50 txog 100 mg txhua 12 teev.
Doxycycline yuav ua haujlwm sai npaum li cas rau tus kab mob sinus?
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Doxycycline feem ntau pib ua hauj lwm li ntawm 2 mus rau 3 hnub, nrog rau cov neeg feem coob zoo nyob rau hauv 3 mus rau 5 hnub, tab sis tus kab mob no yuav siv sij hawm ntev mus kom meej meej, feem ntau yuav tsum tau ib tug tag nrho 5- mus rau 10-hnub chav kawm kom tshem tawm cov kab mob thiab tiv thaiv kev tiv thaiv. Koj yuav tsum pom qhov txo qis ua npaws, qhov mob, thiab congestion nyob rau hauv ib lub lis piam, tab sis ib txwm ua kom tiav tag nrho cov tshuaj txawm tias cov tsos mob ploj lawm.
Koj yuav tsum zam dab tsi thaum noj doxycycline?
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Qee cov khoom noj uas koj yuav tsum tsis txhob noj nrog doxycycline suav nrogmis nyuj, butter, cheese, qe, kale, thiab spinach. Yog tias noj cov zaub mov no, noj lossis haus ob teev ua ntej lossis plaub teev tom qab koj noj doxycycline.
Cim npe nrov: Doxycycline hyclate hmoov CAS 24390-14-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom