Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm vitamin d2 hmoov cas 50-14-6 hauv Suav teb. Txais tos rau kev lag luam wholesale zoo vitamin d2 hmoov cas 50-14-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Vitamin D2 hmoov, tshuaj lub npe yog 9,10-cycloergoste-5,7,10 (19), 22-tetraene-3 - Cawv, tshuaj formula C28H44O, yog xim tsis muaj xim acicular siv lead ua los yog dawb crystalline hmoov, odorless thiab tasteless, thiab yooj yim rau deteriorate thaum raug lub teeb los yog huab cua. Vitamin D2 (Arthin), steroid derivative, yog ib yam khoom muaj feem xyuam rau cov metabolism hauv calcium thiab phosphorus, thiab plays lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab kho rickets hauv cov menyuam yaus thiab cov neeg laus. Tam sim no, muaj 96 hom kev npaj tshuaj tsuas yog tsim los ntawm arthin.Arthin kuj yog ib qho tseem ceeb thiab tseem ceeb additive nyob rau hauv pub, uas muaj peev xwm ua kom lub qe ntau npaum li cas thiab lean nqaij ntau lawm ntawm nqaij qaib thiab tsiaj nyeg.
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Tshuaj Formula |
C28H44O |
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Exact Mass |
396 |
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Molecular Luj |
397 |
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m/z |
396 (100.0%), 397 (30.3%), 398 (2.7%), 398 (1.7%) |
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Elemental Analysis |
C, 84.79; H, 11.18; O, 4.03 |
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Vitamin D2, raws li ib qho tseem ceeb roj soluble vitamin, plays ib tug indispensable luag hauj lwm nyob rau hauv tib neeg noj qab haus huv. Nws tsis tsuas yog koom nrog kev tswj hwm qhov sib npaug ntawm calcium thiab phosphorus hauv lub cev, tswj cov pob txha noj qab haus huv, tab sis tseem muaj kev cuam tshuam rau ntau yam xws li cov thyroid ua haujlwm thiab kev tiv thaiv kab mob.
Regulating qhov sib npaug ntawm calcium thiab phosphorus hauv lub cev
Lub luag haujlwm tseem ceeb yog txhawb kev nqus ntawm calcium thiab phosphorus los ntawm lub cev, yog li tswj hwm qhov sib npaug ntawm calcium thiab phosphorus hauv lub cev. Qhov kev ua haujlwm no tseem ceeb heev rau kev loj hlob thiab kev loj hlob ntawm cov pob txha thiab kev tsim kho ntawm cov pob txha.
Txhawb nqa calcium nqus: Tom qab nkag mus rau tib neeg lub cev, nws tuaj yeem txhim kho txoj hnyuv nqus ntawm calcium, tso cai rau calcium ions ntau nkag mus rau hauv cov hlab ntsha thiab muab cov calcium txaus rau cov pob txha.
Txhawb nqa phosphorus nqus: phosphorus yog ib qho tseem ceeb ntawm cov pob txha, thiabvitamin D2 hmoovtuaj yeem txhawb nqa phosphorus nqus kom ntseeg tau cov txheej txheem ntxhia ntxhia ntawm cov pob txha.
Ua kom cov pob txha ntom ntom: Los ntawm kev txhawb nqa kev nqus ntawm calcium thiab phosphorus, nws pab tswj cov pob txha ceev thiab lub zog, txo qhov kev pheej hmoo ntawm pob txha.
Txhawb cov pob txha rov tsim kho: Thaum cov pob txha puas lawm los yog muaj hnub nyoog, nws tuaj yeem txhawb kev kho thiab rov tsim kho cov pob txha, tswj kev ncaj ncees thiab ruaj khov ntawm cov pob txha.
Regulating thyroid ua haujlwm
Kev tswj hwm ntawm cov thyroid ua haujlwm kuj tseem ceeb heev.
Txhawb cov thyroid hormone synthesis: Nws tuaj yeem cuam tshuam rau kev loj hlob thiab kev sib txawv ntawm cov thyroid hlwb, yog li txhawb kev sib txuas thiab tso tawm ntawm cov thyroid hormones.
Kev tswj cov thyroid hormones: Cov thyroid hormones ua lub luag haujlwm tseem ceeb hauv tib neeg cov metabolism thiab kev loj hlob thiab kev loj hlob. Arthin tswj lub cev metabolic ntawm tib neeg lub cev los ntawm kev tswj cov thyroid hormones.
Tiv thaiv cov kab mob hauv cov thyroid: Kev noj cov vitamin D2 me ntsis tuaj yeem pab txo qis kev pheej hmoo ntawm cov thyroid kab mob, xws li hyperthyroidism thiab hypothyroidism.
Kho osteoporosis thiab rickets
Ua lub luag haujlwm tseem ceeb hauv kev kho mob osteoporosis thiab rickets.
Txhawb cov pob txha calcification: Nws tuaj yeem txhawb cov calcium deposition ntawm qhov chaw ntawm cov pob txha tshiab, tso cai rau citrate rau hauv cov pob txha, yog li txhawb cov pob txha calcification.
Txhim khu cov pob txha muaj nuj nqi: Nws tuaj yeem txhawb kev ua haujlwm thiab kev loj hlob ntawm cov pob txha hlwb, thiab txhim kho cov pob txha muaj peev xwm.
Kev kho mob osteoporosis: Osteoporosis yog ib yam kab mob ntawm cov pob txha uas tshwm sim los ntawm kev txo cov pob txha thiab cov pob txha tawg. Kev txhawb ntxiv tuaj yeem pab ua kom cov pob txha ceev kom qeeb thiab txo qhov kev pheej hmoo ntawm pob txha.
Kev tiv thaiv thiab kev kho mob ntawm rickets: Rickets yog kab mob pob txha los ntawm vitamin D tsis txaus, feem ntau tshwm sim raws li pob txha deformities thiab softening. Ntxiv nrog rau cov vitamin D2 tuaj yeem tiv thaiv thiab kho rickets thiab txhawb kev loj hlob ntawm pob txha.
Kho vitamin D Deficiency
Vitamin D2 hmoovNws kuj tseem siv los kho cov vitamin D tsis txaus, uas yog qhov tseem ceeb tshwj xeeb rau cov neeg tshwj xeeb.
Cov neeg tsis noj nqaij: Vim tsis muaj cov tsiaj txhu hauv lawv cov zaub mov, cov neeg tsis noj nqaij muaj qhov tsis muaj vitamin D. Kev ntxiv tuaj yeem pab ua kom tau raws li qhov xav tau ntawm cov vitamin D ntawm cov neeg tsis noj nqaij.
Cov neeg txhawb nqa khoom noj khoom haus parenteral: Cov neeg txhawb nqa ntawm cov khoom noj khoom haus parenteral tsis tuaj yeem nqus cov vitamin D los ntawm cov hnyuv thiab yog li yuav tsum tau ntxiv cov tshuaj arthin ntxiv.
Cov neeg mob uas muaj pancreatic insufficiency: Cov neeg mob uas muaj pancreatic insufficiency tej zaum yuav tsis muaj peev xwm mus ua synthesize activated cov ntaub ntawv ntawm vitamin D (xws li vitamin D3) ib txwm, yog li ntawd yuav tsum tau supplementation.
Txhim khu kev tiv thaiv kab mob ua haujlwm
Nws kuj tseem ua lub luag haujlwm qee yam hauv kev ua haujlwm ntawm lub cev tsis muaj zog.
Txhim kho lub cev tiv thaiv kab mob: Nws tuaj yeem txhim kho kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab txhim kho lub cev muaj peev xwm tiv thaiv kab mob thiab kab mob.
Txhawb kev tiv thaiv kab mob sib txawv: tuaj yeem cuam tshuam rau kev sib txawv thiab kev loj hlob ntawm lub cev tiv thaiv kab mob, yog li tswj kev ua haujlwm ntawm lub cev tiv thaiv kab mob.
Txo qhov kev pheej hmoo ntawm kev kis kab mob: Kev noj tshuaj ntxiv tuaj yeem pab txo qis kev pheej hmoo ntawm kev kis kab mob xws li ua pa thiab plab hnyuv.
Txhim kho kev xav thiab tiv thaiv kev nyuaj siab
Nws kuj muaj qhov cuam tshuam zoo rau kev puas siab puas ntsws.
Txhawb nqa dopamine secretion: Dopamine yog ib qho neurotransmitter ze ze rau kev lom zem thiab kev zoo siab. Arthin tuaj yeem txhawb qhov tso tawm ntawm dopamine, yog li txhim kho ib tus neeg lub siab.
Cov nyhuv Antidepressant: Cov kev tshawb fawb tau pom tias nws muaj qee yam tshuaj tiv thaiv kev ntxhov siab. Kev noj cov vitamin D2 nruab nrab tuaj yeem pab txo cov tsos mob ntawm kev nyuaj siab thiab txhim kho lub neej zoo.
Tiv thaiv kab mob plawv
Nyob rau hauv xyoo tas los no, kev tshawb fawb tseem pom muaj peev xwm tiv thaiv kab mob plawv.
Txo cov ntshav siab: Nws tuaj yeem txo cov ntshav siab thiab txo qhov kev puas tsuaj ntawm cov ntshav siab rau cov hlab plawv.
Txhim kho vascular muaj nuj nqi: nws tuaj yeem txhim kho txoj haujlwm thiab cov qauv ntawm cov hlab ntsha thiab txo qhov kev pheej hmoo ntawm atherosclerosis.
Tiv thaiv kab mob plawv: Kev noj tshuaj ntxiv tuaj yeem pab tiv thaiv qhov tshwm sim thiab kev loj hlob ntawm cov kab mob plawv.
Lwm cov haujlwm
Ntxiv nrog rau cov haujlwm saum toj no, nws tseem muaj cov teebmeem hauv qab no:
Txhawb nqa kev noj qab haus huv ntawm cov hniav: pab tswj kev txhim kho ib txwm thiab cov txheej txheem mineralization ntawm cov hniav, thiab tiv thaiv cov hniav caries thiab kab mob periodontal.
Txhim kho cov leeg nqaij ua haujlwm: tuaj yeem txhim kho cov leeg nqaij thiab kev ua siab ntev, thiab txhim kho kev ua kis las.
Txhawb nqa kev noj qab haus huv ntawm daim tawv nqaij: Nws tuaj yeem tswj hwm qhov cuam tshuam kev ua haujlwm thiab muaj peev xwm moisturizing ntawm daim tawv nqaij, tiv thaiv daim tawv nqaij qhuav thiab khaus.
Vitamin D2 hmoovtxheej txheem ntau lawm:
Dissolve 20 grams ntawm ergosterol nyob rau hauv 250 ml ntawm cyclohexane, ntxiv antioxidants, txias rau 0 degree, sau cov tshuaj tiv thaiv kab mob nrog nitrogen, thiab cov tshuaj nkag mus rau thawj photochemical reactor ntawm ib tug txaus txaus tus nqi.
Lub photochemical nplhaib qhib cov tshuaj tiv thaiv tshwm sim nyob rau hauv lub illumination ntawm LED teeb nrog ib tug wavelength ntawm 275 nm. Cov tshuaj tiv thaiv kub yog tswj ntawm 0 ± 5℃C. Los ntawm kev hloov pauv ntawm tus nqi ntws, qhov hloov pauv ntawm raw ergosterol yog lav kom ncav cuag ntau dua 75%, tom qab ntawd cov tshuaj tom qab lub nplhaib qhib cov tshuaj tiv thaiv ncaj qha dhau los ntawm qhov thib ob photochemical reactor thiab undergoes photochemical kaw -loop cov tshuaj tiv thaiv nyob rau hauv lub illumination ntawm LED teeb nrog wavelength ntawm 3 ± 3 cov tshuaj tiv thaiv, thiab 3 nm.℃C.
Tag nrho cov tshuaj tiv thaiv lub sijhawm yog li 4 teev. Tom qab ua tiav cov tshuaj tiv thaiv, cov khoom raug tso tawm, cov tshuaj tiv thaiv hnyav tau rov qab los ntawm kev txo qis, cov ethyl acetate ntxiv, rhuab thiab refluxed rau 5 feeb, thiab tom qab ntawd txias rau 0℃. 4.2g ntawm unconverted ergosterol yog zoo los ntawm kev nqus pom, thiab tus nqi rov qab ntawm ergosterol yog txog 21%.
Ntxiv cov isooctane rau hauv cov kua txiv lim dej, cua sov thiab reflux li 0.5 teev, thiab tom qab ntawd txias rau 0℃kom precipitate feem ntau ntawm cov vitamin D2. Thawj pawg ntawm vitamin D2 cov khoom yog tau los ntawm kev nqus pom . 6.8 grams ntawm vitamin D2 yog qhuav nyob rau hauv lub tshuab nqus tsev vacuum, nrog ib tug purity ntawm ntau tshaj 95%.
Cov cawv niam uas tseem tshuav yog ntxiv rau qhov sov li 0.5 teev, thiab tom qab ntawd txias rau 0℃tom qab tshem tawm cov kuab tshuaj ib nrab nyob rau hauv qhov txo qis. Arthin raug cais tawm, thiab cov khoom thib ob ntawm cov vitamin D2 tau txais los ntawm kev nqus pom.
Lub tshuab nqus tsev dries 3.6 grams ntawm arthin, nrog ib tug purity ntawm ntau tshaj 97%. Cov cawv niam uas tseem tshuav yog ntxiv rau 20 feeb, tom qab ntawd depressurized tshem tawm ib feem ntawm cov kuab tshuaj, txias rau 0 degree, thiab peb pawg ntawm cov vitamin D2 raug cais tawm. Lub tshuab nqus tsev dries 1.6 grams ntawm arthin, nrog ib tug purity ntawm ntau tshaj 97%. Tag nrho cov txiaj ntsig ntawm peb cov khoom yog 60%, thiab purity ntau dua 96%.
txheej txheem extraction:
Ib txoj hauv kev rau rho tawm cov ntsiab lus siab arthin los ntawm hydrangea txiv hmab txiv ntoo lub cev suav nrog cov hauv qab no:
S1. Sib tov 100 mesh ntawm 100 g hydrangea txiv hmab txiv ntoo lub cev tom qab sib tsoo thiab tshuaj ntsuam nrog 5 µ g dej -soluble nano- cov khoom fluorescent, thiab disperse nws nyob rau hauv dej distilled nrog 20 KHz ultrasound kom disperse lub ncua kev kawm ntawv;
S2. Muab cov khoom tshem tawm pov tseg rau hauv qhov hluav taws xob hluav taws xob nrog lub zog hluav taws xob ntawm 30Kv / cm2 thiab pulse dav ntawm 6 µs, thiab irradiate lub dispersed suspension nyob rau hauv lub excitation wavelength ntawm cov dej -soluble nano- cov khoom fluorescent. Lub excitation wavelength ntawm cov dej-soluble nano- cov khoom siv fluorescent yog 200-380nm, thiab emission wavelength ntawm dej{10}}soluble nano{14}} cov khoom siv fluorescent yog 280{15}}400nm. Tom qab 2 teev ntawm irradiation, lim cov lim residue kom tau txais thawj cov khoom rho tawm, Cov dej-soluble nano fluorescent khoom yog dej-soluble CdSe / ZnS quantum dot;
S3. Thawj cov khoom muab rho tawm yog ultrasonically dispersed nrog alkaline tov nrog pH nqi ntawm 9, thiab saponification cov tshuaj tiv thaiv yog nqa tawm nyob rau hauv qhov kev txiav txim ntawm pulsed hluav taws xob teb nrog hluav taws xob teb siv ntawm 20Kv / cm thiab mem tes dav ntawm 40 µs. Lub saponification cov tshuaj tiv thaiv kub yog 95 degree, thiab lub sij hawm saponification yog 2h. Tom qab cov tshuaj tiv thaiv, cov lim residue raug coj mus rau qhov thib ob muab rho tawm;
S4. Ntxiv 500 ml ntawm 100% ethanol tov rau qhov thib ob extraction khoom, do nws tusyees, thiab lim cov filtrate kom tau cov extraction tov;
S5. Cov extract yog qhuav los ntawm lub tshuab nqus tsev evaporation ntawm 30℃kom tau txais arthin extract.
Cov txheej txheem synthesis saum toj no yuav tsum raug xaiv thiab siv raws li tus kheej qhov xwm txheej. Ib txoj hauv kev yooj yim dua yog xa peb cov lus nug. Peb yog cov chaw muag khoom arthin thiab peb yuav muab cov vitamin d2 v d3 zoo tshaj rau koj.
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Solubility
Insoluble hauv dej tab sis yooj yim soluble hauv cov kuab tshuaj organic:
Soluble heev hauv chloroform, chloroform
Soluble hauv ethanol, acetone, diethyl ether
Me ntsis soluble nyob rau hauv zaub roj
Tsis ua rau hauv cov tshuaj digitalis saponin (tsis zoo digitalis saponin test).
Stability thiab Reactivity
rhiab heev rau lub teeb thiab huab cua: Degrades thaum raug lub teeb los yog huab cua; khaws cia rau hauv lub teeb- tiv thaiv, ntim ntim.
Zoo thermal stability: Melting point 115-118 degree; kuj ruaj khov ntawm qhov kub thiab txias, txawm tias lub sijhawm ntev cua sov tuaj yeem ua kom tawg.
Decomposition accelerated los ntawm inorganic ntsev: stability txo thiab decomposition tus nqi nce nyob rau hauv ib puag ncig uas muaj inorganic ntsev.
Tshuaj lom neeg cov xim:
Cov tshuaj tiv thaiv nrog acetic anhydride-sulfuric acid: daws xim hloov mus rau daj → liab → ntshav → ntsuab.
UV Absorption Yam ntxwv: Pom qhov tseem ceeb ntawm qhov nqus ntawm 265 nm, tsim nyog rau kev soj ntsuam ntau.
Spectroscopic Properties
Infrared Spectrum: Sib phim cov qauv qauv nrog cov yam ntxwv nqus siab siab.
UV Spectrum: Absorption coefficient ntawm 265 nm ranges ntawm 460 txog 490, muaj feem xyuam rau kev txiav txim siab cov ntsiab lus.
Purity thiab impurity Control
Khoom noj khoom haus-qib/pharmaceutical-qib cov khoom feem ntau xav tau ntau tshaj los yog sib npaug rau 97.0% purity, nrog impurity theem raws li cov qauv:
Cheeb tsam ntawm ib qho impurity ncov Tsawg dua los yog sib npaug rau 0.5% ntawm qhov chaw ncov tseem ceeb hauv kev siv tshuaj
Tag nrho cov impurity ncov cheeb tsam Tsawg dua los yog sib npaug rau 1.0% ntawm lub ntsiab ncov cheeb tsam hauv kev siv tshuaj
Cov tshuaj uas muaj nyob hauv precursor xws li precursor vitamin D2 yuav tsum tau tswj.
I. Kev sib txheeb nrog Kab Mob thiab Kev Tshawb Fawb Ua Ntej
Los ntawm lub xyoo pua puv 19 txog rau thaum ntxov xyoo pua 20th, rickets tau nthuav dav ntawm cov menyuam yaus hauv Tebchaws Europe thiab Amelikas. Cov kws tshawb fawb kho mob tau pom tias kev raug tshav ntuj thiab qee yam khoom noj tuaj yeem txo tus kab mob. Hauv kev tshawb fawb thaum ntxov, cov rog no - cov khoom noj uas muaj kuab lom tau raug cais raws li cov khoom muaj feem xyuam nrog cov vitamin A thiab tsis tau cais tawm ntawm nws tus kheej. Xyoo 1919, cov kws tshawb fawb tau lees paub tias cov kab hluav taws xob ultraviolet nyob rau hauv tshav ntuj tuaj yeem txhawb nqa tib neeg lub cev los tsim cov tshuaj tiv thaiv rickets. Qhov kev tshawb pom no tau txheeb xyuas cov khoom xyaw nquag thiab ncaws tawm kev tshawb fawb txog vitamin D.
II. Isolation thiab Nomenclature
Tom qab xyoo 1920, cov kws tshawb fawb tau ntxuav cov khoom xyaw nquag los ntawm cod siab roj, fungi thiab nplej. Xyoo 1927, pab pawg tshawb fawb irradiated ergosterol nrog ultraviolet rays, ua tiav kev hloov pauv thiab cais cov arthin, thiab qhia meej txog nws cov tshuaj ua ntej thiab cov yam ntxwv ntawm cov qauv. Cov tshuaj no tau raug hu ua ergocalciferol, kom paub qhov txawv ntawm vitamin D₃ ntawm tsiaj keeb kwm. Ob lub tebchaw siv los tiv thaiv -rickets teebmeem.
III. Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab Kev Siv Dav Hlau
Nyob rau xyoo 1930, cov qauv tshuaj ntawm arthin tau ua tiav tag nrho, thiab nws cov khoom siv hluavtaws maj mam loj hlob. Nrog zoo- tsim cov txheej txheem tsim khoom, nws tau dav ntxiv rau cov khoom noj thiab cov khoom noj khoom haus. Cov kev tshawb fawb tom ntej tau nthuav tawm nws cov haujlwm physiological. Dhau li tiv thaiv thiab kho rickets, nws tswj cov calcium thiab phosphorus metabolism. Txog rau hnub no, nws tseem yog ib qho khoom siv vitamin raw khoom siv rau kev tiv thaiv zaub mov thiab khoom noj qab haus huv.
FAQ
Vim li cas cov kws kho mob muab tshuaj vitamin D2 es tsis yog D3?
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Cov kws kho mob feem ntau sau cov vitamin D2 (ergocalciferol) es tsis yog D3 (cholecalciferol) vimsiab- koob tshuaj D2 yog qhov yooj yim tshaj plaws uas muaj FDA- pom zoo kev xaiv tshuajrau kev kho mob tsis txaus. Thaum cov vitamin D3 feem ntau zoo dua ntawm kev nce ntshav, cov tshuaj D2 tso cai rau cov koob tshuaj loj, tus qauv txhua lub lim tiam lossis txhua hli.
Cov tsos mob ntawm vitamin D2 tsis txaus yog dab tsi?
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Cov tsos mob ntawm vitamin D2 tsis muaj peev xwm ua tau yooj yim thiab feem ntau tig mus ncig ntawm pob txha thiab leeg mob, qaug zog, kev nyuaj siab, thiab mob heev. Cov qib qis tuaj yeem cuam tshuam loj npaum li cas koj lub cev nqus calcium, ua rau lub cev tsis xis nyob.
Cim npe nrov: vitamin d2 hmoov cas 50-14-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom