Emodin hmoovyog cov organic compound nrog cov tshuaj formula C15H10O5, CAS 518-82-1. Nws yog ib lub txiv kab ntxwv daj koob zoo li tus siv lead ua uas crystallizes txiv kab ntxwv hauv acetone thiab daj hauv methanol. Nws muaj qhov melting point ntawm 256℃rau 257℃thiab nthuav tawm cov tshuaj tiv thaiv tshwj xeeb ntawm anthraquinone. Nws yuav luag insoluble hauv dej thiab soluble hauv ethanol thiab alkaline daws. Cov rhizomes qhuav thiab cov hauv paus hniav ntawm Polygonaceae cog Polygonum cuspidatum. Lub rhizome ntawm Rheum palmatum yog cov nroj tsuag -raws li tshuaj ntsuab. Nws lub cev ua haujlwm txiav txim siab tias nws tuaj yeem siv tsis tau tsuas yog rau kev kho mob, tab sis kuj rau kev noj qab haus huv thiab cov khoom siv tshuaj txhua hnub. Qee tus neeg siv nws hauv cov khoom siv plaub hau thiab tawv nqaij, thaum lwm tus siv nws rau hauv cov xim ntuj. Txawv teb chaws, tib neeg siv nws ua laxative. Nws tuaj yeem siv los ua laxative, txawm hais tias nws muaj kev ua haujlwm laxative, nws cov nyhuv laxative yog qhov tsis muaj zog vim nws qhov cuam tshuam rau oxidation thiab kev puas tsuaj hauv lub cev. Yog tias nws synthesizes glycosides nrog cov suab thaj, nws tuaj yeem ua rau cov nyhuv laxative. Emodin-1-O-beta-D-glucoside thiab Emodin-8-O-beta-D-glucoside yog glycosides uas khi emodin rau qabzib. Ob leeg tsuas muaj txoj haujlwm sib txawv thiab muaj nyob ib txhij hauv rhubarb. Kuj tseem muaj cov tshuaj tua kab mob, hnoos tshem tawm, tiv thaiv qog, thiab ntsuas ntshav siab.
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Tshuaj Formula |
C15H10O5 |
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Exact Mass |
270 |
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Molecular Luj |
270 |
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m/z |
270 (100.0%), 271 (16.2%), 272 (1.2%), 272 (1.0%) |
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Elemental Analysis |
C, 66.67; H, 3.73; O, 29.60 |
Emodin hmoovyog ib qho tyrosine kinase inhibitor, thiab kev tshawb fawb tshuaj niaj hnub no tau pom tias nws muaj kev tiv thaiv - mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam cov qog loj hlob, tiv thaiv lub raum interstitial fibrosis thiab diuresis, tiv thaiv ob lub raum, tiv thaiv thiab kho lub siab rog, nrog rau ntau yam kev ua haujlwm lom neeg xws li antioxidant thiab tiv thaiv kab mob plawv.
1) Kev tiv thaiv kab mob: Kev tshawb fawb tau pom tias ib qho gavage ntawm emodin ntawm 30 thiab 60mg / kg tuaj yeem cuam tshuam cov paw o hauv cov nas los ntawm carrageenan, thaum gavage ntawm 60 thiab 100mg / kg tuaj yeem cuam tshuam paw o hauv nas los ntawm carrageenan, thiab cov nyhuv inhibitory nce ntxiv; Ib qho gavage ntawm 90 thiab 150mg / kg tuaj yeem cuam tshuam qhov nce hauv capillary permeability tshwm sim los ntawm acetic acid hauv nas; Intraperitoneal txhaj ntawm 20 thiab 40mg / kg tuaj yeem cuam tshuam qhov exudation thiab leukocyte tsiv teb tsaws ntawm cov kab mob pleurisy hauv nas los ntawm carrageenan.
2) Antibacterial: Emodin muaj qhov dav -spectrum antibacterial nyhuv thiab tsis yooj yim tiv taus Staphylococcus aureus. Nws kuj yog rhiab heev rau Streptococcus, thiab zoo tiv thaiv kab mob diphtheria, quav nyab, anthrax, paratyphoid fever, dysentery, influenza bacteria, as well as pneumococcal and catarrhal bacteria. Nws muaj zog inhibitory nyhuv ntawm cov kab mob anaerobic.
3) Antiviral: Emodin muaj cov tshuaj tiv thaiv kab mob siab B, cytomegalovirus, EB tus kab mob, tus mob coronavirus, poliovirus, thiab kab mob caws pliav yooj yim. Txhawm rau kawm txog cov tshuaj tiv thaiv kab mob hauv vitro ntawm emodin ua ke nrog cov khoom xyaw sib txawv ntawm cov tshuaj suav tshuaj, cov tshuaj ua ke nrog cov txiaj ntsig ncaj qha ntawm tus kab mob yog emodin: curcumin: matrine=2: 1: 2; Kev sib xyaw ntawm cov tshuaj uas muaj cov tshuaj tua kab mob siab tshaj plaws yog emodin: curcumin: matrine=2: 0: 1. Cov tshuaj tiv thaiv caws pliav ntawm rhubarb tsuas yog tiv thaiv tus kab mob rov ua dua los ntawm inhibiting cov adsorption thiab nkag mus ntawm tus kab mob.
4) Antifungal kev ua ub no: Kev tshuaj xyuas tau ua los ntawm kev ua haujlwm ntawm cov tshuaj tua kab mob ntawm Rubiaceae, Rhamnaceae, thiab lwm yam, thiab nws tau pom tias cov dos tseem ceeb ketone ligands, nrog rau emodin, muaj cov tshuaj tua kab mob.
5) Antigen worm: Kev tshawb fawb tau pom tias emodin muaj ntau hom kab mob antigen, suav nrog Trypanosoma rhodesii, Leishmania donovani, thiab LK hom ntawm Plasmodium falciparum.
Ntau cov ntaub ntawv tau tshaj tawm tias emodin muaj inhibitory kev ua haujlwm hauv vitro thiab hauv vivo tawm tsam ntau yam qog nqaij hlav (xws li mob ntsws cancer, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, neurocytoma, mob qog noj ntshav hauv tsev menyuam, mob qog noj ntshav ntawm zes qe menyuam thiab lwm yam qog nqaij hlav, nrog rau cov qog nqaij hlav tsis muaj zog, thiab lwm yam. proliferation, txhawb cov qog apoptosis, thim rov qab qog ua haujlwm, inhibiting qog angiogenesis, inhibiting qog invasion thiab metastasis, thiab ua rau cov qog rhiab heev rau kev kho mob.
3. Kev tiv thaiv lub raum, tiv thaiv lub raum interstitial fibrosis, thiab cov teebmeem diuretic
1) Kev tiv thaiv lub raum: emodin tuaj yeem cuam tshuam kev ua haujlwm ntawm p38 mitogen activated protein kinase txoj hauv kev thiab txo cov kev qhia ntawm fibronectin hauv cov kab mob ntshav qab zib nephropathy nas, yog li ua lub luag haujlwm tiv thaiv hauv lub raum ntawm cov nas ntshav qab zib.
2) Anti lub raum interstitial fibrosis: Kev tshawb fawb tau pom tias emodin tuaj yeem cuam tshuam kev loj hlob ntawm tib neeg lub raum fibroblast cell voj voog.
3) Diuretic nyhuv: Emodin muaj qee yam diuretic nyhuv, yog li nws kuj muaj qee yam tshuaj tiv thaiv. Kev tshawb fawb tau pom tias emodin muaj ib koob tshuaj -lub sij hawm nyob ntawm qhov tshwm sim ntawm kev loj hlob thiab kev sib txawv ntawm cov nas preadipocytes, thiab tuaj yeem ua rau apoptosis ntawm preadipocytes rau qee qhov, yog li muaj peev xwm lipid- txo qis thiab poob phaus.
Emodin hmoovmuaj cov txiaj ntsig ntawm kev tiv thaiv thiab kho mob qog noj ntshav siab, rog rog, daim siab fibrosis, inhibiting kab mob siab B, thiab tiv thaiv lub siab puas hlwb. Hauv kev tiv thaiv thiab kho mob qog noj ntshav, kev tshawb fawb tau pom tias emodin muaj cov nyhuv inhibitory ntawm daim siab mob qog noj ntshav. Emodin muaj qee yam kev tiv thaiv thiab kev kho mob ntawm kev haus dej cawv thiab siab - noj zaub mov uas ua rau muaj rog rog hauv cov nas. Kev tshawb fawb tau pom tias qhov ncaj qha inhibitory nyhuv ntawm emodin ntawm kev loj hlob ntawm cov kab mob siab stellate thiab extracellular matrix synthesis yuav yog lub ntsiab mechanism ntawm nws cov tshuaj tiv thaiv daim siab fibrosis nyhuv. Emodin muaj qee yam cuam tshuam rau tus kab mob siab B hauv vitro; Emodin muaj kev tiv thaiv ntawm daim siab ischemia-reperfusion raug mob, uas cuam tshuam txog kev txo qis lipid peroxidation thiab daim siab sinusoidal endothelial cell puas tom qab daim siab ischemia-reperfusion.
Emodin muaj cov tshuaj laxative, tab sis vim nws qhov cuam tshuam rau oxidation hauv lub cev, nws cov nyhuv laxative tsis muaj zog. Yog tias nws synthesizes glycosides nrog cov suab thaj, nws tuaj yeem ua rau cov nyhuv laxative. Rhein tshwm sim tsis tau tsuas yog nyob rau hauv lub xeev dawb xwb, tab sis kuj nyob rau hauv lub xeev txo (xws li derivatives ntawm anthraquinone thiab anthraquinone) los yog nyob rau hauv glycosides synthesized los ntawm glycosylation. Piv txwv li, emodin anthraquinone los yog emodin anthraquinone (melting point 250-258 degree) pom nyob rau hauv cov nroj tsuag tshiab yog txo cov khoom ntawm emodin, uas feem ntau oxidized rau anthraquinone tebchaw tom qab ntev - lub sij hawm cia. Lub melting point ntawm emodin 1-O - - D-glucoside yog 189-190℃; Lub melting point ntawm emodin 8-O- - D-glucoside yog 239-241 degree, thiab ob leeg yog glycosides uas khi emodin rau qabzib thiab muaj nyob rau hauv ib txhij nyob rau hauv rhubarb. Cov qub kuj yog ib qho ntawm cov khoom xyaw nquag nrog cov tshuaj tua kab mob hauv Polygonum cuspidatum.
Muaj ob txoj hauv kev rau rho tawmemodin hmoov: organic solvent extraction thiab acid{0}}base extraction.
Method 1: Organic solvent extraction method
Cov kuab tshuaj organic xws li chloroform thiab benzene tuaj yeem siv rau kev rho tawm ncaj qha, thiab cov tshuaj extraction tej zaum yuav crystallize thaum lub sij hawm txheej txheem concentration. Methanol lossis ethanol kuj tuaj yeem siv rau kev rho tawm, thiab cov tshuaj extraction tuaj yeem ua kom muaj zog thiab tom qab ntawd muab faib nrog cov kuab tshuaj sib txawv lossis muab rho tawm nrog cov tshuaj aqueous ntawm cov pH sib txawv kom ua tiav qhov kev sib cais ua ntej. Vim muaj cov phenolic hydroxyl lossis hydroxyl pawg hauv emodin, nws khi nrog cov hlau ions xws li sodium, potassium, thiab magnesium nyob rau hauv cov nroj tsuag lub cev thiab muaj nyob rau hauv daim ntawv ntawm ntsev. Yog li ntawd, kua qaub yog siv los ua kom dawb emodin thaum lub sij hawm rho tawm, thiab tom qab ntawd rho tawm yog nqa tawm.
Txoj Kev 2: Alkaline extraction method
Nws yog vim hais tias emodin muaj hydroxyl pawg, thiab dos ketone tebchaw uas muaj hydroxyl pawg tuaj yeem raug rho tawm ncaj qha nrog cov tshuaj alkaline thiab tom qab ntawd precipitated nrog acid rau extraction. Ib txoj kev sib cais emodin siv co crystallization tau tsim, uas siv tag nrho anthraquinone extract ntawm rhubarb li raw khoom. Tag nrho anthraquinone extract ntawm rhubarb yog ib qho extract tau los ntawm cov hauv paus hniav thiab stems ntawm rhubarb siv cawv raws li tus neeg sawv cev extraction thiab reflux txoj kev. Cov txheej txheem suav nrog cov kauj ruam hauv qab no: sib tov tag nrho cov anthraquinone extract ntawm rhubarb nrog tert butylamine thiab isopropanol, siv 75-95% aqueous ethanol ua cov kuab tshuaj, nplawm cov tshuaj tiv thaiv kom huv si ntawm 70-100℃kom tau txais cov tshuaj ntshiab; Maj mam txias qhov tau txais kev daws teeb meem rau -10-20℃hauv 4-8 teev, cia nws sawv ntsug kom txog thaum nws crystallizes, lim kom tau cov ncuav qab zib lim thiab lim. Lub ncuav mog qab zib lim yog recrystallized nrog methanol los yog 75% -85% aqueous ethanol, thiab cov khoom siv lead ua crude yog decomposed los ntawm kev ntxiv acidic aqueous tov los kho tus nqi pH rau 2-4. Tom qab ntawd, chloroform yog ntxiv rau kev rho tawm, thiab cov txheej txheem organic yog evaporated kom tau emodin crude. Lub crude emodin yog recrystallized kom tau txais cov ntshiab emodin.
Emodin hmoovmuaj ntau yam tshuaj tiv thaiv- mob qog noj ntshav, thiab cov hauv qab no yog qee qhov tseem ceeb tiv thaiv -mob qog noj ntshav thiab cov teebmeem:
Inhibits cancer cell proliferation thiab induce apoptosis
Nws tuaj yeem txo qhov kev muaj peev xwm ntawm cov qog nqaij hlav hauv plab thiab ua rau lub voj voog ntawm tes raug ntes thiab apoptosis.
Hauv vitro, nws tuaj yeem ua rau cov qog cell apoptosis los ntawm kev cuam tshuam rau kev qhia ntawm caspase-3 thiab caspase-9, thiab muaj kev kho mob rau mob qog noj ntshav pancreatic.
Inhibiting qog epithelial mesenchymal hloov pauv (EMT) thiab txhawb cov qog cell migration
Nws inhibits qog EMT thiab cell migration los ntawm Wnt/ - catenin thiab VEGFR2-AKT-ERK1/2 signaling pathways.
Emodin inhibits Wnt/ - catenin signaling nyob rau hauv txoj hnyuv EMT thiab cell mob.
Txo cov qog cell ntxeem tau thiab tsiv teb tsaws
Nws txo qhov kev ntxeem tau thiab kev tsiv teb tsaws ntawm cov qog nqaij hlav hauv plab los ntawm kev txo qis VEGF (vascular endothelial kev loj hlob zoo).
Kev tswj cov kev qhia ntawm qog suppressor miRNAs
Nws muaj txiaj ntsig zoo txhawb kev qhia ntawm cov qog nqaij hlav miR-34a hauv daim siab mob qog noj ntshav thiab inhibits VEGFR2 induced activation ntawm AKT, ERK1/2, SMAD2, thiab SMAD4.
Inhibit Tumor Angiogenesis
Nws inhibits angiogenesis ntawm pancreatic cancer los ntawm kev txo cov theem qhia ntawm miRNAs (xws li miR-155 thiab miR-210) ntsig txog cov qog nqaij hlav thiab angiogenesis, thiab nce kev qhia ntawm anti angiogenesis miR-20b.
Raws li kev kho mob adjuvant los txhim kho kev ua tau zoo ntawm chemotherapy
Thaum siv ua ke nrog cov tshuaj khomob, nws tuaj yeem txhim kho kev siv tshuaj khomob, txo cov qog loj hlob thiab kev loj hlob ntawm tes.
Thaum siv ua ke nrog sorafenib, nws tuaj yeem cuam tshuam cov qog loj hlob thiab txhim kho cov txiaj ntsig ntawm sorafenib.
Thaum siv ua ke nrog EGFR inhibitor afatinib, nws tuaj yeem txo qhov kev loj hlob ntawm PANC-1 thiab BxPC-3 hlwb, thiab pom muaj kev sib koom ua ke los tiv thaiv qog nqaij hlav hauv pancreatic cancer nas qauv.
Siv ua ke nrog gemcitabine
Hauv cov qauv xenotransplantation ntawm gemcitabine resistant PANC-1 pancreatic cancer hlwb, nws ua ke nrog gemcitabine tuaj yeem txo qhov ntim ntawm xenotransplantation thiab qog loj hlob.
Cov lus nug nquag
Dab tsi yog emodin siv rau?
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Emodin muaj ntau yam kev ua haujlwm lom neeg, suav nrogdiuretic, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv -inflammatory, anticancer thiab antinociceptive. Raws li cov kev tshawb fawb tsis ntev los no, emodin ua raws li cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob, thiab tuaj yeem thim rov qab rau cov tshuaj kho mob.
Cov zaub mov twg muaj emodin siab?
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Emodin yog anthraquinone phytochemical pom nyob rau hauv cov nroj tsuag -raws li cov khoom noj xws lirhubarb, cabbage thiab taum[18], [19], [20]. Tsis tas li ntawd, emodin- cov nroj tsuag nplua nuj, suav nrog buckthorn thiab knotweed, tau siv rau hauv cov tshuaj niaj hnub rau ntau pua xyoo los tiv thaiv kab mob, kab mob thiab plab hnyuv.
Puas yog emodin pab nrog kev ntxhov siab?
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Cov ntaub ntawv pov thawj kev sim tshiab qhia tau hais tias emodin muab ntau yam kev ua haujlwm tshuaj;Kev tsom xam tshwj xeeb tau siv rau cov kab mob neurodegenerative, suav nrog Alzheimer's disease, Parkinson's disease, cerebral ischemia, ntxhov siab vim thiab kev nyuaj siab., schizophrenia, mob hyperglycemic peripheral.
Puas yog emodin yog cortisol blocker?
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Yog lawm, emodin tuaj yeem thaiv cortisol los ntawm kev xaiv inhibiting enzyme 11 -hydroxysteroid dehydrogenase type 1 (\\(11\\beta -HSD1\\)). Cov enzyme no hloov cortisone tsis ua haujlwm rau hauv cov tshuaj hormone cortisol, yog li los ntawm inhibiting nws, emodin tuaj yeem txo lub cev muaj peev xwm tsim cortisol. Kev tshawb fawb qhia tau hais tias emodin muaj cov nyhuv no ob qho tib si hauv kev tshawb fawb ntawm tes thiab hauv cov qauv tsiaj.
Dab tsi yog qhov zoo tshaj ntxiv los txo cortisol?
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Ashwagandha, magnesium, thiab omega -3 fatty acids yog cov tshuaj pab tau zoo tshaj plaws los txo cortisol. L-theanine, phosphatidylserine, thiab vitamin C kuj tau pom zoo. Txawm li cas los xij, qhov zoo tshaj plaws ntxiv yog nyob ntawm tus neeg xav tau kev pab thiab nws yog ib qho tseem ceeb uas yuav tau tham txog ib qho kev ntxiv tshiab nrog tus kws kho mob ua ntej pib, vim tias lawv tsis yog ib qho kev hloov rau kev noj qab haus huv.
Cim npe nrov: Emodin hmoov CAS 518-82-1, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom