Adrenochrome hmoovyog qhov tseem ceeb ntawm adrenaline hmoov. Nws yog cov khoom oxidation ntawm adrenaline. Nws yog hmoov liab. Nws yog ib qho zoo vasoconstrictor rau lub plawv nas. Cov xim adrenal tuaj yeem siv rau hauv kev tshawb fawb ntawm cov kab mob neurological. Ntau cov pov thawj qhia tau hais tias nws tuaj yeem oxidized los ntawm cov kua dej hauv lub cev thiab cov ntaub so ntswg hauv ntau hom tsiaj. Raws li kev tshawb fawb, muaj kev ua haujlwm hallucinogenic. Nws yog ib qho ua rau mob schizophrenia. Nws tuaj yeem txo capillary permeability. Nws yog siv 1 ~ 2 ib kilogram ntawm tib neeg lub cev μ G muaj cov nyhuv hemostatic ntxiv, melanin muaj nyob rau hauv cov tsiaj, thiab kuv yog ib qho nruab nrab rau melanin ntau lawm 34) Predecessors taw qhia tias thaum kis kab mob los ntawm kab hlau los yog coexisting nrog II. , cov kev sim tshuaj pharmacological tsis raug. Raws li cov lus hais ntawm sigma reagent tuam txhab nyob rau hauv 1997, tus I ib gram yog siab li 304 90 las, thiab txog 10 las ib gram. Yog li ntawd, nws yog ntawm theoretical thiab economic nqi los kawm cov txheej txheem ntawm kev npaj kuv muaj ob qho teeb meem nyob rau hauv cov kev npaj uas twb muaj lawm cov kev npaj ntawm adrenaline liab Feem ntau hais lus, qhov siab dua qhov yield (50%), qhov qis purity (6 ~ 10); Thaum cov purity siab, cov yield yog feem ntau tsuas yog 17% 1, thiab cov kev khiav hauj lwm tej yam kev mob yuav tsum tau tswj ntawm - 80 degree C. Nws kuj tau tshaj tawm hais tias cov organic oxidants kuj siv tau rau kev npaj, tab sis cov txheej txheem ntawm kev npaj. xws li oxidants yog complex thiab koom nrog ntau cov pa phem.
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Melting point |
115-120 degree C |
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Boiling point |
311.69 ° C (kev kwv yees kwv yees) |
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Qhov ntom |
1.2822 (kev kwv yees kwv yees) |
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Cia tej yam kev mob |
-20 ° C |
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Cov khoom txaus ntshai kos npe |
Xis |
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Acidity coefficient (pKa) |
3.31 ± 0.20 (kwv yees) |
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Refractive Index |
1.5600 (kwv yees) |
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Cov khoom txaus ntshai kos npe |
Xis |
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Hazard qeb code |
36 / 37 / 38 |
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Cov lus qhia kev nyab xeeb |
36-26 |
|
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Melting point {{0}} degree C, Boiling point 311.69 degree C (kwv yees ntxhib), Ceev 1.2822 (kwv yees ntxhib), Refractive index 1.5600 (kwv yees), Cia tej yam kev mob - 20 degree C, Acidity coefficient (PKA) 13.31 ± 0.20 (kwv yees), kev ruaj ntseg cov ntaub ntawv, Dangerous goods sign Xi, Hazard qeb code 36 / 37 / 38, Safety lus qhia 26-36, WGK Lub teb chaws Yelemees 3.
Hauv kev sim yav dhau los, feem ntau ntawm cov hluavtawsadrenochrome hmoovtau npaj los ntawm cov organic oxidants, tab sis cov txheej txheem kev npaj ntawm hom oxidant no nyuaj thiab cuam tshuam ntau cov pa phem. Yog li ntawd, tom qab rov nug thiab kev sim, peb lub chaw kuaj mob tau muab cov txheej txheem hluavtaws. Txoj kev no yog txoj kev yooj yim tshaj plaws los npaj high-purity adrenaline liab los ntawm kev siv tshuaj lom neeg tam sim no, thiab cov txiaj ntsig tau ntau dua 30%. Txoj kev xyaum tau ua pov thawj tias qhov purity ntawm adrenaline liab tau los ntawm txoj kev no tuaj yeem khaws cia rau lub sijhawm ntev ntawm - 10 ~ 20 degree C thiab hauv qhov tsaus ntuj. Nrog rau kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis thiab kev ua kom tob tob ntawm kev tiv thaiv ib puag ncig, Kev npaj ntawm adrenaline liab yuav maj mam txhim kho rau kev npaj electrochemical thiab kev tswj tsis siv neeg. Nyob rau tib lub sijhawm, cov tshuaj tiv thaiv nruab nrab yog maj mam hloov los ntawm cov kuab tshuaj organic mus rau cov kuab tshuaj aqueous (16 ~ 18) Qhov kev tshawb fawb no yuav muaj txiaj ntsig zoo rau kev paub txog kev txawj ntse technology.
Cov kev ceev faj tshwj xeeb yog raws li hauv qab no: muab adrenaline nyob rau hauv methanol hnyav thiab ntxiv formic acid dropwise kom txog thaum nws pom tseeb Ntxiv cov tshiab npaj Ag2O rau hauv cov tshuaj saum toj no nyob rau hauv batches nyob rau hauv muaj zog nplawm thiab nruj me ntsis tswj lub sij hawm cov tshuaj tiv thaiv, ces lim cov tshuaj los ntawm anhydrous sodium sulfate. txaj, ntxuav cov seem nrog rau qhov tsim nyog ntawm methanol thiab muab tso rau hauv lub filtrate, tso cov filtrate nyob rau hauv ib da dej uas tsis muaj kub thiab txias nws ntawm - 30 degree C kom tau purplish liab siv lead ua, ntxuav lub crystal nrog txias methanol. ether, thiab qhuav nws ntawm qhov kub thiab txias kom tau txais cov khoom, muab tso rau hauv lub thawv ntim thiab khaws cia rau hauv qhov chaw tsaus ntawm - 10 ~ 20 ° C Raws li cov txiaj ntsig ntawm cov khoom siv lead ua hauv UV kuaj, qhov purity ntawm cov khoom tau los ntawm txoj kev no yog siab.
Peb yog cov chaw tsim khoomAdrenochrome hmoov
Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog lub chaw pabcuam ntawm peb.
Ib txoj kev npaj rau dl adrenaline, siv sinephrine hydrochloride ua raw khoom, uas yog tiv thaiv los ntawm boc pawg nyob rau hauv qhov kev txiav txim ntawm ib tug acid binding tus neeg saib xyuas kom tau cov compound a, uas yog ces oxidized los ntawm 2-iodobenzoic acid thiab txo los ntawm sodium. bisulfite kom tau cov compound b. Compound b ces deprotected los ntawm hydrochloric acid kom tau dl adrenaline zoo li cov hmoov dawb. Cov kauj ruam ntawm kev npaj rau dl adrenaline yog raws li nram no:
Ntxiv Xinfulin hydrochloride rau cov tshuaj tiv thaiv lub khob, ua ntej ntxiv cov kuab tshuaj thiab cov kua qaub khi, tom qab ntawd ntxiv boc anhydride thiab do hauv chav sov li 1 teev. Tom qab ntawd, tsa qhov kub thiab txias rau 60 degree ~ 70 degree, tshem tawm cov tshuaj thiab sau cov organic theem. Ntxuav cov organic theem nrog 0.1n hydrochloric acid thiab saturated ntsev dej raws. Tom qab ntxuav, ntxiv n-hexane, txo qhov kub kom precipitate, lim, thiab qhuav kom tau cov compound a;
Ntxiv cov tshuaj sib xyaw ua ke thiab cov kuab tshuaj 1 rau cov tshuaj tiv thaiv lub khob, tom qab ntawd ntxiv 2-iodoylbenzoic acid, thiab hnov mob rau 1-3 teev. Tom qab ntawd, ntxiv dej thiab sodium hydrosulfite, thiab ua rau 1 teev ua ntej lim. Lub filtrate yog distilled nyob rau hauv lub siab txo kom txog thaum ib tug oily tshuaj tshwm nyob rau hauv cov tshuaj. Extract ob zaug nrog hnyav 2, ntxuav ib zaug nrog saturated sodium bicarbonate tov thiab ib zaug nrog saturated ntsev dej. Qhuav nrog anhydrous sodium sulfate thiab rov qab cov kuab tshuaj los ntawm kev txo qis distillation. Dissolve nrog hnyav 3, ces ntxiv n-hexane thiab do nyob rau hauv chav tsev kub rau crystallization, Lim thiab qhuav lub lim ncuav mog qab zib kom tau compound b;
Ntxiv cov tshuaj hydrochloric acid nrog rau qhov concentration ntawm 3mol / l rau cov tshuaj tiv thaiv lub raj mis, nce qhov kub ntawm 45 ° C -60 degree C, thiab tom qab ntawd ntxiv cov tshuaj b rau 1-3 teev. Tom qab cov tshuaj tiv thaiv tiav, txo qis rau hauv chav tsev kub, kho tus nqi pH nrog cov dej ntshiab ammonia, crystallize, lim, ntxuav nrog dej, ntxuav nrog methanol, thiab nqus kom qhuav kom tau dl adrenaline.
Tag nrho cov molar yield ntawm dl adrenaline npaj los ntawm txoj kev no yog ntau dua 50%, lub chromatographic purity yog ntau dua 96%, thiab tus nqi ee yog ze rau xoom, txo cov nqi npaj ntawm dl adrenaline. Kev ua haujlwm yog yooj yim, ib puag ncig tus phooj ywg, thiab yog qhov tsim nyog rau kev tsim khoom, nrog rau kev siv dav dav.
Adrenochrome hmoovRaws li ib qho tseem ceeb fluorescent dye, nws cov qauv molecular tshwj xeeb endows nws nrog fluorescence kev ua tau zoo thiab biocompatibility. Hauv kev tsom xam cov qauv molecular, peb tsis tsuas yog yuav tsum tsom mus rau nws cov tshuaj lom neeg muaj pes tsawg leeg, tab sis kuj nkag siab tob txog nws qhov kev teeb tsa thiab kev faib hluav taws xob kom nthuav tawm nws cov khoom thiab cov txheej txheem ntawm kev ua haujlwm hauv kev siv.
1. Cov tshuaj muaj pes tsawg leeg ntawm D, L-adrenergic liab
D. Cov qauv hauv paus ntawm L-adrenergic liab suav nrog ntau pawg ua haujlwm thiab lub nplhaib benzene. Ntawm lawv, qhov tseem ceeb tshaj plaws yog sulfonyl (-SO3H) thiab Rhodamine B skeleton. Sulfonyl pawg endows molecules nrog zoo solubility thiab stability, thaum lub Rhodamine B moj khaum muab muaj zog fluorescence emission. Tsis tas li ntawd, cov molecule tseem muaj cov pab pawg ua haujlwm xws li amino (-NH2) thiab carboxyl (-COOH), uas tsis yog tsuas yog cuam tshuam rau kev solubility thiab kev ruaj ntseg ntawm cov molecule, tab sis kuj muab tau rau nws daim ntawv thov nyob rau hauv biomarkers thiab nrhiav kom tau.
2. Lub spatial configuration ntawm D, L-adrenergic liab
D. Lub spatial configuration ntawm L-adrenergic liab nthuav tawm ib tug qauv planar conjugated qauv. Lub nplhaib benzene thiab dimethylaminophenyl nyob rau hauv Rhodamine B skeleton yog txuas los ntawm ob daim ntawv cog lus los ua ib tug planar π - conjugated system. Qhov no conjugated system yog ib cheeb tsam tseem ceeb rau fluorescence emissions, qhov twg electron hloov thiab lub zog hloov. Tsis tas li ntawd, cov pab pawg ua haujlwm xws li sulfonyl thiab amino pawg nyob rau ntawm ob sab ntawm cov kab ke sib txuas thiab sib txuas nrog cov pob txha Rhodamine B.
3. Kev faib hluav taws xob ntawm D, L-adrenergic liab
Kev faib hluav taws xob yog qhov tseem ceeb cuam tshuam rau cov khoom fluorescence ntawm D, L-adrenergic liab molecules. Lub π - conjugated system nyob rau hauv Rhodamine B lub moj khaum tso cai rau cov electrons mus dawb ntws thiab hloov lub zog nyob rau hauv nws. Thaum raug lub teeb sab nraud, cov hluav taws xob yuav hloov ntawm lub xeev hauv av mus rau lub xeev zoo siab, thiab tom qab ntawd rov qab mus rau hauv av thiab tawm fluorescence nyob rau lub sijhawm luv luv. Tsis tas li ntawd, cov pab pawg ua haujlwm xws li sulfonyl thiab amino pawg tuaj yeem cuam tshuam rau kev faib tawm thiab kev hloov pauv ntawm electrons. Piv txwv li, sulfonyl pawg tuaj yeem nyiam cov dej nyob ib puag ncig los ntawm kev sib cuam tshuam ntawm electrostatic, tsim cov txheej txheem dej ruaj khov los tiv thaiv pawg fluorescent los ntawm kev cuam tshuam sab nraud.
Cim npe nrov: adrenochrome hmoov cas 54-06-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom