Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm loperamide hydrochloride hmoov cas 34552-83-5 nyob Suav teb. Txais tos rau cov lag luam wholesale bulk zoo loperamide hydrochloride hmoov cas 34552-83-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Loperamide Hydrochloride hmoov, nws cov mis molecular yog C29H33ClN2O2, yog dawb los yog tawm -dawb crystalline hmoov, yooj yim soluble nyob rau hauv organic solvents xws li chloroform, ethanol thiab methanol, tab sis insoluble nyob rau hauv dej. Nws muaj thermal stability thiab zoo cia ruaj khov ntawm chav tsev kub. Dissolved nyob rau hauv ib tug acidic ib puag ncig (xws li kua txiv hmab txiv ntoo), nws yuav sai sai hloov mus rau hauv inactive tshuaj, uas yuav metabolized thiab tawm hauv lub siab. Nyob rau hauv X-ray hmoov diffraction tsom xam, Loperamide hydrochloride nthuav tawm qhov tseeb diffraction peaks, uas tuaj yeem siv los txiav txim siab nws cov qauv siv lead ua thiab cov lattice tsis. Hauv Fourier hloov pauv infrared spectroscopy (FT-IR) tsom xam, Loperamide hydrochloride nthuav tawm cov yam ntxwv ntawm infrared absorption peaks, uas tuaj yeem siv los txheeb xyuas nws cov qauv thiab purity. Nws yog qhov tseem ceeb ntawm ntau yam kev npaj xws li kev npaj ntawm qhov ncauj, cov kua hauv qhov ncauj thiab cov tshuaj ntsiav. Nws yog ib hom tshuaj tiv thaiv kab mob raws plab, siv dav hauv kev kho mob, kev kho mob thiab cov khoom siv thiab lwm yam.
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Loperamide hydrochloride yog ib qho peripheral opioid receptor agonist uas inhibits plab hnyuv overactivity los ntawm ntau txoj hauv kev kom ua tiav cov tshuaj tiv thaiv kab mob. Nws cov txheej txheem ntawm kev txiav txim suav nrog inhibition ntawm plab hnyuv peristalsis, kev tswj kev zais cia, txhim kho kev ua haujlwm ntawm sphincter, thiab cuam tshuam ntawm neural signals. Nws yog qhov tsim nyog rau cov xwm txheej xws li tsis kis mob hnyav thiab mob raws plab, kev tswj xyuas tom qab ileostomy, thiab rov qab los tom qab phais anorectal.
1. Inhibit smooth nqaij contraction ntawm txoj hnyuv phab ntsa
Los ntawm stimulating lub plab hnyuv phab ntsa μ - opioid receptors, influx ntawm calcium ions mus rau hauv cov leeg nqaij hlwb yog ncaj qha inhibited, txo cov contraction zaus ntawm lub voj voog thiab longitudinal leeg txheej. Kev sim cov ntaub ntawv qhia tau hais tias tom qab noj tshuaj, qhov zaus ntawm cov hnyuv me peristalsis tuaj yeem txo tau los ntawm 50% -70%, thiab lub sijhawm ua haujlwm ntawm cov hnyuv tuaj yeem ua kom ntev li 2-3 zaug, yog li txo qhov zaus ntawm cov hnyuv. Piv txwv li, nyob rau hauv cov neeg mob uas chim siab plob tsis so tswj kab mob raws plab, cov tshuaj muaj peev xwm txo tau lub niaj hnub zaus ntawm lub plab zom mov ntawm 4-6 zaug mus rau 1-2 zaug.
2. Thaiv cov neurotransmitter tso tawm
Cov tshuaj reversibly inhibits kev tso tawm ntawm acetylcholine thiab prostaglandins los ntawm cov hlab ntsha xaus nyob rau hauv lub plab hnyuv phab ntsa, tsis muaj zog lub zos stimulation ntawm txoj hnyuv phab ntsa receptors los ntawm irritant raws plab (xws li zaub mov seem thiab kua tsib acids). Noj tshuaj kho mob raws plab raws li piv txwv, loperamide hydrochloride tuaj yeem txo qhov 5-HT3 receptor-mediated plab hnyuv cov lus teb thiab txo qhov tshwm sim ntawm cov quav dej.
3. Txhim kho qhov quav sphincter nro
Los ntawm kev ua kom lub paj hlwb parasympathetic ntawm sacral qaum, cov tshuaj muaj peev xwm ua rau kom lub siab so ntawm qhov quav sphincter li ntawm 30% -40% thiab inhibit fecal incontinence.
Cov txheej txheem no yog qhov tseem ceeb tshwj xeeb rau cov neeg mob tom qab phais qhov quav, vim nws tuaj yeem txo qhov zaus ntawm lub plab txhua hnub (los ntawm 8-10 txog 3-5) thiab ua kom cov quav sib xws.
4. Tswj cov dej hauv plab hnyuv thiab nqus electrolyte
Cov tshuaj ua kom lub sijhawm khaws cia ntawm cov khoom hauv plab hnyuv, txhawb nqa kev sib koom ua ke ntawm sodium, chlorine, thiab qabzib, thiab nce dej nqus. Piv txwv li, nyob rau hauv cov neeg mob raws plab raws plab, cov ntsiab lus ntawm cov dej fecal tuaj yeem txo los ntawm 85% mus rau qis dua 60% tom qab noj tshuaj.
Cov txheej txheem ua haujlwm tshwj xeeb
1. Kev kho mob raws plab
Thawj koob tshuaj: Cov neeg laus thawj koob tshuaj 4mg (2 tsiav tshuaj), cov menyuam yaus hnub nyoog 5 xyoos 2mg (1 tsiav tshuaj), noj ntawm lub plab khoob lossis 30 feeb ua ntej noj mov los txhim kho bioavailability.
Kev tswj hwm tom qab: Ntxiv 2mg tom qab txhua lub plab zom mov, nrog qhov siab tshaj plaws txhua hnub tsis pub tshaj 16mg rau cov neeg laus lossis 3mg rau 20kg lub cev hnyav rau menyuam yaus.
Kev tswj cov chav kawm: Cov tshuaj rau mob raws plab yuav tsum tsis pub tshaj 48 teev. Yog tias cov tsos mob tsis zoo, cov tshuaj yuav tsum raug tso tseg tam sim ntawd thiab qhov ua rau kis tau yuav tsum tau tshawb xyuas. Piv txwv li, yog tias tus neeg mob uas muaj kab mob dysentery siv cov tshuaj no tsis raug, nws tuaj yeem npog cov tsos mob ntawm cov quav ntshav thiab ncua kev kho tshuaj tua kab mob.
Txheej txheem tswj kev mob raws plab
Kev hloov kho koob tshuaj: thawj koob tshuaj yog 4mg ib hnub rau cov neeg laus thiab 2mg ib hnub rau cov menyuam yaus, maj mam hloov kho cov tshuaj noj raws li cov quav sib xws (4-8mg ib hnub rau cov neeg laus thiab 1-6mg ib hnub rau menyuam yaus).
Kev saib xyuas lub sij hawm ntev: Rov xyuas cov electrolytes (tshwj xeeb tshaj yog cov poov tshuaj thiab sodium) thiab lub siab thiab lub raum ua haujlwm txhua 3 lub hlis kom tsis txhob muaj hypokalemia (nrog rau qhov tshwm sim ntawm kwv yees li 5%) thiab tshuaj lom lom. Piv txwv li, cov neeg mob cirrhosis yuav tsum tau txo lawv cov koob tshuaj los ntawm 50% vim qhov txo qis ntawm cov metabolism hauv thawj zaug.
Daim ntawv thov txheej txheem ntawm ileostomy rau cov neeg mob
Kev npaj ua ntej: Cov tshuaj yuav tsum tau muab 24 teev tom qab kev phais, nrog thawj koob tshuaj 4mg ib hnub rau cov neeg laus thiab 2mg ib hnub rau menyuam yaus.
Kev ntsuam xyuas cov txiaj ntsig: Kho qhov ntau npaum li cas los ntawm kev sau cov ntim quav txhua hnub (lub hom phiaj<500ml/day) and consistency (Bristol grade 3-4) of the ostomy bag. Research shows that standardized medication can reduce bowel movements by 60% -70%.
1. Mob plab tom qab siv tshuaj kho mob
Loperamide hydrochloride tuaj yeem siv ua ke nrog octreotide rau kev siv tshuaj khomob mus rau qhov mob hnyav nrog rau kev mob raws plab (CTCAE qib Ntau dua lossis sib npaug rau 2). Cov txheej txheem tshuaj yog raws li hauv qab no: thawj koob tshuaj yog 4mg, thiab tom qab ntawd 2mg txhua 2 teev kom txog thaum zawv plab nres. Qhov siab tshaj plaws txhua hnub koob tshuaj tsis pub tshaj 16mg. Nws yuav tsum raug sau tseg tias cov neeg mob AIDS tuaj yeem tsim cov tshuaj lom megacolon thaum siv nws, thiab cov tsos mob plab yuav tsum tau saib xyuas kom zoo.
2. Irritable bowel Syndrome (IBS-D)
Raws li qhov thib ob - cov tshuaj kho kab, nws tsim nyog rau cov neeg mob uas tsis muaj txiaj ntsig nrog loperamide lossis xav tau kev tswj xyuas cov tsos mob sai.
Txais yuav ib qho ntawm - xav tau cov tshuaj noj: Noj 2mg 30 feeb ua ntej noj mov, tsis pub ntau tshaj 4 zaug hauv ib hnub. Cov kev sim tshuaj ntsuam xyuas tau pom tias cov txheej txheem no tuaj yeem txo cov neeg mob cov qhab nia mob plab (VAS tus qhab nia poob ntawm 6.2 txog 3.8).
3. Kev ua haujlwm raws plab hauv cov menyuam yaus
Cov menyuam yaus hnub nyoog qis dua 5 xyoos tuaj yeem muab 0.1mg / kg lub cev qhov hnyav, nrog rau ib hnub tsis pub tshaj 8mg. Kev hloov pauv kev noj zaub mov (xws li kev noj zaub mov tsawg FODMAP) thiab kev noj tshuaj ntxiv yuav tsum ua ke. Piv txwv li, kev siv lactase ua ke nrog lactose intolerance hauv cov menyuam yaus tuaj yeem ua rau muaj kev tiv thaiv raws plab los ntawm 40%.
Loperamide hydrochloride yog ib qho tshuaj tua kab mob uas siv dav hauv kev kho mob, kev kho mob thiab cov khoom siv. Nws lub luag haujlwm tseem ceeb suav nrog inhibiting plab hnyuv motility thiab secretion, nce qhov nro ntawm qhov quav sphincter, thiab lwm yam, kom ua tiav lub hom phiaj ntawm inhibiting raws plab thiab txo cov tsos mob. Txhua qhov kev siv ntawm Loperamide hydrochloride yuav qhia meej hauv qab no.
Loperamide Hydrochloride hmoovyog ib qho tshuaj zoo rau kev kho mob raws plab. Mob raws plab yog ib hom kab mob plab, thiab nws cov tsos mob tseem ceeb muaj xws li raws plab, mob plab, xeev siab, thiab ntuav. Loperamide tuaj yeem cuam tshuam txoj hnyuv motility thiab secretion los ntawm ob qho kev ua, yog li txo tus nqi thiab lub sij hawm ntawm excretion thiab txo cov tsos mob raws plab. Cov kev tshawb fawb soj ntsuam tau pom tias qhov ua tau zoo ntawm Loperamide hydrochloride hauv kev kho mob raws plab yog siab li 90%, thiab nws yog cov tshuaj xaiv rau kev kho mob raws plab.
2. Kev kho mob raws plab:
Ntxiv nrog rau nws cov txiaj ntsig zoo kawg nkaus rau kev mob raws plab, Loperamide hydrochloride tuaj yeem siv los kho mob raws plab. Mob raws plab yog ib hom kab mob raws plab uas kav ntev tshaj 4 lub lis piam, thiab nws cov tsos mob muaj xws li raws plab, mob plab, plab zom mov, thiab lwm yam. Piv nrog rau mob raws plab, lub etiology ntawm tus mob raws plab yog complex thiab yuav tsum tau kev kho mob. Loperamide hydrochloride tuaj yeem txo tus nqi thiab lub sijhawm ntawm kev tso tawm thiab txo cov tsos mob raws plab los ntawm inhibiting plab hnyuv motility thiab secretion, thiab muaj qhov zoo ntawm kev ceev, nyab xeeb, zoo thiab yooj yim.
Diarrhea dependence yog hais txog qhov rov tshwm sim ntawm raws plab uas ua rau cov tsos mob ntawm kev quav tshuaj yeeb hauv cov neeg mob. Loperamide hydrochloride tuaj yeem txo tus nqi thiab lub sijhawm ntawm kev tso tawm los ntawm inhibiting plab hnyuv motility thiab secretion, tshem tawm raws plab dependence, thiab restore lub cev defecation.
4. Kev kho mob plab hnyuv:
Loperamide hydrochloride tuaj yeem siv los kho cov kab mob hauv plab. Gastrointestinal kab mob yog ib hom kab mob plab, thiab nws cov tsos mob tseem ceeb muaj xws li raws plab, xeev siab, ntuav, thiab mob plab. Loperamide hydrochloride tuaj yeem txo tus nqi thiab lub sijhawm ntawm kev tso tawm thiab txo cov tsos mob raws plab los ntawm inhibiting plab hnyuv motility thiab secretion. Nyob rau tib lub sijhawm, nws tseem tuaj yeem ua rau lub suab nrov ntawm qhov quav sphincter thiab txo cov leeg nqaij qaug zog los ntawm raws plab.
Radiation enteritis yog kab mob plab hnyuv loj los ntawm kev kho hluav taws xob, thiab nws cov tsos mob tseem ceeb suav nrog raws plab, mob plab, xeev siab, thiab ntuav. Loperamide hydrochloride tuaj yeem txo tus nqi thiab lub sijhawm ntawm kev tso tawm thiab txo cov tsos mob raws plab los ntawm inhibiting plab hnyuv motility thiab secretion, thiab muaj qhov zoo ntawm kev ceev, nyab xeeb, zoo thiab yooj yim. Yog li ntawd, nws kuj yog dav siv nyob rau hauv kev kho mob ntawm hluav taws xob enteritis.
6. Rau cov khoom siv:
Ntxiv nrog rau kev kho mob, Loperamide hydrochloride kuj tau siv dav hauv ntau yam khoom siv. Ntawm lawv, feem ntau yog cov tshuaj siv tshuaj xws li cov kua hauv qhov ncauj, ntsiav tshuaj, thiab tshuaj ntsiav. Tsis tas li ntawd, Loperamide hydrochloride kuj tseem siv rau hauv kev npaj cov khoom siv tu xws li lub qhov quav xiav, uas muaj lub luag haujlwm ntawm dyeing thiab antibacterial.
Ntxiv nrog rau cov kev siv saum toj no, Loperamide hydrochloride kuj tseem siv rau ntau qhov chaw. Piv txwv li, nws tuaj yeem siv rau kev kho qhov ncauj, uas muaj qee yam kev cuam tshuam rau cov hniav rhiab, los ntshav cov pos hniav thiab lwm yam teeb meem; Nyob rau tib lub sijhawm, nws tseem tuaj yeem siv los txhim kho cov khoom noj tsiaj, yog li txhim kho kev noj qab haus huv thiab kev ua haujlwm ntawm cov tsiaj nyeg thiab nqaij qaib thiab lwm yam tsiaj.
Hauv kev xaus,Loperamide Hydrochloride hmoovyog ib qho tshuaj tiv thaiv kab mob tseem ceeb heev, uas yog siv dav hauv kev kho mob, kev kho mob thiab cov khoom siv. Hauv kev siv sib txawv, nws cov txheej txheem ntawm kev nqis tes ua thiab cov txiaj ntsig tiag kuj tseem yuav txawv, thiab nws yuav tsum tau xaiv thiab siv raws li qhov tseeb.
Loperamide hydrochloride yog ib qho tshuaj tua kab mob uas siv dav hauv kev kho mob, kev kho mob thiab cov khoom siv. Cov hauv qab no yuav qhia tag nrho cov txheej txheem synthesis ntawm Loperamide hydrochloride, feem ntau suav nrog cov tshuaj synthesis, microbial fermentation thiab inorganic ntsev pauv.
Cov txheej txheem hluavtaws ntawm Loperamide hydrochloride:
Siv 2,2-diphenyl- -butyrolactone nruab nrab raws li cov khoom pib, lub nplhaib- qhib kev hloov hauv hydrogen bromide-glacial acetic acid kua nyob rau hauv chav tsev kub kom tau 2,2-diphenyl-4-bromobutyric acid , 2,2-diphenyl-4-bromobutyric acid yog acylated thiab reacted nrog dimethylamine los npaj dimethyl-(tetrahydro-3,3-diphenyl-2-furylidene) ammonium bromide, nyob rau hauv alkaline tej yam kev mob, condense nrog hydroxypiperidine kom tau loperamide, thiab ces tsim ib tug ntsev-chloropropanide nyob rau hauv hydroxypiperidine.Loperamide Hydrochloride hmoov.
1. Tshuaj synthesis method:
Cov tshuaj synthesis yog ib txoj hauv kev tseem ceeb ntawm Loperamide hydrochloride.
Ua ntej, methyl phenylacetylcarbamate yog condensed nrog 4-aminomethyl- 4-piperidinol (tseem hu ua propylene glycol piperidine) nyob rau hauv muaj sodium carbonate muab 4-(4-oxo-4-phenyl). piperidin-1-yl)-N, N-dimethyl-2,2-diphenylacetamide. Tom qab ntawd cov amine compound yog reacted nyob rau hauv lub xub ntiag ntawm sodium hydroxide los tsim thioacetic anhydride, thaum 4-propylaminopiperidine yog reacted nrog 1,3-diphenylacetone los tsim 4-propylamino-4-piperidinol. Condensation ntawm ob intermediates nyob rau hauv lub xub ntiag ntawm trichloroacetic acid affords Loperamide. Thaum kawg, Loperamide tau kho nrog hydrochloric acid daws kom tau cov khoom lag luam Loperamide hydrochloride.
2. Microbial fermentation txoj kev:
Microbial fermentation yog lwm txoj kev tsimLoperamide Hydrochloride hmoov, uas tsuas yog siv cov kab mob microorganisms rau fermentation.
Ua ntej, los ntawm kev tsim cov txheej txheem metabolic, cov txheej txheem metabolic ntawm Escherichia coli (E. coli) thiab lwm yam kab mob raug hloov kho kom lawv tuaj yeem rho tawm saponins, tus thawj coj ntawm Loperamide, los ntawm Himalayan daus lotus (Loperamide cog). Tom qab ntawd, cov tshuaj precursor no tau hloov mus rau hauv Loperamide, thiab thaum kawg tau txais Loperamide hydrochloride.
Qhov kom zoo dua ntawm txoj kev no yog tias nws zam cov teeb meem ntawm kev siv cov tshuaj lom thiab tsis haum tshuaj thiab cov tshuaj tiv thaiv hnyav hauv cov txheej txheem tshuaj synthesis ib txwm muaj, thiab tuaj yeem paub txog kev tswj cov synthesis thiab loj - teev ntau lawm ntawm Loperamide tib lub sijhawm. Txawm li cas los xij, qhov tsis zoo ntawm txoj kev no yog tias cov txheej txheem microbial fermentation yog qhov nyuaj, ntau yam tsis tas yuav tsum tau lees paub thiab ua kom zoo dua qub, thiab piv nrog cov txheej txheem tshuaj synthesis, cov txiaj ntsig qis thiab yuav tsum tau txhim kho ntxiv.
3. Inorganic ntsev pauv txoj kev:
Txoj kev sib pauv ntsev inorganic yog ib qho yooj yim thiab yooj yim -- ua haujlwm npaj rau Loperamide hydrochloride. Cov txheej txheem feem ntau tau txais Loperamide hydrochloride los ntawm kev ua haujlwm ntawm Loperamide thiab sodium hydrochloride. Nws qhov kev sib npaug sib npaug yog raws li hauv qab no:
C29H33ClN2O2+ HCl → C29H34Cl2N2O2
Qhov kom zoo dua ntawm txoj kev no yog tias nws yooj yim rau kev khiav lag luam, tuaj yeem nqa tawm ntawm chav tsev kub, thiab cov txiaj ntsig siab. Txawm li cas los xij, qhov tsis zoo yog qhov purity tsawg, thiab purity yuav tsum tau txhim kho ntxiv.
Cim npe nrov: Loperamide hydrochloride hmoov CAS 34552-83-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom