Mesna, luv luv rau 2-Mercaptoethane sulfonic acid sodium ntsev, yog cov tshuaj feem ntau siv los tiv thaiv lossis txo cov kev tsis zoo cuam tshuam nrog kev tswj hwm ntawm qee cov tshuaj khomob, tshwj xeeb yog cyclophosphamide thiab ifosfamide. Cov tshuaj chemotherapeutics tuaj yeem ua rau hemorrhagic cystitis, mob thiab ua rau lub zais zis mob hnyav, vim lawv cov metabolites tsim cov tshuaj lom neeg. Nws ua raws li uroprotectant los ntawm kev muab cov sulfur pab pawg uas cuam tshuam nrog cov tshuaj lom metabolites, hloov lawv mus rau hauv cov ntaub ntawv tsis muaj zog, dej-soluble uas tau nkag los ntawm cov zis, yog li txo lawv cov zais zis toxicity. Nws yog feem ntau muab tso rau hauv cov hlab ntsha lossis qhov ncauj, nyob ntawm qhov kev kho mob thiab tus neeg mob tus mob.
Ntxiv rau nws lub luag haujlwm tiv thaiv, nws kuj tseem pab tswj kev ua haujlwm ntawm cov tshuaj khomob los ntawm kev tiv thaiv kev ua haujlwm ntxov ntxov ntawm cov tshuaj sab nraud ntawm cov ntaub so ntswg. Qhov kev ua ob no ua rau nws yog ib qho tseem ceeb ntxiv rau hauv ntau txoj kev kho mob qog noj ntshav.
Txawm hais tias feem ntau ua tau zoo - zam, nws yuav ua rau mob me me xws li xeev siab, ntuav, thiab raws plab. Cov tshuaj tiv thaiv hnyav dua, txawm tias tsis tshua muaj, tuaj yeem suav nrog kev ua xua thiab kev hloov pauv hauv cov ntshav chemistry. Kev saib xyuas kom ze thiab ua raws li cov lus qhia ntau npaum li cas yog qhov tseem ceeb los xyuas kom cov neeg mob muaj kev nyab xeeb thiab kev kho kom zoo.
Hauv cov ntsiab lus,mesnayog ib qho tshuaj tseem ceeb hauv kev tswj cov tshuaj tua kab mob - ua rau lub zais zis toxicity, txhim kho kev nyab xeeb thiab kev zam ntawm kev kho mob qog noj ntshav tseem ceeb.
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| Tshuaj Formula | C2H6O3S2 |
| Exact Mass | 141.98 |
| Molecular Luj | 142.19 |
| m/z | 141.98 (100.0%), 143.97 (9.0%), 142.98 (2.2%), 142.98 (1.6%) |
| Elemental Analysis | C, 16.89; H, 4.25; O, 33.76; S, 45.10 |
Chemotherapy tiv thaiv
Chemical Structure: Mesnayog ib qho thiol compound, uas, raws li cov metabolism, hloov mus rau di-mesna thiab tawm los ntawm lub raum. Thaum nws ncav cuag lub zais zis, nws rov ua haujlwm thiab khi rau acrylaldehyde, ua kom muaj txiaj ntsig zoo.
Mechanism ntawm Kev Tiv Thaiv: Nyob rau hauv cov hlab ntsha, nws yog thawj zaug inactivated tsim cov disulfide. Txawm li cas los xij, thaum nws tau lim los ntawm ob lub raum thiab tawm mus rau hauv lub zais zis, nws rov ua haujlwm dua. Cov pab pawg dawb sulfhydryl tsim khi rau acrylaldehyde hauv lub zais zis, yog li tiv thaiv lub zais zis mucosa los ntawm kev puas tsuaj thiab tiv thaiv qhov tshwm sim ntawm hemorrhagic cystitis.
Tiv thaiv Hemorrhagic Cystitis
Feem ntau siv los tiv thaiv hemorrhagic cystitis tshwm sim los ntawm siab - koob tshuaj cyclophosphamide lossis ifosfamide chemotherapy. Los ntawm kev khi rau cov tshuaj lom metabolites hauv lub zais zis, nws txo cov zais zis toxicity thiab tiv thaiv lub zais zis ua haujlwm.
Dosage thiab Administration
Cov koob tshuaj yuav tsum raug xam raws li tag nrho cov koob tshuaj ifosfamide txhua hnub. Feem ntau, cov koob tshuaj pom zoo yog sib npaug rau 60% ntawm tag nrho cov koob tshuaj niaj hnub ntawm ifosfamide. Nws raug muab faib ua peb koob: 15 feeb ua ntej txhua koob tshuaj ifosfamide, thiab 4 teev thiab 8 teev tom qab txhua koob. Thaum siv nrog kev txhaj tshuaj tas li ntawm ifosfamide, koob tshuaj bolus sib npaug li 20% ntawm tag nrho cov koob tshuaj ifosfamide tuaj yeem muab, ua raws li kev txhaj tshuaj tas li sib npaug rau 40% ntawm cov koob tshuaj ifosfamide, infused tshaj 12 mus rau 24 teev tom qab ua tiav kev tswj hwm ifosfamide.
Cov Lus Qhia
- Dilution thiab Administration Route: tuaj yeem diluted hauv 5% qabzib txhaj tshuaj, 0.45% sodium chloride txhaj, 0.9% sodium chloride txhaj, lossis lactate Ringer txhaj kom tau txais qhov kawg ntawm 20 mg / mL rau kev txhaj tshuaj. Nws kuj tseem tuaj yeem siv rau hauv qhov ncauj li 400 mg ntsiav tshuaj, txawm hais tias cov ntsiav tshuaj muaj cov ntxhiab tsw ntxhiab tsw thiab saj, thiab feem ntau pom zoo kom noj nrog kua txiv los yog zaub mov.
- Cov lus qhia rau tus neeg mob: Cov neeg mob yuav tsum tau qhia kom haus dej tsawg kawg 2 litres ib hnub twg thiab ua kom lawv lub zais zis khoob kom ntau li ntau tau los txhim kho cov excretion ntawm cov tshuaj lom metabolites.
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Hais txog HC
Hemorrhagic cystitis (HC) yog ib qho mob uas tshwm sim los ntawm qhov mob thiab los ntshav hauv lub zais zis. Qhov kev mob no tuaj yeem ua rau muaj cov kab mob, cov ntshav txhaws, thiab txawm tias muaj qhov cuam tshuam ntawm lub zais zis, ua rau muaj kev tsis xis nyob thiab muaj peev xwm ua rau muaj teeb meem hauv urinary.
Cov tsos mob ntawm hemorrhagic cystitis feem ntau muaj xws li mob lossis tsis xis nyob hauv plab plab, tso zis ntau zaus, tso zis sai, thiab qee zaum muaj ntshav hauv cov zis (hematuria). Hauv cov xwm txheej hnyav, cov zis tuaj yeem tshwm xim liab, qhia tias los ntshav tseem ceeb. Tus mob tuaj yeem ua rau me me mus rau qhov hnyav, thiab nws qhov hnyav feem ntau hais txog txoj kev kho mob.
Hemorrhagic cystitis tuaj yeem tshwm sim los ntawm ntau yam, suav nrog kev kis kab mob, kev kho hluav taws xob, qee yam tshuaj (xws li cyclophosphamide thiab ifosfamide, uas yog siv rau hauv kev kho mob qog noj ntshav), thiab raug rau cov tshuaj lom. Qee zaum, qhov laj thawj tseeb yuav tsis paub.
Kev kuaj mob hemorrhagic cystitis suav nrog keeb kwm kho mob thiab kuaj lub cev, nrog rau kev kuaj zis thiab kev tshawb fawb xws li cystoscopy (tus txheej txheem uas siv lub koob yees duab me los saib sab hauv ntawm lub zais zis) thiab ultrasound.
Kev kho mob ntawm hemorrhagic cystitis nyob ntawm qhov tshwm sim thiab qhov hnyav ntawm cov tsos mob. Hauv cov mob me me, nws yuav suav nrog kev haus dej ntau ntxiv, tsis txhob ua rau khaus, thiab siv cov tshuaj tua kab mob. Cov mob hnyav dua tuaj yeem yuav tsum tau tso zis tso zis (ntxuav lub zais zis nrog cov kua ntsev), tshuaj los tswj cov ntshav thiab mob, lossis txawm tias muaj kev phais mob tsawg.
Nws yog ib qho tseem ceeb kom nrhiav kev kho mob yog tias koj muaj cov tsos mob ntawm hemorrhagic cystitis, vim tias kev kuaj mob ntxov thiab kev kho mob tuaj yeem pab tiv thaiv cov teeb meem thiab txhim kho cov txiaj ntsig. Nrog kev saib xyuas tsim nyog, feem ntau cov neeg mob uas muaj hemorrhagic cystitis tuaj yeem pom cov tsos mob zoo thiab rov qab mus rau lub zais zis ua haujlwm.
muaj peev xwm kho mob utilities
Cov pab pawg thiol endows nws nrog cov khoom antioxidant, ua rau nws yog ib tus neeg sib tw zoo rau kev kho mob uas cuam tshuam nrog oxidative kev nyuaj siab. Cov kev tshawb fawb qhia tias nws qhov ua tau zoo hauv kev txo qis hluav taws xob- ua rau cov ntaub so ntswg puas, tshwj xeeb tshaj yog nyob rau hauv lub zais zis thiab qhov quav, los ntawm kev tshem tawm cov dawb radicals thiab txo qhov mob.
Tsis tas li ntawd, nws qhia txog kev tiv thaiv kev tiv thaiv - kev ua ub no, qhia txog nws qhov muaj peev xwm siv tau rau hauv cov kab mob plab hnyuv, xws li mob plab hnyuv, los ntawm kev hloov kho lub cev tiv thaiv kab mob thiab txo cov ntaub so ntswg puas. Nws lub peev xwm los tiv thaiv ischemia- raug mob reperfusion kuj ua rau nws muaj peev xwm kho tau hauv cov xwm txheej xws li myocardial infarction thiab mob stroke, qhov uas ua kom cov ntshav ntws rov qab tuaj yeem ua rau cov ntaub so ntswg tsis zoo.
Ntxiv mus, lub peev xwm los khi thiab detoxify aldehydes tuaj yeem txuas ntxiv nws daim ntawv thov rau kev tswj hwm ntawm qee yam tshuaj lom thiab cov kab mob metabolic. Kev tshawb fawb txuas ntxiv mus tshawb nrhiav nws siv hauv cov xwm txheej zoo li uremic pruritus, qhov twg nws tuaj yeem txo qhov khaus los ntawm kev tshem tawm cov co toxins.
Tsis tas li ntawd, cov teebmeem cytoprotective raug tshawb xyuas rau kev tiv thaiv kev khomob -induced peripheral neuropathy, aiming kom khaws cov paj hlwb thiab txhim kho cov neeg mob lub neej zoo.
Hauv cov ntsiab lus, cov khoom siv ntau yam tso nws ua ntau yam kev kho mob uas muaj peev xwm hla ntau qhov chaw kho mob, los ntawm kev txo cov hluav taws xob puas tsuaj rau kev kho mob inflammatory thiab kab mob metabolic. Kev tshawb fawb tsis tu ncua txuas ntxiv nthuav tawm nws cov peev txheej kho mob tag nrho.
MesnaSodium 2-mercaptoethanesulfonate, tseem hu ua Sodium 2-mercaptoethanesulfonate, yog ib qho kev sib xyaw nrog cov khoom siv roj ntsha tseem ceeb thiab cov khoom siv tshuaj. CAS Nr .: 19767-45-4.
Hais txog kev ua haujlwm lom neeg, nws ua haujlwm ua antioxidant nrog cell -cov teebmeem tiv thaiv. Nws tau dav siv los ua ib qho kev tiv thaiv kab mob tiv thaiv kab mob toxicity. Nws tuaj yeem txo qhov concentrations ntawm H2O2, HOCl, thiab OH• nyob rau hauv ib koob tshuaj -nyob ntawm seb, nrog IC50 qhov tseem ceeb ntawm 32, 21, thiab 305 μM feem hauv cell{10}}kev sim dawb. Qhov no qhia tau tias nws muaj peev xwm tshem tawm cov pa oxygen reactive thiab tiv thaiv cov hlwb los ntawm oxidative kev nyuaj siab.
Pharmacologically, nws feem ntau yog siv los txo qhov tshwm sim ntawm hemorrhagic cystitis txuam nrog qee yam tshuaj kho mob, xws li cyclophosphamide. Nws ua tiav qhov no los ntawm kev tiv thaiv urothelium thiab zais zis los ntawm kev puas tsuaj los ntawm cov tshuaj lom neeg ua haujlwm. Tsis tas li ntawd, nws tau qhia txog kev tiv thaiv hauv cov qauv tsiaj tiv thaiv kev raug mob ntawm lub hlwb thiab cisplatin- ua rau lub zes qe menyuam puas tsuaj, ntxiv rau nws qhov kev nthuav dav ntawm cov tshuaj siv tshuaj.
Hauv cov ntsiab lus, nws yog ntau yam sib xyaw nrog muaj zog antioxidant thiab cell -cov khoom tiv thaiv. Nws muaj peev xwm tshem tawm cov pa oxygen reactive hom thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj ua rau nws yog ib qho cuab yeej tseem ceeb hauv kev kho tshuaj kho mob -induced toxicities, tshwj xeeb tshaj yog hemorrhagic cystitis. Nrog kev tshawb fawb ntxiv,mesnatuaj yeem pom cov ntawv thov ntxiv hauv kev kho mob.
Mesna sawv cev rau kev nce qib tseem ceeb hauv kev tswj cov tshuaj tua kab mob -induced hemorrhagic cystitis, muab txoj hauv kev nyab xeeb thiab siv tau los tiv thaiv qhov teeb meem tsis zoo no hauv cov neeg mob tau txais oxazaphosphorine chemotherapeutic agents. Nws cov txheej txheem tshwj xeeb ntawm kev nqis tes ua, qhov zoo tshaj plaws pharmacokinetic profile, thiab qhov ua tau zoo hauv kev sim tshuaj tau ua kom nws txoj haujlwm ua tus qauv ntawm kev saib xyuas hauv kev coj ua oncology. Ntxiv mus, nws lub luag haujlwm tseem ceeb hauv kev tiv thaiv ifosfamide-induced encephalopathy thiab lwm yam tshuaj khomob- cuam tshuam cuam tshuam qhib txoj hauv kev tshiab rau nws daim ntawv thov kho mob.
Raws li peb txoj kev nkag siab ntawm mesna cov khoom siv tshuaj thiab kev siv tshuaj kho mob txuas ntxiv mus, kev tshawb fawb tsis tu ncua yuav tsis paub tseeb nthuav tawm cov lus qhia ntxiv thiab kho nws lub luag haujlwm hauv kev tswj cov tshuaj tua kab mob - ntxias cov tshuaj lom. Nrog nws cov ntaub ntawv kev nyab xeeb zoo heev thiab muaj peev xwm sib cuam tshuam cov tshuaj tsawg tsawg, mesna tau npaj los ua lub hauv paus ntawm kev txhawb nqa kev saib xyuas hauv oncology rau xyoo tom ntej.
Cov lus nug nquag
Puas yog mesna chemotherapy lossis immunotherapy?
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Cov tshuaj no yog dab tsi? MESNA (MES na) txo qhov kev pheej hmoo los ntshav hauv lub zais zis los ntawm ifosfamide, ib hom tshuaj khomob. Nws ua haujlwm los ntawm kev tiv thaiv koj lub zais zis los ntawm cov tshuaj hauv cov zis uas yuav ua rau nws khaus.
Puas yog mesna nyab xeeb coj?
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Cov tshuaj notej zaum yuav ua rau mob hnyav ntawm daim tawv nqaij. Lawv tuaj yeem tshwm sim ntau lub lis piam mus rau hli tom qab pib noj tshuaj. Hu rau koj pab neeg saib xyuas tam sim ntawd yog tias koj pom ua npaws lossis mob khaub thuas- zoo li cov tsos mob ua pob liab liab. Cov pob khaus tuaj yeem yog xim liab lossis ntshav liab thiab tom qab ntawd tig mus ua hlwv lossis tev ntawm daim tawv nqaij.
Dab tsi chemo xav tau mesna?
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Cov neeg raug kho nrogifosfamideyeej yuav muaj mesna. Cyclophosphamide tsuas yog ua rau los ntshav los ntawm lub zais zis thaum nws tau txais koob tshuaj ntau. Feem ntau cov neeg uas tau kho nrog cyclophosphamide tsis muaj koob tshuaj ntau. Qhov no txhais tau tias lawv yuav tsis xav tau mesna.
Txoj cai 7 hnub hauv chemotherapy yog dab tsi?
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Txoj cai 7-hnub rau chemotherapy yogtsim los ua ob peb yam kom tshem tau cov qog nqaij hlav thiab ua kom yooj yim kho koj lub cev: Nws pab tswj kom muaj kev sib haum xeeb ntawm cov qog nqaij hlav cancer los ntawm kev ua kom muaj kev sib haum xeeb uas tuaj yeem cuam tshuam lub voj voog loj hlob. Nws txo cov tshuaj toxicity ntawm kev kho mob thiab tuaj yeem pab txo cov kev mob tshwm sim.
Dab tsi yog cov cim zoo uas chemo ua haujlwm?
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Tej zaum koj yuav pom kev txhim kho ntawm cov tsos mob qog noj ntshav, xws limob tsawg dua, txo cov qog nqaij hlav o, thiab txhim kho qib zog. Yog tias koj siv tshuaj tua kab mob rau ntawm daim tawv nqaij, qhov chaw yuav hnov mob thiab saib liab thiab o rau thawj ob peb lub lis piam. Cov no yog tag nrho cov cim qhia tias chemotherapy ua haujlwm.
Cim npe nrov: Mesna CAS 19767-45-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom