Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub tshaj plaws thiab cov neeg muag khoom ntawm methyllergonovine hmoov cas 113-42-8 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo methylergonovine hmoov cas 113-42-8 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Methylergonovine hmoovyog ib tug compound uas yog ib qho alkylation khoom ntawm LSA (Lysergic acid amide) derivative. Nws yog ib yam khoom uas feem ntau tshwm sim ua hmoov los yog muaju. Nws tuaj yeem yog xim dawb, daj lossis xim av xim thiab muaj qee yam tsw. Solubility tsis zoo nyob rau hauv dej, nyuaj rau dissolve kiag li. Nyob rau hauv acidic los yog alkaline daws, nws muaj kev ruaj ntseg tsis zoo thiab yooj yim rau decompose, thiab muaj siab solubility hauv ethanol thiab methanol. Nws yog cov tshuaj uas muaj cov qauv zoo ib yam li lysergic acid thiab feem ntau yog siv los kho cov kab mob gynecological xws li mastitis, uterine cramping thiab los ntshav. Vim nws cov txiaj ntsig kho tau zoo heev, nws tau siv dav hauv kev kho mob.
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Tshuaj Formula |
C20H25N3O2 |
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Exact Mass |
339 |
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Molecular Luj |
339 |
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m/z |
339 (100.0%), 340 (21.6%), 341 (2.2%), 340 (1.1%) |
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Elemental Analysis |
C, 70.77; H, 7.42; N, 12.38; O, 9.43 |
Methylergonovine hmoovyog ib tug derivative ntawm ergot alkaloids nrog tshwj xeeb pharmacological teebmeem. Nws txoj kev siv tseem ceeb yog nyob ib puag ncig uterine contraction function, thiab nws kuj muaj kev tiv thaiv - qog adjuvant therapy, kev cuam tshuam rau cov kab mob neurological, thiab kev siv tshwj xeeb kho mob.
Obstetrics thiab Gynecology: Core Regulation of Uterine Contraction Function
Daim ntawv thov nyob rau hauv obstetrics thiab gynecology yog raws li nyob rau hauv muaj zog uterine contraction, uas ncaj qha activates serotonin receptors thiab alpha adrenergic receptors ntawm uterine smooth nqaij hlwb, ua rau ib tug nce nyob rau hauv intracellular calcium ion concentration thaum inhibiting phosphodiesterase kev ua los txhim kho contractile protein rhiab heev. Nws lub zog ntawm kev ua yog kwv yees li 10-20 npaug ntawm oxytocin, nrog rau lub sijhawm ntawm 3-6 teev, thiab nws cov nyhuv contraction ntawm lub ncauj tsev menyuam tseem ceeb dua.
Kev tiv thaiv thiab kho mob ntshav qab zib
Cov ntshav tom qab yug me nyuam yog ib qho teeb meem loj heev thaum yug me nyuam, uas txo qhov kev pheej hmoo los ntshav los ntawm kev txhawb nqa uterine contractions. Cov txheej txheem kev tswj hwm ib txwm siv yog txhaj tshuaj intramuscular ntawm 0.2mg, nrog kev rov ua haujlwm txhua 2-4 teev yog tias tsim nyog, thiab tag nrho cov koob tshuaj tsis pub tshaj 1mg hauv 24 teev. Thaum los ntshav hnyav, kev txhaj tshuaj tuaj yeem siv tau, tab sis kev hloov ntshav siab yuav tsum tau saib xyuas kom zoo. Thaum lub sijhawm phais mob, 0.2mg ntawm cov tshuaj tuaj yeem raug txhaj ncaj qha rau hauv cov leeg nqaij hauv tsev menyuam kom ua tiav cov kev cog lus hauv zos.
Kev cuam tshuam rau kev ua tsis tiav uterine involution
Tom qab yug me nyuam, lub tsev menyuam yuav tsum tau rov qab mus rau nws lub xeev ua ntej cev xeeb tub los ntawm kev cog lus. Kev kho tsis zoo tuaj yeem ua rau cov ntshav los yog kis kab mob. Kev tswj qhov ncauj ntawm 0.2-0.4mg, 3-4 zaug hauv ib hnub, nrog rau kev kho mob feem ntau tsis pub dhau 7 hnub, tuaj yeem txhim kho cov txheej txheem ntawm uterine involution.
Kev tswj cov ntshav uterine tom qab nchuav menyuam
Tom qab kev rho menyuam tawm los yog raug rho tawm, qhov tsis muaj zog uterine contractions tuaj yeem ua rau los ntshav, uas tuaj yeem ua kom nrawm los ntawm kev txhim kho uterine contractions kom tsis txhob los ntshav. Tom qab txhaj tshuaj intramuscular ntawm 0.2mg, cov tshuaj yuav siv sijhawm li 2-5 feeb thiab kav li 3 teev, muab cov txiaj ntsig zoo rau kev tswj ntshav tom qab rho menyuam.
Kev cai ntawm kev coj khaub ncaws ntau dhau
Rau kev coj khaub ncaws los ntshav los ntawm kev ua haujlwm ntawm lub tsev menyuam los ntshav, qhov txawv txav tuaj yeem raug txo los ntawm kev tswj hwm endometrial contractions thiab mucus dissolution. Clinically, nws yog ib qho tsim nyog yuav tsum ua raws li cov lus qhia kho mob nruj me ntsis los tswj cov koob tshuaj thiab tsis txhob muaj kev sib kis ntau dhau uas yuav ua rau mob.
Lub peev xwm tus nqi ntawm kev kho adjuvant hauv thaj tsam ntawm kev tiv thaiv- kho qog
Cov tshuaj tiv thaiv -cov nyhuv qog ntawm ergometrine yog muab los ntawm nws cov txiv neej cov tshuaj hormones tsis muaj zog thiab kev tswj hwm ntawm cov kev taw qhia tshwj xeeb. Tam sim no, nws feem ntau yog siv los ua kev kho mob ntxiv rau cov qog nqaij hlav qog nqaij hlav thiab cov qog ntshav qog ntshav.
Adjuvant therapy rau mob qog noj ntshav prostate
Qhov tshwm sim ntawm prostate cancer yog ze ze rau theem ntawm androgen, uas inhibits qog cell proliferation los ntawm kev tswj cov kev qhia ntawm androgen receptors. Clinically, nws yog feem ntau siv ua ke nrog lwm cov tshuaj tiv thaiv androgen los txhim kho cov nyhuv kho.
Kev cuam tshuam ntawm mob qog noj ntshav mis
Qee cov qog nqaij hlav cancer mis qhia cov androgen receptors, uas tuaj yeem cuam tshuam cov qog loj hlob los ntawm kev thaiv cov kev taw qhia androgen. Nws ua ke nrog cov tshuaj chemotherapy tuaj yeem txo qhov kev pheej hmoo ntawm kev rov qab los thiab ua kom muaj sia nyob ntev.
Kev tshawb nrhiav kev siv tshuaj hepatocellular carcinoma
Cov kev tshawb fawb thaum ntxov tau pom tias nws muaj kev loj hlob inhibitory cuam tshuam rau hepatocellular carcinoma cell kab, thiab nws cov txheej txheem yuav cuam tshuam rau inducing cell apoptosis lossis inhibiting angiogenesis. Tam sim no, nws tseem nyob rau theem kev tshawb fawb preclinical thiab ntxiv validation ntawm nws cov hauj lwm zoo thiab kev nyab xeeb yog xav tau.
Adjuvant therapy rau malignant lymphoma
Cov nyhuv immunomodulatory yuav muaj kev sib koom ua ke ntawm kev kho mob qog nqaij hlav malignant. Cov kev soj ntsuam soj ntsuam tau pom tias nws ua ke nrog cov tshuaj chemotherapy tuaj yeem txhim kho tus neeg mob cov tsos mob, tab sis cov txheej txheem tshwj xeeb tseem yuav tsum tau tshawb nrhiav ntxiv.
Ob lub luag haujlwm ntawm migraine thiab wakefulness nyob rau hauv lub paj hlwb
Raws li 5-HT receptor antagonist (pA2 tus nqi 9.6),Methylergonovine hmoovmuaj cov txiaj ntsig tshwj xeeb hauv kev kho cov kab mob neurological, tshwj xeeb tshaj yog nyob rau hauv kev tiv thaiv ntawm migraine thiab kev txhawb nqa ntawm coma awakening.
Tiv thaiv kev kho mob migraine
Qhov pib ntawm migraine yog cuam tshuam nrog qhov tsis sib xws ntawm 5-HT neurotransmitters, uas ua kom 5-HT receptor kev ua haujlwm thiab txo qhov zaus ntawm kev tawm tsam migraine. Cov kev tshawb fawb soj ntsuam tau pom tias cov tshuaj noj mus sij hawm ntev tuaj yeem txo qhov tshwm sim ntau dua 50%, tab sis kev saib xyuas yuav tsum tau them rau qhov kev pheej hmoo ntawm kev vam khom tshuaj.
Kev kho mob ntshav qab zib cerebrovascular
Rau cov neeg mob comatose tshwm sim los ntawm kev raug mob lub hlwb los yog mob stroke, qis - kev tswj hwm koob tshuaj tuaj yeem txhawb nqa lub hlwb cortex thiab txhawb kev nco qab rov qab los tom qab tus mob stabilizes.
Cov txheej txheem yuav cuam tshuam txog kev txhim kho dopaminergic paj hlwb, tab sis lub sij hawm thiab kev noj tshuaj yuav tsum tau tswj nruj me ntsis.
Kev txhim kho ntawm Blurred State of Consciousness
Cov neeg mob uas tsis tsaug zog thaum lub sij hawm siv tshuaj loog, cov neeg laus dementia, los yog delirium tuaj yeem txhim kho lawv txoj kev nco qab los ntawm kev tswj hwm cov paj hlwb. Clinically, nws yog feem ntau siv ua ke nrog lwm cov tshuaj tsaug zog los txhim kho kev ua tau zoo.
Tshawb nrhiav kev rho menyuam tawm thiab Luteal Kev Tswj Xyuas Kev Ua Haujlwm hauv Kev Kho Mob Tshwj Xeeb
Txawm hais tias nws txoj kev siv tseem ceeb yog tsom mus rau kev mob ntawm lub tsev menyuam, nws daim ntawv thov hauv cov xwm txheej tshwj xeeb kho mob kuj tsim nyog tau txais kev saib xyuas, tab sis kev ua raws li kev tswj hwm contraindication yog tsim nyog.
Kev ceev faj thov ntawm Selective Induced Abortion
Thaum tsis muaj qhov qhia txog kev phais mob thaum lub sij hawm puv - lub sij hawm cev xeeb tub, uterine contractions tuaj yeem ua rau pib yug menyuam. Txawm li cas los xij, nws yuav ua rau uterine rigidity contractions ua rau fetal ntxhov siab, yog li nws yuav tsum tsuas yog siv nrog ceev faj thaum lwm txoj kev tsis zoo, thiab lub plawv dhia yuav tsum tau saib xyuas tag nrho cov txheej txheem.
Kev tswj ntawm luteal insufficiency
Rau kev xeeb tub los ntawm kev ua haujlwm tsis txaus luteal, ergometrine tuaj yeem txhim kho kev ua haujlwm ntawm ovulation los ntawm kev tswj cov kua qaub ntawm luteinizing hormone. Clinically, nws yog feem ntau siv ua ke nrog ovulation inducing tshuaj los txhim kho qhov kev vam meej ntawm cev xeeb tub, tab sis cov organic lesions xws li tubal obstruction yuav tsum tau txiav tawm.
Kev cuam tshuam rau Postpartum Placental Retention
Postpartum placental retention yuav ua rau los ntshav loj, txhawb nqa placental abruption los ntawm kev txhim kho uterine contractions. Tom qab txhaj tshuaj intramuscular ntawm 0.2mg, cov tshuaj tau siv sai sai, muab kev xaiv rau kev kho mob xwm txheej ceev ntawm placental retention.
Adjuvant therapy rau los ntshav cuam tshuam nrog coagulation teeb meem
Rau kev mob ntshav qab zib tom qab yug me nyuam los ntawm kev coagulation tsis ua haujlwm, cov tshuab ua haujlwm hauv tsev menyuam tuaj yeem siv los txo cov ntshav thiab yuav lub sijhawm rau coagulation yam hloov kho. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias cov tshuaj yuav npog qhov tseeb ntawm cov coagulation abnormality, thiab kev ntsuam xyuas tag nrho ntawm cov tshuaj txaus ntshai yog tsim nyog.
txheej txheem synthesis
Methylergonovine hmoovyog ib qho tshuaj hluavtaws, ib nrab -synthetic derivative. Nws yog ib nrab - cov khoom siv hluavtaws hluavtaws, Ameslikas muab rho tawm los ntawm lysergic acid thiab tam sim no tsuas yog npaj los ntawm cov tshuaj synthesis.
- Kev npaj ntawm 8-bromo-1-methyl-6-methylergoline. 5-methyl-8-bromo-1H-indole-3-acetic acid thiab 1-methyl acetate tau tshwm sim rau ntau tshaj 4 teev, thiab cov tshuaj tiv thaiv tau ntxiv rau acetone. Rau kev tiv thaiv ntawm 6-txoj hauj lwm ntawm cov tsim 6-bromo-8-methylergolin, qhov twg ib pab pawg neeg acetyl ntxiv, polystyrene resin muaj ib tug affinity rau acetone. Tom qab cov tshuaj tiv thaiv, cov reactant raug ntxuav los ntawm adsorption-type silica gel kem chromatography kom tau 8-bromo-1-methyl-6-methylergoline.
- Kev npaj ntawm Methylergonovine. 8-Bromo-1-methyl-6-methylergoline tau tshwm sim nrog cyanobenzoate. Ntxiv dibenzoyl chloride (DPC) rau cov tshuaj tiv thaiv tuaj yeem tsim cyanobenzoate nruab nrab. Qhov nruab nrab no yog hydrogenated (siv txhuas trihydride) thiab esterified (siv dipropyl malonate) muab Methylergonovine. Thaum kawg, Methylergonovine yog purified los ntawm txoj kev xws li crystallization lossis kem chromatography.
Cov khoom siv tshuaj
Methylergonovine yog qhov ruaj khov dua li ergotamine thiab tuaj yeem khaws cia hauv chav sov ntev. Nws tsis yooj yim cuam tshuam los ntawm huab cua, dej thiab lub teeb, thiab tsis cuam tshuam los ntawm me ntsis acids lossis alkalis. Lub ultraviolet absorption spectrum ntawm nws muaj ib tug tej yam absorption ncov ntawm 220nm, thiab lub nqus siv zog yog lub zog tshaj nyob rau lub sij hawm no. Uas tuaj yeem hydrolyzed nyob rau hauv alkaline tej yam kev mob, thiab nws cov khoom yog ergoline. Nyob rau hauv physiological tej yam kev mob, lub hydrolysis tus nqi ntawm Methylergonovine kuj qeeb, yog li nws muaj lub sij hawm ntev ntawm cov tshuaj. Thiab muaj huab cua muaj zog thiab muaj zog nucleophilicity, thiab tuaj yeem ua rau muaj kev cuam tshuam nucleophilic ntxiv nrog rau lwm yam tshuaj. Piv txwv li, nws tuaj yeem dhau los ua cov tshuaj tiv thaiv nucleophilic ntxiv nrog phenols los tsim phenol-zoo li cov khoom. Tej zaum yuav muaj cov kuab tshuaj organic residual hauv kev npaj Methylergonovine, xws li ethanol, n-butanol, thiab lwm yam. Cov kuab tshuaj organic no yuav cuam tshuam rau qhov zoo ntawmMethylergonovine hmoov, yog li kev purification thiab nrhiav kom tau zoo yuav tsum tau ua.
FAQ
Cov tshuaj methylergonovine siv rau dab tsi?
Methylergonovine belongs rau ib chav kawm ntawm cov tshuaj hu ua ergot alkaloids. Methylergonovine yog sivtiv thaiv lossis kho los ntshav los ntawm lub tsev menyuam uas tuaj yeem tshwm sim tom qab yug menyuam lossis rho menyuam tawm.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm methylergonovine thaum cev xeeb tub?
Methergine (methylergonovine txiv neej)ua ncaj qha rau ntawm cov nqaij mos ntawm lub tsev menyuam thiab ua rau kom lub suab nrov, tus nqi, thiab amplitude ntawm rhythmic contractions. Yog li, nws ua rau muaj kev cuam tshuam sai thiab txhawb nqa tetanic uterotonic nyhuv uas ua rau lub sijhawm thib peb ntawm kev ua haujlwm thiab txo qis ntshav.
Puas yog methylergonovine nce ntshav siab?
Nce ntshav siab (Hypertension). Methylergonovine tuaj yeem ua rau koj cov ntshav siab nce lossis ua rau nws hnyav dua yog tias koj muaj keeb kwm ntawm ntshav siab.
Kuv yuav tsum zam dab tsi thaum noj methylergonovine?
Cov Lus Qhia rau Cov Neeg Siv Khoom: Nojkua txiv kab ntxwvNrog Methylergonovine tuaj yeem ua rau muaj kev pheej hmoo ntawm mob hauv siab, ntshav siab, xeev siab, palpitations, lossis lwm yam kev mob tshwm sim loj, xws li mob, loog lossis txo qis hauv tes, ko taw lossis ob txhais ceg.
Cim npe nrov: Methylergonovine hmoov CAS 113-42-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom