Aceglutamide CAS 2490-97-3

Cov tshuaj no muaj cov nyhuv txo cov ntshav ammonia. Cov kev tshawb fawb txog kev sim tau pom tias nws tau faib rau ntau qhov chaw ntawm tib neeg lub cev, tshwj xeeb tshaj yog nyob rau hauv lub raum tubular hlwb, thiab decomposes ammonia hauv cov ntshav rau hauv acetyl glutamate. Ammonia nyob rau hauv cov ntshav yog tawm los ntawm lub raum tubular hlwb.

Tsis tas li ntawd, lub compound kuj muaj ib tug detoxification mechanism. Tom qab nkag mus rau tib neeg lub cev, nws yuav dhau los ntawm cov ntshav - lub hlwb thaiv thiab decompose glutamate, uas tuaj yeem koom ncaj qha rau hauv cov ntaub ntawv xa mus rau hauv nruab nrab paj hlwb. Txawm li cas los xij, lwm yam tshuaj decomposed tuaj yeem inhibit qhov excitability ntawm glutamate. Ob yam khoom no sib tw ua ke thiab tuaj yeem txhim kho cov paj hlwb zoo, ua tiav cov txiaj ntsig ntawm kev txhim kho lub hlwb.

Cov tshuaj no tuaj yeem siv los kho cerebral embolism thiab lub cev muaj zog tsis ua haujlwm. Cov ntaub ntawv tshawb fawb txog kev kho mob ntsig txog qhia tau hais tias nws muaj txiaj ntsig los txhawb kev loj hlob ntawm tes, thiab yog li ntawd tuaj yeem siv los ua cov khoom noj khoom haus thaum lub sij hawm siab - kev siv zog rov ua haujlwm. Cov tshuaj no tuaj yeem hla cov ntshav- lub hlwb thaiv, ua rau glutamate thiab gamma aminobutyric acid (GABA), txhim kho cov metabolism hauv neuronal, thiab tswj kev ntxhov siab zoo. Hauv kev kho mob, nws feem ntau yog siv rau cov kab mob loj heev xws li mob coma, neurosurgical coma, thiab hepatic coma.

Txhawb kev ua haujlwm ntawm lub paj hlwb rov qab: Rau lub cev muaj zog ua haujlwm los ntawm kev raug mob neurological xws li hemiplegia, siab paraplegia, thiab sequelae ntawm infantile paralysis, cov tshuaj no tuaj yeem pab txhawb kev ua haujlwm ntawm lub paj hlwb thiab txhim kho cov neeg mob lub cev muaj zog.
Relieve neuropathic mob thiab mob taub hau: Cov tshuaj no tuaj yeem siv los kho cov tsos mob xws li mob taub hau neuropathic thiab mob nraub qaum, los ntawm kev tswj cov qib neurotransmitter kom txo cov neeg mob mob.

Cov ntsiab lus tseem ceeb: Cov khoom no tsuas yog siv los txhawb kev rov qab los ntawm cov neeg mob comatose tom qab phais neurosurgery (xws li mob qog nqaij hlav hlwb, mob hlwb raug mob, kab mob cerebrovascular, thiab lwm yam), lub hlwb raug mob, siab coma, hemiplegia, siab paraplegia, neuroma, neuropathic mob taub hau, thiab mob nraub qaum. Coma, nco thiab kev xav tsis zoo los ntawm ntau yam xws li kev tsis taus ntawm kev txawj ntse, kev nco tsis zoo, qhov tshwm sim ntawm cov menyuam mos liab tuag tes tuag taw, thiab kev puas siab puas ntsws tshwm sim los ntawm cov tshuaj xws li tshuaj tiv thaiv ntshav 846 (xws li carbon monoxide lom, mob cawv thiab tshuaj lom, mob purulent meningitis, viral pencephalopathy encephalopathy, hluav taws xob raug mob, thiab lwm yam).

Kev nco poob rau cov neeg laus thiab kev nco poob tom qab kab mob cerebrovascular. Adjuvant kev kho mob rau cov neeg laus lub hlwb poob qis muaj xws li mob puas hlwb, geriatric psychiatric disorder syndrome, thiab kev nyuaj siab. Hauv kev soj ntsuam kev puas siab puas ntsws, cov khoom no feem ntau muab tso rau hauv kev sib xyaw nrog lwm cov tshuaj txhawm rau txhim kho cellular metabolism thiab noj zaub mov zoo.

Cov ntaub ntawv qhia txog kev kis mob encephalitis B tau pom qhov ua tau zoo ntawm kev sib xyaw ua ke ntawm kev kho mob ntawm ribavirin thiab acetanilide hauv kev kho mob encephalitis B. Cov mob tau muab faib ua ob pawg, thiab ob pab pawg tau zoo ib yam ntawm poj niam txiv neej, hnub nyoog, hom tshuaj kho mob, thiab hnub pib kho mob, uas yog sib piv. Ob pab pawg tau txais kev kho mob zoo xws li kev ua kom txias, expectorant, sedation, lub cev qhuav dej, txo intracranial siab, hloov dej, thiab tiv thaiv kab mob. Ntxiv nrog rau kev kho mob dav dav, pab pawg kho mob tau txhaj tshuaj ribavirin ntawm koob tshuaj 15mg / kg ib hnub thiab acetanilide ntawm koob tshuaj 0.02g / kg ib hnub.

Ob qho tshuaj tau ntxiv rau 10% cov kua qabzib rau kev txhaj tshuaj rau hauv cov hlab ntsha mus txog 10 hnub ntawm kev mob, nrog rau qhov nruab nrab ntev ntawm 5.7 hnub. Cov txheej txheem ntsuas kev ua tau zoo yog: kho: ploj ntawm cov tsos mob thiab cov tsos mob, tsis muaj cov tsos mob rov qab los; siv tau: cov tsos mob. Thiab cov tsos mob ntawm lub cev tau zoo tuaj, nrog rau qhov sib txawv ntawm cov tsos mob rov zoo dua. Cov pab pawg kho mob muaj lub sijhawm luv luv ntawm kev txo qis kub taub hau, kev nco qab, kev qaug dab peg, thiab kev ploj ntawm ncauj tsev menyuam tsis zoo piv rau pawg tswj hwm. Qhov tshwm sim ntawm qhov ua tsis taus pa hauv nruab nrab yog 17.9% hauv pab pawg kho mob thiab 43.3% hauv pawg tswj hwm, nrog qhov sib txawv tseem ceeb ntawm ob pawg (x2=4.39, p<0.05).

Qhov tshwm sim ntawm kev ua pa tsis ua haujlwm hauv pab pawg kho mob tau qis dua li hauv pawg tswj hwm. Hauv pab pawg kho mob, 20 tus neeg mob tau kho nrog tus nqi kho mob ntawm 71.4%, 6 tus neeg tau txais txiaj ntsig, 2 tus neeg mob tsis zoo, thiab tag nrho cov txiaj ntsig tau zoo yog 92.8%; Hauv pawg tswj hwm, 13 tus neeg mob tau kho nrog tus nqi kho mob ntawm 43.3%, 11 tus neeg mob tau txais txiaj ntsig, 6 tus neeg mob tsis zoo, thiab tag nrho cov txiaj ntsig tau zoo yog 80%. Muaj qhov sib txawv tseem ceeb hauv kev kho tus nqi ntawm ob pawg (x2=4.66, p<0.05), while there was no significant difference in the total effective rate between the two groups (x2=1.08, p>0.05).

Kev sib xyaw ua ke ntawm virazole thiab acetylglutamine thaum ntxov hauv kev kho mob Japanese encephalitis tuaj yeem tswj cov mob hnyav zuj zus, txhim kho lub hlwb ua haujlwm, txhawb kev txo qis kub taub hau, tsis nco qab, txo qhov tshwm sim thiab kev tuag ntawm kev ua pa tsis ua haujlwm, thiab nce tus nqi kho. Kev sib xyaw ntawm ob yam tshuaj tseem tsis tau pom qhov tseem ceebaceglutamideKev mob tshwm sim thiab tuaj yeem siv los ua ib txoj hauv kev kho mob rau Japanese encephalitis.

Nyob rau hauv daim ntawv qhia txog kev ua tau zoo ntawm kev siv acetylglutamine los cawm 30 tus neeg mob fluoride lom, 1: 5000 poov tshuaj permanganate tov yog niaj zaus siv rau plab hnyuv, thiab acetylglutamine tau muab tshuaj tam sim ntawm tus nqi ntawm 0.1-0.3 / hnub, muab faib ua 1-2 hnub rau cov me nyuam hauv plab los yog tso tseg tag nrho. lub convulsions nres. Ib txhij siv dexamethasone, ntau cov vitamin C, phosphatidylcholine lossis lub hlwb ua haujlwm hormone, thiab lub zog sib xyaw los tiv thaiv lub cev ua haujlwm. Ntawm tag nrho cov xwm txheej, 20 tau kho, 8 tau ua haujlwm zoo, thiab 2 muaj qhov tshwm sim, tshwm sim raws li spasticity thiab cerebral palsy nrog kev tsis taus kev txawj ntse.

Cov neeg uas tuag los yog muaj sia nyob nrog kev mob hnyav yog cov menyuam yaus uas tau noj tshuaj ntau, cov menyuam yaus, thiab cov uas tsis tuaj yeem siv acetylglutamine tam sim ntawd. Lub tshuab ua haujlwm rau kev kho cov tshuaj fluoride lom yog vim acetylglutamine muaj cov qauv zoo sib xws rau hom tshuaj lom no. Acetylglutamine tsim cov noob amide hauv lub cev lossis kev sib tw nrog fluoroacetic acid uas tsim los ntawm sodium fluoroacetate kom ua tiav detoxification. Nyob rau tib lub sijhawm, nws muaj cov teebmeem ntawm kev txhim kho neuronal metabolism, tswj kev ua haujlwm ntawm neural stress, thiab lwm yam, yog li txo qhov tshwm sim ntawm neurological sequelae.

Kev kho kom zoo ntawm ob qhov xwm txheej ntawm fluoroacetamide lom nrog acetylglutamine qhia tau hais tias kev kho mob ntawm fluoroacetamide lom nrog acetylglutamine koom nrog kev sib ntxiv ntawm ib pawg acetamide (- CH2CONH2) hauv cov qauv tshuaj acetylglutamine, uas zoo ib yam li cov qauv tshuaj acetamide. Daim ntawv thov kev kho mob tau lees paub tseeb cov teebmeem kev kho mob. Vim tias feem ntau cov tsev kho mob thawj zaug tsis muaj tshuaj acetamide, thaum ntsib kev lom fluoroacetamide, acetyl glutamine tuaj yeem siv los hloov kho.

Lub paj hlwb hypoplasia tau kho nrog tawv taub hau acupuncture ua ke nrog kev txhaj tshuaj acupoint rau cov kab mob cerebrovascular nyuaj nrog kev txawj ntse. Txoj kev: 74 tus neeg mob tau muab faib ua ob pawg. Cov pab pawg kho mob muaj 40 tus neeg mob, uas tau kho cov tawv taub hau acupuncture rau Zhisan koob thiab Sishen koob, thiab kuj tau txhaj nrog acetylglutamine thiab furosemide ntawm acupoints xws li Baihui . 34 cov neeg mob hauv pawg tswj tau kho nrog intravenous infusion ntawm 20% kev txhaj tshuaj ntawm Sudium thiab chloride. kev kho mob ntawm ob pawg tau muab piv thiab pom.

Qhov txiaj ntsig zoo hauv pab pawg kho mob yog 95.0%, thaum tag nrho cov txiaj ntsig zoo hauv pawg tswj hwm yog 85.3%. Muaj qhov sib txawv tseem ceeb ntawm ob pawg (p<0.05). Conclusion: The combination of scalp acupuncture and acupoint injection therapy has the effects of awakening the brain and opening the orifices, strengthening the brain and marrow, improving brain cell vitality, and enhancing brain function. It has a definite therapeutic effect on treating cerebrovascular disease complicated with intellectual disability. 50 cases of cerebral hypoplasia were treated with head acupoint injection of acetylglutamine and furothiamine, with good therapeutic effects.

Thaum xub thawj, cov tawv taub hau acupuncture tau siv los kho cov kab mob hauv lub hlwb, thiab tom qab ntawd hloov kho nrog cov tawv taub hau acupuncture thiab dej acupuncture (acetylglutamine thiab furothiamine) tau sim, thiab nws tau pom tias yav tas los muaj kev kho zoo dua qub. Tam sim ntawd hloov mus rau kev siv cov koob dej es tsis siv cov koob ntawm tawv taub hau los kho tus kab mob no, ua rau muaj txiaj ntsig zoo dua piv rau yav dhau los. Los ntawm kev txheeb xyuas kev sib raug zoo ntawm cov txiaj ntsig kev kho mob thiab hnub nyoog, cov hnub nyoog qis dua, qhov kev kho mob zoo dua. Yog li ntawd,aceglutamidentseeg tau tias kev kho mob thaum ntxov yog tsim nyog rau cerebral hypoplasia. Acetylglutamide thiab furosemide lub taub hau acupoint txhaj tshuaj kho rau cerebral hypoplasia pom qhov cuam tshuam tseem ceeb ntawm 74%, tus nqi zoo ntawm 14%, thiab tag nrho cov txiaj ntsig zoo ntawm 88%.