Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm nefiracetam hmoov hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo nefiracetam hmoov muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Lub npe tshuaj ntawmNefiracetam hmoovyog N-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidine acetamide, ib qho hluavtaws pyrrolidinone derivative cais raws li lub zog kev txawj ntse, lossis nootropic tus neeg sawv cev. Cov qauv sib txawv ntawm cov tshuaj racetam ib txwm muaj, nws tau tsim tshwj xeeb los tsom rau lub hauv paus paj hlwb kev ua haujlwm ntsig txog kev kawm, nco, thiab kev paub txog kev ua haujlwm. Nws feem ntau nthuav tawm raws li dawb mus rau dawb crystalline hmoov nrog cov tshuaj zoo ruaj khov, ua rau nws tsim nyog rau kev tshawb fawb thiab kev tsim kho. Pharmacologically, Nefiracetam exerts nws cognition-txhawb cov teebmeem los ntawm ntau yam complementary mechanisms. Nws feem ntau modulates central neurotransmitter systems, nrog rau cov txiaj ntsig tshwj xeeb ntawm acetylcholine (ACh) kis.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab tshuaj txhaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
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Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Nefiracetam hmoov | Nefiracetam Capsules | Nefiracetam kua |
| Yam khoom | Hmoov | Capsules | ua kua |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | 100g / 1kg / thiab lwm yam. | 50mg / lub raj mis | 5 mg/10 mg/25 mg |
| Daim ntawv khoom | Organic synthesis | Noj Orally | Organic synthesis |
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Nefiracetam COA
Nefiracetam cuam tshuam nrog GABA receptors, pab kom sib npaug ntawm thaj chaw neurotransmitter los ntawm kev cuam tshuam zoo rau excitatory thiab inhibitory neurotransmitters, txhim kho kev mloog thiab kev paub tag nrho. Nws kuj tseem tuaj yeem cuam tshuam rau qib ntawm monoamine neurotransmitters xws li dopamine thiab norepinephrine, ntxiv tswj kev paub txog kev ua haujlwm. Nws txhim kho kev nco qab los ntawm kev txhawb nqa kev sib txuas lus ntawm cov neurons, nce synaptic plasticity. Nws kuj tseem tuaj yeem cuam tshuam rau kev ua haujlwm ntawm L / N- hom calcium channels thiab plasma channels, yog li tswj hwm kev ua kom muaj zog neuronal.
Nws yog tsuas yog siv los txhim kho kev nco thiab kev paub tsis meej, xws li Alzheimer's kab mob, vascular dementia, thiab lwm yam. Txawm li cas los xij, kev tshawb fawb tam sim no ntawm nws qhov kev kho mob tsis zoo, nrog qee cov kev tshawb fawb qhia txog kev ua tau zoo los yog muaj teeb meem. Nws kuj muaj cov nyhuv anticonvulsant thiab tuaj yeem siv los kho qee yam mob vwm lossis qaug dab peg.
Nefiracetam hmoovyog ib tug pyrrolidone compound uas belongs rau kev txawj ntse enhancers thiab muaj tej yam nqi daim ntawv thov nyob rau hauv cov tshuaj thiab kev txawj ntse science. Cov hauv qab no yuav piav qhia txog nws lub hom phiaj los ntawm ntau yam:
Kho kev paub txog kev puas hlwb ntsig txog kab mob
Vascular dementia yog ib qho kev puas siab puas ntsws los ntawm kab mob cerebrovascular. Nefiracetam tuaj yeem pab cov neeg mob uas muaj vascular dementia los ntawm kev txhim kho cerebral ntshav ncig, tswj cov kab mob neurotransmitter, thiab lwm yam.
Nws tuaj yeem qhib L/N- hom calcium channels, cholinergic, monoaminergic, thiab GABAergic systems, txhim khu kev sib txuas lus neuronal thiab txhawb nqa neural plasticity, txhim kho synaptic plasticity, thiab txhim kho kev nco. Qee qhov me me - qhov kev sim tshuaj ntsuam xyuas tau pom tias Nefiracetam tuaj yeem txhim kho kev txawj ntse thiab lub neej zoo hauv cov neeg mob vascular dementia. Piv txwv li, tom qab noj Nefiracetam, cov neeg mob yuav muaj qee qhov kev txhim kho hauv kev nco, kev mloog, kev muaj peev xwm hais lus, thiab lwm yam, uas ua rau lawv ua haujlwm zoo dua hauv kev ua haujlwm niaj hnub xws li hnav khaub ncaws, noj mov, thiab ntxuav. Tab sis cov kev tshawb fawb soj ntsuam loj thiab nruj dua kuj tseem xav tau kom paub meej tias nws ua tau zoo.
Kev siv hauv kev kho mob vascular dementia
Nefiracetam tuaj yeem txhim kho cerebral ntshav ncig, ua kom cov ntshav xa mus rau cov ntaub so ntswg hauv hlwb, thiab txo cov kev puas hlwb neuronal. Piv txwv li, nws tuaj yeem txhim kho cov ntshav perfusion hauv lub hlwb los ntawm dilating cerebral hlab ntsha thiab txo cov ntshav viscosity. Lub caij no, nws tseem tuaj yeem tswj hwm cov kab mob neurotransmitter thiab tswj kev ua haujlwm ntawm cov neurons. Rau cov neeg mob uas muaj vascular dementia, kev cuam tshuam rau cov kab mob cerebrovascular yog qhov tseem ceeb. Lub dual mechanism ntawm kev txiav txim ntawm Nefiracetam muab nws tej yam zoo hauv kev kho mob vascular dementia. Nyob rau hauv lub neej yav tom ntej, nrog rau kev txhim kho ntawm ntau cov kev tshawb fawb soj ntsuam, Nefiracetam yuav tsum tau los ua ib qho ntawm cov tshuaj tseem ceeb rau kev kho mob vascular dementia.
Nefiracetam hmoovyog ib qho tshiab racetam chav kawm ntse tshuaj (nootropy), koom nrog pyrrolidone derivative, muaj peev xwm paub txog kev txawj ntse, neuroprotective, thiab los tiv thaiv kev ntxhov siab. Nws qhov kev tshawb pom tshwm sim los ntawm kev tshawb fawb txog kev hloov kho cov qauv ntawm piracetam, tsom rau kev txhim kho ntau dua thiab xaiv cov tshuaj neuroactive tebchaw. Kev tshawb fawb ntawm Nefiracetam pib nrog kev tshawb nrhiav cov tshuaj racetam. Xyoo 1964, Romanian chemist Corneliu E. Giurgea thawj zaug synthesized piracetam thiab nrhiav pom nws cov teebmeem ntawm kev txhim kho kev nco thiab kev txawj ntse, tab sis cov txheej txheem tseem tsis meej.
Piracetam yog suav hais tias yog thawj cov tshuaj "nootropy" tiag tiag, txhais tau tias:
Txhim khu kev txawj ntse (xws li kev nco, kev kawm)
Tiv thaiv lub hlwb los ntawm kev puas tsuaj rau lub cev lossis tshuaj lom neeg
Tsawg toxicity thiab tsawg kawg kev phiv
Txoj kev vam meej ntawm Piracetam tau tsav cov kws tshawb fawb los kawm cov tebchaw nrog cov qauv zoo sib xws, sim tsim cov derivatives zoo dua. Cov qauv tseem ceeb ntawm Piracetam yog 2-oxo-1-pyrrolidinoacetamide.
Cov kws tshawb fawb tau tsim ib qho kev sib txuas los ntawm kev hloov kho nws cov saw hlau sab, suav nrog:
- Aniracetam - Ntau dua li lipid solubility thiab muaj zog ua haujlwm
- Oxiracetam - txhim kho cholinergic kis tau tus mob
- Pramiracetam - muaj zog nco ua kom cov nyhuv
Kev tshawb fawb thaum ntxov pom tias Nefiracetam muaj ntau yam teebmeem neuroregulatory:
- Txhim kho cholinergic system: nce acetylcholine tso tawm, txhim kho kev nco (koom nrog Alzheimer's kab mob).
- Kev tswj cov glutamate receptors (NMDA/AMPA): txhawb nqa ntev -lub sij hawm potentiation (LTP) thiab txhim kho synaptic plasticity.
Neuroprotective nyhuv:
- Txo cov neuronal tuag tom qab ischemic hlwb raug mob.
- Kev tiv thaiv kev ntxhov siab thiab tshuaj tiv thaiv kev ntxhov siab: tuaj yeem tswj kev xav los ntawm GABAergic lossis 5-HT systems.
Nefiracetam tau tsim nyob rau hauv cov ntsiab lus no, tus cwj pwm los ntawm kev qhia ntawm ib pawg diphenylmethyl ntawm lub nplhaib pyrrolidone, muab nws cov khoom siv tshuaj tshwj xeeb. Nws tau tsim los ntawm Nyij Pooj lub tuam txhab Daiichi Sankyo thaum xyoo 1980s, pib codenamed DM-9384. Nws lub npe tshuaj yog N - (2,6-dimethylphenyl) -2- (2-oxo-1-pyrrolidine) acetamide, uas yog lipophilic ntau dua li piracetam thiab tuaj yeem txhim kho cov ntshav-hlwb barrier nkag mus.
Hauv xyoo 1990, ntau qhov kev sim tsiaj tau pom tias Nefiracetam tau zoo tshaj rau cov tshuaj racetam hauv kev txhim kho kev kawm tsis taus, tiv thaiv hypoxia raug mob, thiab tiv thaiv qaug dab peg.
Nyob rau xyoo 1990, Nefiracetam tau nkag mus rau theem kev sim tshuaj ntsuam xyuas, feem ntau kawm txog nws cov txiaj ntsig kho mob ntawm cov kab mob cerebrovascular (xws li kev paub tsis meej tom qab mob stroke) thiab Alzheimer's disease.
Txhim kho vascular dementia: Qee cov kev tshawb fawb tau pom tias nws tuaj yeem nce cov qhab nia xeem (xws li MMSE).
Cov nyhuv Antiepileptic: txo cov mob qaug dab peg hauv cov qauv tsiaj, tab sis tib neeg cov ntaub ntawv raug txwv.
Kev tiv thaiv kev ntxhov siab thiab tiv thaiv kev nyuaj siab: tuaj yeem siv los ua cov tshuaj kho mob ntxiv.
Txawm li cas los xij, vim qhov ua tau zoo tsis sib xws thiab kev hloov pauv tswv yim ua lag luam, Nefiracetam tsis tau muaj kev lag luam thoob ntiaj teb thiab tsuas yog siv los ua tshuaj hauv qee lub tebchaws Esxias, xws li Nyiv.
Thaum pib ntawm lub xyoo pua 21st, cov kws tshawb fawb tau tshawb fawb ntxiv txog cov txheej txheem molecular ntawm Nefiracetam:
- Txhim kho hippocampal synaptic plasticity ( tswj los ntawm Ca ² ⁺ signaling)
- Kev tswj hwm nicotinic acetylcholine receptors (nAChRs) yuav pab tau rau kev tshem tawm nicotine
- Txhawb nqa BDNF (lub hlwb- tau txais txiaj ntsig neurotrophic) tso tawm los txhawb kev muaj sia nyob ntawm neuronal
- Cov kev tshawb pom no ua rau nws tseem muaj txiaj ntsig tshawb fawb hauv thaj chaw ntawm cov kab mob neurodegenerative thiab kev paub tsis meej.
kev mob tshwm sim
Nefiracetam hmoovyog ib qho pyrrolidine ketone compound nrog kev txawj ntse txhim kho cov teebmeem. Txawm hais tias nws tau pom tias muaj peev xwm txhim kho kev txawj ntse hauv kev siv tshuaj kho mob, nws kuj muaj cov kev mob tshwm sim, raws li hauv qab no:
Kev ua xua
(I) Cov tawv nqaij pob khaus:
Mechanism ntawm qhov tshwm sim
Qee tus neeg mob yuav ua xua rau qee yam ntawm Nefiracetam. Thaum cov tshuaj nkag mus rau hauv lub cev, lub cev tiv thaiv kab mob lees paub tias nws yog khoom txawv teb chaws, ua rau muaj kev tsis haum tshuaj thiab ua rau muaj pob liab liab ntawm daim tawv nqaij.
Clinical manifestations
Cov pob khaus tuaj yeem tshwm sim raws li erythema, papules, wheals, thiab lwm yam, feem ntau faib rau hauv pob tw, ceg, thiab lwm qhov chaw. Cov pob khaus feem ntau yog nrog khaus, thiab thaum mob hnyav, cov tsos mob xws li hlwv thiab yaig tuaj yeem tshwm sim.
Kev cuam tshuam
Cov neeg mob uas muaj kev fab tshuaj tiv thaiv kab mob feem ntau ua rau muaj kev tsis haum tshuaj xws li pob khaus. Tsis tas li ntawd, yam xws li tshuaj purity thiab formulation txheej txheem kuj yuav cuam tshuam qhov tshwm sim ntawm kev tsis haum tshuaj.
Kev ntsuas teb
Thaum cov tsos mob ua xua xws li pob khaus tshwm sim, cov tshuaj yuav tsum raug tso tseg tam sim ntawd thiab kev kho tshuaj tiv thaiv kev tsis haum yuav tsum tau ua raws li kev qhia ntawm tus kws kho mob. Cov neeg mob yuav tsum tsis txhob khawb qhov chaw pob khaus kom tsis txhob kis kab mob.
(II) Khawb:
Mechanism ntawm qhov tshwm sim:
Inflammatory mediators xws li histamine tso tawm los ntawm kev tsis haum tshuaj tuaj yeem ua rau cov hlab ntsha ntawm daim tawv nqaij, ua rau khaus khaus. Qhov kev khaus khaus txawv ntawm ib tus neeg mus rau ib tus neeg, thiab thaum mob hnyav, nws tuaj yeem cuam tshuam rau tus neeg mob pw tsaug zog thiab lub neej zoo.
Clinical manifestations:
Cov neeg mob tuaj yeem hnov qhov khaus ntawm tus kheej, uas tuaj yeem txwv rau thaj tsam pob liab liab lossis kis thoob plaws lub cev. Kev hnov qab khaus tuaj yeem ua rau hmo ntuj, cuam tshuam rau tus neeg mob so.
Kev ntsuas teb
Cov neeg mob tuaj yeem siv qee cov tshuaj tiv thaiv khaus khaus, xws li calamine lotion, los txo cov tsos mob khaus khaus. Nyob rau tib lub sijhawm, daim tawv nqaij yuav tsum tau ua kom huv si thiab cov khoom siv da dej yuav tsum zam. Yog tias cov tsos mob khaus khaus hnyav, qhov ncauj tshuaj tiv thaiv kab mob xws li loratadine tuaj yeem raug coj los ntawm tus kws kho mob.
(III) Lwm yam kev tsis haum tshuaj loj:
Mechanism ntawm qhov tshwm sim
Muaj tsawg zaus, cov neeg mob yuav muaj kev tsis haum tshuaj hnyav, xws li kev poob siab anaphylactic. Qhov no yog vim muaj kev tsis haum tshuaj ua rau lub cev vasodilation thiab poob qis hauv cov ntshav siab.
Clinical manifestations
Kev ua xua tshwm sim tau tshwm sim tam sim ntawd, thiab cov neeg mob yuav ntsib cov tsos mob xws li ua pa nyuaj, tawv nqaij daj ntseg, hws txias, thiab tsis nco qab. Hauv qhov xwm txheej hnyav, nws tuaj yeem ua rau txoj sia - hem.
Kev ntsuas teb
Allergic shock yog ib qho mob ceev heev, thiab thaum nws tshwm sim, kev kho mob sai sai yuav tsum tau ua.
Nws ua rau kom muaj kev tso tawm ntawm acetylcholine hauv cerebral cortex thiab hippocampus- cov cheeb tsam hauv hlwb tseem ceeb rau kev tsim thiab kev kawm. Nefiracetam kuj tseem tuaj yeem txhim kho qhov kev ua haujlwm ntawm qhov hluav taws xob- nyob ntawm Ca²⁺ channels ntawm cAMP-nyob ntawm cov protein kinases, ntxiv dag zog rau calcium influx thiab pab txhawb cov synaptic tso tawm ntawm ACh. Raws li acetylcholine yog ib qho tseem ceeb neurotransmitter ncaj qha mus rau hauv lub cim xeeb encoding, cov ntaub ntawv ua, thiab saib xyuas, kev txhim kho ntawm cholinergic muaj nuj nqi txhawb tag nrho cov kev txawj ntse kev ua tau zoo.
Tshaj li cholinergic modulation, Nefiracetam kuj txhawb synaptic plasticity, txhim kho cov metabolism hauv neuronal, thiab pab tswj cov teeb liab neural ib txwm muaj nyob rau hauv cov xwm txheej ntawm kev txawj ntse me ntsis. Cov kev cuam tshuam ua ke no ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb los txhawb kev paub txog kev ua haujlwm, nrog rau cov ntawv thov hauv kev tshawb fawb txog hnub nyoog -txog kev paub txog kev hloov pauv, kev kawm tau zoo, thiab kev ua haujlwm ntawm lub paj hlwb.
Cim npe nrov: nefiracetam hmoov, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom