Nortropinone Hydrochloride CAS 25602-68-0

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm nortropinone hydrochloride cas 25602-68-0 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo nortropinone hydrochloride cas 25602-68-0 rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Nortropinone Hydrochlorideyog ib qho tseem ceeb derivative ntawm tropane -hom alkaloids, uas yog nws cov cim bicyclic nitrogen heterocyclic moj khaum. Raws li cov txheej txheem nucleus ntawm cov tshuaj pharmacophores tseem ceeb hauv cov khoom ntuj xws li atropine thiab cocaine, nws tuav txoj haujlwm tseem ceeb hauv tshuaj chemistry thiab kev tshawb fawb neuropharmacology. Daim ntawv hydrochloride ntawm qhov sib xyaw ua ke no txhawb nqa nws cov dej solubility thiab crystallization stability, ua kom yooj yim rau kev ua haujlwm hauv chav kuaj thiab cov txheej txheem tsim tshuaj.

Cov ntaub ntawv tshuaj lom neeg ntawm nws tau qhia hauv cov lus hauv qab no:

Nws cov tshuaj pharmacological feem ntau yog los ntawm kev cuam tshuam ncaj qha hauv nruab nrab thiab peripheral cholinergic paj hlwb, thiab tuaj yeem thaiv muscarinic acetylcholine receptors zoo li kev sib tw antagonist, yog li siv hauv kev tshawb fawb los tshawb txog lub cev thiab cov txheej txheem xws li cov leeg nqaij du, glandular secretion. Tam sim no, nws tsis yog tsuas yog ib qho tseem ceeb ntawm cov cuab yeej molecule rau elucidating cov qauv - kev sib raug zoo ntawm tropane- hom tebchaw, tab sis kuj yog ib qho tseem ceeb pib cov ntaub ntawv thiab cov qauv qauv rau kev tsim thiab synthesizing tshiab antispasmodics, tiv thaiv -Parkinson tus kab mob tshuaj, thiab lub hauv paus ntawm lub paj hlwb kev ua haujlwm tsis tu ncua, cov txheej txheem tseem ceeb hauv kev ua haujlwm ntawm lub paj hlwb. kho mob teb.

Nortropinone Hydrochloride(CAS naj npawb: 25602-68-0) yog biochemical reagent nrog cov qauv tshuaj tshwj xeeb, nrog rau cov mis mos molecular C ₇ H ₁ ClNO thiab molecular hnyav 161.63. Qhov kev sib xyaw no tau pom muaj txiaj ntsig zoo hauv kev tshawb fawb txog lub neej, kev tsim tshuaj, thiab kev tshawb fawb tshuaj. Hauv qab no yog cov lus piav qhia ntxaws txog nws cov kev siv:

Nws tuaj yeem ua ib qho kev hloov kho ntawm cov kab mob extracellular, simulating tshwj xeeb physiological lossis pathological ib puag ncig los ntawm kev tswj cov cell adhesion, proliferation, thiab kev sib txawv. Piv txwv li, hauv kab lis kev cai neuronal, qhov sib xyaw no tuaj yeem ua rau muaj kev hloov pauv hloov pauv hauv cov paj hlwb hauv cov paj hlwb, muab cov qauv rau kev kawm txog cov kab mob neurodegenerative xws li Alzheimer's disease. Tsis tas li ntawd, nitrogen atoms thiab carbonyl functional pawg nyob rau hauv nws cov qauv muaj peev xwm undergo tsis covalent kev cuam tshuam nrog biomolecules xws li cov proteins thiab nucleic acids, uas yog siv los kawm intermolecular paub thiab binding mechanisms.

 

Tsim cov tshiab bioactive molecules ua cov organic synthesis intermediates

Nws yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm ntau yam bioactive derivatives. Los ntawm kev hloov kho nws cov nitrogen atom lossis carbon skeleton, cov pab pawg ua haujlwm sib txawv tuaj yeem raug qhia kom tau txais cov khoom sib txuas nrog cov tshuaj tiv thaiv - qog, tiv thaiv - mob, lossis cov kab mob tua kab mob.Piv txwv li, kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj tiv thaiv- qog nqaij hlav: cov tshuaj nrog tubulin inhibitory kev ua haujlwm tuaj yeem ua ke los ntawm kev qhia txog cov tshuaj fluorine atoms nrog cov aromatic.

Cov ntawv thov hauv Neuroscience Research:

Cov qauv tshuaj ntawm cov tshuaj no sib piv nrog qee cov neurotransmitters xws li acetylcholine, ua rau nws tsim nyog rau kev kawm txog cov teeb meem neural. Hauv kev sim neuronal electrophysiological, qhov sib xyaw ua ke no sib tw rau nicotinic acetylcholine receptors thiab nthuav tawm cov receptor- mediated ion channel qhib qauv los ntawm kev kaw cov membrane muaj peev xwm hloov pauv. Tsis tas li ntawd, nws cov derivatives kuj tseem tuaj yeem ua cov fluorescent probes rau tiag tiag -lub sij hawm saib xyuas ntawm calcium ion concentration dynamics nyob rau hauv lub hlwb, muab kev pab rau kev kawm neuronal excitability.

Kev tshawb fawb txog tshuaj antiepileptic: Los ntawm kev qhia cov sulfur atoms lossis cyclopropane pawg, inhibitory nyhuv ntawm cov tebchaw ntawm voltage-gated sodium channels tuaj yeem txhim kho, yog li txo qis neuronal hyperexcitability. Tsiaj thwmsim tau pom tias cov derivatives no tuaj yeem txo qhov zaus ntawm kev qaug dab peg yam tsis muaj kev paub tsis meej.

Muaj peev xwm hauv ntau- lub hom phiaj kev txhim kho tshuaj:

Nrog rau kev nkag siab tob txog qhov nyuaj ntawm cov kab mob, kev txhim kho ntau yam - cov tshuaj tau dhau los ua lub ntsiab lus kub tam sim no. Qhov no vim nws ntau qhov chaw hloov kho hauv nws cov qauv, tuaj yeem ua ib txhij rau ntau yam kab mob-txog lub hom phiaj.

Piv txwv li, los tiv thaiv- kho qog ua ke: Los ntawm kev sib txuas Cov tshuaj no nrog paclitaxel, ib qho kev sib xyaw ua ke uas tsom rau ob qho tib si microtubule protein thiab epidermal growth factor receptor (EGFR) tuaj yeem ua ke. Hom kev sib xyaw no tau pom muaj kev sib koom ua ke ntawm kev tua neeg tsis yog -mob ntsws qog noj ntshav cell kab A549 hauv vitro kev sim, thiab tuaj yeem kov yeej qhov teeb meem ntawm ib qho tshuaj tiv thaiv.

Kev kho mob metabolic:-Los ntawm kev qhia txog peroxisome proliferator activated receptor (PPAR) agonist structural fragments, cov tebchaw uas ib txhij tswj cov piam thaj thiab lipid metabolism thiab muaj kev tiv thaiv - cov teebmeem inflammatory tuaj yeem tau. Cov kev sim tsiaj tau pom tias cov derivatives zoo li no tuaj yeem txhim kho insulin rhiab heev hauv cov nas rog rog thiab txo cov ntshav qab zib ntau ntau.

Daim ntawv thov hauv cov tshuaj xa tshuaj:

Nortropinone Hydrochloridekuj tseem siv tau los tsim cov phiaj xwm xa tshuaj. Los ntawm kev sib txuas nrog cov ntaub ntawv polymer xws li polylactic acid hydroxyacetic acid copolymer (PLGA), nanoparticle carriers tuaj yeem tsim kom ua tiav cov tshuaj xa tuaj.

Piv txwv li, lub hlwb lub hom phiaj xa tuaj: Los ntawm kev siv Nortropine Hydrochloride lub peev xwm nkag mus rau hauv cov ntshav - lub hlwb teeb meem, nws tuaj yeem hloov kho mus rau saum npoo ntawm nanoparticles kom ua tiav cov tshuaj tiv thaiv Alzheimer's kab mob (xws li donepezil) hauv lub hlwb. Cov kev sim tsiaj tau pom tias cov tshuab xa khoom zoo li no tuaj yeem ua kom cov tshuaj nyob hauv cov ntaub so ntswg ntau dua 5 zaug thiab txhim kho kev paub tsis meej. Kev kho mob qog noj ntshav: Los ntawm kev sib txuas ntawm Nortropinone Hydrolide nrog folate molecules, lub hom phiaj xa khoom rau cov qog nqaij hlav nrog kev qhia siab ntawm folate receptors (xws li mob qog noj ntshav thiab qog noj ntshav ntawm zes qe menyuam) tuaj yeem tsim. Hom kab ke no tuaj yeem ua tiav cov tshuaj tshwj xeeb hauv cov ntaub so ntswg thiab txo cov tshuaj lom rau cov ntaub so ntswg.

Koom nrog cov tshuaj tiv thaiv hluavtaws raws li cov tshuaj reagent & Standardized daim ntawv thov hauv kev sim:

Nws muaj nuj nqis tseem ceeb hauv cov organic synthesis. Cov nitrogen atoms thiab carbonyl functional pawg nyob rau hauv nws cov qauv tuaj yeem koom nrog ntau yam kev cuam tshuam, xws li kev hloov pauv nucleophilic cov tshuaj tiv thaiv: reacting nrog cawv sib txuas los tsim cov ether derivatives, uas feem ntau siv hauv cov tshuaj synthesis los tsim cov chaw chiral.

Cov tshuaj tiv thaiv ntxiv: Reacts nrog Grignard reagent los tsim cov cawv sib txuas, uas ua lub luag haujlwm tseem ceeb hauv tag nrho cov khoom siv ntuj tsim. Cov tshuaj tiv thaiv Redox: Raws li qhov kev txiav txim ntawm lub catalyst, nws tuaj yeem txo qis rau demethylpyrrolidone los yog oxidized rau cov carboxylic acid derivatives, muab ntau txoj hauv kev rau kev hloov kho.

Piv txwv li, siab -kev ua tau zoo ua kua chromatography (HPLC) tsom xam: siv los ua lub sijhawm khaws cia los txiav txim siab qhov chaw siab tshaj ntawm lub hom phiaj sib xyaw hauv cov qauv. Mass spectrometry (MS) tsom xam: siv los ua tus qauv hnyav molecular los xyuas qhov tseeb calibration ntawm huab hwm coj spectrometers. Cell viability assay: siv los ua kev tswj xyuas qhov zoo lossis qhov tsis zoo los ntsuas kev ua haujlwm lom neeg ntawm lwm cov tebchaw.

Qhia lub luag haujlwm hauv kev kawm chemistry:

Cov qauv tshwj xeeb thiab cov khoom ntawm nws ua rau nws zoo tagnrho rau kev kawm chemistry.

Los ntawm kev coj cov tub ntxhais kawm los koom nrog hauv kev sim ua haujlwm xws li kev sib txuas, kev tshawb fawb txog vaj tse, lossis kev tshawb nrhiav, nws tuaj yeem txhawb nqa lawv txoj kev txaus siab rau cov organic chemistry thiab tshuaj chemistry.

Piv txwv li, kev hloov kho cov qauv kev sim: Cov tub ntxhais kawm yuav tsum tau tsim cov derivatives ntawm qhov no los ntawm esterification lossis amidation cov tshuaj tiv thaiv, thiab sib piv lawv cov kev hloov hauv lub cev thiab tshuaj lom neeg.

Kev sim tshuaj lom neeg lom neeg: Siv cov txheej txheem kab lis kev cai ntawm tes, cov tub ntxhais kawm raug tso cai los ntsuas qhov cuam tshuam cuam tshuam ntawm cov khoom sib txawv ntawm cov qog cell proliferation, thiab txhim kho lawv cov kev sim tsim thiab cov ntaub ntawv tsom xam muaj peev xwm.

Kev npaj ntawm methyl ethyl ketone (Ketone A):

Ntxiv acetone (90 g) rau hauv lub beaker, tom qab ntawd ntxiv methyl acetate (80 mL), sulfuric acid (4 mL), thiab do ntawm kev kub ceev. Ntxiv cov hmoov txhuas oxide (35 g) ntxiv, kom nplawm ntawm qhov kub ceev kom tsis txhob muaj kev sib txuam, thiab tom qab ntawd txuas ntxiv nrog cov sib nqus stirrer rau 30 feeb. Alumina tau lim tawm, thiab 160 mL ntawm glacial acetic acid tau ntxiv rau cov tshuaj lim. Cov tau txais methyl ethyl ketone (Ketone A) tau qhuav thiab txias hauv cov dej nitrogen kom tau 70 g ntawm cov muaju dawb nrog cov txiaj ntsig ntawm 82.5%.

Synthesis ntawm 3,4,5-methoxybenzaldehyde (Vanillin B):

3,4,5-Trimethoxybenzoic acid (10 g) tau ntxiv rau formaldehyde (2 mL), sodium hydroxide tov (3.6 g NaOH hauv 8 mL H2O) ntxiv, thiab stirred rau 30 min. Cov tshuaj tau raug xa mus rau cov cuab yeej reflux, nplawm hauv qab reflux rau 2 h, ces cov kua sib xyaw yog acidified, thiab HCl (6N, hauv dej khov) tau ntxiv rau pH=1.0, thiab ib qho dawb precipitate tsim. Tom qab sib cais, ntxuav thiab pom, 3,4,5-methoxybenzaldehyde (Vanillin B) tau txais nrog cov txiaj ntsig ntawm 86.3%.

Kev npaj ntawm compound K thiab lwm yam intermediates:

Sib tov methyl ethyl ketone (Ketone A, 8.19 g), 3,4,5-methoxybenzaldehyde (Vanillin B, 15 g) thiab butanone (25 mL), ntxiv chromium oxide (VI) (6.8 g). Cov sib tov tau sov los ntawm cov dej khov da dej mus rau chav tsev kub, thiab lub sij hawm tshuaj tiv thaiv yog 2h. Tom qab cov tshuaj tiv thaiv sib tov sib xyaw nrog dej (75 mL) thiab formaldehyde (25 mL), sodium hydroxide (3.7 g) thiab hydrochloric acid Cl (6N, hauv dej khov) tau txuas ntxiv mus txog rau pH=5.5, thiab hmoov dawb dawb precipitate (compound K). Lub precipitate tau ntxuav thiab qhuav kom 98% purity nyob rau hauv 62% tawm los. Compound K (2.13g) thiab aldehyde (2.47g) tau sib xyaw, thiab ethanol (50 mL) tau ntxiv, thiab sodium persulfite (Na2SO3, 1.29 g) tau ntxiv kom txo cov aldehyde, thiab lub sijhawm tshuaj tiv thaiv yog 0.5h. Acetic acid (1.8 g) tau ntxiv kom tshem tawm impurities kom muab cov pob zeb liab liab (intermediate).

Kev npaj ntawm Nortropinone Hydrochloride:

Cov khoom lag luam tau nruab nrab, acetic acid (3 mL) thiab 10% HCl (10 mL) tau sib xyaw rau lub sijhawm tshuaj tiv thaiv ntawm 2 teev, lim, muab rho tawm thiab qhuav kom tau txais cov txiaj ntsig ntawm 78%.

Zuag qhia tag nrho, cov synthesis ntawm no yog muab faib ua plaub kauj ruam, kev npaj ntawm compound K thiab lwm yam intermediates yog nyuab dua, tab sis tag nrho cov yield tuaj yeem mus txog qib siab dua.

Nyob rau hauv cov ntsiab lus, nws tsis yog tsuas yog ib tug structurally txawv tropane alkaloid derivative tab sis kuj yog ib tug pivotal choj txuas tej yam ntuj tso khoom chemistry, receptor pharmacology, thiab tshiab tshuaj txoj kev loj hlob. Nws qhov tshwj xeeb bicyclic nitrogen heterocyclic qauv, zoo heev physicochemical zog, thiab meej cholinergic tswj mechanism ua rau nws irreplaceable nyob rau hauv ob qho tib si kev tshawb fawb thiab kev tshawb fawb tshuaj. Raws li cov cuab yeej tseem ceeb molecule thiab ntau yam khoom siv ua ntej, nws tseem txhawb nqa hauv - kev tshawb fawb tob txog kev ua haujlwm ntawm cholinergic thiab cov kab mob ntawm cov kab mob. Tsiv mus tom ntej, qhov no yuav tseem yog ib qho tseem ceeb rau kev tsim kom muaj kev nyab xeeb thiab xaiv ntau dua cov neeg ua haujlwm neuroactive, muab kev txhawb nqa theoretical thiab cov ntaub ntawv txhawb nqa rau kev tshawb pom cov kev kho tshiab hauv spasmolysis, neurodegenerative disorders, thiab cov kab mob hauv nruab nrab paj hlwb.

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