Nortropinone hydrochloride CAS 25602-68-0

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov chaw muag khoom ntawm Nortopinone Hydrochloride CAS 25602-68-0 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale ntau yam zoo tsis zoo los sis 25602-68-0 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Nortropinone hydrochlorideyog ib qho tseem ceeb derivative ntawm tropane -}} hom alkaloids, tus cwj pwm los ntawm nws cov bricyclic lub moj khaum heterocyclic. Raws li cov qauv ntawm cov khoom tseem ceeb ntawm cov khoom tseem ceeb hauv cov khoom siv ntuj xws li kev tshawb nrhiav hauv cov tshuaj chemicalment thiab cov kev tshawb fawb ntawm neuropharmacology thiab neuropharmacacacacology. Lub fydrochloride daim ntawv ntawm no compound ua tau zoo tshaj nws cov dej solubility thiab crystallization ruaj khov thiab muaj peev xwm ua cov tshuaj txhim kho. Nws lub twj siv tshuaj feem ntau yog cov kev cuam tshuam los ntawm kev tshawb nrhiav thiab cov kab mob patipy, thiab tuaj yeem siv cov leeg ua kom du Tam sim no, nws tsis yog tsuas yog ib qho kev sib tw tsis tseem ceeb rau kev tsim qauv, tab sis kuj tseem ceeb} Parkous system nquag ua tebchaw, txuas ntxiv tsav tsheb Cov txheej txheem tsim kho tshiab hauv kev neuroscience thiab muaj feem xyuam rau cov teb.

Cov ntaub ntawv siv tshuaj ntawm nws yog qhia nyob rau hauv cov lus hauv qab no:

Nortropinone hydrochloride(Suav lub npe: Nortropinone hydrochloride, cas tus lej: 25602-6) yog cov qauv molecular nrog cov qauv molecular muaj cov qauv molecular nrog lub cev hnyav thiab qhov hnyav ntawm 161.63. Qhov no ua ke tau pom cov ntawv thov uas muaj nuj nqis uas muaj txiaj ntsig zoo nyob hauv lub chaw ua yeeb yam ntawm lub neej, kev tsim tshuaj, thiab kev tshawb fawb tshuaj. Cov hauv qab no yog cov ncauj lus kom ntxaws ntawm nws cov kev siv:

Raws li kev tshawb nrhiav qauv rau lub tsev biomaterials

 

Nortropinone hydrochloride tau dhau los ua cov cuab yeej tseem ceeb rau kev tsim cov qauv roj ntsha vim nws cov qauv tshuaj tshwj xeeb (8-azabicyclo [3.2.1] Oct-3-ib lub cev pob txha). Hauv kev sim ntawm tes caud, nws tuaj yeem ua haujlwm ua kev hloov kho ntawm cov khoom siv hluav taws xob hauv lub cev lossis ib puag ncig ntawm tes nplaum, muaj kev sib txawv, thiab cov txheej txheem sib txawv. Piv txwv li, hauv kev coj noj coj ua neuronal, cov compound no tuaj yeem ua rau cov qauv ntawm neurodegeneratis ntawm neurodegenerarative cov kab mob neverodegenates xws li Alzheimer tus kab mob. Tsis tas li ntawd, cov nitrogen atoms thiab carbonyl functional pawg nyob rau hauv nws cov qauv tuaj yeem cuam tshuam nrog cov protein thiab nucleic acids, uas tau siv los kawm kev paub txog kev sib xyaw thiab cov qauv siv.

Kev Tsim Kho Tshiab Bioactive Molecules ua cov organic synmediates

 

Nortropinone hydrochloride yog qhov tseem ceeb hauv nruab nrab rau cov synthesis ntawm ntau qhov kev ua tsis tau muaj ntau yam. Los ntawm kev kho nws cov nitrogen atom lossis cov roj carbon monoxide, pab pawg sib txawv tuaj yeem qhia tau kom muaj cov sib txawv nrog arti {{otion} mob. Piv txwv li, tshawb nrhiav thiab kev txhim kho {{4 4}} Kev ua cov tshuaj me me los ntawm tubulin intoms lossis cov lus teb uas muaj ntxhiab nrog Nortropinone Hydroporide li lub cev pob txha. Xws li cov derivatives qhia cov txiaj ntsig tseem ceeb rau cov kab mob cancer mis MCF-7 hauv cov kev sim vitro. Anti Kev Tsim Kho Yeeb Tshuaj: Los ntawm kev siv tshuaj eserification lossis kev siv tshuaj esteridor, tsis txhob hloov kho nws lub qhov ncauj thiab txo nws txoj kev chim siab thiab txo nws txoj hnyuv. Hom kev nthuav tawm derivative cov tswv yim no rau mob rheumatoid hauv tsiaj.

Cov ntawv thov hauv Kev Tshawb Fawb Neuroscience

 

Cov qauv tshuaj ntawm Nortropinone Hydroporide Shares cov kev sib xws nrog cov neurotransmitters xws li acetylcholine, ua rau nws tsim nyog rau kev kawm neural signaling mechanisms. Nyob rau hauv neuronal electrophysiological sim, no compound exps mus rau nicotinic acetylcholine recetors thiab qhia cov qauv los ntawm cov ntaub ntawv membra av muaj peev xwm hloov tau. Ib qho ntxiv, nws cov derivatives tseem tuaj yeem ua cov kev sim ua fluorescent ntawm cov calcium ion ion concome kev txhawb nqa ntawm cov kev them nyiaj yug los ntawm kev kawm neuronal expitility.

Txhim kho cov qauv raws li kev ua yeeb tshuaj txhuas

 

Cov tshuaj ruaj khov thiab hloov kho cov tshuaj ruaj khov thiab kho cov khoom siv ntawm Nortropinone Hydrochloride ua rau nws muaj kev tsim qauv zoo tagnrho rau kev tsim tshuaj tshuaj. Los ntawm cov txheej txheem ua kom zoo rau nws cov qauv, cov neeg sib tw tshuaj nrog cov haujlwm siab dua thiab xaiv tau tuaj yeem tau txais. Piv txwv li, hauv kev txhim kho cov tshuaj tiv thaiv kev ntxhov siab, ib pawg tshiab xaiv serotonin reptoritor (SSRI Hom kev sib txuas no tau qhia lub sijhawm dhau los thiab qis dua ntawm cov kev mob tshwm sim piv rau cov kev tshawb fawb ib txwm muaj nyob rau hauv cov kev tshawb fawb ua ntej. Kev tshawb fawb txog cov tshuaj antiepileptic: los ntawm kev qhia cov txiv ntoo sulfur atoms lossis cyclopriarane {} Cov txiaj ntsig ntawm cov pej xeem muaj peev xwm siv tau, yog li txo cov neuronal hyperexcitability. Cov kev sim tsiaj tau pom tias cov derivatives zoo li no tuaj yeem txo qis ntau zaus uas tsis muaj kev puas tsuaj loj.

Muaj peev xwm nyob rau hauv multi - Lub Hom Phiaj Kev Txhim Kho

 

Nrog kev nkag siab tob tob txog kev nyuaj ntawm cov kab mob, kev txhim kho ntawm ntau {}} Cov hom phiaj phiaj los ua cov ncauj lus kub tam sim no. Nortropinone hydrochloride, vim nws cov chaw muaj kev hloov kho hauv nws cov qauv, muaj peev xwm ib txhij ua rau ntau tus kabmob- sib xws cov hom phiaj. Piv txwv li, anti {- qog ua ke kho: Los ntawm couplingNortropinone hydrochlorideNrog Paclitaxel, ib qho kev sib txuas lus sib xyaw ua ke uas cov phiaj xwm obliv muaj protein thiab Epidermal kev loj hlob FACEror (EGFR) tuaj yeem suav ua ke. Hom kev sib txuas no tau pom syneroistic tua cov nyhuv ntawm tsis yog- Cell Cancer Media, thiab tuaj yeem kov yeej cov teeb meem ntawm ib qho tshuaj tiv thaiv. Kev kho mob metabolic syndrome: los ntawm kev qhia poliisome proliferator aitabolism thiab lipid metabolism thiab lipid metabolism thiab muaj anti {}} pa hluav taws xob tuaj yeem tau txais. Cov kev sim tsiaj tau pom tias cov derivatives zoo li no tuaj yeem txhim kho cov insulin rhiab nyob rau hauv cov nas rog ntawm cov khoom rog.

Daim Ntawv Thov hauv Kev Siv Tshuaj System

 

Nortropinone hydrochloride tseem siv tau los tsim cov tshuab tshuaj tiv thaiv cov tshuaj. Los ntawm kev sib txuas nrog nws nrog cov ntaub ntawv polymer xws li polylacicic acid hydroxyacetic acid copolymer (PLGA), nanoparticle cov nqa khoom tuaj yeem tsim kom tau txais kev xa khoom siv tshuaj. Piv txwv li, lub hlwb tsom iav: los ntawm kev siv Norplopine hydrochloride lub peev xwm mus rau anti Alzheimer cov tshuaj tua kab mob (xws li TasPeezil) hauv lub hlwb. Cov neeg sim tsiaj tau pom tias cov kev hloov pauv ntawm cov tshuaj muaj ntau dua 5 zaug thiab txhim kho kev txawj ntse. Cov Tumal Lub Hom Phiaj Kev Kho Mob: Los ntawm Coupling Nortropinone hydrolide nrog cov kev qhia txog cov qog noj ntshav (xws li mob cancer mis thiab zes qe menyuam yaus) tuaj yeem tsim. Hom kev kaw lus no tuaj yeem ua tiav kev tsub zuj zus hauv cov tshuaj hauv cov leeg nqaij qog thiab txo cov tshuaj lom rau cov ntaub so ntswg zoo li qub.

Koom nrog cov hluavtaws cov tshuaj tiv thaiv xws li cov tshuaj lom neeg

 

Nortropinone hydrochloride muaj tus nqi tseem ceeb hauv synthic. Cov Nitrogen atoms thiab carbonyl cov pab pawg ua haujlwm hauv nws cov qauv tuaj yeem koom nrog cov cawv sib xyaw ua ke Ntxiv rau cov tshuaj tiv thaiv: reacts nrog grignard reagent los tsim cov cawv txiv kab ntxwv, uas ua rau lub luag haujlwm tseem ceeb hauv lub synthesis ntawm cov khoom ntuj. Redeb Reedox Cov Lus Tiv Thaiv: Raws li kev txiav txim ntawm cov catalyst, nws tuaj yeem txo kom demethylyrrolidone lossis oxidized rau cov carboxylic acid derivatives, muab ntau txoj hauv kev hloov kho qauv.

Nortropinone hydrochloride feem ntau siv los ua cov qauv txheem lossis siv cov khoom siv rau kev sim ua kom zoo, siv cov txheej txheem kev sim ua ntej, lossis pabcuam ua kev sim. Piv txwv li, siab {{{{{{1} Kev ua kua chromatography (HPLC) Cov Spectrometry (MS) Kev Ntsuam Xyuas: Siv ua molecular qhov hnyav los xyuas qhov ntsuas qhov tseeb ntawm cov huab hwm coj. Cell tobility assay: siv raws li kev tswj hwm zoo lossis tsis zoo los ntsuas kev ua haujlwm roj ntsha ntawm lwm cov chaw sib txuas.

Kev coj lub luag haujlwm hauv kev kawm chemistry

 

Tus qauv tshwj xeeb thiab cov khoom ntawm Nortropinone Hydrochloride ua rau nws muaj teeb meem zoo rau kev kawm. Los ntawm kev coj cov tub ntxhais kawm koom tes nrog kev sim ua xws li kev tshawb fawb txog cov khoom ntiag tug, nws tuaj yeem txhawb txoj kev xav hauv cov ensistry thiab tshuaj chemistry. Piv txwv, kev hloov kho qauv qauv: Cov tub ntxhais kawm yuav tsum tau muab cov tshuaj tiv thaiv hydropinone hydropinone hydropinone, thiab kev hloov pauv ntawm lub cev thiab tshuaj. Kev ua haujlwm txheeb xyuas txheeb xyuas kev sim: Siv cov txuj ci ntawm kev coj noj coj ua ntawm qog ntawm cov neeg ua haujlwm qog thiab txhim kho lawv cov qauv kev sim thiab cov ntaub ntawv muaj peev xwm.

Synthesis txoj kev ntawmNortropinone hydrochlorideyog raws li nram no:

1. Npaj ntawm methyl keetone (Ketone a):

Ntxiv acetone (90 g) rau hauv beaker, tom qab ntawd ntxiv methyl acetate (80 ml), sulfuric acid (4 ml), thiab do ntawm kev kub ceev. Ntxiv aluminium oxide (35 g) dua, khaws stirring ntawm qhov kev kub ceev kom tsis txhob agglomeration, thiab tom qab ntawd txuas ntxiv stirring nrog lub sib nqus stirrer rau 30 feeb. Alumina tau lim tawm, thiab 160 ml ntawm glacial acetic acid tau ntxiv rau cov tshuaj lim. Cov tau txais methyl ketone (Ketone a) tau qhuav thiab txias nyob rau hauv ib tug nitrogen kwj mus tau 70 g ntawm cov muaju dawb nrog cov txiaj ntsig ntawm 82.5%.

2. Khoom cua ntawm 3,4,5-methoxybenzaldehyde (Vanillin B):

3,4,5-trimethoxybenzoic acid (10 g) tau ntxiv rau formaldehyde (2 ml), sodium hydroxide tov (thiab ua kom zoo rau hauv 8 m min. Txoj kev daws teeb meem tau pauv mus rau ib qho khoom siv reflux, nplawm nyob rau hauv reflux rau 2 h, tom qab ntawd hcn, hauv dej khov) tau ntxiv rau pH= 1.0, thiab precipite nag los tsim. Tom qab sib cais, ntxuav thiab lim, 3,4,5-methoxybenzaldehde (vanillin b) tau txais los ntawm86.3%.

3. Kev npaj ntawm compound k thiab lwm yam nruab nrab:

Sib tov methyl ketone (Ketone A, 8.19 g), 3,4,5-metanybenhalhyde (15 ml), ntxiv chromium oxide (vi) (6.8 g). Cov dej sib tov tau ua kom sov los ntawm cov dej khov dej rau chav sov mus rau chav sov, thiab lub sijhawm cov tshuaj tiv thaiv yog 2h. Tom qab cov tshuaj tiv thaiv tau sib xyaw ua ke nrog dej sib xyaw (75 mL) thiab fydium dej Cov nag los tau ntxuav thiab qhuav los muab 98% purity hauv 62% tawm los. Compound k (2.13g) thiab aldehyde (2.47g) tau sib xyaw, thiab ethanol (na2so3, 1.29 g) tau ntxiv, thiab lub sijhawm cov tshuaj tiv thaiv yog 0.5h. Acatic acid (1.8 g) tau ntxiv rau tshem tawm impurities los muab cov iav muaju liab (nruab nrab).

4. Kev npaj ntawm Nortropinone hydrochloride:

Qhov tau txais cov khoom nruab nrab, acetic acid (3 ml) thiab 10 mL) tau sib xyaw rau lub sijhawm tshuaj tiv thaiv ntawm 2 teev kom tau txais Nortropinone hydrochloride nrog cov txiaj ntsig ntawm 78%.

Zuag qhia tag nrho, cov synthesis ntawm nortopinone hydrochloride tau muab faib ua plaub kauj ruam, kev npaj ntawm cov comprediates tau yooj yim, tab sis cov txiaj ntsig tag nrho tuaj yeem ncav cuag qib siab dua.

Cim npe nrov: Nortropinone hydrochloride CAS 25602-68-0, tus neeg tsim khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav khoom, rau muag