Sodium Phenyylbutyrinst Hmoov CAS 1716-12-7

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm sodium phenylbutyrate hmoov cuab tam 1716-12-7 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo sodium phenylbutyrinst hmoov CAS 1716-12-7 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Sodium phenylbutyrinte hmoov, yav tas los paub raws li sodium 4-phenylbutyrate, tseem hu ua Sodium phenylbutyrinte, yog hmoov dawb cov hmoov siv ua cov kws tshuaj nruab nrab thiab lwm yam tshuaj zoo. Sodium 4-phenylbutyrate yog cov organic sib xyaw uas muaj nyob hauv daim ntawv ntawm cov xim tsis muaj kob lossis dawb khoom muaju. Tshuaj mis mis yog c10h11nao2, nrog tus coj molecular hnyav ntawm 186.19 g / mol, feem ntau tsis muaj ntxhiab tsw. Muaj cov solubility zoo hauv dej. Nws tseem tuaj yeem rhuav tshem qee cov tshuaj kuab tshuaj organic, xws li Methanol, ethanol, cleanoform, etc. kuj tseem ceeb ntawm qhov kub siab. Txawm li cas los xij, yog tias rhuab ntev ntev, nws yuav ua rau poob siab. Cov kua tshuaj aqueous yog alkaline thiab muaj tus nqi pH siab. Nws yog cov tshuaj uas muaj nplaim taws uas tuaj yeem hlawv raws li cov nplaim hluav taws, ua cov pa roj carbon dioxide, dej organic. Nws tau siv dav hauv qee cov tshuaj pleev ib ce thiab cov khoom lag luam zoo nkauj. Nws muaj moisturizing, antioxidant, thiab cov tshuaj tua kab mob, uas tuaj yeem siv los txhim kho cov tawv nqaij kom huv, thiab cov teeb meem kev laus tawv nqaij xws li pob txuv. Kuj tseem muaj lwm thaj chaw thov, xws li kev neuroprot, anti ililepsy, thiab kev kho mob ntawm angiodensin hloov enzyme tsis txaus. Tsis tas li ntawd, nws tseem siv tau ua cov reabent reagent thiab ua lub luag haujlwm hauv kev tshawb fawb biomedical.

Kev Cia Khoom Siv Chav Temp, Solubility H2O: Ntau dua los yog sib npaug ntawm cov lus qhia, xim dawb} {2} {2} {{ P {351 + p338, cov khoom txaus ntshai tshaj tawm xi, cov lus qhia kev nyab xeeb 26, Wgk Lub teb chaws Yelemees 3, RTECS TSIS MUAJ.: CY9057220.

Sodium 4-phenylbutyrate (CAS NUMBER: 1716-12-7), raws li kev tshawb fawb muaj nuj nqis, thiab khoom noj yog vim nws cov tshuaj lom neeg thiab cov tshuaj lom neeg.

Daim teb Kho Mob: Los ntawm cov kab mob metabolic kho rau anti - cov tub nrhiav kev tshawb fawb

 

1. Kev kho mob zoo rau urea lub voj voog cuam tshuam
Nws yog cov tshuaj classic rau kev kho urea lub voj voog cuam tshuam (UCD). Tus kab mob no yog tshwm sim los ntawm daim siab enzyme tsis xws luag ua rau tsis txawv txav ammonia metabolism, ua rau hyperammonemia, lub hlwb tuag. Nws cov tshuab ntawm kev ua yog:
Ua kom nrawm ammonia clearance: raws li ua ntej phenylacetic acid, nws tau hloov mus rau hauv phenylacetylgrodamine, uas tau tshaj tawm los ntawm cov zis thiab txo cov ntshav ammonia converration.

 

Kev kho mob Efficacy: Kev siv lub sijhawm ntev yuav tau txo qis ntau zaus ntawm hyperpphamonemia tawm tsam thiab txhim kho cov kev ua haujlwm neurocogrogitive. Piv txwv li, kawm kuaj mob ntawm cov menyuam kawm qib siab uas muaj hnub nyoog 6 lub hlis tom qab muaj kev txwv tsis pub dhau los ntawm 60% thiab cov neeg sawv cev ntawm Epileptic

2. Synergistic txhim kho ntawm anti - kev cai kho
Raws li cov tswv yim txog Deacetylase (HDAC) inhibitorase (HDAC) inhibitor, nws tiv thaiv cov qog cell proltosation thiab inducctetic hloov kho:
Kev ntsuas mechanism: thim rov qab ntawm chav kawm I / II HDAC enzymes, ua kom cov synaticalcation, thaum ua rau muaj cov tshuaj tiv thaiv Apoptotic (xws li BCL-2).

 

Cov Ntaub Ntawv Kho Ua ke:

Prostate cancer: Thaum sib txuas nrog kev ionizing hluav taws xob, cov lej agning ntawm cov qog ua kom nce los ntawm 2.3 zaug piv rau Radiotherapy ib leeg. Tus kws tshuab yuav cuam tshuam nrog dna restent protein Kinase (DNA} pk) thiab inhibiting DNA kho.
Tsis yog MOB MOB MOB MOB MOB Cancer Med Cancer me me (NSCLC): Inhibits A549 LINE Cov kab kev nthuav dav ntawm ib qho siab ntawm 2 hli, nrog tus nqi IC50 ntawm 1.8mm. Lub synergistic nyhuv yog qhov tseem ceeb thaum ua ke nrog prometazine.
Neeg Asmeskas tus kab mob swog rev kis mob (ASFV) muaj kab mob rau H3k9 / K14 Hyphoacetylation xeev, thiab ua tiav kev tshem tawm ntawm tus kab mob replication thaum ua ke nrog enrofloxacin.

 

3. Cov kev kho mob muaj peev xwm rau cov kab mob neurodegenerative
Hauv cov qauv tsiaj, kev ua haujlwm neural tau zoo dua los ntawm kev tswj cov epigenetic thiab kev kub ntxhov
Amyotrophic tom qab sclerosis (als): hauv G93a Transgenic nas muaj peev xwm nthuav tawm muaj sia nyob rau hauv nroog Cytochrome C thiab Caspase-3 qib.
Huntington tus kab mob (HD): Hauv cov qib Transgenic nas hlwb txo qis los ntawm 25% thiab txo cov protein txawv txav.

Kev Tshawb Fawb: Tuam Txhab Teb Chaws rau Epigenetics thiab Kev Nyuaj Siab Cellular

 

1. Cov cuab yeej ua qauv rau kev tshawb fawb epigenetic
Raws li HDac inhibitor, sodium 4-phenylbutyrate yog dav siv nyob rau hauv kev kawm ntawm chromatin remodeling tshuab
Cov thawj coj qhia kev cai tswj hwm Kev tswj hwm tuaj yeem tsim kho cov tswv yim H3 acetylation qib hauv cheeb tsam txhawb nqa thaj tsam li 15%.
Kev tshuaj ntsuam tshuaj: raws li kev tswj tau zoo, nws yog siv rau high -} Kev ntsuas tus tshiab HDAC inhibitors. Thaum ua ke nrog Trichostatin A (FA), nws tuaj yeem paub qhov txawv tshwj xeeb ntawm chav kawm I / Qib II HDAC enzymes.

 

2. Regulators ntawm Endoplasmic Reticulum Kev Nyuaj Siab (Er Kev Nyuaj Siab)
Txhawm rau kawm cov kev mob cellular thiab txoj kev nthuav tawm endoldly endoplasmic reticulum cov lus teb (UPR):
Neuroprotecious tshuab: hauv cov nas teeb liab kev raug mob, txo cov qib ntawm grep78 / pen}} perm /%% thiab txo cov neuronal apoptosis.
Autophagy Kev Tshawb Fawb Txog Kev Tshawb Fawb: Hauv LPS ua qauv rau pob txha poob, inhibition ntawm kev ua tiav ntawm 40%, thaum thim rov qab p62 protein degradation tsis sib haum.

 

3. Cov kev cuam tshuam rau kev kis tus kab mob kis tus kab mob
Txhawm rau txhim kho cov tswv yim tua kab mob antiviral tsom cov kev cai epigenetic hauv kev ua haujlwm ntawm cov kab mob:
ASFV Kev Kho Mob Tsis Txaus Siab: Kev txwv Theem Protein synthesis ntawm tus kab mob ntawm ib qho siab ntawm 0.5 hli, tus kab mob kab mob txo qis los ntawm 5 lub rooj sib tham nrog enrofloxacin.
Kev ua kom muaj kev tiv thaiv HIV LEENENT POOT: hauv j - lator kab ntxiv rau hauv tus nqi HIV ntawm Latent HIV tus kab mob piv rau kev txhawb nqa ib leeg.

Kev lag luam thiab khoom noj khoom noj: los ntawm catalysts ntxiv rau ntxiv

 

1. Khoom cua hlob nyob rau hauv cov tshuaj zoo
Kev npaj ESTer derivatives: nucleophilic hloov kev coj ua nrog Alkylal cov lus sib txuas, uas tau siv rau kev sib txuas ntawm polymer tshuab yas.
Polymer catalysis: raws li ib lub nplhaib alkaline, nws txhawb nqa lub nplhaib qhib qhib cov tshuaj tiv thaiv kab mob thiab cov nqaim ntawm cov khoom lag luam.

 

2. Kev sib ntxiv rau cov khoom noj khoom haus
Miancer: Ntxiv 0.05% -0.1% rau cov kua txiv hmab txiv ntoo tuaj yeem npog cov ntxhiab tsw yog xim hlau, thaum lub sij hawm showhordically muab lub qab zib qaub saj nrog citric acid.
Antioxidant khaws cia: los ntawm compounding 0.02% tshuaj yej polyphenols hauv cov nqaij cov khoom lag luam, thiab lub txee kev tswj hwm tuaj yeem txuas ntxiv ntawm 7 hnub rau 18 hnub.
Microbial tswj: Hauv cov zaub mov kaus poom, qhov ntsuas ntawm Escherichia

Cov xwm txheej tshwj xeeb thiab kev tshawb nrhiav Frontier

 

1. Kev cuam tshuam rau cov kabmob pob txha metabolism
Nyob rau hauv LPS ua rau pob txha poob, txhim kho pob txha zoo los ntawm ntau {{0} {hom phiaj kev cai:
Pob txha ua kom muaj kev txhim kho: Tom qab cov nom tswv txuas ntxiv rau 3 lub lis piam, cov pob txha ntxhia (BV / TV) nce li 18%.
Inflammatory inhibition: txo ntshav ntshav mcp- 1 qib, thaiv NF - κ B Txoj kev ua kom muaj kev sib txawv.

 

2. Kev loj hlob ntawm cov tshuaj ntxuav tawm rau cov tshuaj tiv thaiv kab mob tsis tshua muaj tshuaj tiv thaiv
Rau cov organic acidemia xws li propionic acidemia, sodium 4-phenylbutyrate txhim kho cov tsos mob ntawm txoj kev ntawm Metabolic los ntawm txoj kev ntawm cov kev coj ua:
Cov kev ua kom metabolic bypass kom ua: induces qhov kev hais tawm ntawm propionic acid metabolism ntsig txog cov pa roj ntsha (xws li ACATE1, MUT), txo ntshav prodic prod siab los ntawm 50%.
Cov ntaub ntawv kuaj mob: Qhov qhib qhib daim ntawv qhia txog kev kho prodemia uas tau ua rau muaj txiaj ntsig ntawm 70% txhim kho cov qhab nia zoo ntawm lub neej.

Peb yog tus xa khoom ntawmSodium phenylbutyrinte hmoov.

Cov Lus Cim: Bloom Tech (Txij xyoo 2008), ua tiav chem - tech yog peb cov neeg pab cuam ntawm peb.

Sodium 4-phenylbutyrate yog ib cov organic compound uas tuaj yeem npaj los ntawm ntau txoj kev hluavtaws. Cov hauv qab no yog ntau cov qauv hluavtaws:

1. Nyob rau hauv situ tiam

Txoj kev no ua rau tsim 4-phenylodium phenylbutyrate nyob rau hauv situ los ntawm kev tiv thaiv.

- Cov tshuaj tiv thaiv kauj ruam: benzoic acid thiab bromobutane ntxiv rau cov tshuaj tiv thaiv hws nyob hauv lub xub ntiag ntawm Alkali kom tsim 4-phenylbutyrate. Tom qab ntawd, 4-phenylester ntawm phenylbutyrate yog reacted nrog sodium hydroxide rau daim 4-phenylodium phenylbutyrinate.

C₇H₆O₂+C₄H₉Br → 4-phenylbutyrate

4-phenylbutyrate + Naoh → C₁₀H₁₃Nao₂

2. Cov tshuaj tiv thaiv

{{0 {}} Cov tshuaj tiv thaiv theem: 4-phenylomutyric acid yog refium hydrothide) nyob rau hauv ib tug uas tsim nyog carbonate) nyob rau hauv ib tug tsim nyog cov kuab tshuaj lossis sodium carbonate) nyob rau hauv ib tug tsim nyog cov kuab tshuaj lossis sodium carbonate) nyob rau hauv ib tug tsim nyog cov kuab tshuaj lossis sodium carbonate) nyob rau hauv ib tug tsim nyog cov kuab tshuaj los tsim 4-phenylsodium phenylbutyrinate.

C₁₀H₁₂O₂ + Naoh → c₁₀H₁₃Nao₂

3. Ammonia txoj kev

-} Cov tshuaj tiv thaiv steps: 4-phenylomutyric acid tau ua rau muaj ib qho kev tsim nyog los tsim 4-phenylammonium phenylbutyrate.

C₁₀H₁₂O₂ + NH₃ → C₁₀H₁₃Nao₂

4. Photocatalytic txoj kev

{- Cov tshuaj tiv thaiv steply (xws li ib tug derravensitive catalyst) nyob rau theem tsim nyog los tsim 4-phenylsodium phenylutyrate.

C₁₀H₁₂O₂ + Photicensitive catalyst + teeb iradiation → c₁₀H₁₃Nao₂

Nws yuav tsum raug sau tseg tias thaum ua cov kev coj ua kev nyab xeeb saum toj no thiab xaiv cov tshuaj tiv thaiv kab mob, thiab catalysts hauv cov khoom siv tau. Nyob rau tib lub sijhawm, nws raug nquahu kom xa mus rau cov ntawv sau thiab phau ntawv qhia ua haujlwm kom ntxaws cov kev ua haujlwm thiab kev sim ua haujlwm.

Cim npe nrov: Sodium Phenyylbutyryrinst hmoov CAS 1716-12-7, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag