Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm Pefloxacin Mesylate CAS 14967-4 hauv Suav teb. Txais tos rau kev lag luam wholesale pulloxacin mesylate ua haujlwm 149676-40-4 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
PefloxCin Mesylate DihydratePuas yog cov tshuaj sib xyaw ua ke feem ntau siv nyob rau hauv kev kho mob teb ua ib tus neeg sawv cev antibacterial. Nws zwm rau cov chav kawm ua roj fluoroquinolone ntawm cov tshuaj tua kab mob, uas tau paub rau lawv cov dav {{2} {- cov kab mob tsis zoo. Daim foos tshwj xeeb no, lub Dihydrate, muaj ob lub lwg me me ntawm cov dej ntawm crystallization ib molecule ntawm Peffoxacin Mesylate.
Pefloxacin, tus ua kom nquag plias, ua haujlwm los ntawm inhibiting bacterial DNA gyrase enzyme, ib qho txheej txheem tseem ceeb rau cov kab mob rov qab. Los ntawm kev cuam tshuam cov txheej txheem no, Pefloxacin tau zoo rau cov kab mob muaj zog los tawm tsam lub cev kom tshem cov kab mob ntawm nws tus kheej.
Cov paj lug mesylate ntawm pefloxacin txhim kho nws solubility thiab ruaj khov, ua rau nws tsim nyog rau cov tshuaj. Raws li ib qho tshuaj tua kab mob, nws yog qhia rau kev kho mob ntawm ntau yam kab mob, suav nrog kev mob khaub thuas, tawv nqaij, thiab mos mos nqaij.
Txawm li cas los xij, zoo li lwm cov tshuaj fluoroquinolones, nws yuav tsum tau siv nrog kev phiv los ntawm kev mob plab yog xws li kev cuam tshuam tsis zoo, thiab, tsis tshua muaj xwm txheej zoo li cov tshuaj lom zem thiab muaj kev sib xyaw. Nws yog qhov tseem ceeb heev los ua raws cov lus qhia kho mob kom zoo thiab ua tiav cov chav kho mob kom tsis txhob muaj cov kab mob tshwm sim.
Hauv cov ntsiab lus xaus,PefloxCin Mesylate Dihydrateyog cov tshuaj tua kab mob uas siv tau siv los kho ntau yam kab mob. Nws txoj kev ua tau zoo thiab kev nyab xeeb profile ua nws muaj txiaj ntsig ntxiv rau cov kev kho mob uas muaj txiaj ntsig ntawm cov tshuaj tiv thaiv kab mob
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Tshuaj Cov Qauv |
C17H20Fn3o3 |
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Muaj pes tsawg leej |
333.15 |
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Molecular hnyav |
333.36 |
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m/z |
333.15 (100.0%), 334.15 (18.4%), 335.16 (1.6%), 334.15 (1.1%) |
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Kev Ntsuam Xyuas |
C, 61.25; H, 6.05; F, 5.70; N, 12.61; O, 14.40 |
Tus neeg sawv cev tua kabmob
Mechanism ntawm Kev Ua
- Teej tug rau cov chav fluoroquinolone ntawm tshuaj tua kab mob.
- Nws ua los ntawm inhibiting DNhase, ib qho enzyme tseem ceeb rau cov kab mob DNA replication thiab kev sib sau. Los ntawm kev cuam tshuam kev ua haujlwm ntawm DNA Gyrase, PefloxCin txwv tsis pub DNAns los ntawm kev ua kom zoo dua qub, ua rau cov kab mob ntawm kev tuag.
Spectrum ntawm kev ua si
- Peffoxacin pom pom dav - spectrum ove} {1} {- cov kab tsis zoo.
- Nws yog nquag tawm tsam cov muaj sia xws li Staphyrococcus aureus, eschchia coli, lwm yam enterobacteriaae, thiab pseudomonas aeruginosa.
Kho cov kev siv
- Vim nws cov kev ua kom muaj zog tiv thaiv kab mob, nws yog feem ntau siv los kho mob hnyav thiab lub neej- kev tiv thaiv kab mob.
- Tej zaum nws yuav raug tshuaj rau kev kis tus kab mob ua pa, tso zis, tawv nqaij thiab cov nqaij mos, thiab lwm lub cev.
Kev Tshawb Fawb & Kev Txhim Kho Lwm Yam
Tshuaj Txha
- Ua haujlwm raws li qhov tseem ceeb hauv nruab nrab hauv cov xwm txheej ntawm lwm yam kev sib txuas ntawm cov tshuaj hauv tsev.
- Nws cov qauv tshuaj tshwj xeeb cov khoom thiab cov khoom ua rau nws muaj txiaj ntsig pib rau kev txhim kho cov kab mob tua kab mob tshiab.
Kev Tshawb Fawb
- Cov kws tshawb nrhiav siv nws hauv kev tshawb fawb txog kev tshawb fawb nws cov tshuaj tua kab mob, thiab muaj peev xwm rau kev txhim kho ntawm kev kho tshiab kho cov tswv yim.
- Nws tau nthuav tawm hauv cov ntawv nyeem scientific, pab txhawb rau kev nce qib ntawm kev paub hauv kev sib kis kabmob thiab tshuaj tua kab mob.
Taw qhia rau cov tshuaj tua kab mob fluoroquinolones tshuaj tua kab mob
Cov tshuaj fluoroquinolones, muaj cov pab pawg hluavtaws hluavtaws cov tshuaj tua kab mob, tau daws cov kev kho mob ntawm cov tshuaj tiv thaiv kab mob antimicrobial kho txij thaum lawv tshawb pom. Ntawm no yog cov ncauj lus kom ntxaws ntawm kev tshawb pom keeb kwm ntawm fluoroquinolones:
- Xyoo 1962, thawj Quinolone tshuaj, nidcic acid, tau qhia rau hauv kev tshawb fawb. Nws tau pom tias yog los ntawm kev tsim los ntawm kev sim ua ke chloroquine los ntawm George Y. Lesher ntawm Sterling Wintrop Lub Chaw Haujlwm Hauv Tebchaws Asmeskas. Nidixic acid, tab sis feem ntau siv rau kev mob tso zis vim nws cov zis siab ua kom zoo, tau ntev ntev vim nws qhov qis qis dua.
- Lub tsev ua cov kua qaub rau ntawm cov av lojliv, kev txhim kho cov tshuaj ua kua roj fluoroquinolones pib. Cov lus qhia txog cov tshuaj roj fluorine atoms loj dua cov tshuaj tua kab mob ntawm cov teb no.
- Xyoo 1974, pipemidic acid, thib ob -} Nplooj Nplooj Quinolone, tau synthesized. Nws nthuav qhia dav dav ntawm cov tshuaj tua kab mob thiab tsawg dua kev phiv tshuaj piv rau covlixic acid.
- Thawj hom tshuaj fluoroquinolone, Norfloxacin, tau synthesized xyoo 1978. Qhov no cim thaum pib ntawm kev txhim kho fluoroquinolone derivatives.
Qhov thib peb {-}}}}}}}}}}}}}}}}}} inech fluoroxacin thiab levofledboxacin, tawm hauv xyoo 1980 thiab 1990s.
- Ciprofloflin: Tshawb pom thaum xyoo 1981 thiab patented los ntawm Bayer, Ciprofloxacin tau ua rau muaj cov kab mob muaj zog, ua rau nws muaj kab mob sib luag hauv kev kho mob.
- Levofloxacin: Tsim kev tsim ua ke ntawm Heechst (tam sim no Sanoici) thiab Dailoch Sankyo, Levofloxacin tau nkag rau xyoo 1985 hauv Tebchaws Yelemees thiab 1993 hauv Nyij Pooj. Nws yog cov ntau zog thiab cov ntawv nyeem tsawg dua ntawm ofloxacin, nrog cov spectrum ntau ntawm cov tshuaj tua kab mob.
Qhov plaub {{-}}}} Nplooj Fluoroquinolones, xws li Moxifloxacin thiab Gatifloxacin, tau qhia nyob rau xyoo 1990 thiab ntxov 2000s.
- Moxifloxacin: Pom zoo rau kev siv nyob rau hauv ntau lub tebchaws, Moxifloxacin muaj cov dav - spectrum cov kev pab them nqi thiab cov ntaub so ntswg zoo.
- Gatifloxacin: Hmoov tsis zoo, Gatifloxacin tau rho tawm ntawm Asmeskas thiab Canadian lag luam hauv xyoo 2006 vim yog qhia txog kev tshaj tawm txog kev ua haujlwm loj lossis kev tuag taus.
- Despite the success of fluoroquinolones, concerns about adverse effects, such as QT interval prolongation and blood glucose disturbances, led to the exploration of non-fluoroquinolone quinolones.
- Nyob rau hauv lub xyoo 1990, Toyama Lub Tuam Txhab Siv Hluav Taws Xob Hluav Taws Xob Tebchaw zoo li garenoxacin tawm los ntawm cov kev tshawb fawb no.
- Lwm qhov tseem ceeb tsis yog {{0} emoroquinolone yog nememoquinolone yog neminoxolin, tsim los ntawm procast & Gamble thiab tom qab ntawv tso cai rau Taigen Biotechnology. Nemonoxacin tau qhia txog kev ua haujlwm tawm tsam meticillin- awnive staphylococcus aureus (Multidrug {{}} Resiveant pathogen.
Cov tshuaj tiv thaiv tsis zoo
PefloxCin Mesylate DihydrateYog ib feem peb {{-}} {{{1} {1} {{{1} {{1} {{1 {1} {{{1 {1 }omerase IV, thaiv cov kab mob DNA replication. Nws cov kab mob tawm tsam Gram cov kab mob tsis zoo (xws li cov kab mob Eschericha), xws li cov kab mob staphyoccus), thiab qee cov kab mob anaerobic. Nws yog feem ntau siv tau kho mob los kho tus mob ua pa, cov kab mob mob plab, mob plab, tawv nqaij thiab sepdis.
Hom nquag muaj kev cuam tshuam thiab kev kho mob ua haujlwm
Kev tiv thaiv lub plab zom mov
Kev tiv thaiv lub plab zom mov yog cov kev cuam tshuam ntau tshaj plaws ntawm Pefloxacin Mesylate Dihydrate, nrog qhov tshwm sim ntawm kwv yees li 5% -15%. Cov chaw kho mob tshwm sim muaj xws li:
Xeev siab thiab ntuav: feem ntau pom nyob rau hauv thaum ntxov muaj feem cuam tshuam txog kev ua kom ncaj qha rau cov pa roj plab los ntawm cov tshuaj. Ib txoj kev tshawb nrhiav yav dhau los muaj 200 tus neeg mob pom tias qhov tseem ceeb ntawm xeev yog 8.5% thiab ntuav yog 4.2%.
Zawv plab: Qee cov neeg mob tuaj yeem muaj cov quav dej, thiab mob plab), nws yuav tsim kho mob plab ntawm txog 0.1%), nws yuav ua npaws ntshav, thiab ua npaws, xav tau kev kho mob ceev.
Digestive kev tsis sib haum xeeb: suav nrog lub plab me me tsis xis nyob, uas yuav cuam tshuam nrog kev noj tshuaj tsawg dua lossis mob dysbiosis.
Kev ua kom mechaeatchism ntawm qhov tshwm sim: Fluoroquinolone tshuaj yuav inhibit txoj kev loj hlob ntawm cov kab mob pathogenic), xws li clostridium cov kab mob difficile) thiab ua rau mob plab.
Central Qeervous System Teb Teb Teb
Central Ntshav Cov Tshuaj Muaj Zog yog lwm cov kev sib raug zoo ntawm Peffloxacin Mesylate Resihdrate, nrog tus nqi ntawm kwv yees li 3%, feem ntau yog suav nrog:
Mob taub hau thiab kiv taub hau: feem ntau yog me, tuaj yeem daws lawv tus kheej, yuav cuam tshuam nrog cov vasow ua cov tshuaj ntawm cov hlab ntshav lossis nce hauv cerebospinal dej.
Insomnia thiab kev tsaug zog: Qee tus neeg mob yuav muaj kev pw tsaug zog, tshwm sim ua nyuaj li nruab hnub pw tsaug zog.
Kev tsis ncaj ncees: suav nrog kev ntxhov siab, nyob tsis tswm, tsis meej pem, qaug dab peg, thiab muaj qhov tshwm sim ntawm 0.1% -0.5%). Kev kawm sib koom tes rau cov neeg mob laus uas pom tias kev pheej hmoo ntawm kev qaug dab peg uas epileptic yog ze rau lub raum tsis sib xws thiab tshuaj ntau dua.
Kev ntsuas mechanism ntawm qhov tshwm sim: Fluoroquinolone tshuaj tuaj yeem hla cov ntshav {}} Amino lub hlwb acid (GAMA), thiab yog li qis dua qhov pib rau epileps. Tsis tas li ntawd, Metabolites yuav muaj qhov kev lom zem ncaj qha rau lub hauv nruab nrab ntawm cov hlab hlwb.
Kev tsis haum
Kev ua xua yog ib qho kev nyuaj siab ntawm Pefloxacin Mesylate Dihydrate, nrog qhov muaj feem muaj kwv yees li 1% -5% thiab cov kev kho mob ntau yam
Cov tawv nqaij tiv thaiv: Qhov feem ntau yog pob (nrog rau eryshage, papulested li Erethema, Papules, lossis UrTICARIA, feem ntau tshwm sim 1-3 hnub tom qab noj tshuaj. Cov mob hnyav tuaj yeem tsim kev exudative artthema multiforme, Stevens Johnson Syndrome (Kaum), tus cwj pwm los ntawm kev tuag ntawm kev tuag mus txog 10% -30%.
Vascular neuroedema: manifested li ntsej muag, di ncauj lossis caj pas, tuaj yeem ua rau muaj kev tiv thaiv kev ua pa, xav tau kev kho mob ceev.
Cov tshuaj tiv thaiv kab mob: Qee tus neeg mob yuav hnov cov tawv nqaij liab qab, mob ntshav, lossis hlawv qhov mob ntawm 0.5% -1%. Qhov no cuam tshuam nrog kev tsim cov phototoxic metabolites tom qab cov tshuaj nqus hluav ncaig hluav taws xob.
Mechanism ntawm qhov tshwm sim: kev ua xua feem ntau tshwm sim los ntawm oge kho kho kho cov hom kuv hypersensitivity los yog t cell horiated hom iv hypiated hom. Cov tshuaj tiv thaiv photensivitive yog cuam tshuam rau tiam ntawm cov dawb radicals los ntawm cov tshuaj tom qab nqus lub teeb ulteriolet, uas ua kev puas tsuaj rau cov tawv nqaij tawv nqaij.
Mob pob txha cov lus teb
Cov pob txha pob txha cov leeg system yog ib qho kev tsis zoo ntawm kev sib raug zoo ntawmPefloxCin Mesylate Dihydrate, nrog cov xim tshwj xeeb them rau nws cov kev puas tsuaj rau pob txha mos hauv cov tsiaj uas hluas
Kev mob sib koom tes: qee tus neeg mob yuav muaj lub hauv caug, pob taws, lossis tus mob dab teg, nrog qhov muaj feem ntawm 1% -2%. Nws yog feem ntau hloov chaw thiab tuaj yeem tau txais kev nyab xeeb tom qab ua kom tsis muaj tshuaj.
Tendinitis thiab tupton rupture: feem ntau pom nyob rau hauv lub achilles tendon, tus cwj pwm los ntawm kev mob, o, lossis kev siv zog. Nyob rau hauv cov neeg mob hnyav, leeg puas ntsoog yuav tshwm sim (nrog tus nqi ntawm kwv yees li 0.01%- 0.1%). Kev tsom xam meta-tsom kwm qhia tau tias cov neeg siv tshuaj fluoroquinolone muaj 2.5 ntau dua cov achilles malilles tupture piv rau cov neeg tsis yog cov neeg siv.
Rhabdomyolysis: manifested li mob leeg, cov leeg tsis muaj zog, thiab cov mob siab thiab cov mob hnyav tuaj yeem ua rau lub raum tsis ua tiav (qhov tshwm sim ntawm 0.01%).
Kev siv tshuab ntawm qhov tshwm sim: Fluoroquinolone tshuaj yuav cuam tshuam nrog cov pob txha mos kho kom zoo los ntawm kev ua haujlwm proteoglycans los ntawm Chondrocytes; Lub caij no, cov tshuaj yuav tuaj yeem puas tsuaj ncaj rau caj ces, ua rau collagen fiber ntau.
Cim npe nrov: Pefloxacin Mesylate Cas 149676-40-4, Tus neeg muab khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag