Phenibut HCl hmoov 25kgcov khoom lag luam nthuav tawm raws li kev nplua, tawm - cov khoom siv dawb crystalline nrog cov khoom sib txawv hygroscopic, xav tau airtight cia los tiv thaiv kev nqus dej. Qhov no synthetic GABA analog, tshuaj hu ua -phenyl- -aminobutyric acid hydrochloride, nthuav tawm dual anxiolytic thiab stimulatory los ntawm tshwj xeeb GABA-B agonism thiab dopamine modulation. Cov ntim ntim ntau qhia txog cov ntawv thov kev lag luam hauv kev siv tshuaj sib xyaw lossis loj - cov khoom lag luam ntxiv, txawm hais tias nws qhov hloov pauv thoob ntiaj teb raws li txoj cai-xws li los ntawm kev tswj tsis tau mus rau daim ntawv xaj-tsuas yog- yuav tsum tau ceev faj txog kev ua raws cai rau kev lag luam thoob ntiaj teb. Daim ntawv hydrochloride muaj kev ruaj ntseg zoo thiab dej solubility rau kev tsim, nrog cov yam ntxwv iab saj thiab 98-99% purity ib txwm nyob rau hauv cov tshuaj-qib batches. Kev ua tiav yuav tsum muaj cov cuab yeej siv tau zoo vim nws qhov nqaim ntau npaum li cas (250-1500mg), raws li cov hmoov pib qeeb (2-4 teev) thiab lub sijhawm ntev (txog 24 teev) tsim cov tshuaj pharmacokinetic tshwj xeeb rau kev tsim khoom. Cov neeg yuav khoom ntau yuav tsum txheeb xyuas daim ntawv pov thawj ntawm kev tsom xam rau cov kuab tshuaj seem thiab cov hlau hnyav, tshwj xeeb tshaj yog txij li tsis tau tshaj tawm phenibut tau raug txheeb xyuas hauv cov khoom lag luam kev paub txog kev txawj ntse. Cov txheej txheem tuav tau zoo yog qhov tseem ceeb vim nws muaj peev xwm ua rau muaj kev nyuaj siab ua pa hauv cov xwm txheej dhau los.
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Khoom npe |
Phenibut HCL hmoov |
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Yam khoom |
Hmoov |
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Khoom Purity |
100g / 1kg / thiab lwm yam. |
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Daim ntawv khoom |
Organic synthesis |
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Phenibut COA
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Phenibut HCL hmoov 25kg, raws li ib yam khoom tshwj xeeb, feem ntau tsuas yog siv rau kev tshawb fawb tshawb fawb lossis daim ntawv pov thawj tshuaj. Raws li kev cai lij choj thiab ua raws li kev tshawb fawb lub hom phiaj, nws siv yuav tsum nruj me ntsis ua raws li kev tshawb fawb txog kev tshawb fawb thiab cov lus qhia, thiab tsis muaj qhov sib txawv ntawm cov qauv siv rau cov pej xeem zoo li cov tshuaj zoo tib yam. Cov hauv qab no yog cov ntsiab lus tseem ceeb ntawm kev siv tau los ntawm kev pom kev tshawb fawb:
Kev npaj cov kev daws teeb meem
01
Txiav txim siab lub hom phiaj concentration thiab hnyav
Txiav txim siab lub hom phiaj ntawm cov tshuaj cia tseg raws li kev sim, xws li 1 mM, 5 mM, lossis 10 mM. Tsis yog nitroprusside hydrochloride yog yooj yim soluble nyob rau hauv dej, yog li dej yog ib tug nquag siv hnyav.
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Xam qhov xav tau cov kua nplaum loj
Xam qhov xav tau loj ntawm non nitroprusside hydrochloride raws li lub hom phiaj concentration thiab hnyav ntim. Piv txwv li, txhawm rau npaj 100 mL ntawm 1 mM cov tshuaj hauv Tshuag, qhov xav tau ntawm cov tsis muaj nitroprusside hydrochloride yog 0.1 mmol × 215.68 g / mol=21.568 mg (215.68 g / mol yog qhov hnyav molecular ntawm non nitroprusside hydrochloride).
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Dissolve cov kua
Ntsuas qhov ntsuas qhov hnyav ntawm cov tsis muaj nitroprusside hydrochloride thiab ntxiv rau qhov tsim nyog cov kuab tshuaj, xws li dej. Co los yog do kom tag nrho dissolve nws.
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Lub ntim tas li
Hloov cov tshuaj yaj mus rau lub khob ntim ntim thiab dilute nrog hnyav rau qhov xav tau ntim, xws li 100 mL.
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Ntim thiab khaws cia
Ntim cov tshuaj npaj cia rau hauv lub raj mis me me kom tsis txhob rov khov thiab thawing. Thaum khaws cia ntawm -80 ° C, nws raug nquahu kom siv tsis pub dhau 6 lub hlis; Thaum khaws cia ntawm -20 ° C, nws raug nquahu kom siv hauv ib hlis.
Txoj kev npaj ntawm tsiaj sim kev cia cia daws
1. Kev npaj ua ntej
(1) Qhia meej cov kev xav tau ntawm kev sim: Raws li kev sim lub hom phiaj, sab laj cov ntaub ntawv tseem ceeb lossis ua qhov kev sim ua ntej los txiav txim siab npaum li cas ntawm nitroprusside hydrochloride hauv kev sim tsiaj, feem ntau hauv mg / kg units. Piv txwv li, thaum kawm txog nws cov teebmeem ntawm kev ntxhov siab hauv cov nas, cov tshuaj sib txawv xws li 10 mg / kg, 30 mg / kg, thiab 50 mg / kg yuav tsum tau tsim.
(2) xam qhov xav tau concentration ntawm cov tshuaj cia tseg: Raws li tus naj npawb ntawm cov tsiaj sim, lub cev qhov hnyav, thiab qhov ntim ntawm kev tswj hwm, suav cov concentration ntawm cov tshuaj cia tseg. Piv txwv tias muaj 20 nas nyob rau hauv qhov kev sim nrog qhov nruab nrab lub cev hnyav ntawm 20 g thiab ntau npaum li cas ntawm 200 μ L / nas, yog tias qhov ntau npaum li cas tau teem rau 30 mg / kg, qhov ntau npaum li cas rau txhua tus nas yog 30mg / kg × 0.02kg=0.6mg, thiab tag nrho cov koob tshuaj rau 20.1 mg × 20 mg. Yog tias nws tau npaj kom dilute cov tshuaj hauv Tshuag rau qhov tsim nyog ua haujlwm concentration rau kev tswj hwm, cov khoom lag luam ntau dua cov tshuaj concentration, xws li 100 mg / mL, tuaj yeem tsim ua ntej los pab txhawb kev dilution tom qab raws li qhov xav tau tiag tiag.
(3) xyuas kom meej tias purity ntawmPhenibut HCL hmoov 25kgua tau raws li cov kev xav tau ntawm kev sim, feem ntau ncav cuag tshaj 99%. Npaj cov kuab tshuaj uas tsim nyog, feem ntau yog xaiv physiological saline lossis dej tsis muaj menyuam. Physiological saline yog nyob ze rau lub physiological ib puag ncig hauv cov tsiaj thiab tuaj yeem txo qhov cuam tshuam ntawm cov kuab tshuaj sib txawv ntawm qhov kev sim; Aseptic dej yog ib qho yooj yim rau kev khiav lag luam, tab sis yuav tsum tau them nyiaj mloog mus rau nws muaj feem xyuam rau physiological ntsuas xws li osmotic siab nyob rau hauv cov tsiaj.
(4) Reagent: Xyuas kom meej tias qhov purity ntawm non nitroprusside hydrochloride ua tau raws li qhov kev sim, feem ntau ncav cuag ntau dua 99%. Npaj cov kuab tshuaj uas tsim nyog, feem ntau yog xaiv physiological saline lossis dej tsis muaj menyuam. Physiological saline yog nyob ze rau lub physiological ib puag ncig hauv cov tsiaj thiab tuaj yeem txo qhov cuam tshuam ntawm cov kuab tshuaj sib txawv ntawm qhov kev sim; Aseptic dej yog ib qho yooj yim rau kev khiav lag luam, tab sis yuav tsum tau them nyiaj mloog mus rau nws muaj feem xyuam rau physiological ntsuas xws li osmotic siab nyob rau hauv cov tsiaj.
(5) Kev ntxuav thiab tshuaj tua kab mob: ntxuav thiab tshuaj tua kab mob txhua yam khoom siv sim kom tsis txhob muaj impurities thiab kab mob microbial uas yuav cuam tshuam rau qhov zoo ntawm cov tshuaj cia. Koj tuaj yeem yaug cov cuab yeej nrog dej deionized, so nws nrog 75% ethanol rau tshuaj tua kab mob, thiab thaum kawg qhuav nws hauv lub chaw ua haujlwm huv super rau kev siv tom qab.
2. Cov kauj ruam npaj
Qhov tseeb hnyav uas tsis yog nitroprusside hydrochloride
Ua kom raug qhov hnyav qhov xav tau ntawm cov tsis muaj nitroprusside hydrochloride siv lub siab - qhov tseeb hluav taws xob sib npaug. Piv txwv li, txhawm rau npaj 100 mL ntawm cov tshuaj hauv Tshuag nrog cov concentration ntawm 100 mg / mL, nws yuav tsum hnyav 100 mL x 100 mg / mL =10000 mg=10 g ntawm non nitroprusside hydrochloride. Thaum lub sij hawm lub cev hnyav, yuav tsum tau them nyiaj mloog kom tsis txhob poob thiab kis ntawm cov tshuaj. Cov diav tshuaj yuav siv tau zoo thiab ua haujlwm ntawm daim ntawv hnyav.
Dissolve cov kua
Ntxiv cov ntsev uas tsis yog nitroprusside hydrochloride rau qhov tsim nyog cov kuab tshuaj. Yog tias siv lub khob ntim ntim rau kev npaj, me me ntawm cov kuab tshuaj (kwv yees li 1/3-1/2 ntawm tag nrho cov ntim) tuaj yeem ntxiv ua ntej, thiab maj mam nplawm nrog lub iav pas nrig los txhawb kev sib cais. Yog tias kev tawg yooj yim, lub tshuab nqus hlau nplaum tuaj yeem siv rau kev nplawm thiab cua sov kom tsim nyog (tab sis kev tswj kub yuav tsum tau coj mus rau hauv tus account kom tsis txhob decomposition ntawm non nitroprusside hydrochloride). Piv txwv li, thaum lub sij hawm dissolution txheej txheem, lub beaker yuav muab tso rau ntawm ib tug sib nqus stirrer, teem lub tsim nyog stirring ceev thiab kub (feem ntau tsis tshaj 40 ° C), thiab soj ntsuam lub dissolution kom txog thaum nws yog kiag li yaj tag.
Kev txiav txim siab txog kev xaiv cov kuab tshuaj
Physiological saline: Nws qhov zoo dua yog tias nws tuaj yeem tswj hwm lub siab osmotic zoo ib yam li cov tsiaj, txo kev cuam tshuam nrog lawv lub cev lub cev, thiab tsim nyog rau cov kev sim uas nkag siab rau osmotic siab. Piv txwv li, thaum kawm txog cov teebmeem ntawm cov tshuaj nyob rau hauv lub plawv system ntawm cov tsiaj, siv physiological saline raws li ib tug hnyav yog tsim nyog.
Aseptic dej: Kev ua haujlwm yog qhov yooj yim thiab tus nqi qis. Tab sis yog tias muaj kev txwv nruj rau osmotic siab ntawm cov tshuaj hauv qhov kev sim, lossis yog tias lub sijhawm sim ntev, nws yuav tsum xav txog kev siv lub cev saline, vim tias cov dej tsis huv tuaj yeem ua rau muaj qhov tsis txaus ntawm osmotic siab hauv tus tsiaj lub cev, cuam tshuam rau kev sim.
isochoric
Hloov cov tshuaj yaj thaum pib mus rau lub khob ntim ntim. Ntxuav lub beaker thiab iav pas nrig ntau zaus nrog ib qho me me ntawm cov kuab tshuaj, thiab hloov cov tshuaj ntxhua mus rau lub raj ntim ntim kom paub meej tias tag nrho cov tshuaj tau hloov mus. Tom qab ntawd, ntxiv cov kuab tshuaj rau hauv lub ntim ntim 1-2 cm hauv qab ntawm kab kab, thiab siv lub dropper nrog lub taub hau roj hmab kom maj mam ntxiv cov kuab tshuaj kom txog rau thaum lub concave kua theem yog tangent mus rau scale kab. Thaum lub sij hawm tus txheej txheem ntawm sizing, nws yog ib qho tseem ceeb uas yuav tsum tau kom cov kab ntawm pom theem nrog rau scale kab kom tsis txhob yuam kev.
Ntim thiab khaws cia
Faib cov tshuaj npaj tseg rau hauv cov raj centrifuge tsis muaj menyuam lossis lub raj mis reagent, nrog rau qhov ntim ntawm txhua lub raj lossis lub raj mis txiav txim siab raws li kev sim. Thaum lub sij hawm ntim cov txheej txheem, yuav tsum tau them nyiaj mloog kom tsis txhob muaj kev sib kis, thiab cov txheej txheem ua haujlwm tsis muaj menyuam tuaj yeem siv tau. Tom qab lub ntim tiav lawm, sau nws nrog cov ntaub ntawv xws li lub npe, concentration, thiab hnub npaj ntawm cov tshuaj tov. Cov xwm txheej khaws cia yog qhov tseem ceeb rau kev ruaj ntseg ntawm cov tshuaj cia. Feem ntau hais lus, cov tshuaj uas tsis yog nitroprusside hydrochloride Tshuag yuav tsum muab khaws cia rau hauv ib qho kev kaw kom tsis txhob raug lub teeb thiab kub. Thaum khaws cia ntawm -80 ° C, nws raug nquahu kom siv tsis pub dhau 6 lub hlis; Thaum khaws cia ntawm -20 ° C, nws raug nquahu kom siv hauv ib hlis. Tsis tu ncua ua qhov kev ntsuam xyuas zoo ntawm cov kev daws teeb meem, xws li kev ntsuas concentration, kev ntsuas purity, thiab lwm yam, kom ntseeg tau tias nws qhov zoo raws li kev sim.
3. kev tswj kom zoo
Cov txheej txheem raug xws li siab -kev ua haujlwm ua kua chromatography (HPLC) yog siv los kuaj xyuas qhov concentration ntawm cov tshuaj cia tseg. Sib piv cov qhabnias xeem nrog cov theoretical concentration thiab xam cov concentration deviation. Yog hais tias qhov sib txawv nyob rau hauv qhov kev tso cai (feem ntau tsis tshaj ± 5%), cov tshuaj cia tuaj yeem siv tau ib txwm; Yog tias qhov sib txawv tseem ceeb, qhov laj thawj yuav tsum tau txheeb xyuas thiab kho dua tshiab. Piv txwv li, yog tias qhov concentration ntawm cov tshuaj khaws cia tau pom tias qis dua qhov kev xav tau los ntawm kev kuaj xyuas HPLC, nws yuav yog vim tsis tiav kev tawg lossis poob thaum lub sijhawm hloov pauv. Nyob rau hauv tas li ntawd, lub solute yuav tsum tau rov qab hnyav thiab npaj.
Siv cov txheej txheem tsim nyog txhawm rau txheeb xyuas qhov purity ntawm cov tshuaj cia tseg, xws li kev tsom xam ntawm huab hwm coj spectrometry, nuclear magnetic resonance, thiab lwm yam. Xyuas kom meej tias qhov purity ua tau raws li qhov yuav tsum tau ua. Yog tias qhov purity tsis tau raws li tus qauv, tshawb xyuas qhov laj thawj thiab ua cov kev ntsuas sib xws, xws li rov ua kom huv huv los yog ua kom zoo rau cov txheej txheem npaj.
Tsis tu ncua ua kev ntsuam xyuas kev ruaj ntseg ntawm cov kev daws teeb meem thiab saib xyuas nws cov kev hloov pauv hauv cov tsos, concentration, purity, thiab lwm yam. Kho cov xwm txheej khaws cia lossis lub sijhawm siv raws li qhov ntsuas tau. Piv txwv li, yog tias nws pom tias qhov concentration ntawm cov tshuaj khaws cia txo qis heev tom qab khaws cia ntawm -20 ° C rau ib lub sijhawm, nws yuav raug txiav txim siab ua kom lub neej ua haujlwm luv luv hauv qhov xwm txheej no lossis hloov mus rau -80 ° C cia.
Kev ntxhov siab vim
Cov nyhuv anxiolytic ntawm Phenibut yog piv rau cov benzodiazepines, tab sis nrog tsawg dua kev pheej hmoo ntawm kev vam khom. Nws raug sau tseg rau kev ntxhov siab txog kev ntxhov siab (GAD), kev sib raug zoo phobias, thiab tom qab-kev ntxhov siab ntxhov siab (PTSD), feem ntau ua ke nrog kev kho mob hlwb.
Insomnia
Vim nws cov khoom sedative, nws muaj txiaj ntsig zoo hauv kev kho mob pw tsaug zog, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev ntxhov siab. Tsis zoo li benzodiazepines, Phenibut tsis cuam tshuam nrog REM pw tsaug zog, yog li txo qhov kev pheej hmoo ntawm rebound insomnia.
Cawv tshem tawm syndrome
Phenibut alleviates tshem tawm cov tsos mob xws li tremors, agitation, thiab qaug dab peg los ntawm stabilizing GABAergic tone thiab txo glutamate -mediated excitotoxicity. Hauv cov xwm txheej hnyav, nws yog siv los ua ib qho ntxiv rau benzodiazepines.
Cov kab mob vestibular
Los ntawm modulating GABAB receptors nyob rau hauv lub vestibular nuclei, Phenibut alleviates kiv taub hau thiab motion sickness thiab yog li ntawd ib feem ntawm antiemetic kev kho mob rau astronauts thiab pilots.
Kev paub txog kev txawj ntse
Raws li ib tug nootropic, Phenibut tau hais los txhim kho kev nco, kev xav, thiab kev muaj tswv yim los ntawm kev txo qis kev ntxhov siab thiab txhim kho dopamine signaling. Txawm li cas los xij, cov ntaub ntawv pov thawj los ntawm cov kev tshawb fawb tswj tau txwv, thiab feem ntau cov lus thov yog raws li cov ntaub ntawv qhia tsis tseeb.
Cov lus nug nquag
phenibut HCl ua dab tsi?
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Phenibut (beta-phenyl{1}}gamma-aminobutyric acid HCl) yog ib qho tshuaj neuropsychotropic uas tau tshawb pom thiab qhia rau hauv kev kho mob hauv tebchaws Russia hauv xyoo 1960. Nws muajanxiolytic thiab nootropic (kev paub txhawb nqa) cuam tshuam. Nws ua raws li GABA-mimetic, feem ntau ntawm GABA(B) thiab, rau qee qhov, ntawm GABA(A) receptors.
Nws yuav siv sij hawm ntev npaum li cas los xav phenibut?
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Muaj cov ntaub ntawv tsawg tsawg txog phenibut's pharmacokinetics thiab inter{0}} kev ua. Tom qab kev tswj hwm qhov ncauj, cov neeg siv qhiapib feem ntau nyob rau hauv 2-4 teev nrog tag nrho cov nyhuv ntawm 4-6 teev thiab ntev ntev li 15-24 teev.. Concomitant siv phenibut nrog rau lwm yam tshuaj sedating tej zaum yuav potentiate sedation.
Dab tsi yog tshuaj pleev rau kev ntxhov siab?
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Propranololyog beta blocker thawj zaug pom zoo los ntawm FDA xyoo 1967 los kho mob plawv thiab ntshav siab. Niaj hnub no, ntau tus kws kho mob kuj tau tshaj tawm nws tawm - daim ntawv lo rau luv luv - lub sij hawm, kev ntxhov siab vim nws ua rau lub cev muaj kev ntxhov siab.
Puas yog phenibut ib benzo?
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Raws li GABA agonist,Cov tsos mob ntawm phenibut zoo li cov uas tshwm sim los ntawm cov tshuaj xws li benzodiazepines thiab barbiturates. Txawm li cas los xij, phenibut tsis tshwm sim ntawm cov qauv tshuaj ntsuam xyuas, thiab tsis muaj kev sim ua lag luam rau nws qhov kev tshawb pom.
Cim npe nrov: phenibut hcl hmoov 25kg, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom