Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm Phenylruazone hmoov li 50-33-9 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo phenylbutazone hmoov CAS 50-33-9 kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Phenylomuazone Hmoov, tshuaj lom neeg npe 4-Butyl-1,2-diphenyl-1,5-pyrazolidinone, molecular cov kab mis c19h20nkr2o2, yog cov tshuaj uas ua rau hauv nruab nrab lub paj hlwb. Nws yog dawb lossis yuav luag dawb crystalline hmoov, tsw ntxhiab, thiab ntsim me ntsis. Nws yog yooj yim soluble hauv cov kuab tshuaj muaj acetone, chloroform, lossis benzene, uas txhais tau tias hauv cov kuab tshuaj, cov molecules ntawm paclitaxel tuaj yeem ua tau zoo thiab cuam tshuam nrog lawv. Lub caij no, cov nkauj Baotai tuaj yeem tuaj yeem yaj nyob rau hauv cov kuab organic xws li ethanol lossis ether. Txawm li cas los xij, nws muaj solubility nyob rau hauv dej, yuav luag insoluble hauv dej, thiab yaj nyob rau hauv hydroxide alkaline daws. Tus qauv muaj ntau qhov chaw muaj kev cuam tshuam thiab tuaj yeem ua cov neeg nruab nrab tseem ceeb hauv synthic. Nws tuaj yeem hloov mus rau lwm cov chaw sib txuas nrog cov qauv tshwj xeeb thiab cov haujlwm los ntawm kev siv tshuaj lom neeg ntxiv, yog li ua si lub luag haujlwm Bridging hauv cov suab paj nruag. Hauv qee cov tshuaj tiv thaiv, benzophenone tuaj yeem siv ua catalyst los txhawb kev nce qib ntawm cov tshuaj tiv thaiv thiab txhim kho nws txoj kev ua tau zoo. Piv txwv li, hauv qee cov tshuaj squthic synthesis cov tshuaj tiv thaiv, benzophenone tuaj yeem ua cov tshuaj tua kab lossis txo cov neeg sawv cev, nrawm qhov kev tshwm sim ntawm cov tshuaj tiv thaiv. Raws li cov xwm txheej tshwj xeeb, cov xim hloov lossis lwm cov tshuaj tiv thaiv pom tuaj yeem tshwm sim, ua rau nws qhov ntsuas rau cov tshuaj lom neeg. Los ntawm kev soj ntsuam cov kev hloov pauv ntawm cov txheej txheem kev tawm tsam ntawm Baotai zaj nkauj, cov tshuaj tiv thaiv thiab seb cov tshuaj tiv thaiv puas tuaj yeem txiav txim siab.
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Tshuaj Cov Qauv |
C19H20N2O2 |
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Muaj pes tsawg leej |
308 |
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Molecular hnyav |
308 |
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m/z |
308 (100.0%), 309 (20.5%), 310 (2.0%) |
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Kev Ntsuam Xyuas |
C, 74.00; H, 6.54; N, 9.08; O, 10.38 |
Phenylomuazone HmoovYog qhov tsis yog steroformal anti -} kub siv tshuaj (nsaid) nrog ntau yam siv, tshwj xeeb hauv kev siv kho mob.
Tus txheej txheem thiab cov txiaj ntsig ntawm Antipyretic thiab analgesic cuam tshuam:
Phenylomutazone exerts nws antipyretic nyhuv los ntawm inhibiting synthesis thiab tso tawm prostaglandins hauv hypothalamus. Prostaglandins muaj cov tshuaj uas muaj feem cuam tshuam txog kev kub taub hau thiab qhov mob, thiab lawv cov synthesis thiab tso tawm yog cuam tshuam los ntawm ntau yam. Nws tuaj yeem tsim cov synthesis ntawm prostaglandins, yog li txo lawv cov kev xav hauv lub cev thiab kev mob siab xws li kub ntxhov thiab mob. Tsis tas li ntawd, phenylbutazone kuj tuaj yeem txo qhov mob ntawm kev cuam tshuam los ntawm Insibiting qhov infiltration ntawm cov hlwb thiab cov teb mob. Qhov no ua rau nws tau dav siv nyob rau hauv kev kho ntawm ntau yam me me mus rau mob me ntsis.
Tus mechanism thiab cuam tshuam ntawm anti - kub nyhuv:
Cov anti - ein} proflammatory nyhuv ntawm cov khoom yog ua tiav los ntawm incompting ntawm incegration ntawm cov hlwb thiab cov teb mob. Kev o yog ib qho kev tiv thaiv kev tiv thaiv ntawm lub cev rau kev txhawb nqa, tab sis kev ua pa ntau dhau tuaj yeem ua rau cov tsos mob xws li cov ntaub so ntswg puas tsuaj thiab mob. Nws tuaj yeem cuam tshuam lub tswv yim ntawm cov hlwb ntawm lub xaib ntawm kev o, yog li txo cov pa taws thiab cov nqaij puas tsuaj. Qhov no ua rau nws ua tau zoo hauv kev kho cov kab mob ntau yam. Piv txwv li, hauv kev kho mob ntawm cov kab mob xws li mob rheumatoid mob caj dab, nws tuaj yeem cuam tshuam ntau yam xws li kev sib koom ua mob o, mob, txhav, thiab o.
Tus mechanism thiab cuam tshuam ntawm kev tiv thaiv rheumatism:
Lub anti rheumatic nyhuv ntawm phenylromuazoneg yog tau ua tiav los ntawm inhibitate inflation ntawm lub xaib ntawm kev sib koom tes. Zoo ib yam li nws anti {- inflamic nyhuv, nws tuaj yeem inflammatory hlwb ntawm lub xaib ntawm pob txha kev teb thiab cov nqaij puas tsuaj. Qhov no ua rau nws kho cov kab mob xws li kev mob caj dab thiab mob caj dab. Ib qho ntxiv, nws tseem tuaj yeem txhawb nqa cov kua qaub acid excretion, uas pab kom txo tau cov ntshav, yog li ua si lub luag haujlwm ntawm kev kho mob gout thiab lwm yam kab mob ntsig txog hyperuricemia.
Tus mechanism thiab cuam tshuam rau kev tiv thaiv kev fab tshuaj:
Lub anti ua xua ntawm phenylbutazone yuav cuam tshuam nrog kev txwv ntawm cov kev txwv ntawm cov khoom noj tshuaj histamit enbasine hauv cov khoom teb tsis haum. Cov tshuaj histamine yog cov tshuaj uas cuam tshuam nrog kev fab tshuaj, thiab nws tso tawm tuaj yeem ua cov tsos mob xws li Vasodation, nqaij orde, thiab khaus. Nws tuaj yeem cuam tshuam cov kev ua ntawm cov kev ua haujlwm ntawm cov tshuaj histamine, yog li txo qhov concamine ntawm histramine hauv lub cev thiab kev txo cov tsos mob ntawm kev ua xua. Qhov no ua rau nws muaj peev xwm ua tau ib lub luag haujlwm ntawm kev kho mob ntawm qee yam kab mob.
Hauv cov ntsiab lus xaus, phenylbutazone yog ib qho tshuaj nrog ntau yam kev siv kho mob, uas muaj qhov tsis zoo, anti rheumatic, thiab anti caterpatic, thiab anti kev ua xua. Txawm li cas los xij, nws siv kuj ua rau qee qhov kev pheej hmoo thiab kev mob tshwm sim, thiab nws yog qhov tsim nyog ntsuas tus neeg mob thiab kho mob raws li cov tswv yim kws kho mob thiab ntau npaum li cas thaum siv nws. Nyob rau tib lub sijhawm, nws kuj tseem yuav tau them sai sai rau daim ntawv thov tej zaum muaj peev xwm thiab kev ruaj ntseg ntawm Baotai zaj nkauj hauv lwm thaj chaw.
Phenylomuazone HmoovYog cov tshuaj glucocortiid feem ntau siv los kho cov kab mob xws li mob hawb pob. Nws cov synthesis cuam tshuam ntau yam kev tawm tsam, thiab cov hauv qab no yog cov khoom siv hluav taws xob muaj peev xwm ua tau raws li koj xav tau:
01 hydrogenation cov tshuaj tiv thaiv
C23H32O3+H2 → C25H34O6+C2H4O2
Khoom siv:
-16 dehydobrobnnegnumney acetate
- hydrogen roj
{{0- catalalts (xws li platinum)
Cov kauj ruam:
1. Dissolve 16 Dehydroprobnegnegnumnenolone acetate nyob rau hauv ib tug tsim nyog hnyav.
2. Ntxiv cov catalyst rau cov tshuaj tiv thaiv kab yeeb yam hauv cov cua hydrogen.
3. Cua sov cov tshuaj tiv thaiv sib xyaw rau qhov ntsuas kub tsim nyog thiab tswj hwm lub sijhawm tiv thaiv.
02 hydroxymethylation
C25H34O6+C2H4O2 → Hydroxymethyl Budesonide + Ch2O2
Khoom siv:
- budesonide
- methyl tsim
{{0-} alkaline catalysts (xws li sodium carbonate)
Cov kauj ruam:
1. Dissolve hydroxymethyl budesonide nyob rau hauv ib qho uas tsim nyog hnyav.
2. Maj mam ntxiv sulfuric acid thiab do sib xyaw.
3. Ntxiv tsim nyog ethermication reagents thiab txuas ntxiv nplawm cov tshuaj tiv thaiv kab mob.
4. Cua sov cov tshuaj tiv thaiv sib xyaw rau qhov ntsuas kub tsim nyog thiab tswj hwm lub sijhawm tiv thaiv.
03 herherification cov tshuaj tiv thaiv
Hydroxymethyl budesonide4O → C25H34O6+H2O
Khoom siv:
-} hydroxymethyl budesonide
-}} sulfuric acid
{{0 {{}}} Tsim nyog EhereMomate reagents (xws li Methanol)
Cov kauj ruam:
1. Dissolve hydroxymethyl budesonide nyob rau hauv ib qho uas tsim nyog hnyav.
2. Maj mam ntxiv sulfuric acid thiab do sib xyaw.
3. Ntxiv tsim nyog ethermication reagents thiab txuas ntxiv nplawm cov tshuaj tiv thaiv kab mob.
4. Cua sov cov tshuaj tiv thaiv sib xyaw rau qhov ntsuas kub tsim nyog thiab tswj hwm lub sijhawm tiv thaiv.
Txheej txheem cej luam ntawm synthesis txoj kev ntawmPhenylomuazone Hmoov:
1. Khoom cua ntawm Cyclohexene raws kev ua
-}} synthesize cyclohexene sterols los ntawm cyclohexene cov tshuaj tiv thaiv.
- Kev Tshuaj Muaj Tshuaj: Cyclohexene + Sterol → Cyclohexene raws Sterol
2. Oxidation ntawm Cyclohexene Sterols
{{0- Ua cov tshuaj tiv thaiv oxidation ntawm cyclohexene raws li Sterols.
- Kev Tshuaj Muaj Tshuaj: Cyclohexene Sterol + Oxidant → Cyclohexene Aldehyde
3. Khoom cua ntawm cyclohexene aldehyde
- nthuav tawm cyclohexenylaldehyde nrog cov sib xyaw nrog qee pab pawg ua haujlwm.
- Kev Tshuaj Muaj Tshuaj: Cyclohexenylaldehyde + Cov Pab Pawg Ua Haujlwm Hauv Nruab Nrab
4. Ntxiv hloov dua siab tshiab ntawm kev ntseeg siab
-} Ua cov kev tawm tsam ntawm cov neeg nruab nrab, suav nrog hydroxylation, Esterification, Oxidation, thiab lwm yam.
- Kev Tshuaj Muaj Tshuaj: Qib Nruab Nrab + Resexant → Butzone
Nov yog ib qho txheej txheem qhia yooj yim, thiab cov txheej txheem sapthesis tseeb tej zaum yuav nyuaj, koom nrog ntau cov kauj ruam thiab kev ua kom zoo dua ntawm cov tshuaj tiv thaiv. Yog tias koj xav tau cov ncauj lus ntxaws ntxaws ntxiv thiab tshuaj lom neeg, thov qhia rau kuv paub thiab kuv tuaj yeem muab cov ncauj lus qhia rau koj ntau dua.
Phenybutazone, raws li lub ntsiab lus tseem ceeb los tiv thaiv cov tshuaj (NSAID) Txij li thaum nws tshwm sim hauv nruab nrab - {} Txoj kev txhim kho hauv kev txhim kho cov tshuaj chemistry, kev kho mob, thiab kho mob.
Ua ntej rov tshwm sim ntawm prednisone, steroid anti - Cov tshuaj ntsuab cortex (xws li cov kab mob adrenal) yog lub ntsiab txhais tau tias kho kab mob. Txawm li cas los xij, ntev {-}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Siv cov kev mob tshwm sim loj xws li kev txhaj tshuaj tiv thaiv kab mob thiab cov txha sawv. Yog li, cov kws tshawb fawb tau cog lus los tsim cov nonsteroidal anti {{}}} pa cov kev mob thiab txhim kho kev ua tau zoo.
Xyoo 1946, Swiss cov kws tshawb fawb thawj zaug tau pib nrog 3,5 {{} pyrazolidinionsione qauv los ntawm kev siv tshuaj lom neeg. Qhov kev tshawb pom no yog suav tias yog ib qho kev sib tawg loj hauv thaj chaw anti {{6} Cov tshuaj. Baxotai zaj nkauj muaj zog los tiv thaiv thiab ua piv txwv txog kev txhawb nqa uric acid excretion, uas ua rau nws zoo heev nyob rau hauv kev kho mob ntawm kev mob caj dab xws li gout.
Xyoo 1949, Prednisone pib siv los kho cov mob mob xws li mob rheumatoid. Nws cov anti tseem ceeb - ua rau muaj kev cuam tshuam sai sai tau txais kev lees paub los ntawm cov kws kho mob hauv chaw soj ntsuam. Lub sijhawm ntawd, prednisone raug suav tias yog "Yeeb Txuj Ci Txuj Ci" rau kev kho mob caj dab thiab tau siv dav thoob ntiaj teb. Txawm li cas los xij, nrog qhov tob tob ntawm cov ntawv thov kev kho mob, nws cov kev mob tshwm sim loj tau maj mam ua pom meej.
Cim npe nrov: Phenylomutazone Hmoov CAS 50-33-9, cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, rau muag