L-Epicatechin CAS 490-46-0

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm l-epicatechin cas 490-46-0 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo l-epicatechin cas 490-46-0 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

L-Epicatechinyog cov nroj tsuag ntuj flavanol nrog cov tshuaj formula C15H14O6, CAS 490-46-0. Nws yog dawb siv lead ua, soluble hauv dej thiab methanol, thiab hu ua catechin compound ua ke nrog epigallocatechin (EGC), catechin gallate (CG), epigallocatechin gallate (ECG) thiab epigallocatechin gallate (EGCG). Nws yog isomeric nrog catechin. Buckwheat yog cov rhizome qhuav ntawm Fagopyrum dibotrys, ib tsob nroj ntawm Polygonaceae, uas muaj cov teebmeem ntawm kev tshem tawm cov cua sov thiab detoxifying, tshem tawm cov kua qaub thiab tshem tawm cov ntshav stasis. Nws yog siv nyob rau hauv kev kho mob ntawm lub ntsws carbuncle thiab purulent ntuav, ntsws kub, mob hawb pob thiab hnoos, lub mis npauj o thiab mob. Kev tshawb fawb qhia tau hais tias epicatechin thiab protocatechuic acid yog cov khoom xyaw tseem ceeb ntawm buckwheat rau cov kab mob tua kab mob, tiv thaiv - mob thiab tshuaj tua kab mob. Cov ntsiab lus ntawm epicatechin nyob rau hauv ethanol extract ntawm buckwheat accounted rau 65% ~ 70%, thiab epicatechin los ua ib qho tseem ceeb qhia rau kev txiav txim siab ntawm buckwheat cov ntsiab lus. Tsis tas li ntawd, epicatechin tseem muaj kev tiv thaiv thiab kho cov teebmeem ntawm cardio-cerebral hlab ntsha, nrog rau kev tiv thaiv qog thiab tiv thaiv oxidation.

Epicatechin (EC) yog ib qho tshwm sim ntawm flavanol compound dav dav hauv cov nroj tsuag xws li tshuaj yej, cocoa, txiv hmab txiv ntoo, thiab txiv apples. Ntau pawg phenolic hydroxyl hauv nws cov qauv molecular endowed nws muaj zog antioxidant, tiv thaiv -inflammatory, thiab lom muaj peev xwm tswj. Raws li ib tug tswv cuab tseem ceeb ntawm tsev neeg catechin, epicatechin tau qhia ntau lub peev xwm rau kev siv hauv kev saib xyuas kev noj qab haus huv, kev tiv thaiv kab mob, kev lag luam zaub mov, thiab kev lag luam tshuaj txhua hnub vim nws ntau yam - lub hom phiaj thiab cov yam ntxwv tsis muaj tshuaj lom.

Kev saib xyuas kev noj qab haus huv thiab kev tiv thaiv kab mob: ntau- phiaj xwm kev cuam tshuam rau cov kab mob ntev

 

1. Kev tiv thaiv kab mob plawv: los ntawm vascular muaj nuj nqi rau lipid metabolism
Los ntawm kev txhim kho endothelial muaj nuj nqi, inhibiting qis - ntom lipoprotein (LDL) oxidation, thiab tswj lipid metabolism, nws tau dhau los ua ib qho kev cuam tshuam rau kev tiv thaiv kab mob plawv. Lub mechanism muaj xws li:
Txhawb nqa nitric oxide (NO) ntau lawm: Nws tuaj yeem ua rau endothelial nitric oxide synthase (eNOS), ua kom tsis muaj kev tso tawm, nthuav cov hlab ntsha, thiab txo cov ntshav siab. Cov kev tshawb fawb soj ntsuam tau pom tias kev noj txhua hnub ntawm 100mg epicatechin (sib npaug rau 2 khob tshuaj yej ntsuab) tuaj yeem txo cov ntshav siab los ntawm 5-10mmHg.

Inhibition ntawm atherosclerosis: inhibit qhov kev hloov ntawm macrophages mus rau hauv cov hlwb ua npuas ncauj los ntawm kev txo qis ntawm oxidized LDL, yog li ua kom qeeb ntawm kev tsim cov atherosclerotic plaque. Tsiaj thwmsim tau pom tias kev ntxiv siab - cov nas noj rog nrog epicatechin tuaj yeem txo qhov chaw aortic plaque los ntawm 27%.

 

Kev tswj cov ntshav lipid: Nws tuaj yeem cuam tshuam kev ua haujlwm ntawm pancreatic lipase, txo qis kev nqus rog, txhawb cov roj oxidation ntawm fatty acids, thiab txo qis cov roj cholesterol thiab triglyceride ntau ntau. Kev sim tsom rau cov neeg mob uas muaj cov kab mob metabolic tau pom tias ntxiv cov epicatechin rau 12 lub lis piam sib law liag tuaj yeem txo LDL -C los ntawm 12% thiab nce HDL-C los ntawm 8%.

2. Kev tswj cov metabolism: ib qho cuab yeej tswj hwm ntuj rau ntshav qab zib thiab rog
Kev txhim kho insulin rhiab heev, inhibiting gluconeogenesis, thiab tswj lub zog metabolism tau dhau los ua cov ntsiab lus kub hauv kev cuam tshuam ntawm cov kab mob metabolic.
Txhim kho cov cim qhia tshuaj insulin: Epicatechins tuaj yeem cuam tshuam serine phosphorylation ntawm insulin receptor base-1 (IRS-1), txo kev cuam tshuam ntawm cov kab mob inflammatory (xws li TNF - ) ntawm txoj kev taw qhia insulin, thiab yog li txhim kho cov tshuaj insulin.

 

Tom qab ntxiv cov tshuaj epicatechin nrog cov khoom noj fructose siab hauv cov nas, yoo mov cov ntshav qabzib tsawg dua 20% thiab insulin rhiab heev index (HOMA-IR) nce 35%.

Inhibition ntawm alpha glucosidase kev ua ub no: Epicatechins tuaj yeem ncua lub hydrolysis thiab nqus cov carbohydrates hauv txoj hnyuv, thiab txo qis cov ntshav qabzib hloov pauv tom qab. Kev sim hauv vitro tau pom tias nws tus nqi IC50 rau inhibiting alpha glucosidase yog 0.5mM, uas yog superior rau acarbose.
Txhawb kev rog rog: Epicatechins qhib AMP activated protein kinase (AMPK) thiab peroxisome proliferator activated receptor alpha (PPAR -), ua kom cov haujlwm ntawm cov tshuaj hormones lipase (HSL) hauv cov ntaub so ntswg adipose thiab txhawb kev rog rog. Hauv cov qauv nas rog rog, ntxiv nrog epicatechin tuaj yeem txo cov rog subcutaneous los ntawm 18%.

 

3. Neuroprotection: Los ntawm Oxidative Stress mus rau kev txawj ntse muaj nuj nqi
Nws tuaj yeem nkag mus rau cov ntshav- lub hlwb thaiv, tiv thaiv cov neurons los ntawm kev puas tsuaj los ntawm antioxidant, tiv thaiv- mob, thiab txhawb nqa cov txiaj ntsig neurotrophic qhia:
Txo - amyloid deposition: Hauv Alzheimer tus kab mob qauv, epicatechin tuaj yeem inhibit - secretase 1 (BACE1) kev ua, txo A ntau lawm, thiab txhawb microglial phagocytosis ntawm A plaques. Tom qab ntxiv epicatechin nyob rau hauv cov nas transgenic, hippocampal A load poob 40%.
Tiv thaiv dopaminergic neurons: Epicatechins qhib txoj hauv kev Nrf2, txhim kho glutathione (GSH) qib, thiab txo cov kev ntxhov siab oxidative kev puas tsuaj los ntawm 6-hydroxydopamine (6-OHDA). Nyob rau hauv tus qauv ntawm tus kab mob Parkinson, pretreatment nrog epicatechin tuaj yeem ua rau kom muaj sia nyob ntawm neuronal los ntawm 40%.
Txhim kho kev txawj ntse: Epicatechins tuaj yeem txhawb nqa kev sib txuas ntawm lub hlwb - tau txais txiaj ntsig neurotrophic (BDNF) thiab txhim kho synaptic plasticity.

 

Tom qab ntxiv nrog epicatechin, lub spatial nco muaj peev xwm ntawm cov laus nas nce los ntawm 25% nyob rau hauv lub Morris dej maze xeem.

4. Kev tiv thaiv kab mob qog noj ntshav: los ntawm lub voj voog ntawm tes mus rau kev tiv thaiv kab mob
Txawm hais tias cov pov thawj kho mob tseem tsis tau txaus, epicatechin tau pom ntau txoj hauv kev ntawm kev tiv thaiv kab mob hauv vitro kev sim:
Apoptosis ntawm cov qog nqaij hlav cancer: Apoptosis ntawm lub mis mob cancer thiab prostate cancer hlwb tuaj yeem raug ntxias los ntawm kev ua kom Caspase-3/7 thiab nce kev tswj hwm Bax / Bcl-2 piv.
Inhibition of angiogenesis: Nws tuaj yeem txo qis kev qhia VEGF thiab inhibit lumen tsim ntawm tib neeg cov hlab ntsha endothelial hlwb (HUVEC).
Txhim khu kev tiv thaiv kab mob: tuaj yeem txhawb kev loj hlob ntawm cov hlwb dendritic, txhim kho lawv cov kev nthuav qhia antigen, thiab ua kom muaj kev tua ntawm NK hlwb thiab CTL hlwb.

Kev lag luam khoom noj khoom haus: Natural Additives thiab Functional Ingredients

 

1. Antioxidant preservative
Los ntawm kev tshem tawm cov dawb radicals thiab chelating hlau ions, lub txee lub neej ntawm cov zaub mov yog txuas ntxiv:
Roj antioxidant: Ntxiv 0.02% epicatechin rau lard tuaj yeem txo tus nqi peroxide (POV) los ntawm 60% thiab ncua lub sijhawm induction los ntawm peb zaug.
Khoom noj khoom haus xim tiv thaiv: tuaj yeem tiv thaiv myoglobin oxidation thiab tswj cov xim liab ci ntawm cov khoom noj nqaij. Ntxiv 0.05% epicatechin rau cov hnyuv ntxwm nce xim ruaj khov los ntawm 40%.
Haus dej stabilizer: Ntxiv cov epicatechin rau cov kua txiv hmab txiv ntoo tuaj yeem inhibit qhov degradation ntawm vitamin C thiab txuas lub txee lub neej. Tom qab ntxiv 0.01% epicatechin rau cov kua txiv apple, qhov khaws cia ntawm cov vitamin C nce ntawm 70% mus rau 90%.

 

2. Kev loj hlob ntawm cov zaub mov ua haujlwm
Vim nws cov ntsiab lus calorie tsawg thiab kev ua haujlwm lom neeg siab, nws tau dhau los ua cov khoom xyaw zoo tshaj plaws rau cov khoom noj ua haujlwm
Cov zaub mov hypoglycemic: tuaj yeem cuam tshuam cov hmoov txhuv nplej siab thiab tsim cov khoom noj uas tsis muaj glycemic Performance index (GI). Tus nqi GI ntawm qhob cij nrog 0.1% epicatechin ntxiv txo qis los ntawm 85 txog 65.
Khoom noj khoom haus kev ua si: Los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab txhawb cov leeg endurance. Tom qab ntxiv catechins, cov neeg caij tsheb kauj vab tau txhim kho lawv cov txiaj ntsig 8-kilometer lub sij hawm sim los ntawm 2.3%.
Khoom noj khoom haus hauv plab: tuaj yeem tswj qhov sib npaug ntawm plab microbiota, ua kom muaj ntau ntawm bifidobacteria thiab lactobacilli. Tom qab ntxiv cov epicatechin rau cov neeg rog rog, theem ntawm cov kab mob luv luv fatty acids (SCFAs) hauv cov hnyuv tau nce 30%.

Hauv kev lag luam tshuaj txhua hnub: kev siv tshiab ntawm cov khoom xyaw ntuj

 

1. Anti aging skincare khoom
Los ntawm inhibiting matrix metalloproteinase (MMP) kev ua, txo collagen degradation, thiab txhawb collagen synthesis:
Los tiv thaiv wrinkle nyhuv: tom qab 8 lub lis piam ntawm kev siv cov cream uas muaj 1% epicatechin, qhov tob ntawm wrinkles nyob rau hauv lub ces kaum ntawm lub qhov muag ntawm cov neeg tuaj yeem txo qis los ntawm 18%, thiab cov tawv nqaij elasticity nce 25%.
Cov nyhuv Whitening: Nws tuaj yeem cuam tshuam kev ua haujlwm ntawm tyrosinase thiab txo melanin ntau lawm. Kev sim hauv vitro tau pom tias nws tus nqi IC50 rau inhibiting tyrosinase yog 0.2mM, uas zoo dua li arbutin.

 

2. Cov khoom siv kho qhov ncauj
Tiv thaiv cov hniav caries los ntawm inhibiting qhov tsim ntawm Streptococcus mutans biofilm:
Cov tshuaj txhuam hniav los tiv thaiv kab mob: Cov tshuaj txhuam hniav muaj 0.5% epicatechin tuaj yeem txo cov quav hniav biomass los ntawm 40% thiab txo qhov tshwm sim ntawm cov hniav caries los ntawm 30%.
Ua pa freshener: tuaj yeem ua kom tsis muaj zog sulfur compounds (VSCs) thiab txo cov pa phem. Tom qab cov neeg ua haujlwm pab dawb siv cov tshuaj ntxuav qhov ncauj uas muaj epicatechin, lawv cov qhab nia ua pa tsis zoo (0-5 cov ntsiab lus) poob ntawm 3.2 txog 1.5.

Ua liaj ua teb thiab Biotechnology: Muaj peev xwm thov nthuav dav

 

1. Cog tshuaj txo kev ntxhov siab
Inducing cog systemic acquired resistance (SAR) thiab pab txhawb rau cov kab mob:
Cov nyhuv Antifungal: Txau epicatechin rau ntawm nplooj txiv lws suav ua rau muaj zog tiv thaiv Botrytis cinerea los ntawm 50% thiab txo qhov mob ntawm thaj chaw los ntawm 60%.
Insect resistant effect: Nws tuaj yeem cuam tshuam nrog kev ua haujlwm ntawm kab zom zaub mov enzymes thiab txo kev noj zaub mov. Tom qab pub paj rwb bollworm larvae nrog khoom noj khoom haus uas muaj epicatechin, cov neeg tuag tau nce 35%.
2. Kev loj hlob ntawm biomaterials
Nanoparticles tuaj yeem tsim los ntawm tus kheej - sib dhos rau kev xa tshuaj lossis cov ntaub so ntswg engineering:
Cov neeg nqa tshuaj: Epicatechin chitosan nanoparticles tuaj yeem txhim kho bioavailability ntawm curcumin, ua rau 8-fold nce hauv cov ntshav tshuaj concentration hauv cov nas tom qab kev tswj qhov ncauj.
Lub koom haum scaffold: Collagen scaffold cross-txuas nrog epicatechin tuaj yeem txhawb kev loj hlob ntawm osteoblast thiab ua kom cov pob txha tsis zoo los ntawm 40%.

Ib txoj kev npaj ntawml-epicatechinmonomer suav nrog cov kauj ruam hauv qab no:

(1) Ntxiv tannase rau cov tshuaj uas muaj catechin extract ntawm loj - nplooj ntsuab tshuaj yej, hydrolyze nws tseem nyob ntawm 30℃~ 35 degree, do nws intermittently, thiab centrifuge kom tau cov tshuaj enzymolysis;

(2) Muab cov tshuaj enzymolysis rau hauv chromatographic kem nrog adsorption resin, thiab siv ethanol eluant los ua cov fractionation, sau cov eluent, thiab mloog zoo rau 16 ~ 18 Baume degrees kom tau cov concentrated tov; Muab cov tshuaj concentrated ntawm qhov kub ntawm 0 ~ 4 ° C rau 48 ~ 72h, ntxiv me me ntawm epicatechin monomer crystallization thiab recrystallization, centrifugation thiab ziab kom tau epicatechin (EC) monomer.

Txoj kev no siv tannase rau hydrolyze epicatechin gallate, uas muaj txiaj ntsig zoo hloov dua siab tshiab. Nws yog ib txoj hauv kev npaj nrog tus nqi hloov pauv siab thiab cov khoom lag luam siab purity, thiab muaj lub voj voog npaj luv luv, tus nqi qis, thiab tsim nyog rau loj - teev ntau lawm.

Ethanol extraction txheej txheem:

Qhov kwv yees ntau yam ntawm ethanol concentration, extraction kub, khoom -kua piv thiab lub sij hawm rho tawm tau txiav txim successively los ntawm ib qho tseem ceeb xeem txoj kev, F xeem thiab tshiab ntau ntau txoj kev (SSR txujci); Los ntawm kev ntsuam xyuas orthogonal ntawm plaub yam thiab peb theem, cov txheej txheem extraction optimized tau txais raws li hauv qab no: ethanol ntim feem 60%, rho tawm kub 20 degree, khoom-kua piv (g/mL) 1 ∶ 18, lub sij hawm rho tawm 30 min, thiab qhov nruab nrab rho tawm tus nqi ntawm epicatechin active 7%.} 2%. Cov txheej txheem yog yooj yim thiab tsim nyog, thiab tuaj yeem siv rau kev tsim khoom thaum ntxov ntawm epicatechin monomer industrialization ntawm buckwheat ({10}}).

Kev tshawb nrhiav Antioxidant:

Kawm txog kev ua antioxidant ntawm (-) - epicatechin hauv buckwheat. Qhov kev sim superoxide anion radical scavenging pom tias nws cov tshuaj tiv thaiv antioxidant tau mus txog 83.08%; Qhov kev sim hydroxyl radical scavenging tau pom tias qhov loj ntawm cov tshuaj nquag muaj qhov cuam tshuam loj heev rau kev tshem tawm tus nqi (P<0.01), and the scavenging rate reached 77.30% when the mass concentration was 0.350mg/mL; The test of reductive power showed that its chemicalbook reductive power reached 48.02% of the same mass concentration of VC, and the effect of mass concentration on reductive power was very significant (P<0.01); The content of active substances in the ethanol extract reached 1.40mg/mL, accounting for 2.52% of the dry matter of root tuber. The experiment shows that the active substance of buckwheat l-epicatechinmuaj kev ua haujlwm zoo antioxidant thiab tuaj yeem siv los ua cov tshuaj tiv thaiv antioxidant.

Cim npe nrov: l-epicatechin cas 490-46-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom