Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm pontocaine cas 94-24-6 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo pontocaine cas 94-24-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pentocaine, tseem paub los ntawm nws lub npe hu ua tetracaine hydrochloride, yog ntev - ua ester- hom tshuaj loog hauv zos. Nws tsuas yog ua haujlwm los ntawm kev thim rov qab los thaiv qhov hluav taws xob -gated sodium ion channels, yog li inhibiting depolarization ntawm cov hlab ntsha cell membranes thiab tsim cov peev txheej ua haujlwm, yog li cuam tshuam qhov kev ua ntawm cov hlab ntsha impulses xws li mob teeb meem. Piv nrog rau amide- hom tshuaj loog hauv zos xws li lidocaine, tetracaine hydrochloride muaj zog tshuaj loog ua haujlwm, nrog lub sijhawm pib qeeb me ntsis (li 5-10 feeb), tab sis nws lub sijhawm ua haujlwm tau ntev heev (txog 2-3 teev).
Cov tshuaj no muaj peev xwm nkag mus tau los ntawm cov mucous daim nyias nyias, thiab yog li ntawd dav siv nyob rau hauv cov tshuaj loog (xws li ophthalmic surgeries, pob ntseg-qhov ntswg- caj pas, bronchoscopy) thiab spinal anesthesia (lumbar anesthesia).
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Tshuaj Formula |
C15H24N2O2 |
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Exact Mass |
264 |
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Molecular Luj |
264 |
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m/z |
264 (100.0%), 265 (16.2%), 266 (1.2%) |
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Melting point |
41.0 txog 45.0 degree |
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Boiling point |
407.59℃(kev kwv yees ntxhib) |
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Qhov ntom |
1.0200 (kev kwv yees kwv yees) |
Clinical Anesthetic Applications
Pentocaineyog ib qho tshiab ntev - ua yeeb yam ester- hom tshuaj loog hauv zos. Vim nws cov hlab ntsha zoo tshaj - thaiv kev ua tau zoo, cov tshuaj kho mob me me thiab lub sijhawm ua haujlwm ntev, nws nyob hauv txoj haujlwm tseem ceeb hauv kev kho tshuaj loog. Tsis zoo li ib txwm luv luv- ua yeeb yam hauv zos xws li lidocaine thiab procaine, nws cov txiaj ntsig tseem ceeb suav nrog qhov pib ntawm kev tshuaj loog, kev ncua ntev, thiab kev khaus khaus hauv zos me me, ua rau nws tsim nyog rau kev phais me me thiab cov pa tshuaj loog hauv ntau lub chaw kho mob.
Nws muaj feem xyuam rau ntau yam kev cuam tshuam tsawg kawg nkaus nrog rau kev tshem tawm lub pob txha txawv teb chaws lub cev, kev phais conjunctival, ntsuas qhov siab hauv lub cev, thiab kev kho mob laser. 0.3%–0.5% formulation nkag mus rau hauv lub qhov muag mucosa sai sai thiab ua tiav tshuaj loog nyob rau hauv 5-8 feeb, zoo alleviating stinging thiab txawv teb chaws - lub cev hnov thaum lub sij hawm phais. Nws tsis hloov pauv intraocular siab lossis kev ua haujlwm ntawm cov menyuam hauv plab, nrog rau kev ua haujlwm tsis zoo tom qab kev phais, stinging thiab lwm yam teebmeem tshwm sim; nws qhov kev nyab xeeb profile yog qhov zoo tshaj plaws rau cov pa tetracaine.
Nyob rau hauv otorhinolaryngology, tetracaine hydrochloride yog dav siv rau mucosal tshuaj loog ntawm qhov ntswg kab noj hniav, pharynx thiab auditory kwj dej, txuam cov txheej txheem xws li qhov ntswg polypectomy, turbinate plasty, pharyngeal biopsy thiab sab nraud auditory kwj dej debridement.
Piv nrog rau cov tshuaj loog ib txwm muaj, nws muaj zog mucosal permeability thiab yuav tsum tsis txhob siv tshuaj ntxiv. Ib qho tshuaj tsuag ib zaug muab cov tshuaj loog ua haujlwm ntev li 1.5-2 teev, txaus ua tau raws li qhov xav tau ntawm kev phais mob otorhinolaryngology. Nws tseem suppresses intraoperative pharyngeal reflexes thiab qhov ntswg kev ntxhov siab teb, txo cov neeg mob tsis xis nyob thiab kev pheej hmoo ntawm kev phais.
Hauv kev kho hniav, cov tshuaj tau qhia txog kev kho cov gingival, kev phais mob hauv lub cev, kev txawj ntse tsawg kawg nkaus - tshem tawm cov hniav thiab lwm yam kev cuam tshuam.
Targeting rhiab qhov ncauj mucosa thiab me me phais qhov txhab, nws enables meej lub zos hlab ntsha thaiv nrog controllable tshuaj loog kev pab them nqi, tsis muaj kev cuam tshuam nrog lub hauv paus physiological functions xws li mastication thiab nqos, thiab txhawb kev rov qab sai dua tom qab phais.Beyond superficial mucosal tshuaj loog, tetracaine inthesia thiab chloride canine. paj hlwb.
Hauv kev ua haujlwm me me nrog rau cov qog nqaij hlav sab nraud, kev phais subcutaneous cyst dissection thiab kho caws pliav, subcutaneous infiltration ntawm qis -concentration tetracaine hydrochloride tov ua tiav cov tshuaj loog hauv zos nrog cov tshuaj sib xyaw ua ke thiab ruaj khov, cov nyhuv ruaj khov uas npog tag nrho cov kev phais mob thiab tiv thaiv kev mob tshwm sim. Hauv kev kho mob orthopedics thiab kho cov tshuaj kho mob, cov paj hlwb nrog tetracaine hydrochloride relieves mob neuropathic mob xws li sciatica, trigeminal neuralgia thiab intercostal neuralgia los ntawm kev thaiv cov teeb liab conduction nyob rau hauv lesioned qab haus huv los tsim kom ntev -tshaj analgesia. Ua ke nrog kev kho thaiv thaiv, nws txhim kho cov ntaub so ntswg hauv zos cov ntshav ncig thiab alleviates neurogenic inflammatory edema, xa ob qho tshuaj loog -tshaj tawm thiab kho cov teebmeem.
Mob Analgesia thiab Dermatological Care
PentocaineQhia tau zoo heev hauv zos analgesic, antipruritic thiab los tiv thaiv- cov khoom siv inflammatory, ua ke nrog cov tawv nqaij zoo nkag mus thiab tsis tshua muaj khaus, txhawb kev siv dav hauv kev kho mob ntawm daim tawv nqaij thiab kev tswj qhov mob raws li kev kho mob txhua hnub rau cov qhov txhab. Rau kev raug mob xws li kub hnyiab, scalds, abrasions thiab lacerations, daim ntawv thov ntawm tetracaine hydrochloride qab zib los yog tshuaj tsuag sai sai nkag mus rau hauv lub qhov txhab nqaij daim tawv nqaij thiab thaiv qhov mob teeb liab kis tau tus mob los ntawm cutaneous paj terminals, sai sai relieving mob heev mob. Nws kuj inhibits histamine tso tawm ntawm qhov chaw qhov txhab kom txo tau erythema, pruritus thiab kub hnyiab, tsim kom muaj kev ruaj ntseg hauv zos microenvironment conducive rau kho.
Piv nrog rau cov tshuaj ua kom tsis haum, nws cov nyhuv tshwm sim rau 3-4 teev, obviating nquag rov ua dua, txo qis qhov mob rov ua dua thiab txo cov neeg mob kev ntxhov siab.
Nyob rau hauv dermatology, tetracaine hydrochloride ua hauj lwm pab raws li adjunctive symptomatic tswj rau eczema, allergic dermatitis, herpes zoster thiab lwm yam kab mob ntawm daim tawv nqaij. Cov mob no feem ntau nyuaj los ntawm khaus khaus khaus thiab neuropathic stinging; khawb ua rau muaj kev pheej hmoo kis mob. Tshuaj pleev tetracaine hydrochloride sai txo qhov mob thiab khaus khaus yam tsis muaj antagonizing cov kev kho dermatologic, thiab yog dawb ntawm daim tawv nqaij rhiab heev, pigmentation thiab zoo sib xws.
Nws kuj tau siv dav hauv cov tshuaj kho kom zoo nkauj minimally invasive, xws li laser freckle tshem tawm, photorejuvenation, microneedling thiab kho tattoo. Preoperative topical tetracaine hydrochloride cream ua rau lub ntsej muag zoo nkauj ntawm daim tawv nqaij kom tshem tawm cov txheej txheem stinging, nrog kev tswj qhov tob uas tsis txhob raug mob dermal thiab txhawb kev txhim kho cov tawv nqaij rov qab, haum rau tag nrho cov spectrum ntawm superficial aesthetic minimally invasive txheej txheem.
tetracaine hydrochloride kuj tseem siv rau kev kho mob analgesic hauv cov kab mob anorectal.
Rau qhov chaw rhiab nrog rau hemorrhoids, qhov quav fissures thiab postoperative perianal qhov txhab, mob siab rau qis- cov tshuaj loog ua rau cov tshuaj loog maj mam muab tshuaj loog, txo qhov mob defecation, tom qab phais mob stinging thiab pruritus. Cov tshuaj yog mos thiab nonirritating rau ilv perianal mucosa, zoo txhim kho postoperative zoo ntawm lub neej thiab ua kom lub qhov txhab zoo; Nws yog ib qho kev sib koom ua ke rau kev tswj hwm kev tswj hwm thiab kev saib xyuas tom qab ntawm cov kab mob anorectal.
Medical Adjunct thiab Tshwj Xeeb -Scenario Applications
Tetracaine hydrochloride ua haujlwm raws li qhov tseem ceeb ntawm kev siv tshuaj loog hauv kev kuaj mob thiab cov txheej txheem kev cuam tshuam, txo cov neeg mob tsis xis nyob thaum muaj kev cuam tshuam thiab txhim kho kev kuaj mob thiab kev ua haujlwm zoo. Rau kev kuaj mob endoscopy xws li gastroscopy, colonoscopy thiab bronchoscopy, preoperative spraying los yog txheej nrog tetracaine hydrochloride mucosal tshuaj loog anesthetizes pharyngeal thiab digestive ib ntsuj av mucosa, suppressing xeev siab, ntuav thiab txawv teb chaws - lub cev reflexes thaum lub sij hawm kev kho mob traction. Cov txheej txheem ua smoother thiab ntau tolerable yam tsis muaj kev cuam tshuam ntawm basal gastrointestinal motility los yog cuam tshuam nrog diagnostic txhais.
Nyob rau hauv niaj hnub kev cuam tshuam xws li tso zis catheterization, puncture thiab intubation, lub zos tetracaine hydrochloride relieves stinging thiab tsis xis nyob los ntawm kev taw qhia cov cuab yeej, blunting kev nyuaj siab teb thiab txo cov teeb meem.
Hauv cov tshuaj kho mob xwm txheej ceev, tetracaine hydrochloride yog qhov tsim nyog rau kev mob analgesia sai ntawm kev raug mob hnyav. Nws tswj ceev cov mob uas tshwm sim los ntawm cov lacerations tshiab, mos- cov ntaub so ntswg raug mob thiab pob qij txha, tsim kom muaj kev zoo siab rau kev sib tsoo tom ntej, suturing thiab immobilization. Nws qhov pib sai, tsis muaj tshuaj lom thiab kev nyab xeeb profile phim cov kev xav tau ceev ceev - taug qab kev saib xyuas xwm txheej ceev.
Hauv kev xyaum menyuam yaus, nws yog qhov khaus me me thiab cov txheej txheem tsis tshua muaj kev cuam tshuam zoo dua rau kev mob siab rau cov tshuaj loog. Nws tuaj yeem siv rau kev phais mob rau menyuam yaus, kev siv tshuaj kho mob ntxiv thaum txhaj tshuaj tiv thaiv, thiab kev tswj lub qhov txhab, txo qis kev ntshai thiab mob thiab txhim kho kev koom tes ntawm tus neeg mob.
Nws kuj pom muaj kev siv tsawg hauv kev tshawb fawb biomedical, nquag ua haujlwm raws li kev tswj hwm tshuaj loog hauv zos rau kev sib piv cov txiaj ntsig ntawm cov tshuaj loog tshiab thiab cov tshuaj tua kab mob.
Nws cov kev ua haujlwm pharmacological ruaj khov thiab cov txheej txheem ntawm kev txiav txim siab muab cov qauv kev sim siv rau kev txhim kho tshuaj loog, kev tshawb fawb tshuaj thiab kev soj ntsuam- tshuaj sib piv, ua rau nws yog qhov tseem ceeb ntawm kev tshawb fawb reagent. Nws cov tshuaj toxicity tsawg thiab ntev ntev kuj ua rau nws yog ib qho tshuaj loog kws kho tsiaj, dav siv rau kev phais sab nraud, kev tswj lub qhov txhab thiab kev cuam tshuam qhov mob hauv cov tsiaj txhu thiab cov tsiaj nyeg me me thoob plaws hauv cheeb tsam veterinary - tshuaj loog scenarios.
Core Synthetic Principple thiab Raw Material Preparation
Tshuaj,pentocaineyog 2-diethylaminoethyl 4-(pentylamino)benzoate, canonical ester-hom tshuaj loog hauv zos. Nws cov synthesis feem ntau yog nyob ntawm esterification condensation thiab aminoalkylation. Aromatic carboxylic acid derivatives thiab aminoalcohols ua cov khoom tseem ceeb pib; stepwise los ua ke tsim cov core molecular molecular molecular nyob rau hauv me me tej yam kev mob nrog ob peb sab kev xav thiab siab cov khoom purity, sib xws nrog ob qho tib si industrial batch manufacturing thiab kuaj-scale zoo npaj.
Cov ntaub ntawv tseem ceeb muaj xws li 4-aminobenzoic acid, n-pentyl bromide, 2-diethylaminoethanol, anhydrous potassium carbonate, xylene, dilute hydrochloric acid thiab anhydrous ethanol. 4-aminobenzoic acid muab cov tub ntxhais aromatic; n-pentyl bromide ua rau N-pentyl hloov pauv; 2-diethylaminoethanol muab cov khoom siv sab nraud. Cov khoom siv txhawb nqa catalysis, lub cev qhuav dej, tshem tawm impurity thiab purification. Cov ntaub ntawv raw khoom tau yooj yim muaj thiab tus nqi tswj tau, tsim nyog rau kev tsim khoom loj.
Stepwise Synthetic Workflow
Kauj Ruam 1: N-pentylation los tsim cov core aromatic scaffold
Purified 4-aminobenzoic acid thiab anhydrous potassium carbonate raug them rau hauv lub reactor qhuav, tom qab ntawd los ntawm anhydrous ethanol ua hnyav. Tom qab homogenization, n-pentyl bromide tov yog ntxiv dropwise maj mam, thiab cov sib tov yog rhuab mus rau 75-80℃nyob rau hauv reflux rau 4 teev.
Anhydrous potassium carbonate ua raws li cov kua qaub pov tseg, neutralizing hydrogen bromide byproduct los hloov qhov sib npaug ntawm cov khoom tsim thiab tiv thaiv cov kua qaub -kev sib haum xeeb ntawm cov khoom pib.
Tom qab txias rau ambient kub, ethanol raug tshem tawm los ntawm lub tshuab nqus tsev distillation. Cov dej ntxiv, thiab kev lim tawm cov kua qaub 4-(pentylamino) benzoic acid. Recrystallization muab qhov nruab nrab purity siab los tiv thaiv cov dej hauv qab dej purity.
Kauj ruam 2: Esterification condensation los tsim crude tetracaine hydrochloride
Purified 4-(pentylamino) benzoic acid thiab 2-diethylaminoethanol yog yaj hauv xylene. Ib qho me me ntawm cov concentrated sulfuric acid yog ntxiv ua catalyst, thiab qhov sib tov yog rhuab mus rau 120-125℃nyob rau hauv reflux rau esterification.
Kev sib cais dej tsis tu ncua los ntawm Dean-Stark apparatus tshem tawm cov dej tsim tawm, tshem tawm qhov sib npaug los tsav kev hloov pauv; tag nrho cov tshuaj tiv thaiv lub sij hawm yog tswj ntawm 5-6 teev.
Cov cua sov yog nres thiab qhov sib tov yog txias rau hauv chav sov, yielding cov organic sib tov uas muaj cov khoom lag luam. Ntxuav nrog dej thiab dilute puag tshem cov residual catalyst thiab unreacted pib cov ntaub ntawv. Cov txheej txheem organic yog sib cais, qhuav thiab concentrated kom tawm los daj daj oily crude tetracaine hydrochloride.
Product Purification thiab Final Formulation
Cov khoom Crude yog purified los ntawm hydrochloride ntsev tsim thiab recrystallization los txhim kho purity thiab stability. Concentrated crude roj yog yaj nyob rau hauv acetone. Nyob rau hauv dej khov- da dej, cov concentrated hydrochloric acid yog ntxiv dropwise los kho pH mus rau 3.5-4.0, ua rau tetracaine hydrochloride los nag ua nws cov ntsev hydrochloride.
Crystallization tshwm sim rau 12 teev nyob rau hauv qis kub. Crystals yog cais los ntawm centrifugal pom, ntxuav nrog txias acetone kom tshem tawm cov impurities saum npoo, thiab qhuav nyob rau hauv lub tshuab nqus tsev ntawm qhov kub thiab txias kom yield dawb crystalline tetracaine hydrochloride hydrochloride hmoov.
Cov txheej txheem tag nrho ua tiav cov txiaj ntsig siab tshaj 82% nrog cov khoom purity Ntau dua lossis sib npaug li 99.2%, ntsib cov kws kho mob -qib raw- cov khoom siv tshwj xeeb. Cov txheej txheem ua haujlwm ncaj nraim thiab tswj tau yooj yim rau kev lag luam nplai - nce. Byproducts tuaj yeem rov qab tau thiab ua tiav, txhawb kev ua haujlwm zoo ib puag ncig.
Pontocaine, feem ntau tsis meej pem nrog cov npe zoo sib xws xws li Ponaxen lossis cuam tshuam los ntawm kev sau me me thiab kev hloov pauv hloov pauv, feem ntau yog siv los xa mus rau Ponatinib, cov tshuaj tiv thaiv kab mob zoo heev tau siv dav hauv kev kho mob oncology. Raws li lub qhov ncauj tyrosine kinase inhibitor, nws muaj zog molecular lub hom phiaj thiab tseem ceeb inhibitory kev tiv thaiv kev txawv txav kinase signaling, thiab tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA) rau kev kho mob ntawm ntau refractory malignant qog, feem ntau npog cov qog hematological xws li ntau yam leukemias thiab lymphomas, thiab.
Nws lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog nyob rau hauv kev xaiv khi thiab inhibiting kev ua haujlwm ntawm tyrosine kinases txawv txav, tshwj xeeb tshaj yog Bcr-Abl fusion protein ze ze rau cov kab mob leukemia, yog li txiav tawm cov teeb liab txawv txav hauv cov qog hlwb, inhibiting qhov txawv txav ntawm cov cell proliferation thiab ciaj sia taus, thiab lub hom phiaj ntawm kev ua tiav. Hauv kev sim tshuaj thiab tiag -cov ntawv thov hauv ntiaj teb, ponatinib tau pom tias muaj txiaj ntsig zoo rau cov neeg mob uas muaj kab mob myeloid leukemia (CML) thiab Philadelphia chromosome-tus kab mob lymphoblastic leukemia zoo (Ph+ ALL), tshwj xeeb tshaj yog rau cov neeg uas tiv taus lwm yam tshuaj, muab ib qho tseem ceeb thiab yav dhau los kev kho mob {{6}.
Txawm li cas los xij, vim nws cov tshuaj muaj txiaj ntsig zoo, ponatinib kuj tseem tuaj yeem ua rau muaj ntau yam tsis zoo tshwm sim thaum siv tshuaj kho mob, suav nrog kev kub siab, daim tawv nqaij ua pob, ua rau plab hnyuv xws li raws plab thiab mob plab, qaug zog, thiab hematological toxicity. Cov xwm txheej no xav kom cov kws kho mob ua kev soj ntsuam tas li thiab kev cuam tshuam raws sijhawm. Hauv kev xaus, raws li cov tshuaj tseem ceeb hauv kev kho mob rau cov qog nqaij hlav malignant, ponatinib muaj txiaj ntsig tseem ceeb hauv kev kho mob, tab sis nws txoj kev siv yuav tsum ua raws li cov kev taw qhia kev kho mob nruj, ua raws li cov kev npaj tshuaj kho mob rau tus kheej, ntsuas tus neeg mob hom kab mob, kev zam lub cev thiab kev pheej hmoo - txiaj ntsig piv, thiaj li ua kom muaj txiaj ntsig zoo rau kev kho mob.
Cim npe nrov: pontocaine cas 94-24-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom