Ntshiab rad140 hmoovyog ib qho kev xaiv tsis-steroidal 2-}}}}} [{}}}}}}}}}}}}} {{4- Oxadiazol -2- yl]-2- hydroxyprropyl] amino {14 {}} methylbenzonitrile nrog molecular formula C20h17Cln6o2 thiab molecular hnyav 408 {}}}}}}}}}}}}} {{{{}} nws yuav tsum Khaws cia rau hauv ib puag ncig qhuav ntawm -20 degree, tiv thaiv los ntawm lub teeb thiab kaw.
Rad140 txhawb nqa cov khoom siv hluav taws xob ntawm kev xaiv cov khoom siv thiab cov plaub hau ntshiab uas yuav tsum muaj kev cuam tshuam nrog kev tawm tsam kev ua paug lossis ethanol thiab yog cov ntaub ntawv kev nyab xeeb heev, tab sis tsis muaj tib neeg cov ntaub ntawv kev nyab xeeb, tab sis tsis muaj tib neeg cov ntaub ntawv kev nyab xeeb yuav tsum muaj thiab siv tau txwv rau kev kuaj kev kawm {4 4} Txoj kev nyab xeeb nyab xeeb yuav tsum tau ua raws li kev siv thiab ncaj qha rau kev zam .
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Rad140 hmoov coa
Molecular cov mis thiab molecular hnyav
Molecular Tus Qauv: C₂₀h₁₆cln₅o₂
Molecular hnyav: 393.826 g / mol
Lub nplhaib molecular ntawm cov molecule no muaj ib qho chlorine atom (cl), ib qho kev sib tw ntawm hydroadiapropyl), thiab cov khoom siv hydroadiapropyl), thiab cov khoom siv tshuaj lom neeg ruaj khov thiab ua haujlwm.
Tus lej cas 1182367-47-0
Tus lej no pab tau tias yog cov cim tshwj xeeb rau cov tshuaj yeeb, ua kom muaj kev soj ntsuam cov rad140 hauv kev tshawb fawb thiab kev lag luam.
Cov Lus Txhais thiab Aliases
Testolone, rad -140} 2-}}}}}}}}}}}}}}}}}}}} {{8 }},3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzamide
Cov npe no xav txog cov qauv tshuaj kho thiab hom npe hauv cov ntawv thov kev lag luam ntawm cov khoom .
Lub cev thiab tshuaj
Tsos thiab khoom
Cov hmoov dawb
High-Purity Rad1440 feem ntau nthuav tawm raws li kev nplua, kev ua kom yooj yim ua kom haum, yooj yim precise uas muaj thiab xaus kev ua haujlwm hauv kev tshawb fawb.
So
Soluble me ntsis hauv chloroform, dmo
Nws yuav tsum tau kho ultrasonic rau kev sib cais, feem ntau siv hauv kev npaj cov tshuaj los yog tsiaj cov qauv .
Melting taw tes thiab boiling taw tes
Melting taw tes: 179-183 degree
BLAIL POINTION: 687.7 ± 65.0 DEGREE (kwv yees tus nqi)
Lub siab yaj taw qhia qhia qhov ruaj ntseg ntawm nws cov qauv siv lead ua, thaum lub siab tawg taw qhia tias nws tsis yooj yim rau kev sim ua ntu zus,.
Ntom ntom thiab cov indexing index
Ceev: 1.41 ± 0.1 g / cm³ (kwv yees tus nqi)
Cov ntsiab lus tsis pub: 1.652
Cov ntaub ntawv tuab yuav pab tau rau kev ua kom zoo dua ntawm cov hmoov av ntawm cov hmoov, thaum lub sijhawm tshawb fawb tshiab tuaj yeem siv tau rau hauv cov ntaub ntawv tshawb fawb {}}
Acidity Coefficient (PKA)
PKA: 13.76 ± 0.20 (kwv yees tus nqi)
Lub zog muaj zog (PKA> qhia tias cov molecule yog nquag nqa lub suab tsis zoo rau hauv pH, uas yuav cuam tshuam rau kev sib tw ntawm kev sib tw nrog cov phiaj receptors.
Kev Cia
{{0 {}}℃cryopreservation
Ib puag ncig tsawg-kub tuaj yeem txwv tsis pub muaj lub neej, feem ntau {{1} {{.
Tshuaj lom neeg ruaj khov thiab reflectivity
Thermal ruaj khov
Hauv qab no lub boiling point (< 687.7°C), it remains chemically inert, but at high temperatures it may decompose to produce hydrogen chloride (HCl) or nitrogen oxides (NOₓ), and should be operated in a fume hood.
Lub teeb ruaj khov
Cov hmoov dawb muaj qhov rhiab txaus rau pom lub teeb, tab sis ntev ntev ntawm Cyaniapees ntawm Cyano Group (-ua kom muaj kev sib cav sib ceg {}}
Redox Kev Ua Si
Lub hydroxyl (-oh) thiab cyano (-cn) pawg nyob rau hauv lub molecule tuaj yeem koom nrog cov tshuaj lom neeg (xws li redoDan permanganate) lossis cov neeg caij tsheb (xws li borohydride Sodium) .
Ph rhiab
Nyob rau hauv cov huab acidity (pH <2) lossis alkalinity (Ph> 12), kev cuam tshuam oxadiazole yuav qhib, ua rau muaj kev cuam tshuam rau kev cuam tshuam nrog kev cuam tshuam thiab poob rau hauv kev ua haujlwm cuam tshuam thiab ploj ntawm kev ua haujlwm.
Cov yam ntxwv biochemical
Xaiv Androgen Revenor Modulator (Sarm) Mechism
Rad140 khi rau cov androgen receptor (AR) nrog rau kev sib tw ntawm cov leeg thiab pob txha ua kom tsis txhob muaj cov pa hluav taws kub thiab cov qog nqaij daim duab.
Metabolic ruaj khov
Cov qauv tsis yog-steroidal ua rau nws tsis tshua muaj kev cuam tshuam nrog5 - metitase lossis aratase metabolism, thiab nws cov tshuaj steroids (xws li Testosterone).
Chaw muag tshuaj pharmeters
Ib nrab-lub neej: kwv yees li 24 teev (cov qauv paj nruag), txhawb nqa ib zaug kev noj tshuaj txhua hnub {}}
Faib ntim ntim: lub siab lipid solubility ua rau nws yooj yim rau txhaws cov nqaij mos ntau dua li hauv ntshav .
Kev Nyab Xeeb thiab Tuav Cov Lus Qhia
Cov ntaub ntawv lom
LD₅₀ (RAT, Qhov ncauj): Tsis qhia tawm, tab sis preclinetic index (ti) yog siab dua testosterone (qhia qhov kev pheej hmoo siab tsawg {}}
Kev sim ua si ntev ntev
Kev tiv thaiv kev tiv thaiv kev ua haujlwm
Cov Khoom Siv Tiv Thaiv Tus Kheej (PPE): Lub tsho loj: tsom iav, N95 npog ntsej muag, nitrile hnab looj tes .
Waste Disposal: Classified as "non-hazardous chemicals" by the EPA, but it should not be directly discharged into the sewer. It is recommended to destroy it through high-temperature incineration (>800 DEGREEN) .
Kev Ntsuas Thaum Muaj Xwm Ceev
Inhalation: hloov mus rau cov pa tshiab thiab ua pa ua pa unobstructed .
Daim tawv nqaij Hu: Ntxuav nrog xab npum thiab dej li 15 feeb, nrhiav kev kho mob yog tias tsim nyog .
Kev kov yeej: nqus tau cov khoom siv inert (xws li vermiculite) kom tsis txhob muaj plua plav .
Cov ntawv thov thiab cov lus qhia tshawb fawb
Nqaij Atroph Kho
Kev tshawb fawb preclinical qhia tau tias nws tuaj yeem thim cov leeg mob cancer, thiab cov muaj peev xwm cuam tshuam nrog tus kab mob ntsws sib txuam (Cops-ntsig txog kev tsis muaj txiaj ntsig zoo nkauj li {2}
Osteoporosis
Rad 201140 tuaj yeem nce cov pob txha ceev thiab txo qis lov taus kev pheej hmoo, tshwj xeeb tshaj yog rau cov poj niam postmenopausal {}}
Txhim Kho Kev Ncaws Pob Ua Haujlwm
Txawm hais tias muaj npe raws li kev txwv tsis pub los ntawm lub ntiaj teb anti-doping lub koomhaum (Wada
Kev Kho Mob Cancer Misuvant
Ua ib tus androgen receptor agonist, rad140 tuaj yeem inhibit lub predorer-zoo (EN +) Kev sim (NCT03901419).
Photostility thiab qhov xav tau cia kom deb ntawm lub teeb
Mechanism ntawm lub teeb ruaj khov: molecular qauv qauv thiab cov photodegradation pheej hmoo
Cov qauv molecular ntawm rad140 (tshuaj siv tshuaj: c₂₀h₁₆cln₅o₂) Xws li cov tseem ceeb hauv qab no uas cuam tshuam nws lub teeb ruaj khov:
Cyano (-cn) thiab chlorine atom (cl):
Cov pab pawg Cyano ua raws li cov pab pawg hluav taws xob muaj zog, cov pab pawg cygysis ua rau pom tias muaj cov ntaub ntawv hluav taws xob (U30}} nyob rau hauv ib qho kev txo qis hauv cov ntsiab lus ntawm cov khoom xyaw nquag. om yog nws tus kheej ruaj khov ntawm Cyano Group los ntawm kev ua haujlwm Induction {}}
Ntiv nplhaib Oxadiazole:
Lub nplhaib sib txuas no yuav dhau los hloov hluav taws xob, ua kom lub ntsej muag zoo nkauj ntawm cov duab oxadiazole
HydroxyPropyl sab saw:
Cov pab pawg hydroxyl (-h) tuaj yeem tswj cov molecule los ntawm hydrogen bondging, tab sis ntev-ntev yog ua rau oxidation ntawm cov khoom siv carborony (xws li cov khoom siv carboration (xws li kev ua haujlwm ntawm aldoolhydes {}}
Cov ntaub ntawv tshawb fawb: Kev ntsuas qhov kev ntsuas kom muaj peev xwm
Lub teeb-tiv thaiv vs .} tsis muaj kev tiv thaiv cia
Lub teeb-tiv thaiv cia: hauv cov iav fwj xim av lossis cov tshuaj rad140 muaj cov ntsiab lus ruaj khov (xws li impurities (xws li Cyano Group Cov pab pawg hauv dej khov kho) Cov ntsiab lus<0.1%.
Tsis tshua muaj chaw cia: Tom qab raug rau sab hauv tsev (kwv yees li 500 feeb tsawg dua li 5%, thiab cov impurity cov ntsiab lus nce rau 1. 2%; Raug rau UV teeb (365 nm, 10 w) rau 24 teev, cov ntsiab lus txo qis los ntawm 15%, thiab cov ntsiab lus impurity ncav cuag 3.5%.
Photolysis Kinetics Qauv
Raws li cov tshuaj tiv thaiv thawj zaug, cov nqi℃(k) ntawm lub teeb ci ntsa iab yog kwv yees li 0} 00} 006 h⁻¹, thiab ib nrab-lub neej (T₁ / ₂) yog li 115 teev. Nyob rau hauv lub teeb-tiv thaiv kev tiv thaiv, tus nqi k muaj peev xwm raug txo kom<0.0001 h⁻¹, and the half-life is extended to >7000 teev .
Qhov xav tau ntawm lub teeb-tiv thaiv (los ntawm kev kuaj sim rau cov ntawv thov muaj
Kuaj Tshawb Fawb Kev Tshawb Fawb
Hnyav thiab kev sib txawv: thaum lub sijhawm ua haujlwm, nws yog ib qho tsim nyog los ua kom tiav sai sai hauv kev tsaus ntuj lossis hauv qab lub hmoov kom muaj lub teeb .
Daws cov ruaj khov: yaj nyob rau hauv dmo, kev daws teeb meem khaws cia hauv kev ua haujlwm rau 20% ntawm nws cov haujlwm tsis pub dhau 7 hnub.
Kev lag luam khoom thiab cia
Cov khoom siv raw cia: nws pom zoo kom siv cov hnab ntim xim av iav lossis khaws cia hauv qhov chaw tso pa tawm, tsis txhob rov qab khov thiab yaj.
Lub sij hawm ntev ruaj ruaj: nyob rau hauv lub teeb-tiv thaiv, qhuav (av noo <40%), thiab cov txee rau lub neej rad140 tau ncav cuag 3 xyoos; Yog tias tsis tiv thaiv los ntawm lub teeb, lub txee lub neej yog luv rau {}} lub hlis {{}
Kev loj hlob ntawm cov qauv tsim
Transdermal Patches: UV nqus (xws li titanium dioxide) yuav tsum tau ntxiv kom paub tseeb kev siv yeeb tshuaj .
Nanocrystal Tsim: Los ntawm txheej txheej txheej saum npoo (xws li cov duab txheej txheem saum npoo av), kev pheej hmoo ntawm Photomysis tuaj yeem raug ua tiav ntawm solubility thiab ruaj khov .
Cov tswv yim rau kev ua kom zoo tshaj plaws photoperity: los ntawm molecular hloov kho mus rau kev ntim hloov tshiab
Kev Hloov Tsav Qauv
Cov tshuaj fluorine atid hloov chaw: Qhia cov tshuaj fluorine atom uas nyob ib sab ntawm cov pob zeb cyanopheny) tuaj yeem txhim kho kev ruaj khov ntawm molecular concenitivity .
Methylation Hloov Kho: qhia pawg methyl ntawm cov pa hluav taws xob ntawm Oxadiazole cov tshuaj tiv thaiv tuaj yeem thaiv cov duab hluav taws xob txoj hauv kev hauv Photostability tuaj yeem thaiv photostability reassable, txhim kho photostability tuaj yeem thaiv kev hloov hluav taws xob hauv photolyany, tuaj yeem thaiv photoTsistilation txoj hauv kev hauv photoaltability tuaj yeem thaiv photostabilge cov tshuaj tiv thaiv tuaj yeem thaiv photoTsistility reassable, txhim kho photostabilge cov tshuaj tiv thaiv tuaj yeem thaiv phototerity
Cov Khoom Siv Ntim Tshiab
Ntau-txheej sib xyaw ua yeeb yaj kiab: siv tus tsiaj / al / PE (Polyester / Aluminium / Polyethylene, txuas lub txee lub neej ntawm cov hmoov mus rau 5 xyoos.
Cov Ntawv Cim Ntse: Ua ke ntawm cov ntsuas cov duab uas muaj cov cim kev nyab xeeb, thaum lub teeb hloov pauv tau qhia qhov kev xav tau los hloov lub ntim ....
Kev Cia
Internet ntawm tej yam lub teeb pom kev zoo sensors hauv cov ntaub ntawv ntim cia kom saib xyuas cov ntaub ntawv teeb pom kev zoo nyob rau ntawm cov huab platform {}}
Blockchain traceability: sau tag nrho cov saw ntawm lub teeb raug cov ntaub ntawv ntawm cov hmoov los ntawm kev siv ntau lawm los ua kom muaj qhov zoo .
Cim npe nrov: Rad140 Hmoov, Tuam Tshoj Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, lag luam Wholesale, Yuav, nqe, loj, loj, rau muag