Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm Quinine Sulfate CASE CAS 6119-70-6 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale ntau cov khoom lag luam zoo quinine sulfate ua haujlwm yog 6119-70-6 kev muag khoom ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Quinine sulfate dihydrateyog quinine alkaloid, kuj tseem hu ua Cinchona Alkaloid, Lub Npe Tshuaj: (8s}}}}}}}}}}}}}}} {} {}} Soluble hauv dej kub (I: 35) thiab dej cawv (Kuv: 125), insoluble hauv chloroform thiab ether. Tsaus muag xim av thaum nthuav tawm lub teeb. Nws tsis muaj ntxhiab thiab muaj qhov muaj zog, kav iab iab. Nws yog quinoline derivative, uas tuaj yeem ua ke nrog DAmodium los tsim cov lus sib txawv thiab rov ua cov khoom muaj protein ntawm plasmodium. Nws cov nyhuv muaj zog tshaj li chloroquine. Cov khoom lag luam no siv rau chloroquine thiab Falciparum Malaria tshwm sim los ntawm cov tshuaj tiv thaiv ntau. Nws kuj tseem siv tau los kho VivaX malaria. Nws yuav tsum tau siv nrog kev ceev faj hauv cov neeg mob hawb pob, mob siab rau lwm yam kab mob plawv, thiab cov poj niam thaum lawv coj khaub ncaws. Cov khoom no yog rau kev kuaj siv nkaus xwb.
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Tshuaj Cov Qauv |
C20H30N2O8S |
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Muaj pes tsawg leej |
458 |
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Molecular hnyav |
459 |
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m/z |
458 (100.0%), 459 (21.6%), 460 (4.5%), 460 (2.2%), 460 (1.6%) |
|
Kev Ntsuam Xyuas |
C, 52.39; H, 6.60; N, 6.11; O, 27.91; S, 6.99 |
Hais txog: Bloom Tech (Txij xyoo 2008), ua tiav chem - Tech yog peb cov neeg pabcuam.
Qhov kev kho yeeb yam zoo tshaj plaws ntawm kev kho mob malaria tau pom nyob rau hauv 1737. Xyoo 1820, sib cais los ntawm cov tawv ntoo ntawm quia thiab hu nws quinine lossis quinine. Lub npe los ntawm tsob ntoo npe Quina Quina quina hauv Inca. Nws tau pib siv rau ntawm lub cim loj ib ncig 1850. Quinine sulfate thiab quinine hydrochloride yog cov muaju dawb nrog saj tsis tshua muaj tseeb. Tus qub yog soluble me ntsis hauv dej rau qhov ncauj, thaum lub tom kawg yog yooj yim soluble hauv dej.
Muaj ntau txoj hauv kev rau synthesizingQuinine sulfate dihydrate, ntawm cov hauv qab no yog ob peb cov qauv hluav taws xob ib txwm muaj:
1. Tollard Synthesis
Nov yog tus qauv synthesic, tsuas yog ua tiav los ntawm cov kauj ruam hauv qab no:
-} Ua ntej, nws yuav muaj -}}}}}}}}}}}}}}}}}}}}}}}}}
{{0--}} Cov Pab Pawg Neeg (xws li SulfhydryL pab pawg kom tsim- Carbamate Thiol Ester.
{{0- - Quinine yog tsim los ntawm hydrolysis, ammonolysis, thiab brominy kev tawm tsam ntawm thij carbamate eter.
2 stork synthesis
Qhov no yog lwm qhov kev siv hluav taws xob feem ntau, nrog cov kauj ruam hauv qab no:
{{0-}}}}} Siv Guanine raws li qhov pib cov khoom, yog acid yog tsim los ntawm cov txheej txheem ntawm cov tshuaj lom neeg.
-} ulter yog maj mam hloov mus rau hauv hydroxyquinoline los ntawm ntau kauj ruam, suav nrog entyl chlorination kev tawm tsam, hloov cov tshuaj tiv thaiv entyl, lwm yam.
- hydroxyinquinoline undergoes ntau theem, suav nrog acylation, kom kawg, rau thaum kawg tau txais quinine.
3 cinchonInitine txoj kev
Cov qauv no pib nrog cinchona alkaloid thiab undergoes muaj cov tshuaj lom neeg ntawm cov khoom noj kom kawg.
{{0-} Ua ntej, cov tshuaj tiv thaiv hydrogen ntawm Cinchona Alkaloids yog nqa tawm kom tau Cinchona Alkaloids.
{{0- Quinine yog maj mam hloov mus rau quinine los ntawm ntau yam kev tiv thaiv, suav nrog kev rov qab, oxidation, thiab lwm yam
Melting taw tes ~ 225℃c (Dec.) (Lit.) (Lit.), kev sib hloov tshwj xeeb -245}}, 0.1m hcl), fema 2977|Quinine sulfate, khaws cia rau hauv qhov chaw tsaus, 2-8 solidination Crystal hmoov, tsis muaj zog rau xim av, dej khov rau lub ntsej muag nrog cov xim kas fes, Alkalies, ammonia, cov hauv paus muaj zog, iodine.
Cov tshuaj uas cov tshuaj ntawmQuinine sulfate dihydrateyog tias quinine yog quinoline derivative, uas tuaj yeem ua ke nrog Dasmodium los tsim DNAslit DNA replication thiab siv cov khoom siv protein ntau ntawm plasmodium. Nws cov nyhuv muaj zog tshaj li chloroquine. Ib qho ntxiv, Quinine tuaj yeem txo cov pa oxyen ntawm plasmodium, tiv thaiv lub phosphoralLium thiab cuam tshuam nrog nws cov metabolic. Quinine kuj ua rau molarial xim malations, tab sis kev txhim kho ntawm cov tshuaj mis yog qeeb, tsis tshua muaj kev sib sau ua ke loj, thiab feem ntau nrog kev tuag ntawm tes. Electron tsom tsom iav pom tias lub nucleus thiab sab nraud membrane ntawm Protozoa tau o, thiab muaj lub vacavoles me me. Cov ntshav ntawm cov ntshav tawm hauv cov av me, txawv ntawm cov xim agglutination ntawm chloroquine. Nyob rau hauv cov ntshav, ib qho kev xav tau tshwj xeeb ntawm Quinine tuaj yeem ua rau kev sib tw liab lub cev, yog li tiv thaiv kom loj hlob ntawm cov kab mob liab.
Qhov kev tshawb pom keeb kwm ntawmQuinine sulfate dihydratetuaj yeem raug taug qab rov qab mus rau 17th caug xyoo. Nov yog qee qhov tseem ceeb keeb kwm MINESTONES:
Siv ntxov: Cov tshuaj no tau siv los ua ib qho ntawm cov tawv ntoo ntawm tsob ntoo cinchona thiab tau siv thawj zaug los kho cov txiv neej phem hauv 1600s. Lub sijhawm ntawd, nws tau hu ua "Jesuit tawv ntoo", "Cardinal Barch" lossis "Bratural tawv". Lub npe no tau pib los ntawm cov tub txib Jesuit uas siv nyob rau hauv South America hauv 1630, txawm hais tias muaj cov lus dab neeg uas cov neeg hauv zos twb tau siv nws ua ntej lawm.
Zaj dab neeg: Muaj cov lus dab neeg txog ib tus neeg uas tau ploj hauv Andes zoov nuj txeeg vim tias kub taub hau. Tom qab haus dej ib lub pas dej ntawm cov dej uas phem, nws pom tias cov dej tau ua rau cov ntoo cinchona puag ncig thiab xav tias nws tau lom. Tab sis kuj ceeb tias, nws kub taub hau sai sai uas tau ua tiav, thiab nws qhia qhov kev tshawb pom qhov tsis pom ntawm cov neeg zos. Tom qab, lawv tau siv cov kev rho tawm ntawm cov tawv ntoo ntawm cov ntoo cinchona los kho qhov kub taub hau.
Qhia rau Tebchaws Europe: Lwm cov lus dab neeg tau lees paub txog kev tshawb pom ntawm Quinine cuam tshuam txog cov ntseeg lub cav, uas tau cog lus kub taub hau hauv Peru thiab tau kho los ntawm cov tawv ntoo. Thaum nws rov qab mus rau Spain, nws coj cov khoom mus rau Tebchaws Europe. Xyoo 1742, Botanist Carl Linnaess muaj npe hu ua Tsob Ntoo "Cinchona" hauv nws Honour.
Rho tawm thiab naming: Naming: hauv 1742, Carl Linnaim npe npe no "Cinchona" hauv kev hwm ntawm suav Chinchon thiab nws tus poj niam Ana. Lub npe Quinine los ntawm Lo Lus Peruvian Kina Kina, lub ntsiab lus "tawv ntoo"; Extraction: nyob rau hauv 1817, Fabkis cov kws muag tshuaj sib koom tes sib koom tes tau los ntawm cov tawv ntoo ntawm Cinchona, lees tias cov khoom siv tsis zoo rau cov khoom noj tsis zoo hauv cov tawv nqaij cinchona.
Kev Tshawb Fawb Kev Tshawb Fawb: Nrog rau qhov tob tob ntawm kev tshawb fawb, cov kws tshawb fawb tau ua tiav cov qauv kev ua yeeb yam, molecular cov qauv c20h24n2o2, ntxiv rau nws cov kev kawm ua yeeb yam roj ntsha. Cov kev tshawb xyuas qauv no qhia tawm lub xub ntiag, ib lub davhlau ya nyob qub ob pab pawg, thiab ib pawg metroxy, ib lub nplhaib siv kas fes, thiab pab pawg kas fes, thiab pawg Cov ntaub ntawv no muab cov pov thawj muaj zog rau nws cov qauv.
Cov tshuaj tiv thaiv tsis zoo
Quinine sulfate dulfate yog ib qho alkaloid tau txais los ntawm cov tawv ntoo ntawm cov tawv ntoo xws li antipyretic, antiresic, thiab anti arthythmic. Raws li cov tshuaj tiv thaiv kab mob antimalarial, nws yog ib zaug xaiv rau kev kho cov malaria, tshwj xeeb tshaj yog nyob rau hauv qhov chaw choloroquine tsis tshua muaj zog, nws tseem tuav txoj haujlwm tseem ceeb. Txawm li cas los xij, nws siv yog nrog los ntawm cov kev sib raug zoo uas muaj ntau yam kev cuam tshuam nrog ntau cov khoom siv, thiab muaj lub neej hnyav, nws tuaj yeem yog lub neej {2}.
Cov kev nyuaj siab hauv cov ntshav
Thrombocytop
Mechanism: Quinine tuaj yeem ua rau muaj zog tiv thaiv - kev rhuav tshem cov platelet Platelet kev rhuav tshem, ua rau kom txo qis hauv platelet suav suav.
Cov chaw kho mob: nqaij tawv nqaij, ntshav los ntshav, thiab mob hnyav, intracranial hemorrhage yuav tshwm sim.
Cov ntaub ntawv kuaj mob:
Kev kawm yav tom ntej pom tias hauv cov neeg mob malaria kho nrog quinine sulfate dulfate dihydrate, qhov tshwm sim ntawm thrombocytop (platelets<100 × 10 ⁹/L) was 8%, of which 2% were severe thrombocytopenia (<50 × 10 ⁹/L).
Cov Ntaub Ntawv Tshaj Tawm: Tus neeg mob "tus txiv neej laus tus txiv neej tau txais kev kho mob nrog Quinine Sulfate Dihdrate rau Malaria. Hnub tim 5, nws cov platelet cov nyiaj tsawg tsawg ntawm 150 × 10 ⁹ / l txog 30 × 10 ⁹ / l. Tom qab txuas cov tshuaj thiab kev tswj hwm glucocorticoids, nwsatelet me me tau rov qab los.
Hemolytic anemia
Mechanism: Quinine tuaj yeem ua tsis tau hemolity oxidation hemolysis nyob rau hauv cov neeg mob nrog cov piam thaj (G6pd Dehydriency.
Cov kev kho mob maction: Jaundice, Anemia, Hemoglobinuria, thiab nyob rau hauv cov neeg mob loj, mob raum tsis tau tshwm sim.
Cov ntaub ntawv kuaj mob: Qhov tshwm sim ntawm hemolytic anemia hauv G6PD cov neeg mob tsis muaj peev xwm ncav cuag 10% -20%.
Cov lus qhia rau kev kho: tshuaj ntsuam rau G6PD tsis txaus ua ntej kev kho mob ua ntej kev kho mob thiab zam kev siv rau cov tib neeg uas paub txog G6P qhov tsis txaus; Kev kho mob tam sim ntawd ntawm kev kho mob thiab kev pab txhawb (xws li cov zis hloov ntshav lossis alkalinization ntawm cov zis) yuav tsum muaj thaum hemolysis tshwm sim.
Diffuse intravascular coagulation (dic)
Mechanism: quinine yuav ua rau dic los ntawm kev ua kom lub zog sib xyaw lossis cov hlwb endothelial.
Cov kev kho mob manifestations: Los ntshav thiab thrombosis Cleacist, Kuaj cov ntawv qhia txog Thrombocytopia, sijhawm lub sij hawm prottrinogen.
Cov Ntaub Ntawv Tshaj Tawm: Tus txiv neej tus neeg mob tus txiv laus tau txais kev kho mob nrog Quinine Sulfate Dihydrate rau Malaria. Nyob rau 7 hnub, nws tab tom tsim kev tawv nqaij tawv nqaij thiab tawv nqaij. Qhov ntsuas kev ntsuas kev ntsuas pom tseeb tias kev kuaj mob ntawm dic. Tom qab txuas cov tshuaj thiab tswj hwm hepwin thiab cov ntshav khov tshiab, nws qhov mob txhim kho.
Cov tshuaj tiv thaiv kab mob plawv tsis zoo
Lub xub ntiag
Mechanism: quinine tuaj yeem inhibit lub tshuab myocardial conduction conduction, thiab induce apical torsion, thiab induce apical torsion tachycardia (TDP).
Cov kev kho mob manifestations: kiv taub hau, tsaus muag, tsaus muag, thiab nyob rau hauv cov neeg mob hnyav, yuav raug ntes lub plawv plawv them.
Clinical data: A study involving 100 malaria patients showed that the incidence of QT interval prolongation (>450ms) Thaum lub sijhawm kho nrog quinine sulfate dulfate dihydrate yog 15%, nrog 3% loj hlob mus rau hauv tdp.
Kev mob siab
Mechanism: Quinine tuaj yeem ua rau cov hlab ntshav ua kom tsis kam, thiab ua rau muaj ntshav nce.
Cov kev kho mob ua kom zoo: kiv taub hau, qaug zog, hws tawm hws, thiab muaj mob hnyav, kev poob siab, poob siab yuav tshwm sim.
Tawm tswv yim rau kev kho mob: saib xyuas ntshav siab thaum kho mob thiab zam kev tswj hwm sai sai; Thaum hypotension tshwm sim, kev hloov kua thiab siv cov tshuaj vasooactactive yog qhov tsim nyog.
Cim npe nrov: Quinine Sulfate Ua Cas 6119-70-6, Cov Chaw Tsim Khoom, Chaw Tsim Khoom, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Kev Lag Luam Wholesale, Yuav, Ntaus, loj, rau muag