Shaanxi Bloom Tech Co., Ltd. yog ib qho kev paub txog cov neeg tsim khoom thiab cov chaw muag khoom ntawm Staurosporine CAS 62996-74-1 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale ntau zoo staurosporine CAS 62996-74-1 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Staurosporine, nrog molecular formula c28h26NN4o3 thiab CAS Number 62996 {12 {{14 {{14 {{14 {{14 {{14} {14, muaj qhov hnyav molecular ntawm 466.53. Nws yog feem ntau yog xim dawb lossis lub teeb daj daj. Nws yog lub ntuj alkaloid tau los ntawm streptomyces (xws li Steprosteryces Am-2282 lossis tus mob streptomyces hauv xyoo 1977 thiab yav tas los hu ua tshuaj tua kab mob Am-2282. Nws muaj ntau cov kev ua si lom neeg thiab cov kev tshawb fawb tseem ceeb, tshwj xeeb tshaj yog nyob rau hauv kev sim ua tus ntxhiab thiab ua haujlwm ua protein kinase. Nws yog qhov zoo ATP-sib tw Kinase inhibitor uas txwv tsis pub muaj kev ua si los ntawm kev khi rau ATP Binding site ntawm Kinase. Lub Inhibitory nyhuv no tsis yog tshwj xeeb vim nws tuaj yeem inhibit cov kev ua si ntawm ntau cov kinase (pka
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Staurosporine, tseem hu ua cov tshuaj tua kab mob AM-2282 lossis STS, yog ib qho alkaloid cais los ntawm cov kab lis kev cai ntawm cov Streptomyces. Txij li thaum nws tshawb pom xyoo 1977, nws tau nyiam ntau dua vim nws cov kev sib tw ntau yam. Hauv qab no yog cov lus qhia ntxaws ntxaws ntawm nws cov kev ua haujlwm kom ntxaws, tsom mus rau kev nkag siab nws txoj haujlwm tseem ceeb hauv ntau cov txheej txheem biological.
Ib qho ntawm nws cov kev ua ub no tseem ceeb yog ua rau muaj cov protein kinases los ntawm kev tiv thaiv kev khi ntawm ATP rau Kinases. Raws li tus neeg muaj kev sib tw Kinase inhiboritor, nws tuaj yeem khi rau ntau qhov kev sib cav nrog kev xaiv siab, txawm hais tias nws qhov kev xaiv tau me me. Cov xeeb ceem no ua rau nws muaj feem nyob hauv kev tshawb fawb txog kev tshawb fawb txog kev lom zem ntawm kev teeb tsa ntawm tes, thiab cov tshuaj lom neeg ntawm tes, thiab kuaj mob.
Protein Kinases ua si lub luag haujlwm tseem ceeb hauv kev teeb tsa cell thiab cov txheej txheem proliferation. Lawv xaiv ntau yam txheej txheem biological nyob rau hauv cells los ntawm catalyzing protein phosphardlation. Los ntawm kev nyob ntawm ATP Binding site ntawm Kinase, kev sib cuam tshuam ntawm ATP thiab Kinase yog tiv thaiv, yog thaiv cov catalytic muaj nuj nqi ntawm Kinase. Lub chaw inhibitions cuam tshuam yog qhov cuam tshuam tseem ceeb ntawm cov txheej txheem biological xws li setacellular signaling thiab cell proliferation.
Inducing Cell Apoptosis
Nws kuj muaj peev xwm ua rau lub cev tsis sib xws. ApopTosis yog ib txheej txheem kev tuag ntawm tes tuag uas yog qhov tseem ceeb rau kev tswj hwm kev txhim kho thiab sab nrauv hauv cov muaj sia. Los ntawm kev ua kom muaj cov tshuaj tsw qab rau cov protein xws li Caspase-3, lub xov tooj ntawm tes Apoptosis yog qhov cuam tshuam. Ntawm cov kev sib txawv, nws tuaj yeem ua rau apoptosis hauv ntau hom xov tooj ntawm tes, uas koom nrog cov protein thiab kev tswj hwm cov txheej txheem ntawm lub voj voog ntawm tes.
Kev tshawb fawb tau pom tias cov txheej txheem ntawm inducing ntawm tes Apoptosis tuaj yeem cuam tshuam nrog nws cov kev txwv ntawm cov protein kinase. Los ntawm inhibiting Kinease kev ua si, nws tuaj yeem cuam tshuam rau cov phiajcim nkag mus hauv txoj kev thiab ua rau cov kev kawm apoptosis. Ib qho ntxiv, nws kuj tseem tuaj yeem cuam tshuam cov theem ntawm lub xov tooj ntawm tes, xws li kev tiv thaiv kev ua kom muaj kev vam meej hauv G1 lossis G2 / m theem, yog li txuas ntxiv kev txhawb nqa ntawm tes Apoptosis.
Ntxiv rau inhibiting protein Kinase kev ua si thiab hais lus ntawm lub cev-optosis, nws kuj muaj cov nyhuv neuroprotective. Ntawm qhov qis dua, cyclosporine tuaj yeem txhawb txoj kev loj hlob ntawm cov txheej txheem neural, muab cov tswv yim thiab cov qauv tshiab rau kev kawm ntawm cov kab mob ntawm cov kab mob thiab cov kab mob neurodegenerative.
Cov kab mob nurodegenerative yog hom kab mob uas cuam tshuam los ntawm kev ua tsis xws thiab kev tuag ntawm cov kab mob hlwb, suav nrog Alzheimer tus kab mob, Parkishon tus kab mob, thiab lwm tus. Kev tshawb fawb tau pom tias nws tuaj yeem tiv thaiv cov hlab hlwb los ntawm kev puas tsuaj thiab txhawb kev loj hlob thiab kho cov txheej txheem neural. Qhov kev tshawb fawb no tau muab cov hom phiaj tshuaj tshiab thiab cov tswv yim kho mob rau kev kho mob ntawm cov kab mob nurodegenerative.
Anti -} mob qog ntshav
Nws kuj tau pom muaj peev xwm zoo hauv anti - Kev Kho Mob Cancer. Raws li cov protein zoo heev kinase inhiboritor, nws muaj lub zog cyotoxic muaj zog heev rau cov kabmob kheesxaws. Los ntawm inhibiting kev ua kom lub zog ntawm cov qog nqaij hlav cancer, kev muaj peev xwm thiab kev loj hlob ntawm cov kabmob kheesxaws tuaj yeem raug thuam, thiab lawv cov tshuaj tsis taus.
Cov kev tshawb fawb tau pom tias nws tuaj yeem cuam tshuam rau cov qog ntshav, suav nrog mob plab hnyuv, lwm yam. Ib qho ntxiv, nws tseem tuaj yeem cuam tshuam cov metabolism thiab kev plantion muaj peev xwm ntawm cov qog ntshav, ntxiv txhim kho lawv cov anti- mob qog ntshav.
Ntxiv rau cov tshuaj lom neeg tseem ceeb uas tau hais los saum toj no, Staurosporin tseem muaj lwm yam kev ua haujlwm ntawm cov tshuaj tua kab mob, anti anti anti anti antibe ua cov ntawv thov muaj txiaj ntsig hauv ntau daim teb.
Nyob rau hauv cov nqe lus ntawm cov khoom siv tshuaj tua kabmob, nws tuaj yeem ua rau muaj kev loj hlob thiab kev luam tawm ntawm ntau cov kab mob thiab cov yeeb tshuaj- tiv taus cov kab mob. Qhov kev tshawb fawb no muab cov lus qhia tshiab thiab cov tswv yim rau kev txhim kho cov tshuaj tua kab mob.
Hais txog kev cuam tshuam tiv thaiv kab mob: nws tuaj yeem cuam tshuam cov replication thiab kis cov kab mob, yog li txo cov tsos mob kis tau thiab chav kawm. Txawm hais tias qhov tshwj xeeb kev ua haujlwm ntawm nws cov nyhuv ntawm cov tshuaj antiviral tsis to taub, qhov kev pom ntawm qhov no muaj cov tshuaj muaj peev xwm tshiab rau kev txhim kho cov tshuaj tiv thaiv kab mob.
Nyob rau hauv cov nqe lus ntawm anti -} pamaricinin tuaj yeem cuam tshuam qhov tshwm sim, yog li txo cov ntaub so ntswg thiab mob los ntawm o. Qhov kev tshawb fawb no muaj cov lus qhia tshiab thiab cov tswv yim rau kev txhim kho ntawm anti- Cov tshuaj.
Antifungal thiab antihypertensive meem
Ntxiv rau cov kev ua si dhau los ua si,staurosporineKuj tseem muaj cov tshuaj tiv thaiv kab mob thiab antihypertensive cuam tshuam. Cov haujlwm no ua rau nws muaj cov ntawv thov yuav muaj peev xwm tus nqi nyob rau hauv cov liaj teb ntawm cov tshuaj thiab kev ua liaj ua teb ib yam nkaus.
Nyob rau hauv cov nqe lus ntawm cov tshuaj tiv thaiv kev tiv thaiv, nws tuaj yeem cuam tshuam qhov kev loj hlob thiab kev luam tawm ntawm ntau yam fungi, suav nrog qee qhov kev sib tw. Qhov kev tshawb fawb no muab cov lus qhia tshiab thiab cov tswv yim rau kev txhim kho cov tshuaj tiv thaiv kab mob antifungal.
Nyob rau hauv cov nqe lus ntawm anti bypertension, nws tuaj yeem cuam tshuam cov kev cog lus thiab kev so ntawm cov leeg ntshav du ntawm cov leeg ntshav du. Txawm hais tias qhov tshwj xeeb txheej txheem ntawm nws cov anti hipertensive tsis to taub, qhov kev tshawb pom qhov no muaj lub hom phiaj siv tau tshiab rau kev kho mob tawg.
Staurosporine, tseem hu ua cov tshuaj tua kab mob AM-2282 lossis STS, yog ib qho alkaloid cais los ntawm cov kab lis kev cai ntawm cov Streptomyces. Txij li thaum nws tshawb pom, nws tau pom muaj peev xwm zoo rau kev thov kev tshawb fawb vim nws cov qauv tshuaj lom neeg thiab cov roj ntsha ntau.
Cov cuab yeej hauv kev tshawb fawb Biology
Raws li muaj zog atp sib tw kinerase inhibitor, nws muaj cov ntawv thov dav hauv Biology kev tshawb fawb. Nws tuaj yeem thaiv cov kev ua haujlwm catalytic ntawm Kinase los ntawm kev nyob hauv ATP Binding site ntawm Kinase, tiv thaiv kev sib cuam tshuam ntawm ATP thiab Kinase. Lub Inhibitive nyhuv yog qhov tseem ceeb tshaj plaws rau kev kawm cov txheej txheem biological xws li setacellular signaling, kev muaj peev xwm ntawm tes, thiab tshuaj apoptosis.
(1) Inducing Cell Apoptosis:
Nws tuaj yeem ua rau apoptosis hauv ntau hom xov tooj ntawm tes, thiab qhov no mechanism cuam tshuam nrog cov proteins uas muaj cov protein (xws li caspase-3) thiab tswj cov txheej txheem ntawm tes. Hauv kev tshawb fawb, feem ntau nws yog feem ntau siv los ua cov cuab yeej ua kom tsis muaj kev nkag siab ntawm lub cev thaum apoptosation thiab tau txais kev nkag siab tob txog ntawm cov txheej txheem ntawm lub cell doctosis.
(2) cuam tshuam rau lub voj voog ntawm tes:
Nws kuj tseem tuaj yeem cuam tshuam cov theem sib txawv ntawm lub voj voog ntawm tes, xws li kev tiv thaiv kev ua kom muaj kev vam meej ntawm cov hlwb hauv G1 lossis G2 / m phases. Cov xeeb ceem no lub luag haujlwm tseem ceeb hauv kev kawm biological cov txheej txheem xws li cov kws tshaj lij ntawm tes thiab sib txawv. Los ntawm kev ntxiv tus nqi tsim nyog rau lub cell kab lis kev cai, cov kev hloov pauv ntawm cov protein kinase tuaj yeem pom, yog li pom cov kev cai tswj hwm ntawm cell kev sib tw thiab sib txawv.
Muaj peev xwm hauv Neuroscience Tshawb Fawb
Stellarin kuj tau pom muaj peev xwm loj nyob hauv thaj teb tshawb fawb. Kev tshawb fawb tau qhia tias Staurosporin tuaj yeem txhawb txoj kev loj hlob ntawm ne cov txheej txheem, muab cov tswv yim thiab cov qauv tshiab rau kev kawm ntawm cov kab mob ntawm cov kab mob thiab cov kab mob neurodegenerative.
(1) Cov nyhuv neuroprotective: ntawm cov qis dua, nws muaj qee yam kev ua haujlwm neuroProtective. Nws tuaj yeem tiv thaiv cov hlab hlwb los ntawm kev puas tsuaj, txhawb txoj kev loj hlob thiab kho cov txheej txheem neural. Qhov kev tshawb fawb no muaj cov tswv yim kev kho mob tshiab thiab cov tshuaj kho mob neurodegeneries xws li Alzheimer tus kab mob xws li Alzheimer tus kab mob, Parkinson tus kab mob, thiab lwm yam.
(2) Kev tshawb fawb ntawm kev hloov chaw nyob rau ntawm neasin teeb liab, nws tuaj yeem cuam tshuam cov enzymes tseem ceeb hauv cov txheej txheem ntawm neural teeb liab transduction. Los ntawm kev kawm nws qhov kev cuam tshuam rau neural teeb liab kev hloov pauv, peb tuaj yeem tau txais kev nkag siab tob, muab cov tswv yim thiab cov tswv yim tshiab rau kev tshawb fawb hauv thaj teb neuroscience.
Tus nqi ntawm Kev Tshawb Fawb Txog Oncology
Nws kuj tau pom tus nqi tseem ceeb hauv Kev Tshawb Fawb Txog Oncology. Raws li cov protein zoo heev kineritor, nws muaj cov txiaj ntsig cytopsoxic muaj zog, uas tuaj yeem cuam tshuam lawv cov kev loj hlob thiab kev loj hlob, thiab ua rau lawv lub hom phiaj.
(1) Kev txhim kho ntawm anti -}} Tej kev ua si ua rau muaj kev sib tw tseem ceeb heev. Los ntawm - qhov tob tshawb nrhiav ntawm cov tshuab kev ua ntawm cov kabmob qog nqaij hlav cancer, txhawb nqa cov kev txhim kho kom zoo li cov tshuaj tiv thaiv City. Tsis tas li ntawd, analogues xws li UCN- 01 thiab CGP 41251 tau ua rau muaj kev loj hlob ntawm cov kab mob cell hauv kev ua haujlwm ntawm cov kab mob cancer.
(2) Kev tshawb fawb ntawm cov txheej txheem ntawm cov qog muaj: nws tuaj yeem cuam tshuam ntau yam xws li cov metabolism xws li cov metabolism xws li kev muaj peev xwm, thiab cov phiajcim txoj hauv kev ntawm cov qog ntshav. Los ntawm kev kawm nws qhov cuam tshuam rau cov qog nqaij hlav hlwb, peb tuaj yeem tau txais kev nkag siab tob ntawm cov qog ua thiab kev txhim kho thiab cov tswv yim tshiab thiab kev kho mob qog thiab kho cov qog.
Cov ntawv thov hauv lwm qhov kev tshawb fawb kev tshawb fawb
Ntxiv nrog rau cov teb ua ntej, nws tseem muaj cov ntawv thov txuas ntxiv hauv lwm cov chaw tshawb fawb.
(1) antifungal thiab anti hypeValective cuam tshuam: nws muaj antifungal cuam tshuam: nws muaj cov kabmob anti quab yuam, uas muaj txiaj ntsig zoo nyob rau hauv cov liaj haum ntawm cov tshuaj thiab kev ua liaj ua teb. Los ntawm kev ua nyob rau hauv - qhov tob tshawb ntawm nws cov antihypers me ntsis muaj peev xwm muab tau rau nws cov ntawv thov hauv cov teb ntsig txog.
(3) Kev Tshawb Fawb Yeeb Tshuaj thiab Kev Tshawb Fawb Kev Tshawb Fawb: Raws li kev ua protein Kinase inhibitor, nws tseem muaj cov txiaj ntsig tseem ceeb hauv kev kuaj tshuaj thiab tshuaj lom. Los ntawm kev siv Staurosporin ua cov cuab yeej ua haujlwm, sib txuas lossis tshuaj muaj cov kev ua haujlwm roj ntsha muaj peev xwm tau tshuaj xyuas, thiab lawv cov tshuaj lom thiab kev nyab xeeb tuaj yeem raug ntsuas. Qhov no muab kev txhawb nqa zoo rau kev ntsuas tshuaj tshiab thiab tshuaj muaj kev nyab xeeb.
(2) tiv thaiv kev mob plab thiab tiv thaiv kab mob:
Cov kev tshawb fawb tau pom tias nws tseem muaj anti - kev mob thiab cov kev cai tswj kev cuam tshuam. Nws tuaj yeem cuam tshuam qhov tshwm sim thiab kev loj hlob ntawm cov tshuaj tiv thaiv mob, txo cov ntaub so ntswg puas tsuaj thiab mob los ntawm o. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem cuam tshuam rau kev ua ub no thiab kev ua haujlwm ntawm kev tiv thaiv kab mob, tswj cov xov tooj hauv tsev thiab sib npaug ntawm lub cev tiv thaiv kab mob. Qhov kev tshawb fawb no muab cov tshuaj uas lub hom phiaj tshiab rau kev txhim kho ntawm anti {}}}}}}}}}} pamomodulatory.
Cov tshuaj tiv thaiv tsis zoo
Staurosporineyog ntuj alkaloid cais los ntawm cov kab lis kev cai ntawm cov kab lis kev cai ntawm cov kab lis kev cai ntawm cov kab lis kev cai, tab tom nrog cov tub ntxhais kawm accboxylic acid class acid chav kawm. Raws li dav -} spectrum protein kinase bindoritor, inhibiting kev sib tsoo, inhibiting kev sib tw, kev sib tw ntawm xov tooj ntawm tes, thiab txoj kev muaj sia nyob ntawm lub xov tooj ntawm tes. Nws cov qauv tshuaj lom neeg thiab cov qauv tshuaj lom neeg ua nws cov cuab yeej tseem ceeb rau kev kawm ntawm xov tooj ntawm lub cev, kev kho mob cancer, thiab kev txhim kho mob cancer. Txawm li cas los xij, nws cov teebmeem muaj zog tseem muaj nrog cov kev tsis zoo, txwv nws daim ntawv thov kho mob.
Cytotoxicity
Cell tuag hauv hauv Vitro Cell kev sim
Staurososporine tuaj yeem ua rau apoptosis hauv ntau Jurmat t hlwb thiab hela} μ {μ m), thiab tsim ntawm hypodiploid peaks. Kev ua tau zoo ntawm kev ua kom raug induction yog ze rau lub sijhawm thiab siab ntawm kev nqis tes ua, thiab qhov tseem ceeb cell tuag feem ntau yuav pom nyob hauv 2-3 teev.
Cuam tshuam rau cov hlwb ib txwm
Txawm hais tias Staurosporine muaj kev xaiv dag zog rau cov qog nqaij hlav, muaj kev lom zem rau cov kabmob tsis zoo xws li kev tuag otothel, ua rau cell tuag lossis ua haujlwm tsis taus. Piv txwv li, hauv corneal agothelial induces apoptosis los ntawm kev ua kom tiav Caspase-3, uas tuaj yeem cuam tshuam rau cineeal pob tshab thiab kev ua haujlwm.
Organial SPOXICITY
Mob siab yog toxicity
Mechanism: Staurosporine tuaj yeem ua rau lub siab muaj cov kev puas tsuaj los ntawm kev ua haujlwm ntawm lub siab thiab cov khoom siv cellular thiab detoxification muaj nuj nqi. Ib qho ntxiv, cov oxidative kev nyuaj siab thiab mitochondrial ua rau tsim txom los ntawm nws yuav ntxiv exacerbate txiav txim siab.
Cov kev kho mob ua haujlwm: Hauv kev sim tsiaj, high {{}} Koob tshuaj rau cov dej hiav txwv uas tsis tau), epatocyte necrosis, thiab mob hlwb ntawm tes. Hauv kev tshawb fawb preclinical, kev saib xyuas ze ntawm daim siab ua haujlwm ntsuas yog qhov tsim nyog.
Cov ntshav npau suav
Mechanism: Staurosporine yuav inhein kineses nyob rau hauv lub raum tub rog, cuam tshuam rau CytoKelial sib txuas, ua kom lub raum tsis sib xws. Tsis tas li ntawd, nws qhov kev ua phem rau lub plab zom mov cov tubrog uas raug mob hnyav.
Cov kev kho mob ntawm cov tsiaj: hauv cov tsiaj tsiaj, raug rau cov tsiaj txhu tuaj yeem ua rau cov ntshav muaj zog ntxiv, thiab ua rau tubular ua paug. Lub raum lom txoj kev pheej hmoo yuav tsum tau ntsuas hauv cov ntawv thov kev kho mob.
Cardiotionoxicity
Mechanism: Kev inhibition ntawm cov protein kinases (xws li PKC thiab CDK thiab Cell Kev Cog Lus Ua Haujlwm thiab ua rau Myocardial cell Apoptosis lossis Necrosis.
Cov chaw kho mob: Muaj koob tshuaj rau staurosporine tej zaum yuav ua rau cov koom ua haujlwm arhythmia, txo cov kev ua haujlwm hauv Myocardial, thiab cov mob plawv. Electrocardiogram thiab cardiac Ultrasound Qhov ntsuas yuav tsum tau raug saib xyuas hauv cov kev tshawb fawb preclinical.
Neurotoxicity
Mechanism: Staurostrerine yuav cuam tshuam nrog NeuroTransmitter tso tawm, xws li PKA thiab CDKS Ciaj sia los ntawm Inhibling Protein Kinases los ntawm Neuricals, ua rau Neurological Tysfunction.
Cov kev kho mob manifestents: hauv kev sim tsiaj, raug rau Staurosporine tuaj yeem ua rau Neuronal Apoptosis, thiab kev coj cwj pwm, thiab kev coj cwj pwm. Ceev faj txog kev pheej hmoo ntawm neurotoxicity hauv cov ntawv thov kev kho mob.
Cim npe nrov: Staurosporine CAS 62996-74-1, Cov neeg muab khoom, chaw tsim khoom, chaw tsim khoom, chaw tsim khoom, lag luam Wholesale, yuav, nqe, loj, loj, rau muag