Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov khoom lag luam ntawm Rapamycin Hmoov CAS 53123-88-9 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo rapamycin hmoov CAS 53123-88-9 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Hmoov rapamcin hmoov, tseem hu uasirolimus, yog daj cov tawv khov khov ua ke nrog cov tshuaj noj c51H79Tsis muaj13, lipophilic, soluble hauv cov kuab tshuaj organic,} he} Hexane he} hexane, yuav luag Intoluble hauv ether, yog qhov immunosuppressant tshiab. Nws yog dawb rau milky dawb crystalline khoom, feem ntau nyob rau hauv daim ntawv ntawm rab koob zoo li cov muaju lossis crystalline hmoov. Nws yog insoluble hauv dej nyob rau hauv chav tsev nyob rau hauv chav tsev kub, soluble me ntsis hauv cawv thiab chligoform, thiab solubleorm, thiab solublem sulfoxide. Nws solubility yog heev cuam tshuam los ntawm cov kuab tshuaj thiab kub. Tus me nyuam ruaj khov nyob rau hauv lub teeb thiab cua sov mob, tab sis rhiab rau cov kua qaub thiab alkalis. Nyob rau hauv acidic tej yam kev mob, rapamycin yuav maj mam decompose, yog li nws yog ib qho tsim nyog kom tsis txhob sib cuag nrog cov tshuaj acidic muaj zog.
Tsis tas li ntawd, RapamyCin muaj solubility tsis muaj dej hauv dej, yog li nws yuav tsum cia kom qhuav thaum lub sijhawm cia. Cov qauv molecular muaj cov nplhaib loj sab hauv thiab lub nplhaib sab hauv. Nws sab hauv nplhaib yog tsim ntawm plaub fused macrocycles, tsim tus qauv zoo ib yam li macrolides. Lub caij no, lub nplhaib sab nraud ntawm rapamycin yog suav nrog ntau cov pa oxygen heteroccles thiab sabins. Cov qauv qauv molecular txiav txim siab txog kev ua haujlwm roj ntsha thiab kev sib cuam tshuam hom ntawm rapamycin. Qhov loj me me thiab thaj chaw tshwj xeeb muaj cov teebmeem tseem ceeb rau nws cov solubility, kev ruaj khov, thiab kev xa tshuaj kom ruaj khov, thiab tshuaj muaj yees. Los ntawm kev tswj cov kev loj hlob siv lead ua thiab kev xaiv cov kuab tshuaj thaum lub sijhawm crystallization, qhov loj me thiab morphology ntawm rapamcin hais tuaj yeem hloov kho. Nws yog ib qho khoom lag luam uas dav siv nyob rau hauv cov qauv ntawm cov tshuaj thiab kev siv tshuaj. Nws tau pom tias muaj cov kev ua si lom neeg lom neeg thiab tuaj yeem siv rau kev kho mob qog noj ntshav, hloov kev tsis lees paub, kab mob autoimmune, thiab lwm yam.
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Tshuaj Cov Qauv |
C51h79No13 |
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Muaj pes tsawg leej |
914 |
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Molecular hnyav |
914 |
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m/z |
914 (100.0%), 915 (55.2%), 916 (14.9%), 916 (2.7%), 917 (1.8%), 917 (1.5%) |
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Kev Ntsuam Xyuas |
C, 67.01; H, 8.71; N, 1.53; O, 22.75 |
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Hmoov rapamcin hmoov(Kev Lag Luam Lub Npe Sirolimus) yog mactrocyclic lactone sib xyaw los ntawm av kab mob streptomyces. Txij li thaum nws tshawb pom, nws qhov tshwj xeeb mtor (cov hom phiaj Mtor (Mammalian lub hom phiaj Protein)
1. Anti kev xyeej pov tseg tom qab hloov chaw nruab nrog cev
Nws yog qhov kev immosuppressant nyob hauv thaj chaw nruab nrog cev, tshwj xeeb yog tsim nyog rau kev phais mob xws li lub raum hloov thiab daim siab hloov ntshav
Mechanism ntawm Kev Ua: Los ntawm kev khi rau lub cev tsis muaj affinity protein fkbp12, ib txoj kev nyuaj yog tsim kom inhibit txoj haujlwm ntawm mtor. Mtor yog qhov tseem ceeb tswj hwm rau kev ua haujlwm protein encein, kev sib tw ntawm tes, thiab kev ciaj sia taus. Inhibiting nws cov kev ua dej num tuaj yeem txo cov kev muaj peev xwm ntawm t hlwb thiab borase lub cev tsis muaj zog tsim los ntawm cytokines xws li IL-2 thiab IL-4.
Cov kev kuaj mob: piv nrog cov tshuaj tiv thaiv kab mob hauv qabos, nws tsis cia siab rau lub raum lom zem, thiab muaj qhov zoo dua qub Intitional. Piv txwv li, hauv cov neeg mob raum hloov pauv, kev sib xyaw ua ke thiab nce ib qho{{15}}} xyoo ciaj sia ntawm transplanted cov plab hnyuv siab rau ntau tshaj 90%.
2. Anti qog kev kho
Thiab nws cov derivatives (xws li eventolimus) qhia muaj peev xwm nyob hauv ntau cov kev kho cov qog ua ke los ntawm kev ua haujlwm me me "
Kev kho mob qog nqaij hlav: ua tau zoo rau cov qog nqaij hlav xws li lub raum carcinoma, mob cancer mis thiab mob ntsws. Piv txwv li, hauv cov neeg mob uas yog Metastatic Lub Cev Hluav Taws Xob Carcinoma, Kev Ua Phem Ua Ntej Tsis Muaj Peev Xwm Ua Ntej Muaj sia nyob rau 6.9 lub hlis, nce ntxiv piv rau Monotherapy rau Monotherapy.
Hematological malignancies: hauv Mantle cell liymmphoma, apoptisis ntawm cov qog nqaij hlav tuaj yeem tsim tawm, nrog ib lub hom phiaj kev txhawb nqa ntawm 40%.
Ua ke kho lub tswv yim: Thaum siv hauv kev sib xyaw nrog cov tshuaj orsiogenic (xws li Bevacizumer), nws tuaj yeem ua ke tsis pub lwm tus neeg mob qog ntawm cov qog ntawm cev thiab ua kom loj hlob. Hauv tsis - Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Tag nrho yog txuas ntxiv los ntawm 3.2 lub hlis piv rau pab pawg Monotherapy.
Kev Ntsuas Mechanicial: Cov Cai Txhim Kho ntawm MTOR Signaling Txoj Kev
1. Txoj haujlwm tseem ceeb ntawm mtor signaling txoj kev
Hmoov rapamcin hmoovYog tus tseem ceeb molecule rau cov txheej txheem kev pab cuam uas muaj protabellular, cov khoom siv protein, thiab lub zog ua hluav taws xob, thiab lub zog lipid metabolism, lipid metabolism, thiab autophagy. Nws qhov kev ua haujlwm txawv txav yog cuam tshuam nrog cov qog, thiab kev laus.
2. Lub inisitosity nyhuv ntawm rapamycin ntawm mtor
Ncaj nraim Inhibition: Tom qab khi rau FKBP12, nws tshwj xeeb inhibits MTORC1 (mtor ua kom muaj kev ua kom muaj zog 1), ua kom muaj protein synthesis thiab kev ua voj voog ntawm tes.
Indirect cov kev cai: los ntawm kev ua kom cov organagy, puas nyob rau hauv lub cell yog tshem tawm, tswj hwm ntawm lub tsev pheeb suab. Piv txwv li, hauv Alzheimer tus qauv qauv, cov kev qhia ntawm autophagy marker LC3 {} II tuaj yeem nce thiab - amyloid outpose tuaj yeem txo.
3. Lub mult - txoj kev ua haujlwm ntawm kev tiv thaiv kab tiv thaiv kab mob
Tell inhibition: nws tuaj yeem inhibit ua kom lub zog, thiab cytokine tso tawm ntawm t hlwb ntawm effector t hlwb ntawm cov plab hnyuv siab raum rau cov plab hnyuv siab raum.
B - cell kev cai: los ntawm kev sib txawv ntawm B Cell rau hauv Plasma kev tsim tawm, nws txo tau kev lom zem tsis muaj zog,
Dendritic Cell cuam tshuam: tuaj yeem ua rau cov cell kev thev taus, txhawb nqa tiam kev tswj hwm t hlwb (tregs), thiab txuas ntxiv ntawm kev tiv thaiv kab mob ntawm cov tshuaj tiv thaiv kab mob.
Kev Tshawb Fawb Txog Kev Tshawb Fawb: Los ntawm anti -}}}}}}}}}}}} aging rau neuroprotection
1. Sib tawg hauv anti -} kev tshawb fawb
RapamyCycin yog thawj cov tshuaj muaj pov thawj rau lub sijhawm ntev ntawm cov qauv muaj qauv:
Qauv Txheej Txheem: Hauv cov nas, rapamcin tuaj yeem txuas lub neej ntawm cov poj niam nas los ntawm 14% thiab txiv neej nas los ntawm 9%. Lub tshuab siv hluav taws xob yuav cuam tshuam nrog txo cov oxidative kev nyuaj siab, inhibiting teb, thiab txhawb kev hloov kho autophagy.
Tib neeg daim ntawv thov lub peev xwm: Kev sim kuaj mob tsom mus rau cov neeg laus (6mg ob zaug hauv ib lub lim tiam, thiab tsis muaj kev phiv loj heev tau pom.
2. Kev kho mob ntawm cov kab mob neurodegenerative
Rapamycin qhia cov peev xwm hauv cov kab mob neurodegenerative xws li Alzheimer tus kab mob thiab Parkinson tus kab mob:
Alzheimer tus kab mob: inhibiting mtor signaling txoj kev tuaj yeem txo tau los tau tsim cov protein hyperphosphorylation thiab txhim kho kev ua haujlwm. Hauv tus qauv hloov transgenic, tom qab cov thawj coj txuas ntxiv mus rau 6 lub hlis, kev tsis paub meej lub peev xwm txhim kho los ntawm 30%.
Tus kab mob Parkinson tus kab mob: tuaj yeem tiv thaiv dopaminininergic neurons thiab txo alpha synuclein kev sib sau ua ke. Hauv cov qauv ntawm tes, kev ua tau tuaj yeem ua kom nce tus nqi ntawm neurons los ntawm 40%.
3. Kev cuam tshuam rau cov kab mob metabolic
Nws tuaj yeem tswj cov metabolic syndrome thiab ntshav qab zib:
Insulin rhiab heev: rapamycin tuaj yeem txhim kho cov ntshav siab tiv thaiv thiab txo qis cov ntshav qab zib. Cov txheej txheem yuav cuam tshuam nrog kev cuam tshuam ntawm MTORC2 (mtor complex 2), tab sis nws yuav tsum tau sau tseg yuav inhibit mtorc2 thiab ua rau kom cov ntshav qab zib.
Rog metabolism: nws tuaj yeem txo cov kev sib txuam ntawm dawb cov ntaub so ntswg, nce cov kev ua si ntawm cov rog xim av, thiab yog li txhim kho kev rog cov metabolic cuam tshuam.
1. Kev tiv thaiv tawm tsam cov kab mob plawv
Hmoov rapamcin hmoovCoated stents yog qhov kev nce qib tseem ceeb hauv txoj kev kho mob cardiovascularions:
Kev tiv thaiv nyob rau hauv stent ripenosis: rapamcin tuaj yeem cuam tshuam cov procliver du cov leeg thiab txo qhov tshwm sim ntawm lub hauv kev noj haus stentosis. Cov kev tshawb fawb soj ntsuam tau pom tias cov rapamycin coated stents txo cov nyiaj rov qab los ntawm 20% rau hauv qab 5%.
Atherosclerosis cuam tshuam: los ntawm inhhhiting mtor signaling txoj kev, nws tuaj yeem txo cov hlwb ntawm cov hlwb thiab ncua kev nce qib ntawm atherosclerosis.
2. Cov tshuaj tiv thaiv thiab anti kis
Muaj kev cuam tshuam los ntawm ntau yam kab mob:
Kev ua kom muaj kev tiv thaiv kabmob HIV: tuaj yeem ntxias tus kab mob HIV ntawm Latent Statent, muab cov cuab yeej rau lub "kev poob siab thiab tua" lub tswv yim.
Kev tiv thaiv cyvoWius tiv thaiv: hauv cov neeg mob hloov khoom nruab nrog cyvantirovirus kis tau thiab muaj txiaj ntsig zoo dua li siv ganciclovir ib leeg.
3. Cov tshuaj kho mob thiab kev kho kom haum
Biomarker taw qhia: los ntawm kev ntes cov kev ua ntawm MTOR signaling pathway (xws li cov neeg mob PSY6K1, cov pej xeem ntawm cov neeg mob nkag siab los txhim kho kev kho mob.
Ua ke ntawm cov immunotherapy: thaum siv hauv kev sib xyaw nrog pd - 1 / PD-L1 tus neeg nyob inhibitors, nws tuaj yeem txhim kho t cell kev ua si. Hauv melanoma, lub hom phiaj kho mob ntawm pab pawg kws kho mob yog 20% siab dua li ntawm cov pab pawg monotherapy.
Peb yog tus xa khoom ntawmHmoov rapamcin hmoov.
Cov lus hais: Bloom Tech (Txij xyoo 2008), ua tiav chem - tech yog cov neeg pabcuam ntawm peb.
US PATATE Kev Ntsuam Xyuas PATE qhia meej US20199932A1 nthuav tawm cov txheej txheem lim dej thev naus laus zis ntawm rapamycin. Lub purity ntawm cov khoom siv huv los ntawm fermentation broth yog 98.8%, tag nrho cov ncauj lus tsis loj dua yog tsawg dua 12%, thiab ib tus neeg Irurity tsawg dua 0.15%. Cov phiaj xwm huv si yog raws li hauv qab no:
Rapamcin hauv fermentation broth tau muab rho tawm nrog hydrophobic kuab thiab muaj zog;
Ntxiv Hydrophilic Hneev Kom cais impurities;
Cov khoom tau txais nyob rau hauv cov kauj ruam yog adsorbed ntawm ib qho inert tus inert, txuas ntxiv ntxuav nrog alkali thiab acid, thiab tom qab ntawd eluted;
Sau cov EL
Crystallizing cov khoom tau txais hauv kauj ruam d);
Dissolve cov khoom crystalline hauv kauj ruam F thiab ua hydrophobic txiav txim lossis rov qab ib ntu cov chromatography; Thiab g yog recrystallized kom tau rapamycin nrog siab purity, tab sis lub purification tawm los tsis muaj siab. Hauv qhov piv txwv tshwj xeeb, nws tuaj yeem pom tau tias cov khoom muag kawg ntawm 11kg RapamyCin Fermentation BROTION yog 6G, thiab 3G cov khoom ntshiab tau ua kom huv ntxiv thiab muaj 2.5g.
Synthesis ntawm RapamyCin: tus tseem ceeb ntawm rapamycin biosynthesis ua tiav los ntawm polyneide synthease hom 1 (pks}} ribosomal peptase (NRPS). Lub enzyme sau ntawm rapamycin linear biosintheside muaj peb enzymes, suav nrog RAPA, RAPB thiab RAPC, uas muaj 14 modules. Ntawm peb enzymes, rapa ua tiav thawj plaub polymeride synthesis cov saw txuas ntxiv, rau hauv rapb, thiab plaub kawg hauv rapc. Tom qab ntawd, linear Polymeride synthesis tau hloov kho los ntawm NRPs (Rapp), thiab l} hexahydropyridine carboxylic acid tau ntxiv rau ntawm polyneide synthesis davhlau ya nyob twg. Thaum kawg, cov molecular cyclization ua rau cov khoom ua ntej ua ntej, prerapamycin.
Tus tseem ceeb macrocycle ntawm pre - rapamycin yuav kawg daim ntawv rapamycin los ntawm kev hloov kho tsib enzymes. Firstly, tus tseem ceeb macrocycle tau hloov kho los ntawm rapi, adenosine methionine-}} olygen oxygen pethylase (mthease), thiab C39 yog meTOXYYYYRATE. Thib ob, los ntawm rapej, cytochrome p450 hloov kho, c9 ntxiv carbonyl. Thib peb, lwm methylase, rapm metoxy c16. Plaub, lwm P-450, rapn, yog hydroxylated ntawm C27, ua raws li methylases sib txawv, rapq methoxylates C27 los ua daim ntawv rapamycin.
Hmoov rapamcin hmoov(Kuj tseem hu ua "Sirolimus") yog ib qho kev ntsuas metabolite theem nrab, uas tau pom thawj zaug los ntawm cov av Easter, Chile nyob rau xyoo 1975. Tau pom tias muaj immunosuppressive nyhuv xyoo 1977. Xyoo 1989, Rapa tau sim ua cov tshuaj tshiab los kho cov khoom nruab nrog cev. Vim tias cov khoom noj tsawg ntawm rapamycin thiab cov txheej txheem nyuaj, cov khoom lag luam tsis tau ua tiav thiab ua tiav IT III cov kev sim siab tau ua haujlwm. Tom qab, nws tau teev nyob rau ntau tshaj kaum lub tebchaws nyob teb chaws Europe thiab Amelikas.
Lub sijhawm ntawd, kev taw qhia ntawm RapamyCin pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj (FDA) tsis yog tshuaj tua kab mob tab sis "immunosuppressants". Qhov no yog vim tias rapamycin tau qhia muaj kev txhaj tshuaj tiv thaiv kab mob muaj zog hauv kev sim tshuaj, thiab nws tuaj yeem hloov cov kev sim tshuaj cyclosporine ntau dua 30 xyoo. Ntxiv mus, piv nrog cyclosporine, lub qhov ncauj ua kua rapamycin muaj qhov quav me dua (tsuas yog 2-3mg toj ib zaug los xij Yog li ntawd, rapamyCin tau dhau los ua ib qho kev imolosuppressant rau kev hloov khoom nruab nrog cev nruab nrab thoob ntiaj teb txij li nws cov npe.
Cov khoom lag luam rapamycin, cov khoom lag luam tshiab hu ua lub sijhawm 20th lig, muaj keeb kwm kev tshawb fawb thiab muaj tswv yim hauv cov ntaub ntawv thov kev lag luam. Nws yug tsis tsuas yog muab cov kev kho mob tshiab rau cov tshuaj niaj hnub, tab sis kuj teeb tsa lub cim tshiab rau kev tshawb fawb thiab tshuaj kho.
Zaj dab neeg pib thaum xyoo 1964 thaum xibfwb Stanley Scolina Scolina los ntawm McGill University hauv Canada tau sau cov av uas sau av hauv Canada. Qhov kev ua yeeb yam zoo li no tau tso cov hauv av rau kev txhim kho ntawm rapamycin. Professor skolina tau muab cov qauv sau rau hauv chav kuaj Wyh ntawm Wyh tus kws tshuaj, vam tias yuav tau pom cov tshuaj tua kab mob tshiab los ntawm lawv.
Tom qab xyoo ntawm kev tshuaj xyuas thiab tshawb fawb, cov kws tshawb fawb ntawm kev kho mob ntawm cov poov xab tau cais tawm ntawm cov av hauv av hauv xyoo 1972. Qhov no tau pom zoo heev ntawm kev muaj peev xwm tiv thaiv kev tiv thaiv kab mob. Qhov kev tshawb pom no tau ua rau pom kev txaus siab ntawm cov kws tshawb fawb nyob rau hauv cov khoom muaj peev xwm ntawm cov tshuaj no.
Xyoo 1980s, nrog kev nce qib txuas ntxiv ntawm kev tshawb fawb thiab thev naus laus zis, cov kws tshawb fawb maj mam tob tob rau lawv cov kev tshawb fawb ntawm rapamycin. Lawv pom tias rapamycin tsis yog tsuas yog tiv thaiv kev nthuav dav ntawm cov neeg tiv thaiv kab mob, tab sis kuj tseem muaj cov nyhuv hauv cov qog nqaij hlav. Qhov kev tshawb pom no tau qhib txoj kev tshiab rau daim ntawv thov ntawm RapamyCin hauv lub tshav ntawm cov chaw tshuaj.
Nyob rau hauv 1999, Asmeskas Kev Tswj Xyuas Khoom Noj thiab Tshuaj Siv (FDA) Qhov kev tshwm sim no cim tau qhab nia ntawm rapamcin los ntawm kev kuaj mob rau cov neeg kho mob, nqa cov xov xwm zoo rau cov neeg mob suav tsis txheeb.
Nyob rau lub xyoo pua 21st, nrog rau kev txhim kho sai ntawm kev tshawb fawb kev tshawb fawb thiab thev naus laus zis, kev sib tawg tshiab tau ua rau hauv kev tshawb fawb ntawm RapamyCin. Cov kws tshawb fawb tau pom tias ob lub derivatives ntawm rapamycin, tamoximus thiab Everolimus, tau pom muaj peev xwm ua rau mob cancer ntawm kev kho mob cancer. Ob cov tshuaj no tau tsim los ntawm Pfizer thiab Novartis ntsig thiab tau ua tiav zoo hauv kev tshawb fawb.
Qhov tseem ceeb tshaj plaws tau ua nyob rau hauv kev kawm ntawm rapamycin hauv lub sijhawm ntev. Hauv xyoo 2009, Randy muaj zog chav kuaj ntawm lub koom haum Bashup rau kev sim siab thiab Ricrison A. RapamyCin tuaj yeem nthuav tawm lub neej ntawm cov nas. Qhov kev tshawb fawb no muab cov tswv yim tshiab rau daim ntawv thov ntawm rapamycin hauv thaj chaw anti {5} {} {{}- kev laus.
Nrog kev txuas ntxiv mus tob zuj zus ntawm kev tshawb fawb ntawm lub hom phiaj thiab cov kws tshawb fawb tshiab, pom tias nws kuj muaj cov nqi kho mob muaj peev xwm ua rau lwm yam kab mob. Piv txwv li, cov kws tshawb nrhiav los ntawm xi'an jiaotong University tau lees tias cov tsos mob rapamycin tuaj yeem txhim kho cov tsos mob ntawm cov neeg mob ntawm cov neeg mob los ntawm hom phiaj cd 4+ ctl hlwb. Qhov kev ua tiav no muab cov kev taw qhia tshiab rau daim ntawv thov ntawm Rapamycocin hauv thaj teb ntawm Ophthalmology.
Saib rov qab rau ntawm kev txhim kho keeb kwm ntawmnws, Peb tuaj yeem pom tias nws tau dhau mus lawm los ntawm kev tshawb nrhiav kev paub txog kev tshawb fawb thiab kev kho mob, los ntawm cov khoom siv kho kom yooj yim los ua cov khoom muaj nqis ntawm cov khoom siv niaj hnub no. Thaum lub sijhawm tus txheej txheem no, kev sib koom tes ntawm cov neeg paub ntau thiab cov tuam txhab uas muag tau nqa cov yeeb yaj kiab no rau peb nqa. Yav tom ntej, nrog kev nce qib txuas ntxiv ntawm kev tshawb fawb thiab thev naus laus zis thiab kev txhawb nqa ntawm cov kev cia siab ntawm rapamycin yuav muaj dav dav.
Cov hmoov nplej yog siv los ua kev txhaj tshuaj tiv thaiv kab mob feem ntau kom qeeb lub zog tsis muaj zog tom qab hloov chaw hauv nruab nrog hloov. Txawm li cas los xij, nws siv yog nrog ntau qhov kev mob tshwm sim los yog kev cuam tshuam zoo. Qee qhov kev mob tshwm sim loj lossis cov kev tsis zoo muaj nyob hauv qab no:
1. Lub cev tsis taus
Txo kev tiv thaiv: RapamyCin ntau dua cov nyhuv immunosuppressive cuam tshuam los ntawm inhibiting cov prolferation thiab signaling ntawm t lymphocytes thiab lwm lub hlwb. Qhov no yuav ua rau cov neeg mob tau mob kis tau ntau dua li cov kab mob, fungal, kis tau thiab lwm yam kis tau.
2. Ntshav Ntshav
Thrombocytopia: RapamyCin yuav cuam tshuam hematopoiesis, ua kom txo qis hauv platelet suav thiab muaj kev pheej hmoo los ntshav.
Leukopenia: Cov qe ntshav dawb yog qhov tseem ceeb ntawm kev tiv thaiv kab mob ntawm lub cev thiab lawv qhov kev txo qis tuaj yeem ua rau tus neeg mob tiv thaiv tsis taus ntxiv.
Anemia: Vim yog hemaired hematopoiesis, cov neeg mob kuj tseem tuaj yeem hnov Anemia.
3. Cov teeb meem metabolic thiab cov khoom noj muaj txiaj ntsig
Nce cov ntshav dej siab thiab cov roj (cholesterol) ntev npaum li cas ntawm rapamycin tuaj yeem ua rau dyslipidemia thiab nce kev pheej hmoo ntawm cov kab mob plawv.
4. Kev tawm dag zog lub cev
Xeev siab thiab ntuav: cov no yog cov kev tawm tsam uas muaj kev cuam tshuam uas yuav cuam tshuam rau tus neeg noj qab los noj mov thiab cov khoom noj muaj txiaj ntsig zoo.
Yuav tsum muaj daim siab daim siab rau daim siab: Qhia tau daim siab puas thiab yuav tsum tau saib xyuas lub siab ua haujlwm.
5. Lwm qhov kev cuam tshuam uas tsis zoo
Tawg siab: RapamyCin yuav ua rau muaj ntshav siab nce ntxiv rau ntshav siab thiab hloov kho ntshav siab thiab hloov kho ntawm kev kho mob.
Cov pob tshuaj pob, ntxau: Qee cov neeg mob tuaj yeem tsim kev ua txhaum cai xws li rho tshuaj tawm tshuaj thiab pob txuv.
Ua kom muaj kab mob nce: Cov neeg mob yuav raug kis tau rau ntau yam kis tau rau ntau yam kev tiv thaiv kev tiv thaiv.
Cim npe nrov: Rapamcin Hmoov Cas 53123-88-9, Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, lag luam Wholesale, Yuav, Ntaus, Loj, Rau Cov Muag Khoom