Syn Ake Powder

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm syn ake hmoov nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo syn ake hmoov rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Syn Ake Powder, INCI lub npe Dipeptide Diaminobutyroyl Benzylamide Diacetate, yog cov khoom siv dav siv biomimetic cosmetic peptide raw khoom. Ua raws li lub hauv paus ntsiab lus tseem ceeb ntawm lub tuam tsev viper venom, nws relaxes lub ntsej muag nqaij contraction kom du kab, crow ko taw thiab hauv pliaj wrinkles. Cov hmoov muaj cov dej solubility zoo heev, yooj yim los tsim rau hauv cov tshuaj pleev, cream thiab lwm yam khoom siv tawv nqaij. Raws li tus kws tshaj lij peptide tus neeg muag khoom, peptide muab siab purity Syn Ake Powder nrog cov qauv thiab ntau cov khoom muaj, tag nrho COA & TDS cov ntaub ntawv los txhawb cov tshuaj pleev ib ce R & D thiab kev tsim khoom.

Certificate of Analysis
Compound npe	Dipeptide diaminobutyroyl benzylamide diacetate
Qib	Pharmaceutical qib
CAS Nr.	823202-99-9
Ntau	18g
Ntim txheem	PE hnab + Al foil hnab
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202601090085
MFG	Peb 9, 2026
EXP	Peb 8, 2029
Qauv
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.85%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.32%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.63%
Ib qho impurity	<0.8%	0.57%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	533
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	5 77ppm
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree

Hauv kev lag luam niche ntawm neurotransmitter- tswj kev tiv thaiv -aging peptides,Syn Ake Powdertsis yog ib qho kev sib cais active molecule, tab sis, theej, ua ke nrog cov khoom xyaw xws li Argireline (acetyl hexapeptide-8), Leuphasyl (pentapeptide-18), SNAP-8 (acetyl hexapeptide-}3), thiab Matrixyl 3000-pentapeptide (3000), toxin-zoo li" thiab signaling peptide matrix nyob rau hauv lub khw muag khoom kom zoo nkauj. Txawm li cas los xij, raws li kev txheeb xyuas qhov tob ntawm molecular topology, receptor-binding kinetics, teeb liab txoj hauv kev, thiab bioavailability, SYN-AKE qhia txog qhov sib txawv ntawm qhov zoo ntawm qhov tseeb ntawm nws cov txheej txheem ntawm kev ua, kev ua tau zoo, thiab kev nyab xeeb profile.

Qhov tshwj xeeb ntawm Lub Hom Phiaj thiab qhov sib txawv hauv Receptor Binding Kinetics
SYN-AKE's core kev sib tw kom zoo dua yog los ntawm nws qhov tshwj xeeb lub hom phiaj muaj peev xwm ntawm nicotinic acetylcholine receptors (nAChR) ntawm neuromuscular junction (NMJ). nAChRs yog nyob rau ligand-gated ion channel superfamily; functional receptors feem ntau txais yuav cov qauv pentameric muaj li ntawm 2 δ (fetal type) lossis 2 εδ (tus neeg laus) subunits. Cov qauv tsim molecular ntawm SYN-AKE tau tshwm sim los ntawm Waglerin-1 protein pom nyob rau hauv cov venom ntawm Malaysian mangrove viper (Trimeresurus wagleri), uas nws cov amino acid sequence {beta-Ala}-Pro-{Dab-NHBallyactive fragment} Waglerin-1, ua kom nws paub meej thiab khi rau qhov chaw tshwj xeeb khi ntawm ε subunit (lub subunit hauv hom fetal) ntawm nAChR.

Qhov kev khi no ua raws li kev sib tw antagonistic mechanism: SYN-AKE sib tw nrog acetylcholine (ACh) rau qhov chaw sib khi ntawm cov receptor; Txawm li cas los xij, thaum khi, nws tsis ua rau muaj kev hloov pauv hauv cov ion channel. Hloov chaw, nws kaw cov receptor nyob rau hauv lub xeev kaw, tiv thaiv lub transmembrane ntws ntawm sodium ions (Na⁺) thiab poov tshuaj ions (K⁺), yog li inhibiting lub depolarization ntawm lub postsynaptic daim nyias nyias thiab thaiv cov tiam thiab conduction ntawm tej yam muaj peev xwm. Nyob rau hauv sib piv, lub mechanism ntawm kev txiav txim ntawm Argireline (acetyl hexapeptide-8), uas nws ib theem zuj zus yog Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂, yog txawv kiag li. Nws feem ntau ua raws li N-terminal sequence ntawm SNAP-25 protein nyob rau hauv SNARE complex (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor), sib tw khi rau syntaxin thiab VAMP/synaptobrevin,

cuam ​​tshuam kev sib sau ua ke ntawm SNARE complex, yog li inhibiting fusion ntawm synaptic vesicles nrog presynaptic membrane thiab txo qhov tso tawm ntawm ACh. Hauv lwm lo lus, SYN-AKE ua rau ntawm qhov kawg receptor kawg ntawm postsynaptic membrane kom ncaj qha thaiv cov teeb liab txais tos, thaum Argireline ua rau qhov kawg ntawm lub presynaptic membrane kom txo cov teeb liab kis. Los ntawm cov tshuaj pharmacological, qhov kev txiav txim ntawm postsynaptic receptor antagonism yog ncaj qha, nrawm, thiab tswj tau, qhov uas presynaptic tso tawm inhibition cuam tshuam nrog kev tawm tswv yim cov txheej txheem uas yuav ua rau kom them nyiaj ntau ntxiv hauv kev tso tawm, cuam tshuam rau kev ruaj ntseg ntawm kev ua haujlwm ntev -lub sij hawm ua tau zoo. Leuphasyl (pentapeptide ntawm kev ua haujlwm), tab sis nws zoo sib xws {6} sequence is Tyr-D-Ala-Gly-Phe-Leu. Nws feem ntau ua raws li cov qauv ntawm endorphins thiab tswj cov neuropeptide tso tawm los ntawm activating opioid receptors;

nws txoj kev ntawm kev ua yog ntau indirect, thiab nws potency yog kuj tsis muaj zog. SNAP-8 (acetyl octapeptide-3) yog ib qho txuas ntxiv ntawm Argireline uas txhim kho kev ua tau zoo los ntawm kev ua kom muaj kev sib raug zoo rau SNARE complex; Txawm li cas los xij, nws tseem yuav raug txwv los ntawm cov kev txwv ntawm presynaptic mechanisms ntawm kev ua. Matrixyl 3000 (palmitoyl pentapeptide-4) belongs rau qeb ntawm kev taw qhia peptides. Nws lub luag haujlwm tseem ceeb yog txhawm rau txhawb collagen thiab fibronectin synthesis hauv fibroblasts los ntawm kev ua kom TGF- signaling txoj hauv kev, yog li ua kom yooj yim kev tsim kho ntawm cov dermis es tsis tswj cov teeb liab ntawm qhov sib txuas neuromuscular. Yog li ntawd, nws cov txheej txheem ntawm kev ua yog txawv kiag li ntawm SYN-AKE nyob rau hauv cov nqe lus ntawm tam sim ntawd wrinkle txo thiab kev txhim kho ntawm dynamic wrinkles.

Lub molecular tsim ntawmSyn Ake Powdersuav nrog ntau yam tsis yog-natural amino acid hloov kho, uas sawv cev rau qhov txiaj ntsig tseem ceeb ntawm kev ruaj ntseg piv rau lwm cov kab peptides.

Ua ntej, N-terminal -alanine (-Ala) yog ib qho tsis yog-proteinogenic amino acid. Piv nrog rau cov pa -amino acids, kev taw qhia ntawm -Ala hloov lub ntsiab - chain conformation ntawm peptide, ua rau cov molecule rigidity thiab ua rau nws nyuaj rau endogenous aminopeptidases kom paub thiab cleave nws. Thib ob, Dab (diaminobutyric acid) residue nyob rau hauv cov kab ke tau hloov kho ntawm benzylamidation (Dab-NHBzl); Qhov kev hloov kho no tsis yog tsuas yog ua raws li cov tshuaj tseem ceeb hauv ntuj Waglerin-1 tab sis kuj tiv thaiv peptide daim ntawv cog lus los ntawm hydrolytic nres los ntawm endopeptidases los ntawm steric hindrance.

Tsis tas li ntawd,Syn Ake Powdermuaj nyob rau hauv daim ntawv ntawm diacetate; kev taw qhia ntawm pab pawg acetate txhim kho cov molecule cov dej solubility thiab crystalline stability, ua kom nws muaj cov tshuaj zoo heev inertness nyob rau hauv ob qho tib si khoom- xeev cia thiab kua formulations.
Hauv qhov sib piv, txawm hais tias cov kab peptides xws li Argireline kuj tau ua tiav N-terminal acetylation thiab C-terminal amidation los txhim kho kev ruaj ntseg, lawv cov saw tseem ceeb tseem muaj cov pa L- hom -amino acids, ua rau lawv raug rau degradation los ntawm ntau yam peptidases. carboxypeptidases, thiab endopeptidases), ua rau ib nrab luv luv -lub neej.

Txawm hais tias D-alanine (D-Ala) tau nkag mus rau hauv Leuphasyl txhawm rau txhim kho cov metabolism hauv lub cev, nws cov kab ke tag nrho luv luv, thiab nws txoj kev sib raug zoo raug txwv. SYN-AKE's non-natural amino acid hloov kho lub tswv yim ua kom muaj zog enzymatic ntau dua thiab kev ruaj ntseg ntawm cov qib molecular, ua kom nws tuav lub qhov rais ntev ntawm kev ua haujlwm hauv daim tawv nqaij microenvironment thiab yog li ua kom muaj txiaj ntsig zoo dua.

[1]Gok, B., Budama-Kilinc, Y., & Kecel-Gunduz, S. (2024). Anti-kev ua haujlwm ntawm kev laus ntawm Syn-Ake peptide los ntawm kev ua silico thiab hauv vitro kuaj.Phau ntawv Journal of Biomolecular Structure thiab Dynamics, 42(10), 5015–5029. 

[2] Debono, J., Xie, B., Violette, A., Fourmy, R., Jaeger, M., & Fry, BG (2017). Viper venom botox: Lub hauv paus chiv keeb molecular thiab evolution ntawm waglerin peptides siv los tiv thaiv -wrinkle daim tawv nqaij cream.Phau ntawv Journal of Molecular Evolution, 84(1), 8–11.

[3] Zhu, M., He, X., Zhu, Z., & Li, Y. (2026). Cov nyhuv ntawm cov tshuaj uas muaj acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate thiab gluconolactone ntawm daim tawv nqaij biomarkers, wrinkles thiab daim tawv nqaij zoo nkauj: Ex vivo thiab kev tshawb fawb soj ntsuam.International Journal of Cosmetic Science. 

[4]Schagen, SK (2017). Cov tshuaj peptide kev kho mob uas muaj txiaj ntsig los tiv thaiv - cov txiaj ntsig kev laus.Tshuaj pleev ib ce, 4(2), 16. 

[5]Ferreira, MS, Magalhães, MC, Sousa-Lobo, JM, & Almeida, IF (2020). Trending anti{12}}aging peptides.Tshuaj pleev ib ce, 7(3), 58.

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